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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIMELESS
Full Name:
Protein timeless homologue
Alias:
hTIM; TIM; TIM1; timeless; timeless (Drosophila) homolog
Type:
Transcription, coactivator/corepressor
Mass (Da):
138630
Number AA:
1208
UniProt ID:
Q9UNS1
International Prot ID:
IPI00335541
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000790
GO:0000790
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0046982
GO:0005515
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007623
GO:0009582
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
A
T
C
S
A
L
G
Y
L
E
G
D
T
Y
H
Site 2
T24
L
G
Y
L
E
G
D
T
Y
H
K
E
P
D
C
Site 3
Y25
G
Y
L
E
G
D
T
Y
H
K
E
P
D
C
L
Site 4
S34
K
E
P
D
C
L
E
S
V
K
D
L
I
R
Y
Site 5
Y41
S
V
K
D
L
I
R
Y
L
R
H
E
D
E
T
Site 6
T48
Y
L
R
H
E
D
E
T
R
D
V
R
Q
Q
L
Site 7
T70
S
D
L
L
P
I
L
T
Q
H
H
Q
D
K
P
Site 8
S105
G
N
L
P
K
E
P
S
F
R
H
H
F
L
Q
Site 9
S184
K
K
I
D
D
D
A
S
A
H
D
Q
L
L
W
Site 10
S215
S
S
A
E
E
Q
W
S
L
H
V
L
E
I
V
Site 11
S247
G
R
L
A
Q
E
R
S
A
D
F
A
E
L
E
Site 12
S276
L
Q
R
G
N
R
H
S
R
F
G
G
S
Y
I
Site 13
S281
R
H
S
R
F
G
G
S
Y
I
V
Q
G
L
K
Site 14
Y282
H
S
R
F
G
G
S
Y
I
V
Q
G
L
K
S
Site 15
Y307
G
L
H
N
L
R
N
Y
S
S
D
L
G
K
Q
Site 16
S308
L
H
N
L
R
N
Y
S
S
D
L
G
K
Q
P
Site 17
S309
H
N
L
R
N
Y
S
S
D
L
G
K
Q
P
K
Site 18
S329
R
Q
A
A
R
E
L
S
I
Q
R
R
S
A
L
Site 19
S334
E
L
S
I
Q
R
R
S
A
L
N
V
R
L
F
Site 20
Y354
S
E
F
L
E
N
C
Y
N
R
L
M
G
S
V
Site 21
S360
C
Y
N
R
L
M
G
S
V
K
D
H
L
L
R
Site 22
Y377
A
Q
Q
H
D
E
T
Y
Y
M
W
A
L
A
F
Site 23
S400
S
F
R
P
G
L
V
S
E
T
L
S
V
R
T
Site 24
T402
R
P
G
L
V
S
E
T
L
S
V
R
T
F
H
Site 25
Y418
I
E
Q
N
L
T
N
Y
Y
E
M
M
L
T
D
Site 26
Y419
E
Q
N
L
T
N
Y
Y
E
M
M
L
T
D
R
Site 27
T424
N
Y
Y
E
M
M
L
T
D
R
K
E
A
A
S
Site 28
S431
T
D
R
K
E
A
A
S
W
A
R
R
M
H
L
Site 29
T449
A
Y
Q
E
L
L
A
T
V
N
E
M
D
L
S
Site 30
S456
T
V
N
E
M
D
L
S
P
D
E
A
V
R
E
Site 31
S464
P
D
E
A
V
R
E
S
S
R
I
I
K
N
N
Site 32
S465
D
E
A
V
R
E
S
S
R
I
I
K
N
N
I
Site 33
S497
D
E
R
C
Q
P
R
S
F
L
R
D
L
V
E
Site 34
S552
V
S
G
N
V
P
S
S
P
E
E
V
E
A
V
Site 35
S580
N
S
E
L
S
M
D
S
V
V
P
F
D
A
A
Site 36
T617
G
Q
A
P
Q
A
L
T
L
L
R
S
A
R
E
Site 37
S621
Q
A
L
T
L
L
R
S
A
R
E
V
W
P
E
Site 38
S634
P
E
G
D
V
F
G
S
Q
D
I
S
P
E
E
Site 39
S638
V
F
G
S
Q
D
I
S
P
E
E
E
I
Q
L
Site 40
S651
Q
L
L
K
Q
I
L
S
A
P
L
P
R
Q
Q
Site 41
Y694
K
E
F
N
F
L
D
Y
L
K
R
F
A
C
S
Site 42
Y714
Y
V
L
L
L
R
S
Y
Q
Q
N
S
A
H
T
Site 43
T804
T
A
V
V
R
E
M
T
E
G
Y
G
S
L
D
Site 44
Y807
V
R
E
M
T
E
G
Y
G
S
L
D
D
R
S
Site 45
S809
E
M
T
E
G
Y
G
S
L
D
D
R
S
S
S
Site 46
S814
Y
G
S
L
D
D
R
S
S
S
R
R
A
P
T
Site 47
S815
G
S
L
D
D
R
S
S
S
R
R
A
P
T
W
Site 48
S816
S
L
D
D
R
S
S
S
R
R
A
P
T
W
S
Site 49
T821
S
S
S
R
R
A
P
T
W
S
P
E
E
E
A
Site 50
S823
S
R
R
A
P
T
W
S
P
E
E
E
A
H
L
Site 51
Y834
E
A
H
L
Q
E
L
Y
L
A
N
K
D
V
E
Site 52
T855
A
I
L
A
H
L
N
T
V
P
R
T
R
K
Q
Site 53
S875
V
Q
M
G
L
A
D
S
V
K
D
F
Q
R
K
Site 54
T884
K
D
F
Q
R
K
G
T
H
I
V
L
W
T
G
Site 55
S907
L
F
E
E
F
R
D
S
D
D
V
L
G
H
I
Site 56
T919
G
H
I
M
K
N
I
T
A
K
R
S
R
A
R
Site 57
S923
K
N
I
T
A
K
R
S
R
A
R
I
V
D
K
Site 58
Y944
V
A
E
R
R
E
L
Y
K
K
R
Q
K
K
L
Site 59
S962
I
L
P
N
G
A
E
S
L
K
D
F
C
Q
E
Site 60
S982
E
N
L
P
E
E
D
S
E
E
E
E
E
G
G
Site 61
S990
E
E
E
E
E
G
G
S
E
A
E
Q
V
Q
G
Site 62
S998
E
A
E
Q
V
Q
G
S
L
V
L
S
N
E
N
Site 63
S1002
V
Q
G
S
L
V
L
S
N
E
N
L
G
Q
S
Site 64
S1009
S
N
E
N
L
G
Q
S
L
H
Q
E
G
F
S
Site 65
S1039
D
R
E
E
D
G
C
S
Q
A
V
P
L
V
P
Site 66
T1048
A
V
P
L
V
P
L
T
E
E
N
E
E
A
M
Site 67
S1074
L
G
V
R
P
P
A
S
G
Q
E
T
F
W
R
Site 68
T1078
P
P
A
S
G
Q
E
T
F
W
R
I
P
A
K
Site 69
S1087
W
R
I
P
A
K
L
S
P
T
Q
L
R
R
A
Site 70
T1089
I
P
A
K
L
S
P
T
Q
L
R
R
A
A
A
Site 71
S1097
Q
L
R
R
A
A
A
S
L
S
Q
P
E
E
E
Site 72
S1099
R
R
A
A
A
S
L
S
Q
P
E
E
E
Q
K
Site 73
S1121
K
V
P
G
E
Q
G
S
D
E
E
H
C
K
E
Site 74
S1149
K
K
K
A
G
L
A
S
P
E
E
E
D
A
V
Site 75
S1173
K
K
R
Q
L
L
D
S
D
E
E
Q
E
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation