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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZRN3
Full Name:
PDZ domain-containing RING finger protein 3
Alias:
Ligand of Numb-protein X 3; LNX3; PDZ domain containing RING finger 3; PZRN3; SEMACAP3; semaphorin cytoplasmic domain-associated 3; SEMCAP3
Type:
Uncharacterized
Mass (Da):
119596
Number AA:
1066
UniProt ID:
Q9UPQ7
International Prot ID:
IPI00010322
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S61
A
R
C
R
G
R
L
S
A
K
E
L
N
H
V
Site 2
Y84
K
L
D
I
K
C
A
Y
A
T
R
G
C
G
R
Site 3
T151
E
G
C
G
L
P
L
T
H
G
E
Q
R
A
G
Site 4
S197
R
A
G
K
R
E
K
S
L
V
A
Q
L
A
A
Site 5
T212
A
Q
L
E
L
Q
M
T
A
L
R
Y
Q
K
K
Site 6
Y216
L
Q
M
T
A
L
R
Y
Q
K
K
F
T
E
Y
Site 7
S224
Q
K
K
F
T
E
Y
S
A
R
L
D
S
L
S
Site 8
S229
E
Y
S
A
R
L
D
S
L
S
R
C
V
A
A
Site 9
S231
S
A
R
L
D
S
L
S
R
C
V
A
A
P
P
Site 10
T245
P
G
G
K
G
E
E
T
K
S
L
T
L
V
L
Site 11
S247
G
K
G
E
E
T
K
S
L
T
L
V
L
H
R
Site 12
S269
N
I
I
G
G
R
P
S
V
D
N
H
D
G
S
Site 13
S276
S
V
D
N
H
D
G
S
S
S
E
G
I
F
V
Site 14
S277
V
D
N
H
D
G
S
S
S
E
G
I
F
V
S
Site 15
S278
D
N
H
D
G
S
S
S
E
G
I
F
V
S
K
Site 16
S284
S
S
E
G
I
F
V
S
K
I
V
D
S
G
P
Site 17
S313
E
V
N
G
R
D
L
S
R
A
T
H
D
Q
A
Site 18
T316
G
R
D
L
S
R
A
T
H
D
Q
A
V
E
A
Site 19
T339
V
V
Q
V
L
R
R
T
P
R
T
K
M
F
T
Site 20
T342
V
L
R
R
T
P
R
T
K
M
F
T
P
P
S
Site 21
T346
T
P
R
T
K
M
F
T
P
P
S
E
S
Q
L
Site 22
S349
T
K
M
F
T
P
P
S
E
S
Q
L
V
D
T
Site 23
T358
S
Q
L
V
D
T
G
T
Q
T
D
I
T
F
E
Site 24
T371
F
E
H
I
M
A
L
T
K
M
S
S
P
S
P
Site 25
S375
M
A
L
T
K
M
S
S
P
S
P
P
V
L
D
Site 26
S377
L
T
K
M
S
S
P
S
P
P
V
L
D
P
Y
Site 27
Y384
S
P
P
V
L
D
P
Y
L
L
P
E
E
H
P
Site 28
S392
L
L
P
E
E
H
P
S
A
H
E
Y
Y
D
P
Site 29
Y396
E
H
P
S
A
H
E
Y
Y
D
P
N
D
Y
I
Site 30
Y402
E
Y
Y
D
P
N
D
Y
I
G
D
I
H
Q
E
Site 31
Y423
E
L
E
E
V
D
L
Y
R
M
N
S
Q
D
K
Site 32
S427
V
D
L
Y
R
M
N
S
Q
D
K
L
G
L
T
Site 33
T434
S
Q
D
K
L
G
L
T
V
C
Y
R
T
D
D
Site 34
Y448
D
E
D
D
I
G
I
Y
I
S
E
I
D
P
N
Site 35
S450
D
D
I
G
I
Y
I
S
E
I
D
P
N
S
I
Site 36
S456
I
S
E
I
D
P
N
S
I
A
A
K
D
G
R
Site 37
S490
E
A
V
A
L
L
T
S
E
E
N
K
N
F
S
Site 38
T554
K
H
D
E
D
G
G
T
T
D
T
A
T
I
L
Site 39
T557
E
D
G
G
T
T
D
T
A
T
I
L
S
N
Q
Site 40
T559
G
G
T
T
D
T
A
T
I
L
S
N
Q
H
E
Site 41
S577
G
V
G
R
T
D
E
S
T
R
N
D
E
S
S
Site 42
T578
V
G
R
T
D
E
S
T
R
N
D
E
S
S
E
Site 43
S584
S
T
R
N
D
E
S
S
E
Q
E
N
N
G
D
Site 44
T594
E
N
N
G
D
D
A
T
A
S
S
N
P
L
A
Site 45
S596
N
G
D
D
A
T
A
S
S
N
P
L
A
G
Q
Site 46
S597
G
D
D
A
T
A
S
S
N
P
L
A
G
Q
R
Site 47
T607
L
A
G
Q
R
K
L
T
C
S
Q
D
T
L
G
Site 48
S609
G
Q
R
K
L
T
C
S
Q
D
T
L
G
S
G
Site 49
S621
G
S
G
D
L
P
F
S
N
E
S
F
I
S
A
Site 50
S624
D
L
P
F
S
N
E
S
F
I
S
A
D
C
T
Site 51
S627
F
S
N
E
S
F
I
S
A
D
C
T
D
A
D
Site 52
Y635
A
D
C
T
D
A
D
Y
L
G
I
P
V
D
E
Site 53
S658
E
L
K
C
Q
V
K
S
A
T
P
Y
G
L
Y
Site 54
T660
K
C
Q
V
K
S
A
T
P
Y
G
L
Y
Y
P
Site 55
Y662
Q
V
K
S
A
T
P
Y
G
L
Y
Y
P
S
G
Site 56
Y665
S
A
T
P
Y
G
L
Y
Y
P
S
G
P
L
D
Site 57
Y666
A
T
P
Y
G
L
Y
Y
P
S
G
P
L
D
A
Site 58
S676
G
P
L
D
A
G
K
S
D
P
E
S
V
D
K
Site 59
S680
A
G
K
S
D
P
E
S
V
D
K
E
L
E
L
Site 60
Y729
H
N
S
G
F
R
N
Y
N
T
S
I
D
V
R
Site 61
S732
G
F
R
N
Y
N
T
S
I
D
V
R
R
H
E
Site 62
S741
D
V
R
R
H
E
L
S
D
I
T
E
L
P
E
Site 63
T744
R
H
E
L
S
D
I
T
E
L
P
E
K
S
D
Site 64
S750
I
T
E
L
P
E
K
S
D
K
D
S
S
S
A
Site 65
S754
P
E
K
S
D
K
D
S
S
S
A
Y
N
T
G
Site 66
S756
K
S
D
K
D
S
S
S
A
Y
N
T
G
E
S
Site 67
Y758
D
K
D
S
S
S
A
Y
N
T
G
E
S
C
R
Site 68
T760
D
S
S
S
A
Y
N
T
G
E
S
C
R
S
T
Site 69
S763
S
A
Y
N
T
G
E
S
C
R
S
T
P
L
T
Site 70
S766
N
T
G
E
S
C
R
S
T
P
L
T
L
E
I
Site 71
T767
T
G
E
S
C
R
S
T
P
L
T
L
E
I
S
Site 72
T770
S
C
R
S
T
P
L
T
L
E
I
S
P
D
N
Site 73
S774
T
P
L
T
L
E
I
S
P
D
N
S
L
R
R
Site 74
S778
L
E
I
S
P
D
N
S
L
R
R
A
A
E
G
Site 75
S787
R
R
A
A
E
G
I
S
C
P
S
S
E
G
A
Site 76
S791
E
G
I
S
C
P
S
S
E
G
A
V
G
T
T
Site 77
S805
T
E
A
Y
G
P
A
S
K
N
L
L
S
I
T
Site 78
S810
P
A
S
K
N
L
L
S
I
T
E
D
P
E
V
Site 79
T812
S
K
N
L
L
S
I
T
E
D
P
E
V
G
T
Site 80
T819
T
E
D
P
E
V
G
T
P
T
Y
S
P
S
L
Site 81
T821
D
P
E
V
G
T
P
T
Y
S
P
S
L
K
E
Site 82
Y822
P
E
V
G
T
P
T
Y
S
P
S
L
K
E
L
Site 83
S823
E
V
G
T
P
T
Y
S
P
S
L
K
E
L
D
Site 84
S825
G
T
P
T
Y
S
P
S
L
K
E
L
D
P
N
Site 85
S843
E
S
K
E
R
R
A
S
D
G
S
R
S
P
T
Site 86
S846
E
R
R
A
S
D
G
S
R
S
P
T
P
S
Q
Site 87
S848
R
A
S
D
G
S
R
S
P
T
P
S
Q
K
L
Site 88
T850
S
D
G
S
R
S
P
T
P
S
Q
K
L
G
S
Site 89
S852
G
S
R
S
P
T
P
S
Q
K
L
G
S
A
Y
Site 90
Y859
S
Q
K
L
G
S
A
Y
L
P
S
Y
H
H
S
Site 91
S862
L
G
S
A
Y
L
P
S
Y
H
H
S
P
Y
K
Site 92
Y863
G
S
A
Y
L
P
S
Y
H
H
S
P
Y
K
H
Site 93
S891
M
Q
L
I
Q
Q
K
S
A
V
E
Y
A
Q
S
Site 94
Y895
Q
Q
K
S
A
V
E
Y
A
Q
S
Q
M
S
L
Site 95
S901
E
Y
A
Q
S
Q
M
S
L
V
S
M
C
K
D
Site 96
S904
Q
S
Q
M
S
L
V
S
M
C
K
D
L
S
S
Site 97
S910
V
S
M
C
K
D
L
S
S
P
T
P
S
E
P
Site 98
S911
S
M
C
K
D
L
S
S
P
T
P
S
E
P
R
Site 99
T913
C
K
D
L
S
S
P
T
P
S
E
P
R
M
E
Site 100
S915
D
L
S
S
P
T
P
S
E
P
R
M
E
W
K
Site 101
Y932
I
R
S
D
G
T
R
Y
I
T
K
R
P
V
R
Site 102
T934
S
D
G
T
R
Y
I
T
K
R
P
V
R
D
R
Site 103
S955
L
K
I
R
E
E
R
S
G
M
T
T
D
D
D
Site 104
T958
R
E
E
R
S
G
M
T
T
D
D
D
A
V
S
Site 105
T959
E
E
R
S
G
M
T
T
D
D
D
A
V
S
E
Site 106
S965
T
T
D
D
D
A
V
S
E
M
K
M
G
R
Y
Site 107
Y972
S
E
M
K
M
G
R
Y
W
S
K
E
E
R
K
Site 108
T1048
Q
E
L
L
T
H
G
T
K
S
P
D
G
T
R
Site 109
S1050
L
L
T
H
G
T
K
S
P
D
G
T
R
V
Y
Site 110
T1054
G
T
K
S
P
D
G
T
R
V
Y
N
S
F
L
Site 111
Y1057
S
P
D
G
T
R
V
Y
N
S
F
L
S
V
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation