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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A4
Full Name:
Solute carrier family 12 member 4
Alias:
Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; HKCC1; KCC1; Potassium transport protein; Potassium/chloride cotransporter 1; S12A4; Solute carrier family 12 (potassium/chloride transporters) member 4; Solute carrier family 12 (potassium/chloride transporters), member 4
Type:
Membrane protein, integral; Transporter
Mass (Da):
120650
Number AA:
1085
UniProt ID:
Q9UP95
International Prot ID:
IPI00021057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0015379
GO:0008324
PhosphoSite+
KinaseNET
Biological Process:
GO:0006884
GO:0006821
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
D
G
P
R
R
G
D
Y
D
N
L
E
G
L
S
Site 2
S24
Y
D
N
L
E
G
L
S
W
V
D
Y
G
E
R
Site 3
Y28
E
G
L
S
W
V
D
Y
G
E
R
A
E
L
D
Site 4
S37
E
R
A
E
L
D
D
S
D
G
H
G
N
H
R
Site 5
S46
G
H
G
N
H
R
E
S
S
P
F
L
S
P
L
Site 6
S47
H
G
N
H
R
E
S
S
P
F
L
S
P
L
E
Site 7
S51
R
E
S
S
P
F
L
S
P
L
E
A
S
R
G
Site 8
Y61
E
A
S
R
G
I
D
Y
Y
D
R
N
L
A
L
Site 9
Y62
A
S
R
G
I
D
Y
Y
D
R
N
L
A
L
F
Site 10
S88
S
L
L
G
K
L
V
S
Y
T
N
L
T
Q
G
Site 11
Y89
L
L
G
K
L
V
S
Y
T
N
L
T
Q
G
A
Site 12
T108
E
A
E
S
G
E
G
T
R
R
R
A
A
E
A
Site 13
S190
G
G
S
Y
F
M
I
S
R
S
L
G
P
E
F
Site 14
S192
S
Y
F
M
I
S
R
S
L
G
P
E
F
G
G
Site 15
Y236
A
P
P
A
A
I
F
Y
P
S
G
A
H
D
T
Site 16
S244
P
S
G
A
H
D
T
S
N
A
T
L
N
N
M
Site 17
T260
V
Y
G
T
I
F
L
T
F
M
T
L
V
V
F
Site 18
T263
T
I
F
L
T
F
M
T
L
V
V
F
V
G
V
Site 19
T314
V
C
M
L
G
N
R
T
L
S
R
D
Q
F
D
Site 20
S316
M
L
G
N
R
T
L
S
R
D
Q
F
D
I
C
Site 21
S345
L
W
S
F
F
C
H
S
P
N
L
T
T
D
S
Site 22
T349
F
C
H
S
P
N
L
T
T
D
S
C
D
P
Y
Site 23
S352
S
P
N
L
T
T
D
S
C
D
P
Y
F
M
L
Site 24
Y356
T
T
D
S
C
D
P
Y
F
M
L
N
N
V
T
Site 25
Y384
Q
E
N
L
W
S
A
Y
L
E
K
G
D
I
V
Site 26
S403
L
P
S
A
D
A
P
S
L
K
E
S
L
P
L
Site 27
S438
V
T
G
I
M
A
G
S
N
R
S
G
D
L
R
Site 28
S450
D
L
R
D
A
Q
K
S
I
P
V
G
T
I
L
Site 29
Y486
G
V
V
L
R
D
K
Y
G
D
G
V
S
R
N
Site 30
S491
D
K
Y
G
D
G
V
S
R
N
L
V
V
G
T
Site 31
T498
S
R
N
L
V
V
G
T
L
A
W
P
S
P
W
Site 32
T604
A
V
Q
T
L
L
R
T
P
N
W
R
P
R
F
Site 33
Y651
I
A
G
M
I
Y
K
Y
I
E
Y
Q
G
A
E
Site 34
S669
G
D
G
I
R
G
L
S
L
S
A
A
R
Y
A
Site 35
T687
L
E
E
G
P
P
H
T
K
N
W
R
P
Q
L
Site 36
Y708
D
E
D
L
H
V
K
Y
P
R
L
L
T
F
A
Site 37
S716
P
R
L
L
T
F
A
S
Q
L
K
A
G
K
G
Site 38
T725
L
K
A
G
K
G
L
T
I
V
G
S
V
I
Q
Site 39
S738
I
Q
G
S
F
L
E
S
Y
G
E
A
Q
A
A
Site 40
Y739
Q
G
S
F
L
E
S
Y
G
E
A
Q
A
A
E
Site 41
Y797
S
V
V
L
G
W
P
Y
G
W
R
Q
S
E
D
Site 42
T810
E
D
P
R
A
W
K
T
F
I
D
T
V
R
C
Site 43
Y834
V
P
K
N
I
A
F
Y
P
S
N
H
E
R
Y
Site 44
Y923
S
D
I
S
A
Y
T
Y
E
R
T
L
M
M
E
Site 45
T926
S
A
Y
T
Y
E
R
T
L
M
M
E
Q
R
S
Site 46
T942
M
L
R
Q
M
R
L
T
K
T
E
R
E
R
E
Site 47
T944
R
Q
M
R
L
T
K
T
E
R
E
R
E
A
Q
Site 48
S958
Q
L
V
K
D
R
H
S
A
L
R
L
E
S
L
Site 49
S964
H
S
A
L
R
L
E
S
L
Y
S
D
E
E
D
Site 50
Y966
A
L
R
L
E
S
L
Y
S
D
E
E
D
E
S
Site 51
S967
L
R
L
E
S
L
Y
S
D
E
E
D
E
S
A
Site 52
S973
Y
S
D
E
E
D
E
S
A
V
G
A
D
K
I
Site 53
T983
G
A
D
K
I
Q
M
T
W
T
R
D
K
Y
M
Site 54
T993
R
D
K
Y
M
T
E
T
W
D
P
S
H
A
P
Site 55
T1021
S
N
V
R
R
M
H
T
A
V
K
L
N
E
V
Site 56
T1031
K
L
N
E
V
I
V
T
R
S
H
D
A
R
L
Site 57
S1050
M
P
G
P
P
R
N
S
E
G
D
E
N
Y
M
Site 58
Y1056
N
S
E
G
D
E
N
Y
M
E
F
L
E
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation