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Updated November 2019
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Protein Info
Short Name:
MAPK8IP3
Full Name:
C-jun-amino-terminal kinase-interacting protein 3
Alias:
C-jun-amino-terminal kinase interacting protein 3; Homolog ofSunday driver 2; JIP3; JIP-3; JNK MAP kinase scaffold protein 3; JNK/SAPK-associated protein 1; JNK-interacting protein 3; JSAP1; KIAA1066; Mitogen- activated protein kinase 8-interacting protein 3; Mitogen-activated protein kinase 8 interacting protein 3; Sunday driver 2; SYD2
Type:
Adapter/scaffold protein
Mass (Da):
147457
Number AA:
1336
UniProt ID:
Q9UPT6
International Prot ID:
IPI00219817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0005737
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005078
GO:0019894
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0016192
GO:0007276
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
E
G
G
G
V
V
V
Y
Q
D
D
Y
C
S
G
Site 2
S21
V
Y
Q
D
D
Y
C
S
G
S
V
M
S
E
R
Site 3
S23
Q
D
D
Y
C
S
G
S
V
M
S
E
R
V
S
Site 4
S30
S
V
M
S
E
R
V
S
G
L
A
G
S
I
Y
Site 5
S35
R
V
S
G
L
A
G
S
I
Y
R
E
F
E
R
Site 6
Y37
S
G
L
A
G
S
I
Y
R
E
F
E
R
L
I
Site 7
Y47
F
E
R
L
I
H
C
Y
D
E
E
V
V
K
E
Site 8
S68
N
V
L
E
N
L
D
S
V
L
S
E
N
Q
E
Site 9
S71
E
N
L
D
S
V
L
S
E
N
Q
E
H
E
V
Site 10
T92
E
D
N
E
Q
L
L
T
Q
Y
E
R
E
K
A
Site 11
Y94
N
E
Q
L
L
T
Q
Y
E
R
E
K
A
L
R
Site 12
Y143
L
E
L
K
A
K
N
Y
A
D
Q
I
S
R
L
Site 13
S148
K
N
Y
A
D
Q
I
S
R
L
E
E
R
E
S
Site 14
S155
S
R
L
E
E
R
E
S
E
M
K
K
E
Y
N
Site 15
T174
R
H
T
E
M
I
Q
T
Y
V
E
H
I
E
R
Site 16
Y175
H
T
E
M
I
Q
T
Y
V
E
H
I
E
R
S
Site 17
S191
M
Q
Q
V
G
G
N
S
Q
T
E
S
S
L
P
Site 18
T193
Q
V
G
G
N
S
Q
T
E
S
S
L
P
G
R
Site 19
S195
G
G
N
S
Q
T
E
S
S
L
P
G
R
R
K
Site 20
T206
G
R
R
K
E
R
P
T
S
L
N
V
F
P
L
Site 21
S207
R
R
K
E
R
P
T
S
L
N
V
F
P
L
A
Site 22
S236
A
G
D
H
W
H
L
S
D
L
G
Q
L
Q
S
Site 23
S243
S
D
L
G
Q
L
Q
S
S
S
S
Y
Q
C
P
Site 24
S244
D
L
G
Q
L
Q
S
S
S
S
Y
Q
C
P
Q
Site 25
S245
L
G
Q
L
Q
S
S
S
S
Y
Q
C
P
Q
D
Site 26
S246
G
Q
L
Q
S
S
S
S
Y
Q
C
P
Q
D
E
Site 27
Y247
Q
L
Q
S
S
S
S
Y
Q
C
P
Q
D
E
M
Site 28
S255
Q
C
P
Q
D
E
M
S
E
S
G
Q
S
S
A
Site 29
S257
P
Q
D
E
M
S
E
S
G
Q
S
S
A
A
A
Site 30
S261
M
S
E
S
G
Q
S
S
A
A
A
T
P
S
T
Site 31
T265
G
Q
S
S
A
A
A
T
P
S
T
T
G
T
K
Site 32
S267
S
S
A
A
A
T
P
S
T
T
G
T
K
S
N
Site 33
T268
S
A
A
A
T
P
S
T
T
G
T
K
S
N
T
Site 34
T269
A
A
A
T
P
S
T
T
G
T
K
S
N
T
P
Site 35
T271
A
T
P
S
T
T
G
T
K
S
N
T
P
T
S
Site 36
S273
P
S
T
T
G
T
K
S
N
T
P
T
S
S
V
Site 37
T275
T
T
G
T
K
S
N
T
P
T
S
S
V
P
S
Site 38
T277
G
T
K
S
N
T
P
T
S
S
V
P
S
A
A
Site 39
S278
T
K
S
N
T
P
T
S
S
V
P
S
A
A
V
Site 40
S279
K
S
N
T
P
T
S
S
V
P
S
A
A
V
T
Site 41
T286
S
V
P
S
A
A
V
T
P
L
N
E
S
L
Q
Site 42
S291
A
V
T
P
L
N
E
S
L
Q
P
L
G
D
Y
Site 43
Y298
S
L
Q
P
L
G
D
Y
G
V
G
S
K
N
S
Site 44
S302
L
G
D
Y
G
V
G
S
K
N
S
K
R
A
R
Site 45
S305
Y
G
V
G
S
K
N
S
K
R
A
R
E
K
R
Site 46
S314
R
A
R
E
K
R
D
S
R
N
M
E
V
Q
V
Site 47
T322
R
N
M
E
V
Q
V
T
Q
E
M
R
N
V
S
Site 48
S329
T
Q
E
M
R
N
V
S
I
G
M
G
S
S
D
Site 49
S335
V
S
I
G
M
G
S
S
D
E
W
S
D
V
Q
Site 50
S339
M
G
S
S
D
E
W
S
D
V
Q
D
I
I
D
Site 51
S347
D
V
Q
D
I
I
D
S
T
P
E
L
D
M
C
Site 52
T348
V
Q
D
I
I
D
S
T
P
E
L
D
M
C
P
Site 53
T362
P
E
T
R
L
D
R
T
G
S
S
P
T
Q
G
Site 54
S364
T
R
L
D
R
T
G
S
S
P
T
Q
G
I
V
Site 55
S365
R
L
D
R
T
G
S
S
P
T
Q
G
I
V
N
Site 56
T367
D
R
T
G
S
S
P
T
Q
G
I
V
N
K
A
Site 57
S381
A
F
G
I
N
T
D
S
L
Y
H
E
L
S
T
Site 58
Y383
G
I
N
T
D
S
L
Y
H
E
L
S
T
A
G
Site 59
S387
D
S
L
Y
H
E
L
S
T
A
G
S
E
V
I
Site 60
S391
H
E
L
S
T
A
G
S
E
V
I
G
D
V
D
Site 61
S428
G
N
L
L
L
E
N
S
Q
L
L
E
T
K
N
Site 62
S452
I
A
K
V
D
Q
L
S
G
E
Q
E
V
L
R
Site 63
S488
E
E
L
K
R
V
K
S
E
A
I
I
A
R
R
Site 64
S505
K
E
E
A
E
D
V
S
S
Y
L
C
T
E
S
Site 65
S506
E
E
A
E
D
V
S
S
Y
L
C
T
E
S
D
Site 66
Y507
E
A
E
D
V
S
S
Y
L
C
T
E
S
D
K
Site 67
T510
D
V
S
S
Y
L
C
T
E
S
D
K
I
P
M
Site 68
S512
S
S
Y
L
C
T
E
S
D
K
I
P
M
A
Q
Site 69
T524
M
A
Q
R
R
R
F
T
R
V
E
M
A
R
V
Site 70
Y538
V
L
M
E
R
N
Q
Y
K
E
R
L
M
E
L
Site 71
T552
L
Q
E
A
V
R
W
T
E
M
I
R
A
S
R
Site 72
S558
W
T
E
M
I
R
A
S
R
E
H
P
S
V
Q
Site 73
S563
R
A
S
R
E
H
P
S
V
Q
E
K
K
K
S
Site 74
S570
S
V
Q
E
K
K
K
S
T
I
W
Q
F
F
S
Site 75
S577
S
T
I
W
Q
F
F
S
R
L
F
S
S
S
S
Site 76
S581
Q
F
F
S
R
L
F
S
S
S
S
S
P
P
P
Site 77
S582
F
F
S
R
L
F
S
S
S
S
S
P
P
P
A
Site 78
S583
R
L
F
S
S
S
S
S
P
P
P
A
K
R
P
Site 79
S584
R
L
F
S
S
S
S
S
P
P
P
A
K
R
P
Site 80
S585
R
L
F
S
S
S
S
S
P
P
P
A
K
R
P
Site 81
Y593
P
P
P
A
K
R
P
Y
P
S
V
N
I
H
Y
Site 82
Y600
Y
P
S
V
N
I
H
Y
K
S
P
T
T
A
G
Site 83
S602
S
V
N
I
H
Y
K
S
P
T
T
A
G
F
S
Site 84
T604
N
I
H
Y
K
S
P
T
T
A
G
F
S
Q
R
Site 85
T605
I
H
Y
K
S
P
T
T
A
G
F
S
Q
R
R
Site 86
S609
S
P
T
T
A
G
F
S
Q
R
R
N
H
A
M
Site 87
S620
N
H
A
M
C
P
I
S
A
G
S
R
P
L
E
Site 88
T635
F
F
P
D
D
D
C
T
S
S
A
R
R
E
Q
Site 89
S636
F
P
D
D
D
C
T
S
S
A
R
R
E
Q
K
Site 90
S637
P
D
D
D
C
T
S
S
A
R
R
E
Q
K
R
Site 91
Y647
R
E
Q
K
R
E
Q
Y
R
Q
V
R
E
H
V
Site 92
Y672
G
W
S
L
P
A
K
Y
K
Q
L
S
P
N
G
Site 93
S676
P
A
K
Y
K
Q
L
S
P
N
G
G
Q
E
D
Site 94
T684
P
N
G
G
Q
E
D
T
R
M
K
N
V
P
V
Site 95
Y694
K
N
V
P
V
P
V
Y
C
R
P
L
V
E
K
Site 96
T704
P
L
V
E
K
D
P
T
M
K
L
W
C
A
A
Site 97
S716
C
A
A
G
V
N
L
S
G
W
R
P
N
E
D
Site 98
T739
A
P
G
R
D
P
L
T
C
D
R
E
G
D
G
Site 99
S750
E
G
D
G
E
P
K
S
A
H
T
S
P
E
K
Site 100
S754
E
P
K
S
A
H
T
S
P
E
K
K
K
A
K
Site 101
T769
E
L
P
E
M
D
A
T
S
S
R
V
W
I
L
Site 102
S771
P
E
M
D
A
T
S
S
R
V
W
I
L
T
S
Site 103
T777
S
S
R
V
W
I
L
T
S
T
L
T
T
S
K
Site 104
T779
R
V
W
I
L
T
S
T
L
T
T
S
K
V
V
Site 105
S817
I
S
S
I
P
A
A
S
D
S
D
Y
P
P
G
Site 106
S819
S
I
P
A
A
S
D
S
D
Y
P
P
G
E
M
Site 107
Y821
P
A
A
S
D
S
D
Y
P
P
G
E
M
F
L
Site 108
S830
P
G
E
M
F
L
D
S
D
V
N
P
E
D
P
Site 109
S860
T
R
C
N
V
P
R
S
N
C
S
S
R
G
D
Site 110
S863
N
V
P
R
S
N
C
S
S
R
G
D
T
P
V
Site 111
S864
V
P
R
S
N
C
S
S
R
G
D
T
P
V
L
Site 112
T868
N
C
S
S
R
G
D
T
P
V
L
D
K
G
Q
Site 113
S889
A
N
G
K
V
N
P
S
Q
S
T
E
E
A
T
Site 114
S891
G
K
V
N
P
S
Q
S
T
E
E
A
T
E
A
Site 115
T899
T
E
E
A
T
E
A
T
E
V
P
D
P
G
P
Site 116
T911
P
G
P
S
E
P
E
T
A
T
L
R
P
G
P
Site 117
T913
P
S
E
P
E
T
A
T
L
R
P
G
P
L
T
Site 118
T920
T
L
R
P
G
P
L
T
E
H
V
F
T
D
P
Site 119
T925
P
L
T
E
H
V
F
T
D
P
A
P
T
P
S
Site 120
T930
V
F
T
D
P
A
P
T
P
S
S
G
P
Q
P
Site 121
S932
T
D
P
A
P
T
P
S
S
G
P
Q
P
G
S
Site 122
S933
D
P
A
P
T
P
S
S
G
P
Q
P
G
S
E
Site 123
S939
S
S
G
P
Q
P
G
S
E
N
G
P
E
P
D
Site 124
S947
E
N
G
P
E
P
D
S
S
S
T
R
P
E
P
Site 125
S948
N
G
P
E
P
D
S
S
S
T
R
P
E
P
E
Site 126
S949
G
P
E
P
D
S
S
S
T
R
P
E
P
E
P
Site 127
S957
T
R
P
E
P
E
P
S
G
D
P
T
G
A
G
Site 128
T961
P
E
P
S
G
D
P
T
G
A
G
S
S
A
A
Site 129
S966
D
P
T
G
A
G
S
S
A
A
P
T
M
W
L
Site 130
T970
A
G
S
S
A
A
P
T
M
W
L
G
A
Q
N
Site 131
Y981
G
A
Q
N
G
W
L
Y
V
H
S
A
V
A
N
Site 132
Y1037
G
Q
W
D
L
S
N
Y
H
L
M
D
L
G
H
Site 133
T1074
V
H
V
I
Q
P
K
T
M
Q
I
E
K
S
F
Site 134
S1080
K
T
M
Q
I
E
K
S
F
D
A
H
P
R
R
Site 135
S1089
D
A
H
P
R
R
E
S
Q
V
R
Q
L
A
W
Site 136
S1109
W
V
S
I
R
L
D
S
T
L
R
L
Y
H
A
Site 137
T1110
V
S
I
R
L
D
S
T
L
R
L
Y
H
A
H
Site 138
Y1114
L
D
S
T
L
R
L
Y
H
A
H
T
H
Q
H
Site 139
Y1130
Q
D
V
D
I
E
P
Y
V
S
K
M
L
G
T
Site 140
S1132
V
D
I
E
P
Y
V
S
K
M
L
G
T
G
K
Site 141
S1143
G
T
G
K
L
G
F
S
F
V
R
I
T
A
L
Site 142
T1190
L
G
L
R
A
N
K
T
S
P
T
S
G
E
G
Site 143
S1191
G
L
R
A
N
K
T
S
P
T
S
G
E
G
A
Site 144
S1194
A
N
K
T
S
P
T
S
G
E
G
A
R
P
G
Site 145
Y1207
P
G
G
I
I
H
V
Y
G
D
D
S
S
D
R
Site 146
S1211
I
H
V
Y
G
D
D
S
S
D
R
A
A
S
S
Site 147
S1212
H
V
Y
G
D
D
S
S
D
R
A
A
S
S
F
Site 148
S1217
D
S
S
D
R
A
A
S
S
F
I
P
Y
C
S
Site 149
S1218
S
S
D
R
A
A
S
S
F
I
P
Y
C
S
M
Site 150
S1260
L
N
G
S
V
L
D
S
P
A
E
G
P
G
P
Site 151
S1272
P
G
P
A
A
P
A
S
E
V
E
G
Q
K
L
Site 152
T1304
G
D
G
E
D
D
E
T
E
E
G
A
G
D
M
Site 153
S1312
E
E
G
A
G
D
M
S
Q
V
K
P
V
L
S
Site 154
S1319
S
Q
V
K
P
V
L
S
K
A
E
R
S
H
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation