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Updated November 2019
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Protein Info
Short Name:
TNRC6B
Full Name:
Trinucleotide repeat-containing gene 6B protein
Alias:
KIAA1093; TNC6B; trinucleotide repeat containing 6B; trinucleotide repeat-containing 6B protein
Type:
Unknown function
Mass (Da):
194002
Number AA:
1833
UniProt ID:
Q9UPQ9
International Prot ID:
IPI00152296
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0031047
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
Q
K
V
T
E
Q
K
T
K
V
P
E
V
T
K
Site 2
S46
V
P
E
V
T
K
P
S
L
S
Q
P
T
A
A
Site 3
S48
E
V
T
K
P
S
L
S
Q
P
T
A
A
S
P
Site 4
S54
L
S
Q
P
T
A
A
S
P
I
G
S
S
P
S
Site 5
S58
T
A
A
S
P
I
G
S
S
P
S
P
P
V
N
Site 6
S59
A
A
S
P
I
G
S
S
P
S
P
P
V
N
G
Site 7
S61
S
P
I
G
S
S
P
S
P
P
V
N
G
G
N
Site 8
S82
V
P
N
G
Q
P
P
S
A
A
R
Y
M
P
R
Site 9
Y86
Q
P
P
S
A
A
R
Y
M
P
R
E
V
P
P
Site 10
S114
R
G
Q
P
P
P
P
S
C
M
L
L
G
G
G
Site 11
T128
G
A
G
P
P
P
C
T
A
P
G
A
N
P
N
Site 12
S146
V
T
G
A
L
L
Q
S
E
S
G
T
A
P
D
Site 13
S148
G
A
L
L
Q
S
E
S
G
T
A
P
D
S
T
Site 14
T150
L
L
Q
S
E
S
G
T
A
P
D
S
T
L
G
Site 15
S154
E
S
G
T
A
P
D
S
T
L
G
G
A
A
A
Site 16
T155
S
G
T
A
P
D
S
T
L
G
G
A
A
A
S
Site 17
S162
T
L
G
G
A
A
A
S
N
Y
A
N
S
T
W
Site 18
Y164
G
G
A
A
A
S
N
Y
A
N
S
T
W
G
S
Site 19
S167
A
A
S
N
Y
A
N
S
T
W
G
S
G
A
S
Site 20
S171
Y
A
N
S
T
W
G
S
G
A
S
S
N
N
G
Site 21
S174
S
T
W
G
S
G
A
S
S
N
N
G
T
S
P
Site 22
S175
T
W
G
S
G
A
S
S
N
N
G
T
S
P
N
Site 23
T179
G
A
S
S
N
N
G
T
S
P
N
P
I
H
I
Site 24
S180
A
S
S
N
N
G
T
S
P
N
P
I
H
I
W
Site 25
S205
E
E
W
P
C
I
A
S
K
D
T
E
S
S
S
Site 26
T208
P
C
I
A
S
K
D
T
E
S
S
S
E
N
T
Site 27
S212
S
K
D
T
E
S
S
S
E
N
T
T
D
N
N
Site 28
T215
T
E
S
S
S
E
N
T
T
D
N
N
S
A
S
Site 29
T216
E
S
S
S
E
N
T
T
D
N
N
S
A
S
N
Site 30
S220
E
N
T
T
D
N
N
S
A
S
N
P
G
S
E
Site 31
S222
T
T
D
N
N
S
A
S
N
P
G
S
E
K
S
Site 32
S226
N
S
A
S
N
P
G
S
E
K
S
T
L
P
G
Site 33
S229
S
N
P
G
S
E
K
S
T
L
P
G
S
T
T
Site 34
T230
N
P
G
S
E
K
S
T
L
P
G
S
T
T
S
Site 35
S234
E
K
S
T
L
P
G
S
T
T
S
N
K
G
K
Site 36
T236
S
T
L
P
G
S
T
T
S
N
K
G
K
G
S
Site 37
S237
T
L
P
G
S
T
T
S
N
K
G
K
G
S
Q
Site 38
S243
T
S
N
K
G
K
G
S
Q
C
Q
S
A
S
S
Site 39
S247
G
K
G
S
Q
C
Q
S
A
S
S
G
N
E
C
Site 40
S250
S
Q
C
Q
S
A
S
S
G
N
E
C
N
L
G
Site 41
S261
C
N
L
G
V
W
K
S
D
P
K
A
K
S
V
Site 42
S267
K
S
D
P
K
A
K
S
V
Q
S
S
N
S
T
Site 43
S271
K
A
K
S
V
Q
S
S
N
S
T
T
E
N
N
Site 44
S273
K
S
V
Q
S
S
N
S
T
T
E
N
N
N
G
Site 45
T274
S
V
Q
S
S
N
S
T
T
E
N
N
N
G
L
Site 46
T275
V
Q
S
S
N
S
T
T
E
N
N
N
G
L
G
Site 47
S288
L
G
N
W
R
N
V
S
G
Q
D
R
I
G
P
Site 48
S297
Q
D
R
I
G
P
G
S
G
F
S
N
F
N
P
Site 49
S300
I
G
P
G
S
G
F
S
N
F
N
P
N
S
N
Site 50
S306
F
S
N
F
N
P
N
S
N
P
S
A
W
P
A
Site 51
S309
F
N
P
N
S
N
P
S
A
W
P
A
L
V
Q
Site 52
T327
S
R
K
G
A
L
E
T
D
N
S
N
S
S
A
Site 53
S330
G
A
L
E
T
D
N
S
N
S
S
A
Q
V
S
Site 54
S332
L
E
T
D
N
S
N
S
S
A
Q
V
S
T
V
Site 55
S333
E
T
D
N
S
N
S
S
A
Q
V
S
T
V
G
Site 56
S337
S
N
S
S
A
Q
V
S
T
V
G
Q
T
S
R
Site 57
T370
E
Q
A
Q
I
H
N
T
D
G
P
K
N
G
N
Site 58
T378
D
G
P
K
N
G
N
T
N
S
L
N
L
S
S
Site 59
S380
P
K
N
G
N
T
N
S
L
N
L
S
S
P
N
Site 60
S384
N
T
N
S
L
N
L
S
S
P
N
P
M
E
N
Site 61
S385
T
N
S
L
N
L
S
S
P
N
P
M
E
N
K
Site 62
T403
F
G
M
G
L
G
N
T
S
R
S
T
D
A
P
Site 63
S406
G
L
G
N
T
S
R
S
T
D
A
P
S
Q
S
Site 64
T407
L
G
N
T
S
R
S
T
D
A
P
S
Q
S
T
Site 65
S411
S
R
S
T
D
A
P
S
Q
S
T
G
D
R
K
Site 66
T419
Q
S
T
G
D
R
K
T
G
S
V
G
S
W
G
Site 67
S421
T
G
D
R
K
T
G
S
V
G
S
W
G
A
A
Site 68
S432
W
G
A
A
R
G
P
S
G
T
D
T
V
S
G
Site 69
T434
A
A
R
G
P
S
G
T
D
T
V
S
G
Q
S
Site 70
T436
R
G
P
S
G
T
D
T
V
S
G
Q
S
N
S
Site 71
S438
P
S
G
T
D
T
V
S
G
Q
S
N
S
G
N
Site 72
S443
T
V
S
G
Q
S
N
S
G
N
N
G
N
N
G
Site 73
S456
N
G
K
E
R
E
D
S
W
K
G
A
S
V
Q
Site 74
S461
E
D
S
W
K
G
A
S
V
Q
K
S
T
G
S
Site 75
S465
K
G
A
S
V
Q
K
S
T
G
S
K
N
D
S
Site 76
S468
S
V
Q
K
S
T
G
S
K
N
D
S
W
D
N
Site 77
S472
S
T
G
S
K
N
D
S
W
D
N
N
N
R
S
Site 78
S483
N
N
R
S
T
G
G
S
W
N
F
G
P
Q
D
Site 79
S504
G
E
G
N
K
M
T
S
G
V
S
Q
G
E
W
Site 80
T515
Q
G
E
W
K
Q
P
T
G
S
D
E
L
K
I
Site 81
S517
E
W
K
Q
P
T
G
S
D
E
L
K
I
G
E
Site 82
S526
E
L
K
I
G
E
W
S
G
P
N
Q
P
N
S
Site 83
S533
S
G
P
N
Q
P
N
S
S
T
G
A
W
D
N
Site 84
S561
Q
A
P
C
W
G
R
S
S
S
S
T
G
S
E
Site 85
S562
A
P
C
W
G
R
S
S
S
S
T
G
S
E
V
Site 86
S563
P
C
W
G
R
S
S
S
S
T
G
S
E
V
G
Site 87
S564
C
W
G
R
S
S
S
S
T
G
S
E
V
G
G
Site 88
T565
W
G
R
S
S
S
S
T
G
S
E
V
G
G
Q
Site 89
S567
R
S
S
S
S
T
G
S
E
V
G
G
Q
S
T
Site 90
S573
G
S
E
V
G
G
Q
S
T
G
S
N
H
K
A
Site 91
T574
S
E
V
G
G
Q
S
T
G
S
N
H
K
A
G
Site 92
S576
V
G
G
Q
S
T
G
S
N
H
K
A
G
S
S
Site 93
S582
G
S
N
H
K
A
G
S
S
D
S
H
N
S
G
Site 94
S583
S
N
H
K
A
G
S
S
D
S
H
N
S
G
R
Site 95
S585
H
K
A
G
S
S
D
S
H
N
S
G
R
R
S
Site 96
S588
G
S
S
D
S
H
N
S
G
R
R
S
Y
R
P
Site 97
S592
S
H
N
S
G
R
R
S
Y
R
P
T
H
P
D
Site 98
Y593
H
N
S
G
R
R
S
Y
R
P
T
H
P
D
C
Site 99
T596
G
R
R
S
Y
R
P
T
H
P
D
C
Q
A
V
Site 100
S609
A
V
L
Q
T
L
L
S
R
T
D
L
D
P
R
Site 101
S619
D
L
D
P
R
V
L
S
N
T
G
W
G
Q
T
Site 102
T621
D
P
R
V
L
S
N
T
G
W
G
Q
T
Q
I
Site 103
T632
Q
T
Q
I
K
Q
D
T
V
W
D
I
E
E
V
Site 104
S646
V
P
R
P
E
G
K
S
D
K
G
T
E
G
W
Site 105
T650
E
G
K
S
D
K
G
T
E
G
W
E
S
A
A
Site 106
S655
K
G
T
E
G
W
E
S
A
A
T
Q
T
K
N
Site 107
T658
E
G
W
E
S
A
A
T
Q
T
K
N
S
G
G
Site 108
T660
W
E
S
A
A
T
Q
T
K
N
S
G
G
W
G
Site 109
S671
G
G
W
G
D
A
P
S
Q
S
N
Q
M
K
S
Site 110
S678
S
Q
S
N
Q
M
K
S
G
W
G
E
L
S
A
Site 111
S684
K
S
G
W
G
E
L
S
A
S
T
E
W
K
D
Site 112
S686
G
W
G
E
L
S
A
S
T
E
W
K
D
P
K
Site 113
Y701
N
T
G
G
W
N
D
Y
K
N
N
N
S
S
N
Site 114
T718
G
G
R
P
D
E
K
T
P
S
S
W
N
E
N
Site 115
S720
R
P
D
E
K
T
P
S
S
W
N
E
N
P
S
Site 116
S721
P
D
E
K
T
P
S
S
W
N
E
N
P
S
K
Site 117
S727
S
S
W
N
E
N
P
S
K
D
Q
G
W
G
G
Site 118
S759
E
V
D
Q
T
K
N
S
N
W
E
S
S
A
S
Site 119
S763
T
K
N
S
N
W
E
S
S
A
S
K
P
V
S
Site 120
S764
K
N
S
N
W
E
S
S
A
S
K
P
V
S
G
Site 121
S766
S
N
W
E
S
S
A
S
K
P
V
S
G
W
G
Site 122
S770
S
S
A
S
K
P
V
S
G
W
G
E
G
G
Q
Site 123
T782
G
G
Q
N
E
I
G
T
W
G
N
G
G
N
A
Site 124
S790
W
G
N
G
G
N
A
S
L
A
S
K
G
G
W
Site 125
S793
G
G
N
A
S
L
A
S
K
G
G
W
E
D
C
Site 126
T809
R
S
P
A
W
N
E
T
G
R
Q
P
N
S
W
Site 127
S837
P
P
P
Q
P
E
A
S
G
S
W
G
G
P
P
Site 128
S839
P
Q
P
E
A
S
G
S
W
G
G
P
P
P
P
Site 129
S854
P
P
G
N
V
R
P
S
N
S
S
W
S
S
G
Site 130
S856
G
N
V
R
P
S
N
S
S
W
S
S
G
P
Q
Site 131
S857
N
V
R
P
S
N
S
S
W
S
S
G
P
Q
P
Site 132
S859
R
P
S
N
S
S
W
S
S
G
P
Q
P
A
T
Site 133
S860
P
S
N
S
S
W
S
S
G
P
Q
P
A
T
P
Site 134
T866
S
S
G
P
Q
P
A
T
P
K
D
E
E
P
S
Site 135
S873
T
P
K
D
E
E
P
S
G
W
E
E
P
S
P
Site 136
S879
P
S
G
W
E
E
P
S
P
Q
S
I
S
R
K
Site 137
S882
W
E
E
P
S
P
Q
S
I
S
R
K
M
D
I
Site 138
T893
K
M
D
I
D
D
G
T
S
A
W
G
D
P
N
Site 139
S894
M
D
I
D
D
G
T
S
A
W
G
D
P
N
S
Site 140
Y904
G
D
P
N
S
Y
N
Y
K
N
V
N
L
W
D
Site 141
S914
V
N
L
W
D
K
N
S
Q
G
G
P
A
P
R
Site 142
T927
P
R
E
P
N
L
P
T
P
M
T
S
K
S
A
Site 143
T930
P
N
L
P
T
P
M
T
S
K
S
A
S
V
W
Site 144
S931
N
L
P
T
P
M
T
S
K
S
A
S
V
W
S
Site 145
S933
P
T
P
M
T
S
K
S
A
S
V
W
S
K
S
Site 146
S935
P
M
T
S
K
S
A
S
V
W
S
K
S
T
P
Site 147
S938
S
K
S
A
S
V
W
S
K
S
T
P
P
A
P
Site 148
S940
S
A
S
V
W
S
K
S
T
P
P
A
P
D
N
Site 149
T941
A
S
V
W
S
K
S
T
P
P
A
P
D
N
G
Site 150
S958
A
W
G
E
P
N
E
S
S
P
G
W
G
E
M
Site 151
S959
W
G
E
P
N
E
S
S
P
G
W
G
E
M
D
Site 152
T968
G
W
G
E
M
D
D
T
G
A
S
T
T
G
W
Site 153
S971
E
M
D
D
T
G
A
S
T
T
G
W
G
N
T
Site 154
T978
S
T
T
G
W
G
N
T
P
A
N
A
P
N
A
Site 155
S992
A
M
K
P
N
S
K
S
M
Q
D
G
W
G
E
Site 156
S1000
M
Q
D
G
W
G
E
S
D
G
P
V
T
G
A
Site 157
T1005
G
E
S
D
G
P
V
T
G
A
R
H
P
S
W
Site 158
S1011
V
T
G
A
R
H
P
S
W
E
E
E
E
D
G
Site 159
T1024
D
G
G
V
W
N
T
T
G
S
Q
G
S
A
S
Site 160
S1026
G
V
W
N
T
T
G
S
Q
G
S
A
S
S
H
Site 161
S1029
N
T
T
G
S
Q
G
S
A
S
S
H
N
S
A
Site 162
S1031
T
G
S
Q
G
S
A
S
S
H
N
S
A
S
W
Site 163
S1032
G
S
Q
G
S
A
S
S
H
N
S
A
S
W
G
Site 164
S1035
G
S
A
S
S
H
N
S
A
S
W
G
Q
G
G
Site 165
S1037
A
S
S
H
N
S
A
S
W
G
Q
G
G
K
K
Site 166
S1049
G
K
K
Q
M
K
C
S
L
K
G
G
N
N
D
Site 167
S1057
L
K
G
G
N
N
D
S
W
M
N
P
L
A
K
Site 168
S1067
N
P
L
A
K
Q
F
S
N
M
G
L
L
S
Q
Site 169
S1073
F
S
N
M
G
L
L
S
Q
T
E
D
N
P
S
Site 170
T1075
N
M
G
L
L
S
Q
T
E
D
N
P
S
S
K
Site 171
S1080
S
Q
T
E
D
N
P
S
S
K
M
D
L
S
V
Site 172
S1081
Q
T
E
D
N
P
S
S
K
M
D
L
S
V
G
Site 173
S1086
P
S
S
K
M
D
L
S
V
G
S
L
S
D
K
Site 174
S1089
K
M
D
L
S
V
G
S
L
S
D
K
K
F
D
Site 175
S1091
D
L
S
V
G
S
L
S
D
K
K
F
D
V
D
Site 176
S1116
D
I
M
R
K
D
R
S
G
F
R
P
P
N
S
Site 177
S1123
S
G
F
R
P
P
N
S
K
D
M
G
T
T
D
Site 178
T1128
P
N
S
K
D
M
G
T
T
D
S
G
P
Y
F
Site 179
S1131
K
D
M
G
T
T
D
S
G
P
Y
F
E
K
L
Site 180
Y1134
G
T
T
D
S
G
P
Y
F
E
K
G
G
S
H
Site 181
T1139
G
P
Y
F
E
K
L
T
L
P
F
S
N
Q
D
Site 182
S1143
E
K
L
T
L
P
F
S
N
Q
D
G
C
L
G
Site 183
S1156
L
G
D
E
A
P
C
S
P
F
S
P
S
P
S
Site 184
S1159
E
A
P
C
S
P
F
S
P
S
P
S
Y
K
L
Site 185
S1161
P
C
S
P
F
S
P
S
P
S
Y
K
L
S
P
Site 186
S1163
S
P
F
S
P
S
P
S
Y
K
L
S
P
S
G
Site 187
Y1164
P
F
S
P
S
P
S
Y
K
L
S
P
S
G
S
Site 188
S1167
P
S
P
S
Y
K
L
S
P
S
G
S
T
L
P
Site 189
S1169
P
S
Y
K
L
S
P
S
G
S
T
L
P
N
V
Site 190
S1171
Y
K
L
S
P
S
G
S
T
L
P
N
V
S
L
Site 191
S1204
S
H
G
L
F
G
N
S
T
A
Q
S
R
G
L
Site 192
T1205
H
G
L
F
G
N
S
T
A
Q
S
R
G
L
H
Site 193
S1208
F
G
N
S
T
A
Q
S
R
G
L
H
T
P
V
Site 194
T1213
A
Q
S
R
G
L
H
T
P
V
Q
P
L
N
S
Site 195
S1220
T
P
V
Q
P
L
N
S
S
P
S
L
R
A
Q
Site 196
S1221
P
V
Q
P
L
N
S
S
P
S
L
R
A
Q
V
Site 197
S1223
Q
P
L
N
S
S
P
S
L
R
A
Q
V
P
P
Site 198
S1234
Q
V
P
P
Q
F
I
S
P
Q
V
S
A
S
M
Site 199
S1240
I
S
P
Q
V
S
A
S
M
L
K
Q
F
P
N
Site 200
S1251
Q
F
P
N
S
G
L
S
P
G
L
F
N
V
G
Site 201
S1270
P
Q
Q
I
A
M
L
S
Q
L
P
Q
I
P
Q
Site 202
S1302
L
Q
N
Q
R
K
I
S
Q
A
V
R
Q
Q
Q
Site 203
S1318
Q
Q
L
A
R
M
V
S
A
L
Q
Q
Q
Q
Q
Site 204
S1336
R
Q
P
G
M
K
H
S
P
S
H
P
V
G
P
Site 205
S1338
P
G
M
K
H
S
P
S
H
P
V
G
P
K
P
Site 206
T1364
V
G
L
P
D
L
Q
T
K
G
P
I
P
G
Y
Site 207
Y1371
T
K
G
P
I
P
G
Y
G
S
G
F
S
S
G
Site 208
S1373
G
P
I
P
G
Y
G
S
G
F
S
S
G
G
M
Site 209
S1376
P
G
Y
G
S
G
F
S
S
G
G
M
D
Y
G
Site 210
S1377
G
Y
G
S
G
F
S
S
G
G
M
D
Y
G
M
Site 211
Y1382
F
S
S
G
G
M
D
Y
G
M
V
G
G
K
E
Site 212
T1392
V
G
G
K
E
A
G
T
E
S
R
F
K
Q
W
Site 213
S1394
G
K
E
A
G
T
E
S
R
F
K
Q
W
T
S
Site 214
T1400
E
S
R
F
K
Q
W
T
S
M
M
E
G
L
P
Site 215
S1401
S
R
F
K
Q
W
T
S
M
M
E
G
L
P
S
Site 216
S1408
S
M
M
E
G
L
P
S
V
A
T
Q
E
A
N
Site 217
T1411
E
G
L
P
S
V
A
T
Q
E
A
N
M
H
K
Site 218
T1428
A
I
V
A
P
G
K
T
R
G
G
S
P
Y
N
Site 219
S1432
P
G
K
T
R
G
G
S
P
Y
N
Q
F
D
I
Site 220
Y1434
K
T
R
G
G
S
P
Y
N
Q
F
D
I
I
P
Site 221
T1444
F
D
I
I
P
G
D
T
L
G
G
H
T
G
P
Site 222
S1455
H
T
G
P
A
G
D
S
W
L
P
A
K
S
P
Site 223
S1461
D
S
W
L
P
A
K
S
P
P
T
N
K
I
G
Site 224
S1469
P
P
T
N
K
I
G
S
K
S
S
N
A
S
W
Site 225
S1471
T
N
K
I
G
S
K
S
S
N
A
S
W
P
P
Site 226
S1472
N
K
I
G
S
K
S
S
N
A
S
W
P
P
E
Site 227
S1475
G
S
K
S
S
N
A
S
W
P
P
E
F
Q
P
Site 228
S1496
I
Q
N
I
D
P
E
S
D
P
Y
V
T
P
G
Site 229
Y1499
I
D
P
E
S
D
P
Y
V
T
P
G
S
V
L
Site 230
T1501
P
E
S
D
P
Y
V
T
P
G
S
V
L
G
G
Site 231
T1511
S
V
L
G
G
T
A
T
S
P
I
V
D
T
D
Site 232
T1517
A
T
S
P
I
V
D
T
D
H
Q
L
L
R
D
Site 233
T1526
H
Q
L
L
R
D
N
T
T
G
S
N
S
S
L
Site 234
T1527
Q
L
L
R
D
N
T
T
G
S
N
S
S
L
N
Site 235
S1529
L
R
D
N
T
T
G
S
N
S
S
L
N
T
S
Site 236
S1531
D
N
T
T
G
S
N
S
S
L
N
T
S
L
P
Site 237
S1532
N
T
T
G
S
N
S
S
L
N
T
S
L
P
S
Site 238
T1535
G
S
N
S
S
L
N
T
S
L
P
S
P
G
A
Site 239
S1536
S
N
S
S
L
N
T
S
L
P
S
P
G
A
W
Site 240
S1539
S
L
N
T
S
L
P
S
P
G
A
W
P
Y
S
Site 241
Y1545
P
S
P
G
A
W
P
Y
S
A
S
D
N
S
F
Site 242
S1546
S
P
G
A
W
P
Y
S
A
S
D
N
S
F
T
Site 243
S1548
G
A
W
P
Y
S
A
S
D
N
S
F
T
N
V
Site 244
S1551
P
Y
S
A
S
D
N
S
F
T
N
V
H
S
T
Site 245
T1553
S
A
S
D
N
S
F
T
N
V
H
S
T
S
A
Site 246
S1557
N
S
F
T
N
V
H
S
T
S
A
K
F
P
D
Site 247
T1558
S
F
T
N
V
H
S
T
S
A
K
F
P
D
Y
Site 248
Y1565
T
S
A
K
F
P
D
Y
K
S
T
W
S
P
D
Site 249
S1567
A
K
F
P
D
Y
K
S
T
W
S
P
D
P
I
Site 250
T1568
K
F
P
D
Y
K
S
T
W
S
P
D
P
I
G
Site 251
S1570
P
D
Y
K
S
T
W
S
P
D
P
I
G
H
N
Site 252
T1595
N
H
I
S
S
R
N
T
T
P
L
P
R
P
P
Site 253
T1596
H
I
S
S
R
N
T
T
P
L
P
R
P
P
P
Site 254
T1606
P
R
P
P
P
G
L
T
N
P
K
P
S
S
P
Site 255
S1611
G
L
T
N
P
K
P
S
S
P
W
S
S
T
A
Site 256
S1612
L
T
N
P
K
P
S
S
P
W
S
S
T
A
P
Site 257
S1615
P
K
P
S
S
P
W
S
S
T
A
P
R
S
V
Site 258
S1616
K
P
S
S
P
W
S
S
T
A
P
R
S
V
R
Site 259
T1617
P
S
S
P
W
S
S
T
A
P
R
S
V
R
G
Site 260
S1621
W
S
S
T
A
P
R
S
V
R
G
W
G
T
Q
Site 261
T1627
R
S
V
R
G
W
G
T
Q
D
S
R
L
A
S
Site 262
S1630
R
G
W
G
T
Q
D
S
R
L
A
S
A
S
T
Site 263
S1634
T
Q
D
S
R
L
A
S
A
S
T
W
S
D
G
Site 264
S1636
D
S
R
L
A
S
A
S
T
W
S
D
G
G
S
Site 265
T1637
S
R
L
A
S
A
S
T
W
S
D
G
G
S
V
Site 266
S1639
L
A
S
A
S
T
W
S
D
G
G
S
V
R
P
Site 267
S1643
S
T
W
S
D
G
G
S
V
R
P
S
Y
W
L
Site 268
S1647
D
G
G
S
V
R
P
S
Y
W
L
V
L
H
N
Site 269
Y1648
G
G
S
V
R
P
S
Y
W
L
V
L
H
N
L
Site 270
T1656
W
L
V
L
H
N
L
T
P
Q
I
D
G
S
T
Site 271
T1663
T
P
Q
I
D
G
S
T
L
R
T
I
C
M
Q
Site 272
T1666
I
D
G
S
T
L
R
T
I
C
M
Q
H
G
P
Site 273
T1676
M
Q
H
G
P
L
L
T
F
H
L
N
L
T
Q
Site 274
S1691
G
T
A
L
I
R
Y
S
T
K
Q
E
A
A
K
Site 275
T1692
T
A
L
I
R
Y
S
T
K
Q
E
A
A
K
A
Site 276
T1719
T
I
L
A
E
F
A
T
D
D
E
V
S
R
F
Site 277
T1734
L
A
Q
A
Q
P
P
T
P
A
A
T
P
S
A
Site 278
T1738
Q
P
P
T
P
A
A
T
P
S
A
P
A
A
G
Site 279
S1740
P
T
P
A
A
T
P
S
A
P
A
A
G
W
Q
Site 280
S1748
A
P
A
A
G
W
Q
S
L
E
T
G
Q
N
Q
Site 281
S1756
L
E
T
G
Q
N
Q
S
D
P
V
G
P
A
L
Site 282
S1776
S
T
G
L
G
Q
W
S
S
S
A
G
G
S
S
Site 283
S1777
T
G
L
G
Q
W
S
S
S
A
G
G
S
S
G
Site 284
S1778
G
L
G
Q
W
S
S
S
A
G
G
S
S
G
A
Site 285
S1782
W
S
S
S
A
G
G
S
S
G
A
D
L
A
G
Site 286
S1783
S
S
S
A
G
G
S
S
G
A
D
L
A
G
A
Site 287
S1791
G
A
D
L
A
G
A
S
L
W
G
P
P
N
Y
Site 288
Y1798
S
L
W
G
P
P
N
Y
S
S
S
L
W
G
V
Site 289
S1801
G
P
P
N
Y
S
S
S
L
W
G
V
P
T
V
Site 290
T1807
S
S
L
W
G
V
P
T
V
E
D
P
H
R
M
Site 291
S1816
E
D
P
H
R
M
G
S
P
A
P
L
L
P
G
Site 292
S1830
G
D
L
L
G
G
G
S
D
S
I
_
_
_
_
Site 293
S1832
L
L
G
G
G
S
D
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
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