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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQSEC3
Full Name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Alias:
IQ motif and Sec7 domain-containing 3; IQEC3
Type:
Intracellular, Cytoplasm protein
Mass (Da):
127621
Number AA:
1182
UniProt ID:
Q9UPP2
International Prot ID:
IPI00739462
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
A
I
V
Q
N
Q
Q
S
L
I
H
T
Q
R
E
Site 2
T31
N
Q
Q
S
L
I
H
T
Q
R
E
R
I
D
E
Site 3
S47
E
R
R
L
D
E
L
S
A
E
N
R
S
L
W
Site 4
S101
L
Q
D
Q
G
Q
R
S
A
A
A
P
H
P
A
Site 5
S130
Q
P
Q
R
G
P
G
S
R
A
H
T
P
Q
S
Site 6
T134
G
P
G
S
R
A
H
T
P
Q
S
P
H
K
H
Site 7
S137
S
R
A
H
T
P
Q
S
P
H
K
H
L
G
T
Site 8
S158
K
E
K
E
R
P
P
S
C
C
A
A
A
G
A
Site 9
S171
G
A
L
L
Q
H
K
S
P
S
A
L
G
K
G
Site 10
S173
L
L
Q
H
K
S
P
S
A
L
G
K
G
V
L
Site 11
S181
A
L
G
K
G
V
L
S
R
R
P
E
N
E
T
Site 12
T188
S
R
R
P
E
N
E
T
V
L
H
Q
F
C
C
Site 13
S202
C
P
A
A
D
A
C
S
D
L
A
S
Q
S
D
Site 14
S206
D
A
C
S
D
L
A
S
Q
S
D
G
S
C
T
Site 15
S208
C
S
D
L
A
S
Q
S
D
G
S
C
T
Q
A
Site 16
S211
L
A
S
Q
S
D
G
S
C
T
Q
A
G
G
G
Site 17
T213
S
Q
S
D
G
S
C
T
Q
A
G
G
G
M
E
Site 18
S235
A
V
A
A
G
R
P
S
A
H
A
P
K
A
Q
Site 19
S259
R
P
G
A
G
A
A
S
P
R
A
G
P
Q
H
Site 20
S269
A
G
P
Q
H
K
A
S
P
G
R
Q
Q
P
A
Site 21
S289
C
P
H
A
P
A
A
S
D
Y
E
L
S
L
D
Site 22
Y291
H
A
P
A
A
S
D
Y
E
L
S
L
D
L
K
Site 23
Y309
I
E
M
L
E
H
K
Y
G
G
H
L
V
S
R
Site 24
S315
K
Y
G
G
H
L
V
S
R
R
A
A
C
T
I
Site 25
T321
V
S
R
R
A
A
C
T
I
Q
T
A
F
R
Q
Site 26
Y329
I
Q
T
A
F
R
Q
Y
Q
L
S
K
N
F
E
Site 27
S332
A
F
R
Q
Y
Q
L
S
K
N
F
E
K
I
R
Site 28
S341
N
F
E
K
I
R
N
S
L
L
E
S
R
L
P
Site 29
S345
I
R
N
S
L
L
E
S
R
L
P
R
R
I
S
Site 30
S352
S
R
L
P
R
R
I
S
L
R
K
V
R
S
P
Site 31
S358
I
S
L
R
K
V
R
S
P
T
A
E
S
L
A
Site 32
T360
L
R
K
V
R
S
P
T
A
E
S
L
A
A
E
Site 33
S363
V
R
S
P
T
A
E
S
L
A
A
E
K
A
L
Site 34
T390
R
S
P
S
L
P
P
T
F
A
G
T
L
T
E
Site 35
T396
P
T
F
A
G
T
L
T
E
L
E
D
S
F
T
Site 36
S401
T
L
T
E
L
E
D
S
F
T
E
Q
V
Q
S
Site 37
T403
T
E
L
E
D
S
F
T
E
Q
V
Q
S
L
A
Site 38
S408
S
F
T
E
Q
V
Q
S
L
A
K
S
I
D
D
Site 39
S412
Q
V
Q
S
L
A
K
S
I
D
D
A
L
S
T
Site 40
S418
K
S
I
D
D
A
L
S
T
W
S
L
K
T
M
Site 41
T419
S
I
D
D
A
L
S
T
W
S
L
K
T
M
C
Site 42
S421
D
D
A
L
S
T
W
S
L
K
T
M
C
S
L
Site 43
T424
L
S
T
W
S
L
K
T
M
C
S
L
R
E
S
Site 44
S427
W
S
L
K
T
M
C
S
L
R
E
S
G
A
Y
Site 45
S431
T
M
C
S
L
R
E
S
G
A
Y
Q
L
H
Q
Site 46
Y434
S
L
R
E
S
G
A
Y
Q
L
H
Q
A
L
Q
Site 47
S458
A
E
G
R
A
P
E
S
A
G
P
G
P
G
D
Site 48
T470
P
G
D
D
A
A
E
T
P
G
L
P
P
A
H
Site 49
S498
Q
I
A
N
Q
N
I
S
V
S
S
S
T
A
L
Site 50
S533
K
A
E
Q
G
E
T
S
G
R
E
A
P
E
A
Site 51
S549
A
V
G
R
E
D
A
S
A
E
D
S
C
A
E
Site 52
S553
E
D
A
S
A
E
D
S
C
A
E
A
A
A
S
Site 53
T567
S
G
A
A
D
G
A
T
A
P
K
T
E
E
E
Site 54
T571
D
G
A
T
A
P
K
T
E
E
E
E
E
E
E
Site 55
T580
E
E
E
E
E
E
E
T
A
E
V
G
R
G
A
Site 56
S598
A
G
D
L
E
Q
L
S
S
S
S
T
S
T
K
Site 57
S599
G
D
L
E
Q
L
S
S
S
S
T
S
T
K
S
Site 58
S601
L
E
Q
L
S
S
S
S
T
S
T
K
S
A
K
Site 59
T602
E
Q
L
S
S
S
S
T
S
T
K
S
A
K
S
Site 60
S603
Q
L
S
S
S
S
T
S
T
K
S
A
K
S
G
Site 61
T604
L
S
S
S
S
T
S
T
K
S
A
K
S
G
S
Site 62
S606
S
S
S
T
S
T
K
S
A
K
S
G
S
E
A
Site 63
S609
T
S
T
K
S
A
K
S
G
S
E
A
S
A
S
Site 64
S611
T
K
S
A
K
S
G
S
E
A
S
A
S
A
S
Site 65
S614
A
K
S
G
S
E
A
S
A
S
A
S
K
D
A
Site 66
S616
S
G
S
E
A
S
A
S
A
S
K
D
A
L
Q
Site 67
S618
S
E
A
S
A
S
A
S
K
D
A
L
Q
A
M
Site 68
Y632
M
I
L
S
L
P
R
Y
H
C
E
N
P
A
S
Site 69
S639
Y
H
C
E
N
P
A
S
C
K
S
P
T
L
S
Site 70
S642
E
N
P
A
S
C
K
S
P
T
L
S
T
D
T
Site 71
T644
P
A
S
C
K
S
P
T
L
S
T
D
T
L
R
Site 72
S646
S
C
K
S
P
T
L
S
T
D
T
L
R
K
R
Site 73
T647
C
K
S
P
T
L
S
T
D
T
L
R
K
R
L
Site 74
T649
S
P
T
L
S
T
D
T
L
R
K
R
L
Y
R
Site 75
Y655
D
T
L
R
K
R
L
Y
R
I
G
L
N
L
F
Site 76
S708
I
G
E
F
L
G
N
S
K
K
Q
F
N
R
D
Site 77
S727
V
V
D
E
M
D
F
S
S
M
E
L
D
E
A
Site 78
S728
V
D
E
M
D
F
S
S
M
E
L
D
E
A
L
Site 79
Y794
I
L
L
N
T
D
M
Y
S
P
N
I
K
P
D
Site 80
S795
L
L
N
T
D
M
Y
S
P
N
I
K
P
D
R
Site 81
Y831
R
E
L
V
V
G
I
Y
E
R
I
Q
Q
K
E
Site 82
S841
I
Q
Q
K
E
L
K
S
N
E
D
H
V
T
Y
Site 83
T847
K
S
N
E
D
H
V
T
Y
V
T
K
V
E
K
Site 84
Y848
S
N
E
D
H
V
T
Y
V
T
K
V
E
K
S
Site 85
S874
H
R
R
L
V
C
C
S
R
L
F
E
V
T
D
Site 86
T880
C
S
R
L
F
E
V
T
D
V
N
K
L
Q
K
Site 87
S913
K
L
C
P
K
K
K
S
S
S
T
Y
T
F
C
Site 88
S915
C
P
K
K
K
S
S
S
T
Y
T
F
C
K
S
Site 89
T918
K
K
S
S
S
T
Y
T
F
C
K
S
V
G
L
Site 90
Y937
F
Q
L
F
E
N
E
Y
Y
S
H
G
I
T
L
Site 91
Y938
Q
L
F
E
N
E
Y
Y
S
H
G
I
T
L
V
Site 92
T943
E
Y
Y
S
H
G
I
T
L
V
T
P
L
S
G
Site 93
T946
S
H
G
I
T
L
V
T
P
L
S
G
S
E
K
Site 94
S949
I
T
L
V
T
P
L
S
G
S
E
K
K
Q
V
Site 95
T1001
E
K
Q
Q
G
T
K
T
L
S
F
K
P
C
G
Site 96
S1003
Q
Q
G
T
K
T
L
S
F
K
P
C
G
A
Q
Site 97
S1015
G
A
Q
G
D
P
Q
S
K
Q
G
S
P
T
A
Site 98
S1019
D
P
Q
S
K
Q
G
S
P
T
A
K
R
E
A
Site 99
T1036
R
E
R
P
A
E
S
T
V
E
V
S
I
H
N
Site 100
T1047
S
I
H
N
R
L
Q
T
S
Q
H
N
S
G
L
Site 101
S1048
I
H
N
R
L
Q
T
S
Q
H
N
S
G
L
G
Site 102
S1052
L
Q
T
S
Q
H
N
S
G
L
G
A
E
R
G
Site 103
S1070
P
P
P
D
L
Q
P
S
P
P
R
Q
Q
T
P
Site 104
T1076
P
S
P
P
R
Q
Q
T
P
P
L
P
P
P
P
Site 105
T1085
P
L
P
P
P
P
P
T
P
P
G
T
L
V
Q
Site 106
T1089
P
P
P
T
P
P
G
T
L
V
Q
C
Q
Q
I
Site 107
S1119
P
L
L
S
Q
A
L
S
C
Y
T
S
S
S
S
Site 108
Y1121
L
S
Q
A
L
S
C
Y
T
S
S
S
S
D
S
Site 109
T1122
S
Q
A
L
S
C
Y
T
S
S
S
S
D
S
C
Site 110
S1123
Q
A
L
S
C
Y
T
S
S
S
S
D
S
C
G
Site 111
S1124
A
L
S
C
Y
T
S
S
S
S
D
S
C
G
S
Site 112
S1125
L
S
C
Y
T
S
S
S
S
D
S
C
G
S
T
Site 113
S1126
S
C
Y
T
S
S
S
S
D
S
C
G
S
T
P
Site 114
S1128
Y
T
S
S
S
S
D
S
C
G
S
T
P
L
G
Site 115
S1131
S
S
S
D
S
C
G
S
T
P
L
G
G
P
G
Site 116
T1132
S
S
D
S
C
G
S
T
P
L
G
G
P
G
S
Site 117
S1139
T
P
L
G
G
P
G
S
P
V
K
V
T
H
Q
Site 118
T1144
P
G
S
P
V
K
V
T
H
Q
P
P
L
P
P
Site 119
Y1156
L
P
P
P
P
P
P
Y
N
H
P
H
Q
F
C
Site 120
Y1174
S
L
L
H
G
H
R
Y
S
S
G
S
R
S
L
Site 121
S1175
L
L
H
G
H
R
Y
S
S
G
S
R
S
L
V
Site 122
S1176
L
H
G
H
R
Y
S
S
G
S
R
S
L
V
_
Site 123
S1178
G
H
R
Y
S
S
G
S
R
S
L
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation