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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUSP12
Full Name:
Dual specificity protein phosphatase 12
Alias:
Dual specificity tyrosine phosphatase YVH1
Type:
Mass (Da):
37669
Number AA:
340
UniProt ID:
Q9UNI6
International Prot ID:
IPI00009210
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004721
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein phosphatase 12 pan-specific antibody AB-NP046-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP046-1#Dual specificity protein phosphatase 12 pan-specific antibody AB-NP046-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP046-2#Dual specificity protein phosphatase 12 pan-specific antibody AB-NP046-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP046-3#Dual specificity protein phosphatase 12 (A55-G69, human) peptide - Powder PE-01BAL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAL99#Dual specificity protein phosphatase 12 (H237-M251, human) peptide - Powder PE-01BAM99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAM99#Dual specificity protein phosphatase 12 (C309-V324, human) peptide - Powder PE-01BAN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAN99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
S
D
G
C
E
L
S
N
P
S
A
S
R
V
Site 2
S17
G
C
E
L
S
N
P
S
A
S
R
V
S
C
A
Site 3
S19
E
L
S
N
P
S
A
S
R
V
S
C
A
G
Q
Site 4
S22
N
P
S
A
S
R
V
S
C
A
G
Q
M
L
E
Site 5
S61
T
A
V
L
T
V
D
S
E
E
P
S
F
K
A
Site 6
S65
T
V
D
S
E
E
P
S
F
K
A
G
P
G
V
Site 7
T88
P
A
L
D
K
P
E
T
D
L
L
S
H
L
D
Site 8
S92
K
P
E
T
D
L
L
S
H
L
D
R
C
V
A
Site 9
Y165
F
E
W
Q
L
K
L
Y
Q
A
M
G
Y
E
V
Site 10
Y170
K
L
Y
Q
A
M
G
Y
E
V
D
T
S
S
A
Site 11
S176
G
Y
E
V
D
T
S
S
A
I
Y
K
Q
Y
R
Site 12
Y179
V
D
T
S
S
A
I
Y
K
Q
Y
R
L
Q
K
Site 13
Y191
L
Q
K
V
T
E
K
Y
P
E
L
Q
N
L
P
Site 14
S210
A
V
D
P
T
T
V
S
Q
G
L
K
D
E
V
Site 15
Y219
G
L
K
D
E
V
L
Y
K
C
R
K
C
R
R
Site 16
S227
K
C
R
K
C
R
R
S
L
F
R
S
S
S
I
Site 17
S231
C
R
R
S
L
F
R
S
S
S
I
L
D
H
R
Site 18
S232
R
R
S
L
F
R
S
S
S
I
L
D
H
R
E
Site 19
S233
R
S
L
F
R
S
S
S
I
L
D
H
R
E
G
Site 20
S241
I
L
D
H
R
E
G
S
G
P
I
A
F
A
H
Site 21
T252
A
F
A
H
K
R
M
T
P
S
S
M
L
T
T
Site 22
S255
H
K
R
M
T
P
S
S
M
L
T
T
G
R
Q
Site 23
T258
M
T
P
S
S
M
L
T
T
G
R
Q
A
Q
C
Site 24
T259
T
P
S
S
M
L
T
T
G
R
Q
A
Q
C
T
Site 25
T266
T
G
R
Q
A
Q
C
T
S
Y
F
I
E
P
V
Site 26
Y268
R
Q
A
Q
C
T
S
Y
F
I
E
P
V
Q
W
Site 27
Y303
K
L
G
S
F
N
W
Y
G
E
Q
C
S
C
G
Site 28
S335
K
I
L
P
V
L
G
S
Q
T
G
K
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation