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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D2B
Full Name:
TBC1 domain family member 2B
Alias:
KIAA1055; LOC646938 protein; TBC1 domain family 2B; TBC1 domain family, member 2B; TBD2B
Type:
GTPase activating protein, Rab
Mass (Da):
109880
Number AA:
963
UniProt ID:
Q9UPU7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
E
P
A
R
L
C
G
Y
L
Q
K
L
S
G
K
Site 2
S45
C
G
Y
L
Q
K
L
S
G
K
G
P
L
R
G
Site 3
Y53
G
K
G
P
L
R
G
Y
R
S
R
W
F
V
F
Site 4
S55
G
P
L
R
G
Y
R
S
R
W
F
V
F
D
A
Site 5
Y66
V
F
D
A
R
R
C
Y
L
Y
Y
F
K
S
P
Site 6
Y68
D
A
R
R
C
Y
L
Y
Y
F
K
S
P
Q
D
Site 7
Y69
A
R
R
C
Y
L
Y
Y
F
K
S
P
Q
D
A
Site 8
S72
C
Y
L
Y
Y
F
K
S
P
Q
D
A
L
P
L
Site 9
Y91
I
A
D
A
C
F
S
Y
Q
G
P
D
E
A
A
Site 10
T102
D
E
A
A
E
P
G
T
E
P
P
A
H
F
Q
Site 11
Y129
P
N
R
Q
L
M
T
Y
W
L
Q
E
L
Q
Q
Site 12
Y141
L
Q
Q
K
R
W
E
Y
C
N
S
L
D
M
V
Site 13
S152
L
D
M
V
K
W
D
S
R
T
S
P
T
P
G
Site 14
S155
V
K
W
D
S
R
T
S
P
T
P
G
D
F
P
Site 15
T157
W
D
S
R
T
S
P
T
P
G
D
F
P
K
G
Site 16
T171
G
L
V
A
R
D
N
T
D
L
I
Y
P
H
P
Site 17
Y175
R
D
N
T
D
L
I
Y
P
H
P
N
A
S
A
Site 18
S214
P
A
P
G
H
P
N
S
I
N
F
Y
S
L
K
Site 19
Y218
H
P
N
S
I
N
F
Y
S
L
K
Q
W
G
N
Site 20
S230
W
G
N
E
L
K
N
S
M
S
S
F
R
P
G
Site 21
S232
N
E
L
K
N
S
M
S
S
F
R
P
G
R
G
Site 22
S233
E
L
K
N
S
M
S
S
F
R
P
G
R
G
H
Site 23
S243
P
G
R
G
H
N
D
S
R
R
T
V
F
Y
T
Site 24
T246
G
H
N
D
S
R
R
T
V
F
Y
T
N
E
E
Site 25
Y249
D
S
R
R
T
V
F
Y
T
N
E
E
W
E
L
Site 26
T250
S
R
R
T
V
F
Y
T
N
E
E
W
E
L
L
Site 27
T260
E
W
E
L
L
D
P
T
P
K
D
L
E
E
S
Site 28
T277
Q
E
E
K
K
K
L
T
P
E
G
N
K
G
V
Site 29
T285
P
E
G
N
K
G
V
T
G
S
G
F
P
F
D
Site 30
S287
G
N
K
G
V
T
G
S
G
F
P
F
D
F
G
Site 31
Y298
F
D
F
G
R
N
P
Y
K
G
K
R
P
L
K
Site 32
Y311
L
K
D
I
I
G
S
Y
K
N
R
H
S
S
G
Site 33
S316
G
S
Y
K
N
R
H
S
S
G
D
P
S
S
E
Site 34
S317
S
Y
K
N
R
H
S
S
G
D
P
S
S
E
G
Site 35
S321
R
H
S
S
G
D
P
S
S
E
G
T
S
G
S
Site 36
S322
H
S
S
G
D
P
S
S
E
G
T
S
G
S
G
Site 37
T325
G
D
P
S
S
E
G
T
S
G
S
G
S
V
S
Site 38
S326
D
P
S
S
E
G
T
S
G
S
G
S
V
S
I
Site 39
S328
S
S
E
G
T
S
G
S
G
S
V
S
I
R
K
Site 40
S330
E
G
T
S
G
S
G
S
V
S
I
R
K
P
A
Site 41
S332
T
S
G
S
G
S
V
S
I
R
K
P
A
S
E
Site 42
S338
V
S
I
R
K
P
A
S
E
M
Q
L
Q
V
Q
Site 43
S346
E
M
Q
L
Q
V
Q
S
Q
Q
E
E
L
E
Q
Site 44
S359
E
Q
L
K
K
D
L
S
S
Q
K
E
L
V
R
Site 45
S360
Q
L
K
K
D
L
S
S
Q
K
E
L
V
R
L
Site 46
T371
L
V
R
L
L
Q
Q
T
V
R
S
S
Q
Y
D
Site 47
S375
L
Q
Q
T
V
R
S
S
Q
Y
D
K
Y
F
T
Site 48
Y377
Q
T
V
R
S
S
Q
Y
D
K
Y
F
T
S
S
Site 49
Y380
R
S
S
Q
Y
D
K
Y
F
T
S
S
R
L
C
Site 50
T382
S
Q
Y
D
K
Y
F
T
S
S
R
L
C
E
G
Site 51
S383
Q
Y
D
K
Y
F
T
S
S
R
L
C
E
G
V
Site 52
T394
C
E
G
V
P
K
D
T
L
E
L
L
H
Q
K
Site 53
S410
D
Q
I
L
G
L
T
S
Q
L
E
R
F
S
L
Site 54
S416
T
S
Q
L
E
R
F
S
L
E
K
E
S
L
Q
Site 55
S431
Q
E
V
R
T
L
K
S
K
V
G
E
L
N
E
Site 56
S458
D
E
V
I
I
K
L
S
E
G
E
G
N
G
P
Site 57
T468
E
G
N
G
P
P
P
T
V
A
P
S
S
P
S
Site 58
S473
P
P
T
V
A
P
S
S
P
S
V
V
P
V
A
Site 59
T498
D
N
L
Q
G
Y
K
T
Q
N
K
F
L
N
K
Site 60
S511
N
K
E
I
L
E
L
S
A
L
R
R
N
A
E
Site 61
Y528
E
R
D
L
M
A
K
Y
S
S
L
E
A
K
L
Site 62
S529
R
D
L
M
A
K
Y
S
S
L
E
A
K
L
C
Site 63
S530
D
L
M
A
K
Y
S
S
L
E
A
K
L
C
Q
Site 64
S540
A
K
L
C
Q
I
E
S
K
Y
L
I
L
L
Q
Site 65
Y542
L
C
Q
I
E
S
K
Y
L
I
L
L
Q
E
M
Site 66
T551
I
L
L
Q
E
M
K
T
P
V
C
S
E
D
Q
Site 67
T561
C
S
E
D
Q
G
P
T
R
E
V
I
A
Q
L
Site 68
Y594
K
P
H
L
V
S
E
Y
D
I
Y
G
F
R
T
Site 69
Y597
L
V
S
E
Y
D
I
Y
G
F
R
T
V
P
E
Site 70
T622
V
R
A
L
D
L
K
T
L
Y
L
T
E
N
Q
Site 71
Y624
A
L
D
L
K
T
L
Y
L
T
E
N
Q
E
V
Site 72
Y640
T
G
V
K
W
E
N
Y
F
A
S
T
V
N
R
Site 73
S652
V
N
R
E
M
M
C
S
P
E
L
K
N
L
I
Site 74
T687
T
R
K
F
K
D
N
T
E
P
G
H
F
Q
T
Site 75
T717
I
E
L
D
L
L
R
T
L
P
N
N
K
H
Y
Site 76
Y724
T
L
P
N
N
K
H
Y
S
C
P
T
S
E
G
Site 77
S725
L
P
N
N
K
H
Y
S
C
P
T
S
E
G
I
Site 78
S729
K
H
Y
S
C
P
T
S
E
G
I
Q
K
L
R
Site 79
S743
R
N
V
L
L
A
F
S
W
R
N
P
D
I
G
Site 80
Y751
W
R
N
P
D
I
G
Y
C
Q
G
L
N
R
L
Site 81
Y787
E
V
F
M
P
R
D
Y
Y
T
K
T
L
L
G
Site 82
Y788
V
F
M
P
R
D
Y
Y
T
K
T
L
L
G
S
Site 83
T789
F
M
P
R
D
Y
Y
T
K
T
L
L
G
S
Q
Site 84
T791
P
R
D
Y
Y
T
K
T
L
L
G
S
Q
V
D
Site 85
S795
Y
T
K
T
L
L
G
S
Q
V
D
Q
R
V
F
Site 86
Y820
L
H
G
H
F
E
Q
Y
K
V
D
Y
T
L
I
Site 87
Y824
F
E
Q
Y
K
V
D
Y
T
L
I
T
F
N
W
Site 88
S883
L
K
L
Q
D
S
M
S
I
F
K
Y
L
R
Y
Site 89
Y887
D
S
M
S
I
F
K
Y
L
R
Y
F
T
R
T
Site 90
Y890
S
I
F
K
Y
L
R
Y
F
T
R
T
I
L
D
Site 91
T892
F
K
Y
L
R
Y
F
T
R
T
I
L
D
A
R
Site 92
T894
Y
L
R
Y
F
T
R
T
I
L
D
A
R
K
L
Site 93
Y923
Q
I
R
N
R
R
A
Y
H
L
E
K
V
R
L
Site 94
T948
D
F
L
R
E
R
D
T
S
P
D
K
G
E
L
Site 95
S949
F
L
R
E
R
D
T
S
P
D
K
G
E
L
V
Site 96
S957
P
D
K
G
E
L
V
S
D
E
E
E
D
T
_
Site 97
T963
V
S
D
E
E
E
D
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation