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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PACSIN2
Full Name:
Protein kinase C and casein kinase substrate in neurons protein 2
Alias:
PACN2; Protein kinase C and casein kinase substrate in neurons 2; SDPII; Syndapin II
Type:
Adaptor/scaffold
Mass (Da):
55739
Number AA:
486
UniProt ID:
Q9UNF0
International Prot ID:
IPI00027009
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
Uniprot
OncoNet
Molecular Function:
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
V
T
Y
D
D
S
V
G
V
E
V
S
S
Site 2
S14
D
S
V
G
V
E
V
S
S
D
S
F
W
E
V
Site 3
S17
G
V
E
V
S
S
D
S
F
W
E
V
G
N
Y
Site 4
Y24
S
F
W
E
V
G
N
Y
K
R
T
V
K
R
I
Site 5
T27
E
V
G
N
Y
K
R
T
V
K
R
I
D
D
G
Site 6
Y55
R
A
R
I
E
K
A
Y
A
Q
Q
L
T
E
W
Site 7
Y76
L
V
E
K
G
P
Q
Y
G
T
V
E
K
A
W
Site 8
T78
E
K
G
P
Q
Y
G
T
V
E
K
A
W
M
A
Site 9
S88
K
A
W
M
A
F
M
S
E
A
E
R
V
S
E
Site 10
S94
M
S
E
A
E
R
V
S
E
L
H
L
E
V
K
Site 11
S103
L
H
L
E
V
K
A
S
L
M
N
D
D
F
E
Site 12
S181
A
N
S
K
A
D
P
S
L
N
P
E
Q
L
K
Site 13
T204
C
K
Q
D
V
L
K
T
K
E
K
Y
E
K
S
Site 14
S211
T
K
E
K
Y
E
K
S
L
K
E
L
D
Q
G
Site 15
T219
L
K
E
L
D
Q
G
T
P
Q
Y
M
E
N
M
Site 16
Y222
L
D
Q
G
T
P
Q
Y
M
E
N
M
E
Q
V
Site 17
S258
V
Q
K
H
L
D
L
S
N
V
A
G
Y
K
A
Site 18
Y267
V
A
G
Y
K
A
I
Y
H
D
L
E
Q
S
I
Site 19
S273
I
Y
H
D
L
E
Q
S
I
R
A
A
D
A
V
Site 20
S305
W
P
Q
F
E
E
W
S
A
D
L
N
R
T
L
Site 21
T311
W
S
A
D
L
N
R
T
L
S
R
R
E
K
K
Site 22
S313
A
D
L
N
R
T
L
S
R
R
E
K
K
K
A
Site 23
T321
R
R
E
K
K
K
A
T
D
G
V
T
L
T
G
Site 24
T325
K
K
A
T
D
G
V
T
L
T
G
I
N
Q
T
Site 25
T327
A
T
D
G
V
T
L
T
G
I
N
Q
T
G
D
Site 26
S336
I
N
Q
T
G
D
Q
S
L
P
S
K
P
S
S
Site 27
S339
T
G
D
Q
S
L
P
S
K
P
S
S
T
L
N
Site 28
S343
S
L
P
S
K
P
S
S
T
L
N
V
P
S
N
Site 29
T344
L
P
S
K
P
S
S
T
L
N
V
P
S
N
P
Site 30
S349
S
S
T
L
N
V
P
S
N
P
A
Q
S
A
Q
Site 31
S354
V
P
S
N
P
A
Q
S
A
Q
S
Q
S
S
Y
Site 32
S357
N
P
A
Q
S
A
Q
S
Q
S
S
Y
N
P
F
Site 33
S360
Q
S
A
Q
S
Q
S
S
Y
N
P
F
E
D
E
Site 34
Y361
S
A
Q
S
Q
S
S
Y
N
P
F
E
D
E
D
Site 35
T370
P
F
E
D
E
D
D
T
G
S
T
V
S
E
K
Site 36
S372
E
D
E
D
D
T
G
S
T
V
S
E
K
D
D
Site 37
S375
D
D
T
G
S
T
V
S
E
K
D
D
T
K
A
Site 38
T380
T
V
S
E
K
D
D
T
K
A
K
N
V
S
S
Site 39
S387
T
K
A
K
N
V
S
S
Y
E
K
T
Q
S
Y
Site 40
Y388
K
A
K
N
V
S
S
Y
E
K
T
Q
S
Y
P
Site 41
T391
N
V
S
S
Y
E
K
T
Q
S
Y
P
T
D
W
Site 42
S393
S
S
Y
E
K
T
Q
S
Y
P
T
D
W
S
D
Site 43
Y394
S
Y
E
K
T
Q
S
Y
P
T
D
W
S
D
D
Site 44
T396
E
K
T
Q
S
Y
P
T
D
W
S
D
D
E
S
Site 45
S399
Q
S
Y
P
T
D
W
S
D
D
E
S
N
N
P
Site 46
S403
T
D
W
S
D
D
E
S
N
N
P
F
S
S
T
Site 47
S408
D
E
S
N
N
P
F
S
S
T
D
A
N
G
D
Site 48
S409
E
S
N
N
P
F
S
S
T
D
A
N
G
D
S
Site 49
T410
S
N
N
P
F
S
S
T
D
A
N
G
D
S
N
Site 50
S416
S
T
D
A
N
G
D
S
N
P
F
D
D
D
A
Site 51
T424
N
P
F
D
D
D
A
T
S
G
T
E
V
R
V
Site 52
S425
P
F
D
D
D
A
T
S
G
T
E
V
R
V
R
Site 53
Y435
E
V
R
V
R
A
L
Y
D
Y
E
G
Q
E
H
Site 54
Y437
R
V
R
A
L
Y
D
Y
E
G
Q
E
H
D
E
Site 55
S446
G
Q
E
H
D
E
L
S
F
K
A
G
D
E
L
Site 56
Y477
D
N
G
Q
V
G
L
Y
P
A
N
Y
V
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation