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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP4E1
Full Name:
AP-4 complex subunit epsilon-1
Alias:
Adapter-related protein complex 4 epsilon-1; Adapter-related protein complex 4 subunit epsilon-1; AP-4 adapter complex epsilon; AP-4-epsilon; Epsilon subunit of AP-4; Epsilon-adaptin
Type:
Adaptor/scaffold
Mass (Da):
127287
Number AA:
1137
UniProt ID:
Q9UPM8
International Prot ID:
IPI00010213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030126
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
G
P
A
A
A
K
A
S
F
S
S
R
L
G
S
Site 2
S34
A
A
K
A
S
F
S
S
R
L
G
S
L
V
R
Site 3
T44
G
S
L
V
R
G
I
T
A
L
T
S
K
H
E
Site 4
S48
R
G
I
T
A
L
T
S
K
H
E
E
E
K
L
Site 5
S61
K
L
I
Q
Q
E
L
S
S
L
K
A
T
V
S
Site 6
T66
E
L
S
S
L
K
A
T
V
S
A
P
T
T
T
Site 7
S68
S
S
L
K
A
T
V
S
A
P
T
T
T
L
K
Site 8
T72
A
T
V
S
A
P
T
T
T
L
K
M
M
K
E
Site 9
S225
D
V
G
V
M
A
A
S
L
H
I
Y
L
R
M
Site 10
T244
S
S
G
Y
K
D
L
T
G
S
F
V
T
I
L
Site 11
S246
G
Y
K
D
L
T
G
S
F
V
T
I
L
K
Q
Site 12
Y265
K
L
P
V
E
F
N
Y
H
S
V
P
A
P
W
Site 13
T291
L
G
K
D
D
Q
R
T
S
E
L
M
Y
D
V
Site 14
S292
G
K
D
D
Q
R
T
S
E
L
M
Y
D
V
L
Site 15
Y296
Q
R
T
S
E
L
M
Y
D
V
L
D
E
S
L
Site 16
S302
M
Y
D
V
L
D
E
S
L
R
R
A
E
L
N
Site 17
S326
E
C
V
H
T
V
Y
S
I
Y
P
K
S
E
L
Site 18
Y328
V
H
T
V
Y
S
I
Y
P
K
S
E
L
L
E
Site 19
S331
V
Y
S
I
Y
P
K
S
E
L
L
E
K
A
A
Site 20
T369
Y
V
I
Q
Q
D
P
T
L
A
L
Q
H
Q
M
Site 21
T393
D
P
I
I
K
R
E
T
L
E
L
L
Y
R
I
Site 22
Y398
R
E
T
L
E
L
L
Y
R
I
T
N
A
Q
N
Site 23
T407
I
T
N
A
Q
N
I
T
V
I
V
Q
K
M
L
Site 24
Y416
I
V
Q
K
M
L
E
Y
L
H
Q
S
K
E
E
Site 25
Y424
L
H
Q
S
K
E
E
Y
V
I
V
N
L
V
G
Site 26
T482
A
E
G
F
D
D
E
T
E
D
Q
Q
L
R
L
Site 27
Y490
E
D
Q
Q
L
R
L
Y
A
V
Q
S
Y
L
T
Site 28
Y506
L
D
M
E
N
V
F
Y
P
Q
R
F
L
Q
V
Site 29
T529
S
Y
L
L
D
K
E
T
P
E
E
V
I
A
K
Site 30
S545
Y
K
L
L
M
N
D
S
V
S
S
E
T
K
A
Site 31
S547
L
L
M
N
D
S
V
S
S
E
T
K
A
W
L
Site 32
S563
A
A
V
T
K
L
T
S
Q
A
H
S
S
N
T
Site 33
T570
S
Q
A
H
S
S
N
T
V
E
R
L
I
H
E
Site 34
S605
E
N
V
E
L
M
K
S
L
L
P
V
D
R
S
Site 35
S634
G
F
V
A
E
G
L
S
Q
G
A
A
P
Y
K
Site 36
Y640
L
S
Q
G
A
A
P
Y
K
P
P
H
Q
R
Q
Site 37
S652
Q
R
Q
E
E
K
L
S
Q
E
K
V
L
N
F
Site 38
Y662
K
V
L
N
F
E
P
Y
G
L
S
F
S
S
S
Site 39
S665
N
F
E
P
Y
G
L
S
F
S
S
S
G
F
T
Site 40
S667
E
P
Y
G
L
S
F
S
S
S
G
F
T
G
R
Site 41
S669
Y
G
L
S
F
S
S
S
G
F
T
G
R
Q
S
Site 42
T672
S
F
S
S
S
G
F
T
G
R
Q
S
P
A
G
Site 43
S676
S
G
F
T
G
R
Q
S
P
A
G
I
S
L
G
Site 44
S681
R
Q
S
P
A
G
I
S
L
G
S
D
V
S
G
Site 45
S684
P
A
G
I
S
L
G
S
D
V
S
G
N
S
A
Site 46
S687
I
S
L
G
S
D
V
S
G
N
S
A
E
T
G
Site 47
S700
T
G
L
K
E
T
N
S
L
K
L
E
G
I
K
Site 48
Y715
K
L
W
G
K
E
G
Y
L
P
K
K
E
S
K
Site 49
S721
G
Y
L
P
K
K
E
S
K
T
G
D
E
S
G
Site 50
T723
L
P
K
K
E
S
K
T
G
D
E
S
G
A
L
Site 51
S751
A
I
T
K
K
D
Q
S
Q
V
L
T
Q
S
K
Site 52
T755
K
D
Q
S
Q
V
L
T
Q
S
K
E
E
K
E
Site 53
S757
Q
S
Q
V
L
T
Q
S
K
E
E
K
E
K
Q
Site 54
T788
N
L
L
G
K
A
D
T
V
S
H
K
F
R
R
Site 55
S790
L
G
K
A
D
T
V
S
H
K
F
R
R
K
S
Site 56
S797
S
H
K
F
R
R
K
S
K
V
K
E
A
K
S
Site 57
S804
S
K
V
K
E
A
K
S
G
E
T
T
S
T
H
Site 58
T808
E
A
K
S
G
E
T
T
S
T
H
N
M
T
C
Site 59
S809
A
K
S
G
E
T
T
S
T
H
N
M
T
C
S
Site 60
T810
K
S
G
E
T
T
S
T
H
N
M
T
C
S
S
Site 61
T814
T
T
S
T
H
N
M
T
C
S
S
F
S
S
L
Site 62
S816
S
T
H
N
M
T
C
S
S
F
S
S
L
S
N
Site 63
S817
T
H
N
M
T
C
S
S
F
S
S
L
S
N
V
Site 64
S820
M
T
C
S
S
F
S
S
L
S
N
V
A
Y
E
Site 65
S822
C
S
S
F
S
S
L
S
N
V
A
Y
E
D
D
Site 66
Y826
S
S
L
S
N
V
A
Y
E
D
D
Y
Y
S
N
Site 67
Y830
N
V
A
Y
E
D
D
Y
Y
S
N
T
L
H
D
Site 68
Y831
V
A
Y
E
D
D
Y
Y
S
N
T
L
H
D
T
Site 69
S832
A
Y
E
D
D
Y
Y
S
N
T
L
H
D
T
G
Site 70
T834
E
D
D
Y
Y
S
N
T
L
H
D
T
G
D
K
Site 71
T838
Y
S
N
T
L
H
D
T
G
D
K
E
L
K
K
Site 72
S847
D
K
E
L
K
K
F
S
L
T
S
E
L
L
D
Site 73
S850
L
K
K
F
S
L
T
S
E
L
L
D
S
E
S
Site 74
S855
L
T
S
E
L
L
D
S
E
S
L
T
E
L
P
Site 75
S857
S
E
L
L
D
S
E
S
L
T
E
L
P
L
V
Site 76
T859
L
L
D
S
E
S
L
T
E
L
P
L
V
E
K
Site 77
S868
L
P
L
V
E
K
F
S
Y
C
S
L
S
T
P
Site 78
Y869
P
L
V
E
K
F
S
Y
C
S
L
S
T
P
S
Site 79
S871
V
E
K
F
S
Y
C
S
L
S
T
P
S
L
F
Site 80
S873
K
F
S
Y
C
S
L
S
T
P
S
L
F
A
N
Site 81
T874
F
S
Y
C
S
L
S
T
P
S
L
F
A
N
N
Site 82
S876
Y
C
S
L
S
T
P
S
L
F
A
N
N
N
M
Site 83
S891
E
I
F
H
P
P
Q
S
T
A
A
S
V
A
K
Site 84
S895
P
P
Q
S
T
A
A
S
V
A
K
E
S
S
L
Site 85
S904
A
K
E
S
S
L
A
S
S
F
L
E
E
T
T
Site 86
S905
K
E
S
S
L
A
S
S
F
L
E
E
T
T
E
Site 87
Y913
F
L
E
E
T
T
E
Y
I
H
S
N
A
M
E
Site 88
T926
M
E
V
C
N
N
E
T
I
S
V
S
S
Y
K
Site 89
Y932
E
T
I
S
V
S
S
Y
K
I
W
K
D
D
C
Site 90
S956
K
S
G
L
E
L
K
S
A
D
L
E
I
F
P
Site 91
T970
P
A
E
N
F
K
V
T
E
Q
P
G
C
C
L
Site 92
S984
L
P
V
M
E
A
E
S
T
K
S
F
Q
Y
S
Site 93
T985
P
V
M
E
A
E
S
T
K
S
F
Q
Y
S
V
Site 94
S987
M
E
A
E
S
T
K
S
F
Q
Y
S
V
Q
I
Site 95
S991
S
T
K
S
F
Q
Y
S
V
Q
I
E
K
P
F
Site 96
T999
V
Q
I
E
K
P
F
T
E
G
N
L
T
G
F
Site 97
T1004
P
F
T
E
G
N
L
T
G
F
I
S
Y
H
M
Site 98
T1014
I
S
Y
H
M
M
D
T
H
S
A
Q
L
E
F
Site 99
S1037
F
I
R
P
L
K
I
S
S
D
D
F
G
K
L
Site 100
S1038
I
R
P
L
K
I
S
S
D
D
F
G
K
L
W
Site 101
S1047
D
F
G
K
L
W
L
S
F
A
N
D
V
K
Q
Site 102
S1061
Q
N
V
K
M
S
E
S
Q
A
A
L
P
S
A
Site 103
T1071
A
L
P
S
A
L
K
T
L
Q
Q
K
L
R
L
Site 104
T1121
W
F
R
S
S
C
S
T
L
P
D
Y
L
L
Y
Site 105
Y1125
S
C
S
T
L
P
D
Y
L
L
Y
Q
C
Q
K
Site 106
Y1128
T
L
P
D
Y
L
L
Y
Q
C
Q
K
V
M
E
Site 107
S1137
C
Q
K
V
M
E
G
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation