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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COPS3
Full Name:
COP9 signalosome complex subunit 3
Alias:
COP9 constitutive photomorphogenic homolog subunit 3; COP9 constitutive photomorphogenic subunit 3; CSN3; JAB1-containing signalosome subunit 3; SGN3; Signalosome subunit 3
Type:
Ubiquitin conjugating system
Mass (Da):
47873
Number AA:
423
UniProt ID:
Q9UNS2
International Prot ID:
IPI00025721
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008180
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009416
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
A
L
E
Q
F
V
N
Site 2
S11
A
L
E
Q
F
V
N
S
V
R
Q
L
S
A
Q
Site 3
S16
V
N
S
V
R
Q
L
S
A
Q
G
Q
M
T
Q
Site 4
S31
L
C
E
L
I
N
K
S
G
E
L
L
A
K
N
Site 5
T76
P
S
V
P
D
F
E
T
L
F
S
Q
V
Q
L
Site 6
Y95
C
N
G
E
H
I
R
Y
A
T
D
T
F
A
G
Site 7
T97
G
E
H
I
R
Y
A
T
D
T
F
A
G
L
C
Site 8
T108
A
G
L
C
H
Q
L
T
N
A
L
V
E
R
K
Site 9
Y176
I
C
K
E
N
G
A
Y
D
A
K
H
F
L
C
Site 10
Y203
K
N
F
E
R
A
L
Y
F
Y
E
Q
A
I
T
Site 11
Y205
F
E
R
A
L
Y
F
Y
E
Q
A
I
T
T
P
Site 12
Y224
S
H
I
M
L
E
S
Y
K
K
Y
I
L
V
S
Site 13
Y227
M
L
E
S
Y
K
K
Y
I
L
V
S
L
I
L
Site 14
Y244
K
V
Q
Q
L
P
K
Y
T
S
Q
I
V
G
R
Site 15
T245
V
Q
Q
L
P
K
Y
T
S
Q
I
V
G
R
F
Site 16
S246
Q
Q
L
P
K
Y
T
S
Q
I
V
G
R
F
I
Site 17
S257
G
R
F
I
K
P
L
S
N
A
Y
H
E
L
A
Site 18
S268
H
E
L
A
Q
V
Y
S
T
N
N
P
S
E
L
Site 19
T269
E
L
A
Q
V
Y
S
T
N
N
P
S
E
L
R
Site 20
S273
V
Y
S
T
N
N
P
S
E
L
R
N
L
V
N
Site 21
S283
R
N
L
V
N
K
H
S
E
T
F
T
R
D
N
Site 22
T285
L
V
N
K
H
S
E
T
F
T
R
D
N
N
M
Site 23
T287
N
K
H
S
E
T
F
T
R
D
N
N
M
G
L
Site 24
S301
L
V
K
Q
C
L
S
S
L
Y
K
K
N
I
Q
Site 25
T311
K
K
N
I
Q
R
L
T
K
T
F
L
T
L
S
Site 26
T313
N
I
Q
R
L
T
K
T
F
L
T
L
S
L
Q
Site 27
S318
T
K
T
F
L
T
L
S
L
Q
D
M
A
S
R
Site 28
S324
L
S
L
Q
D
M
A
S
R
V
Q
L
S
G
P
Site 29
Y337
G
P
Q
E
A
E
K
Y
V
L
H
M
I
E
D
Site 30
S350
E
D
G
E
I
F
A
S
I
N
Q
K
D
G
M
Site 31
S359
N
Q
K
D
G
M
V
S
F
H
D
N
P
E
K
Site 32
Y367
F
H
D
N
P
E
K
Y
N
N
P
A
M
L
H
Site 33
T398
K
A
M
D
Q
E
I
T
V
N
P
Q
F
V
Q
Site 34
S407
N
P
Q
F
V
Q
K
S
M
G
S
Q
E
D
D
Site 35
S410
F
V
Q
K
S
M
G
S
Q
E
D
D
S
G
N
Site 36
S415
M
G
S
Q
E
D
D
S
G
N
K
P
S
S
Y
Site 37
S421
D
S
G
N
K
P
S
S
Y
S
_
_
_
_
_
Site 38
Y422
S
G
N
K
P
S
S
Y
S
_
_
_
_
_
_
Site 39
S423
G
N
K
P
S
S
Y
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation