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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP8B1
Full Name:
Alias:
7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;CYPVIIIB1;Cytochrome P450 8B1;Sterol 12-alpha-hydroxylase
Type:
Mass (Da):
58078
Number AA:
501
UniProt ID:
Q9UNU6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
E
P
P
L
D
K
G
T
V
P
W
L
G
H
A
Site 2
T62
E
F
L
K
R
M
R
T
K
H
G
D
V
F
T
Site 3
T69
T
K
H
G
D
V
F
T
V
Q
L
G
G
Q
Y
Site 4
Y76
T
V
Q
L
G
G
Q
Y
F
T
F
V
M
D
P
Site 5
T78
Q
L
G
G
Q
Y
F
T
F
V
M
D
P
L
S
Site 6
T93
F
G
P
I
L
K
D
T
Q
R
K
L
D
F
G
Site 7
Y102
R
K
L
D
F
G
Q
Y
A
K
K
L
V
L
K
Site 8
S115
L
K
V
F
G
Y
R
S
V
Q
G
D
H
E
M
Site 9
S125
G
D
H
E
M
I
H
S
A
S
T
K
H
L
R
Site 10
S127
H
E
M
I
H
S
A
S
T
K
H
L
R
G
D
Site 11
T142
G
L
K
D
L
N
E
T
M
L
D
S
L
S
F
Site 12
Y182
Y
I
L
F
T
A
G
Y
L
S
L
F
G
Y
T
Site 13
Y188
G
Y
L
S
L
F
G
Y
T
K
D
K
E
Q
D
Site 14
S241
R
L
F
H
K
M
L
S
V
S
H
S
Q
E
K
Site 15
S245
K
M
L
S
V
S
H
S
Q
E
K
E
G
I
S
Site 16
S269
L
R
E
Q
G
V
P
S
A
M
Q
D
K
F
N
Site 17
T287
L
W
A
S
Q
G
N
T
G
P
T
S
F
W
A
Site 18
T323
L
G
E
A
R
L
E
T
K
Q
S
F
A
F
K
Site 19
S326
A
R
L
E
T
K
Q
S
F
A
F
K
L
G
A
Site 20
S342
Q
H
T
P
V
L
D
S
V
V
E
E
T
L
R
Site 21
T347
L
D
S
V
V
E
E
T
L
R
L
R
A
A
P
Site 22
Y364
L
R
L
V
H
E
D
Y
T
L
K
M
S
S
G
Site 23
T365
R
L
V
H
E
D
Y
T
L
K
M
S
S
G
Q
Site 24
S369
E
D
Y
T
L
K
M
S
S
G
Q
E
Y
L
F
Site 25
S370
D
Y
T
L
K
M
S
S
G
Q
E
Y
L
F
R
Site 26
Y374
K
M
S
S
G
Q
E
Y
L
F
R
H
G
D
I
Site 27
Y405
P
E
P
T
V
F
K
Y
D
R
F
L
N
P
N
Site 28
S414
R
F
L
N
P
N
G
S
R
K
V
D
F
F
K
Site 29
T422
R
K
V
D
F
F
K
T
G
K
K
I
H
H
Y
Site 30
Y429
T
G
K
K
I
H
H
Y
T
M
P
W
G
S
G
Site 31
T470
L
E
L
V
D
P
D
T
P
L
P
H
V
D
P
Site 32
Y495
S
H
D
V
R
F
R
Y
R
L
H
P
T
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation