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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP22
Full Name:
Ubiquitin-specific-processing protease 22
Alias:
Deubiquitinating enzyme 22; EC 3.1.2.15; Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin thioesterase 22; UBP22; USP3L
Type:
Ubiquitin conjugating system, Protease, Cell cycle regulation, Transcription, coactivator/corepressor
Mass (Da):
59961
Number AA:
525
UniProt ID:
Q9UPT9
International Prot ID:
IPI00852960
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000124
Uniprot
OncoNet
Molecular Function:
GO:0030374
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0009790
GO:0016578
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
P
G
C
S
H
L
G
S
F
K
V
D
N
W
K
Site 2
Y42
K
Q
N
L
R
A
I
Y
Q
C
F
V
W
S
G
Site 3
Y120
F
L
C
Q
D
Y
I
Y
D
K
D
M
E
I
I
Site 4
S146
Q
G
V
G
E
K
F
S
T
W
E
P
T
K
R
Site 5
T147
G
V
G
E
K
F
S
T
W
E
P
T
K
R
E
Site 6
T151
K
F
S
T
W
E
P
T
K
R
E
L
E
L
L
Site 7
T168
N
P
K
R
R
K
I
T
S
N
C
T
I
G
L
Site 8
S169
P
K
R
R
K
I
T
S
N
C
T
I
G
L
R
Site 9
S206
L
L
R
D
F
F
L
S
D
R
H
R
C
E
M
Site 10
S215
R
H
R
C
E
M
Q
S
P
S
S
C
L
V
C
Site 11
Y232
S
S
L
F
Q
E
F
Y
S
G
H
R
S
P
H
Site 12
S233
S
L
F
Q
E
F
Y
S
G
H
R
S
P
H
I
Site 13
S237
E
F
Y
S
G
H
R
S
P
H
I
P
Y
K
L
Site 14
Y258
H
A
R
H
L
A
G
Y
E
Q
Q
D
A
H
E
Site 15
S328
I
D
P
F
W
D
I
S
L
D
L
P
G
S
S
Site 16
S335
S
L
D
L
P
G
S
S
T
P
F
W
P
L
S
Site 17
T336
L
D
L
P
G
S
S
T
P
F
W
P
L
S
P
Site 18
S342
S
T
P
F
W
P
L
S
P
G
S
E
G
N
V
Site 19
S345
F
W
P
L
S
P
G
S
E
G
N
V
V
N
G
Site 20
S357
V
N
G
E
S
H
V
S
G
T
T
T
L
T
D
Site 21
T361
S
H
V
S
G
T
T
T
L
T
D
C
L
R
R
Site 22
T363
V
S
G
T
T
T
L
T
D
C
L
R
R
F
T
Site 23
T370
T
D
C
L
R
R
F
T
R
P
E
H
L
G
S
Site 24
S377
T
R
P
E
H
L
G
S
S
A
K
I
K
C
S
Site 25
S384
S
S
A
K
I
K
C
S
G
C
H
S
Y
Q
E
Site 26
S388
I
K
C
S
G
C
H
S
Y
Q
E
S
T
K
Q
Site 27
T423
A
K
L
R
R
K
I
T
T
Y
V
S
F
P
L
Site 28
T424
K
L
R
R
K
I
T
T
Y
V
S
F
P
L
E
Site 29
S427
R
K
I
T
T
Y
V
S
F
P
L
E
L
D
M
Site 30
S441
M
T
P
F
M
A
S
S
K
E
S
R
M
N
G
Site 31
S444
F
M
A
S
S
K
E
S
R
M
N
G
Q
Y
Q
Site 32
Y450
E
S
R
M
N
G
Q
Y
Q
Q
P
T
D
S
L
Site 33
S456
Q
Y
Q
Q
P
T
D
S
L
N
N
D
N
K
Y
Site 34
Y463
S
L
N
N
D
N
K
Y
S
L
F
A
V
V
N
Site 35
Y480
G
T
L
E
S
G
H
Y
T
S
F
I
R
Q
H
Site 36
T481
T
L
E
S
G
H
Y
T
S
F
I
R
Q
H
K
Site 37
S482
L
E
S
G
H
Y
T
S
F
I
R
Q
H
K
D
Site 38
Y517
S
E
G
Y
L
L
F
Y
H
K
Q
F
L
E
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation