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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC8A2
Full Name:
Sodium/calcium exchanger 2 precursor
Alias:
KIAA1087; Na(+)/Ca(2+)-exchange 2; Na(+)/Ca(2+)-exchange protein 2; NAC2; NCX2; Sodium/calcium exchanger 2; Solute carrier family 8 (sodium/calcium exchanger) member 2
Type:
Transporter
Mass (Da):
100368
Number AA:
921
UniProt ID:
Q9UPR5
International Prot ID:
IPI00010343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005432
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0007154
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
P
P
C
S
G
A
A
T
P
T
P
S
L
P
P
Site 2
T25
C
S
G
A
A
T
P
T
P
S
L
P
P
P
P
Site 3
S27
G
A
A
T
P
T
P
S
L
P
P
P
P
A
N
Site 4
S36
P
P
P
P
A
N
D
S
D
T
S
T
G
G
C
Site 5
T38
P
P
A
N
D
S
D
T
S
T
G
G
C
Q
G
Site 6
S39
P
A
N
D
S
D
T
S
T
G
G
C
Q
G
S
Site 7
T40
A
N
D
S
D
T
S
T
G
G
C
Q
G
S
Y
Site 8
S46
S
T
G
G
C
Q
G
S
Y
R
C
Q
P
G
V
Site 9
Y47
T
G
G
C
Q
G
S
Y
R
C
Q
P
G
V
L
Site 10
S64
V
W
E
P
D
D
P
S
L
G
D
K
A
A
R
Site 11
Y75
K
A
A
R
A
V
V
Y
F
V
A
M
V
Y
M
Site 12
S87
V
Y
M
F
L
G
V
S
I
I
A
D
R
F
M
Site 13
T108
T
S
K
E
K
E
I
T
I
T
K
A
N
G
E
Site 14
T110
K
E
K
E
I
T
I
T
K
A
N
G
E
T
S
Site 15
S117
T
K
A
N
G
E
T
S
V
G
T
V
R
I
W
Site 16
T120
N
G
E
T
S
V
G
T
V
R
I
W
N
E
T
Site 17
Y253
A
D
K
R
L
L
F
Y
K
Y
V
Y
K
R
Y
Site 18
Y255
K
R
L
L
F
Y
K
Y
V
Y
K
R
Y
R
T
Site 19
Y257
L
L
F
Y
K
Y
V
Y
K
R
Y
R
T
D
P
Site 20
T262
Y
V
Y
K
R
Y
R
T
D
P
R
S
G
I
I
Site 21
S266
R
Y
R
T
D
P
R
S
G
I
I
I
G
A
E
Site 22
S279
A
E
G
D
P
P
K
S
I
E
L
D
G
T
F
Site 23
T285
K
S
I
E
L
D
G
T
F
V
G
A
E
A
P
Site 24
S311
E
A
R
E
L
D
A
S
R
R
E
V
I
Q
I
Site 25
S349
A
L
L
H
Q
Q
K
S
R
A
F
Y
R
I
Q
Site 26
Y353
Q
Q
K
S
R
A
F
Y
R
I
Q
A
T
R
L
Site 27
S376
R
R
H
A
A
D
A
S
R
R
A
A
P
A
E
Site 28
S394
E
D
E
D
D
G
A
S
R
I
F
F
E
P
S
Site 29
T426
Q
G
G
E
G
N
S
T
F
Y
V
D
Y
R
T
Site 30
Y428
G
E
G
N
S
T
F
Y
V
D
Y
R
T
E
D
Site 31
Y431
N
S
T
F
Y
V
D
Y
R
T
E
D
G
S
A
Site 32
T433
T
F
Y
V
D
Y
R
T
E
D
G
S
A
K
A
Site 33
S437
D
Y
R
T
E
D
G
S
A
K
A
G
S
D
Y
Site 34
S442
D
G
S
A
K
A
G
S
D
Y
E
Y
S
E
G
Site 35
Y444
S
A
K
A
G
S
D
Y
E
Y
S
E
G
T
L
Site 36
Y446
K
A
G
S
D
Y
E
Y
S
E
G
T
L
V
F
Site 37
S447
A
G
S
D
Y
E
Y
S
E
G
T
L
V
F
K
Site 38
S526
D
D
H
A
G
I
F
S
F
Q
D
R
L
L
H
Site 39
S535
Q
D
R
L
L
H
V
S
E
C
M
G
T
V
D
Site 40
S549
D
V
R
V
V
R
S
S
G
A
R
G
T
V
R
Site 41
T554
R
S
S
G
A
R
G
T
V
R
L
P
Y
R
T
Site 42
Y559
R
G
T
V
R
L
P
Y
R
T
V
D
G
T
A
Site 43
T561
T
V
R
L
P
Y
R
T
V
D
G
T
A
R
G
Site 44
T565
P
Y
R
T
V
D
G
T
A
R
G
G
G
V
H
Site 45
Y573
A
R
G
G
G
V
H
Y
E
D
A
C
G
E
L
Site 46
T587
L
E
F
G
D
D
E
T
M
K
T
L
Q
V
K
Site 47
T590
G
D
D
E
T
M
K
T
L
Q
V
K
I
V
D
Site 48
Y601
K
I
V
D
D
E
E
Y
E
K
K
D
N
F
F
Site 49
S622
Q
W
L
K
R
G
I
S
A
L
L
L
N
Q
G
Site 50
T636
G
D
G
D
R
K
L
T
A
E
E
E
E
A
R
Site 51
S666
L
E
V
I
I
E
E
S
Y
D
F
K
N
T
V
Site 52
S690
A
L
V
I
G
T
H
S
W
R
E
Q
F
L
E
Site 53
S713
E
E
E
E
E
D
G
S
R
E
E
R
L
P
S
Site 54
S720
S
R
E
E
R
L
P
S
C
F
D
Y
V
M
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation