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Updated November 2019
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Protein Info
Short Name:
ANKRD26
Full Name:
Ankyrin repeat domain-containing protein 26
Alias:
Ankyrin repeat domain 26; ANR26; KIAA1074
Type:
DNA binding protein
Mass (Da):
196324
Number AA:
1709
UniProt ID:
Q9UPS8
International Prot ID:
IPI00760833
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
K
I
F
S
K
K
G
E
S
P
L
Site 2
S11
I
F
S
K
K
G
E
S
P
L
G
S
F
A
R
Site 3
S15
K
G
E
S
P
L
G
S
F
A
R
R
Q
R
S
Site 4
S22
S
F
A
R
R
Q
R
S
S
A
G
G
G
G
E
Site 5
S23
F
A
R
R
Q
R
S
S
A
G
G
G
G
E
P
Site 6
Y35
G
E
P
G
E
G
A
Y
S
Q
P
G
Y
H
V
Site 7
S36
E
P
G
E
G
A
Y
S
Q
P
G
Y
H
V
R
Site 8
Y40
G
A
Y
S
Q
P
G
Y
H
V
R
D
R
D
L
Site 9
T82
D
R
D
K
M
N
R
T
A
L
H
L
A
C
A
Site 10
T130
C
Q
E
E
K
C
A
T
I
L
L
E
H
G
A
Site 11
Y152
H
G
N
T
A
L
H
Y
A
V
Y
N
E
D
I
Site 12
S214
A
V
D
K
L
E
S
S
H
Q
L
I
S
E
Y
Site 13
S219
E
S
S
H
Q
L
I
S
E
Y
K
E
E
R
I
Site 14
S230
E
E
R
I
P
K
H
S
S
Q
N
S
N
S
V
Site 15
S231
E
R
I
P
K
H
S
S
Q
N
S
N
S
V
D
Site 16
S234
P
K
H
S
S
Q
N
S
N
S
V
D
E
S
S
Site 17
S236
H
S
S
Q
N
S
N
S
V
D
E
S
S
E
D
Site 18
S240
N
S
N
S
V
D
E
S
S
E
D
S
L
S
R
Site 19
S241
S
N
S
V
D
E
S
S
E
D
S
L
S
R
L
Site 20
S244
V
D
E
S
S
E
D
S
L
S
R
L
S
G
K
Site 21
S246
E
S
S
E
D
S
L
S
R
L
S
G
K
P
G
Site 22
S249
E
D
S
L
S
R
L
S
G
K
P
G
V
D
D
Site 23
S257
G
K
P
G
V
D
D
S
W
P
T
S
D
D
E
Site 24
T260
G
V
D
D
S
W
P
T
S
D
D
E
D
L
N
Site 25
S261
V
D
D
S
W
P
T
S
D
D
E
D
L
N
F
Site 26
T270
D
E
D
L
N
F
D
T
K
N
V
P
K
P
S
Site 27
T283
P
S
L
A
K
L
M
T
A
S
Q
Q
S
R
K
Site 28
S285
L
A
K
L
M
T
A
S
Q
Q
S
R
K
N
L
Site 29
Y296
R
K
N
L
E
A
T
Y
G
T
V
R
T
G
N
Site 30
T298
N
L
E
A
T
Y
G
T
V
R
T
G
N
R
T
Site 31
T305
T
V
R
T
G
N
R
T
L
F
E
D
R
D
S
Site 32
S312
T
L
F
E
D
R
D
S
D
S
Q
D
E
V
V
Site 33
S314
F
E
D
R
D
S
D
S
Q
D
E
V
V
V
E
Site 34
S322
Q
D
E
V
V
V
E
S
L
P
T
T
S
I
K
Site 35
S334
S
I
K
V
Q
C
F
S
H
P
T
Y
Q
S
P
Site 36
T337
V
Q
C
F
S
H
P
T
Y
Q
S
P
D
L
L
Site 37
Y338
Q
C
F
S
H
P
T
Y
Q
S
P
D
L
L
P
Site 38
S340
F
S
H
P
T
Y
Q
S
P
D
L
L
P
K
P
Site 39
S348
P
D
L
L
P
K
P
S
H
K
S
L
A
N
P
Site 40
S351
L
P
K
P
S
H
K
S
L
A
N
P
G
L
M
Site 41
T391
Q
T
N
N
D
N
L
T
Y
V
D
E
V
H
K
Site 42
Y392
T
N
N
D
N
L
T
Y
V
D
E
V
H
K
N
Site 43
S402
E
V
H
K
N
N
R
S
D
M
M
S
A
L
G
Site 44
S406
N
N
R
S
D
M
M
S
A
L
G
L
G
Q
E
Site 45
S418
G
Q
E
E
D
I
E
S
P
W
D
S
E
S
I
Site 46
S422
D
I
E
S
P
W
D
S
E
S
I
S
E
N
F
Site 47
S424
E
S
P
W
D
S
E
S
I
S
E
N
F
P
Q
Site 48
S426
P
W
D
S
E
S
I
S
E
N
F
P
Q
K
Y
Site 49
Y433
S
E
N
F
P
Q
K
Y
V
D
P
L
A
G
A
Site 50
Y458
E
Q
A
E
D
V
F
Y
I
P
S
C
M
S
G
Site 51
S461
E
D
V
F
Y
I
P
S
C
M
S
G
S
R
N
Site 52
T477
K
M
A
K
L
E
D
T
R
N
V
G
M
P
V
Site 53
S489
M
P
V
A
H
M
E
S
P
E
R
Y
L
H
L
Site 54
Y493
H
M
E
S
P
E
R
Y
L
H
L
K
P
T
I
Site 55
S505
P
T
I
E
M
K
D
S
V
P
N
K
A
G
G
Site 56
T518
G
G
M
K
D
V
Q
T
S
K
A
A
E
H
D
Site 57
S539
E
E
Q
E
R
E
G
S
E
N
N
Q
P
Q
V
Site 58
S561
R
N
N
E
M
E
V
S
A
N
I
H
D
G
A
Site 59
S587
G
L
I
Q
K
R
K
S
G
E
T
D
H
Q
Q
Site 60
Y603
P
R
K
E
N
K
E
Y
A
S
G
P
A
L
Q
Site 61
S616
L
Q
M
K
E
V
K
S
T
E
K
E
K
R
T
Site 62
S624
T
E
K
E
K
R
T
S
K
E
S
V
N
S
P
Site 63
S627
E
K
R
T
S
K
E
S
V
N
S
P
V
F
G
Site 64
S630
T
S
K
E
S
V
N
S
P
V
F
G
K
A
S
Site 65
S650
L
L
Q
V
D
D
D
S
S
L
S
E
I
D
E
Site 66
S651
L
Q
V
D
D
D
S
S
L
S
E
I
D
E
D
Site 67
S653
V
D
D
D
S
S
L
S
E
I
D
E
D
E
G
Site 68
T663
D
E
D
E
G
R
P
T
K
K
T
S
N
E
K
Site 69
T666
E
G
R
P
T
K
K
T
S
N
E
K
N
K
V
Site 70
T687
M
D
D
V
D
D
L
T
Q
S
S
E
T
A
S
Site 71
S689
D
V
D
D
L
T
Q
S
S
E
T
A
S
E
D
Site 72
S690
V
D
D
L
T
Q
S
S
E
T
A
S
E
D
C
Site 73
S694
T
Q
S
S
E
T
A
S
E
D
C
E
L
P
H
Site 74
Y704
C
E
L
P
H
S
S
Y
K
N
F
M
L
L
I
Site 75
S723
M
E
C
K
D
S
V
S
L
L
K
I
Q
D
A
Site 76
T749
K
N
H
C
E
L
L
T
V
K
I
K
K
M
E
Site 77
S767
N
V
L
Q
R
E
L
S
E
T
K
E
I
K
S
Site 78
T769
L
Q
R
E
L
S
E
T
K
E
I
K
S
Q
L
Site 79
S774
S
E
T
K
E
I
K
S
Q
L
E
H
Q
K
V
Site 80
S789
E
W
E
R
E
L
C
S
L
R
F
S
L
N
Q
Site 81
S793
E
L
C
S
L
R
F
S
L
N
Q
E
E
E
K
Site 82
T806
E
K
R
R
N
A
D
T
L
Y
E
K
I
R
E
Site 83
Y808
R
R
N
A
D
T
L
Y
E
K
I
R
E
Q
L
Site 84
Y822
L
R
R
K
E
E
Q
Y
R
K
E
V
E
V
K
Site 85
S835
V
K
Q
Q
L
E
L
S
L
Q
T
L
E
M
E
Site 86
S848
M
E
L
R
T
V
K
S
N
L
N
Q
V
V
Q
Site 87
S865
N
D
A
Q
R
Q
L
S
R
E
Q
N
A
R
M
Site 88
S883
G
I
L
T
N
H
L
S
K
Q
K
E
I
E
M
Site 89
S897
M
A
Q
K
K
M
N
S
E
N
S
H
S
H
E
Site 90
S900
K
K
M
N
S
E
N
S
H
S
H
E
E
E
K
Site 91
S902
M
N
S
E
N
S
H
S
H
E
E
E
K
D
L
Site 92
S910
H
E
E
E
K
D
L
S
H
K
N
S
M
L
Q
Site 93
S914
K
D
L
S
H
K
N
S
M
L
Q
E
E
I
A
Site 94
T929
M
L
R
L
E
I
D
T
I
K
N
Q
N
Q
E
Site 95
T967
K
Q
N
E
E
T
L
T
Q
T
I
S
Q
Y
N
Site 96
S971
E
T
L
T
Q
T
I
S
Q
Y
N
G
R
L
S
Site 97
S978
S
Q
Y
N
G
R
L
S
V
L
T
A
E
N
A
Site 98
T981
N
G
R
L
S
V
L
T
A
E
N
A
M
L
N
Site 99
S997
K
L
E
N
E
K
Q
S
K
E
R
L
E
A
E
Site 100
Y1008
L
E
A
E
V
E
S
Y
H
S
R
L
A
A
A
Site 101
S1022
A
I
H
D
R
D
Q
S
E
T
S
K
R
E
L
Site 102
T1024
H
D
R
D
Q
S
E
T
S
K
R
E
L
E
L
Site 103
S1025
D
R
D
Q
S
E
T
S
K
R
E
L
E
L
A
Site 104
S1062
K
D
N
N
E
I
L
S
Q
Q
L
F
K
T
E
Site 105
T1068
L
S
Q
Q
L
F
K
T
E
S
K
L
N
S
L
Site 106
S1070
Q
Q
L
F
K
T
E
S
K
L
N
S
L
E
I
Site 107
S1074
K
T
E
S
K
L
N
S
L
E
I
E
F
H
H
Site 108
T1082
L
E
I
E
F
H
H
T
R
D
A
L
R
E
K
Site 109
T1090
R
D
A
L
R
E
K
T
L
G
L
E
R
V
Q
Site 110
S1101
E
R
V
Q
K
D
L
S
Q
T
Q
C
Q
M
K
Site 111
Y1114
M
K
E
M
E
Q
K
Y
Q
N
E
Q
V
K
V
Site 112
Y1124
E
Q
V
K
V
N
K
Y
I
G
K
Q
E
S
V
Site 113
S1130
K
Y
I
G
K
Q
E
S
V
E
E
R
L
S
Q
Site 114
S1136
E
S
V
E
E
R
L
S
Q
L
Q
S
E
N
M
Site 115
S1140
E
R
L
S
Q
L
Q
S
E
N
M
L
L
R
Q
Site 116
T1162
K
A
D
N
K
E
K
T
V
I
N
I
Q
D
Q
Site 117
S1181
V
Q
K
L
Q
A
E
S
E
K
Q
S
L
L
L
Site 118
S1185
Q
A
E
S
E
K
Q
S
L
L
L
E
E
R
N
Site 119
Y1207
N
H
L
K
E
R
Q
Y
Q
Y
E
N
E
K
A
Site 120
Y1209
L
K
E
R
Q
Y
Q
Y
E
N
E
K
A
E
R
Site 121
T1230
L
Q
Q
E
L
A
D
T
L
K
K
Q
S
M
S
Site 122
S1237
T
L
K
K
Q
S
M
S
E
A
S
L
E
V
T
Site 123
S1240
K
Q
S
M
S
E
A
S
L
E
V
T
S
R
Y
Site 124
T1244
S
E
A
S
L
E
V
T
S
R
Y
R
I
N
L
Site 125
T1255
R
I
N
L
E
D
E
T
Q
D
L
K
K
K
L
Site 126
T1277
Q
E
A
Q
D
R
H
T
E
A
V
R
C
A
E
Site 127
T1303
D
N
A
K
L
K
V
T
V
K
K
Q
M
D
K
Site 128
S1324
N
L
L
N
A
N
L
S
E
D
E
K
E
Q
L
Site 129
S1340
K
L
M
E
L
K
Q
S
L
E
C
N
L
D
Q
Site 130
T1360
V
E
L
E
R
E
I
T
G
F
K
N
L
L
K
Site 131
Y1376
T
R
K
K
L
N
E
Y
E
N
G
E
F
S
F
Site 132
S1382
E
Y
E
N
G
E
F
S
F
H
G
D
L
K
T
Site 133
T1389
S
F
H
G
D
L
K
T
S
Q
F
E
M
D
I
Site 134
S1390
F
H
G
D
L
K
T
S
Q
F
E
M
D
I
Q
Site 135
T1409
K
H
K
I
D
D
L
T
A
E
L
E
T
A
G
Site 136
S1417
A
E
L
E
T
A
G
S
K
C
L
H
L
D
T
Site 137
T1424
S
K
C
L
H
L
D
T
K
N
Q
I
L
Q
E
Site 138
S1435
I
L
Q
E
E
L
L
S
M
K
T
V
Q
K
K
Site 139
T1438
E
E
L
L
S
M
K
T
V
Q
K
K
C
E
K
Site 140
S1523
N
N
F
A
S
M
K
S
Q
M
E
L
R
I
K
Site 141
S1534
L
R
I
K
D
L
E
S
E
L
S
K
I
K
T
Site 142
S1537
K
D
L
E
S
E
L
S
K
I
K
T
S
Q
E
Site 143
T1541
S
E
L
S
K
I
K
T
S
Q
E
D
F
N
K
Site 144
S1542
E
L
S
K
I
K
T
S
Q
E
D
F
N
K
T
Site 145
Y1554
N
K
T
E
L
E
K
Y
K
Q
L
Y
L
E
E
Site 146
Y1558
L
E
K
Y
K
Q
L
Y
L
E
E
L
K
V
R
Site 147
S1567
E
E
L
K
V
R
K
S
L
S
S
K
L
T
K
Site 148
S1569
L
K
V
R
K
S
L
S
S
K
L
T
K
T
N
Site 149
S1570
K
V
R
K
S
L
S
S
K
L
T
K
T
N
E
Site 150
T1573
K
S
L
S
S
K
L
T
K
T
N
E
R
L
A
Site 151
T1575
L
S
S
K
L
T
K
T
N
E
R
L
A
E
V
Site 152
S1595
V
E
K
Q
Q
S
R
S
L
F
T
T
L
T
T
Site 153
T1599
Q
S
R
S
L
F
T
T
L
T
T
R
P
V
M
Site 154
T1601
R
S
L
F
T
T
L
T
T
R
P
V
M
E
P
Site 155
S1617
C
V
G
N
L
N
N
S
L
D
L
N
R
K
L
Site 156
S1633
P
R
E
N
L
V
I
S
T
S
N
P
R
A
S
Site 157
S1635
E
N
L
V
I
S
T
S
N
P
R
A
S
N
N
Site 158
S1640
S
T
S
N
P
R
A
S
N
N
S
M
E
N
Y
Site 159
S1643
N
P
R
A
S
N
N
S
M
E
N
Y
L
S
K
Site 160
Y1647
S
N
N
S
M
E
N
Y
L
S
K
M
Q
Q
E
Site 161
S1649
N
S
M
E
N
Y
L
S
K
M
Q
Q
E
L
E
Site 162
T1660
Q
E
L
E
K
N
I
T
R
E
L
K
E
A
A
Site 163
S1677
L
E
S
G
S
I
A
S
P
L
G
S
T
D
E
Site 164
S1681
S
I
A
S
P
L
G
S
T
D
E
S
N
L
N
Site 165
S1685
P
L
G
S
T
D
E
S
N
L
N
Q
D
L
V
Site 166
Y1699
V
W
K
A
S
R
E
Y
V
Q
V
L
K
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation