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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAMD4
Full Name:
Sterile alpha motif domain-containing protein 4A
Alias:
DKFZP434H0350; KIAA1053; SAM4A; SAMD4A; Smaug; Smaug1; SMG; SMGA; Sterile alpha motif domain containing 4; Sterile alpha motif domain containing 4A; Sterile alpha motif domain-containing 4
Type:
Synaptosome protein
Mass (Da):
58610
Number AA:
529
UniProt ID:
Q9UPU9
International Prot ID:
IPI00010390
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0030425
Uniprot
OncoNet
Molecular Function:
GO:0030371
PhosphoSite+
KinaseNET
Biological Process:
GO:0045727
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
L
S
L
L
K
R
V
S
Q
T
Q
A
R
F
L
Site 2
T36
L
L
K
R
V
S
Q
T
Q
A
R
F
L
Q
L
Site 3
S64
V
L
E
R
E
A
N
S
P
G
I
I
N
Q
W
Site 4
S81
E
S
K
D
K
V
I
S
L
L
L
T
H
L
P
Site 5
S127
E
E
S
R
Q
L
L
S
Y
A
L
I
H
P
A
Site 6
Y128
E
S
R
Q
L
L
S
Y
A
L
I
H
P
A
T
Site 7
S141
A
T
S
L
E
D
R
S
A
L
A
M
W
L
N
Site 8
T154
L
N
H
L
E
D
R
T
S
T
S
F
G
G
Q
Site 9
S155
N
H
L
E
D
R
T
S
T
S
F
G
G
Q
N
Site 10
T156
H
L
E
D
R
T
S
T
S
F
G
G
Q
N
R
Site 11
S157
L
E
D
R
T
S
T
S
F
G
G
Q
N
R
G
Site 12
S166
G
G
Q
N
R
G
R
S
D
S
V
D
Y
G
Q
Site 13
S168
Q
N
R
G
R
S
D
S
V
D
Y
G
Q
T
H
Site 14
Y171
G
R
S
D
S
V
D
Y
G
Q
T
H
Y
Y
H
Site 15
T174
D
S
V
D
Y
G
Q
T
H
Y
Y
H
Q
R
Q
Site 16
Y176
V
D
Y
G
Q
T
H
Y
Y
H
Q
R
Q
N
S
Site 17
Y177
D
Y
G
Q
T
H
Y
Y
H
Q
R
Q
N
S
D
Site 18
S183
Y
Y
H
Q
R
Q
N
S
D
D
K
L
N
G
W
Site 19
S196
G
W
Q
N
S
R
D
S
G
I
C
I
N
A
S
Site 20
Y220
E
N
G
H
V
P
L
Y
S
S
S
S
V
P
T
Site 21
S221
N
G
H
V
P
L
Y
S
S
S
S
V
P
T
T
Site 22
S223
H
V
P
L
Y
S
S
S
S
V
P
T
T
I
N
Site 23
S224
V
P
L
Y
S
S
S
S
V
P
T
T
I
N
T
Site 24
T228
S
S
S
S
V
P
T
T
I
N
T
I
G
T
S
Site 25
T231
S
V
P
T
T
I
N
T
I
G
T
S
T
S
T
Site 26
S237
N
T
I
G
T
S
T
S
T
I
L
S
G
Q
A
Site 27
S241
T
S
T
S
T
I
L
S
G
Q
A
H
H
S
P
Site 28
S247
L
S
G
Q
A
H
H
S
P
L
K
R
S
V
S
Site 29
S252
H
H
S
P
L
K
R
S
V
S
L
T
P
P
M
Site 30
S254
S
P
L
K
R
S
V
S
L
T
P
P
M
N
V
Site 31
T256
L
K
R
S
V
S
L
T
P
P
M
N
V
P
N
Site 32
S272
P
L
G
H
G
W
M
S
H
E
D
L
R
A
R
Site 33
S286
R
G
P
Q
C
L
P
S
D
H
A
P
L
S
P
Site 34
S292
P
S
D
H
A
P
L
S
P
Q
S
S
V
A
S
Site 35
S295
H
A
P
L
S
P
Q
S
S
V
A
S
S
G
S
Site 36
S296
A
P
L
S
P
Q
S
S
V
A
S
S
G
S
G
Site 37
S299
S
P
Q
S
S
V
A
S
S
G
S
G
G
S
E
Site 38
S300
P
Q
S
S
V
A
S
S
G
S
G
G
S
E
H
Site 39
S302
S
S
V
A
S
S
G
S
G
G
S
E
H
L
E
Site 40
T312
S
E
H
L
E
D
Q
T
T
A
R
N
T
F
Q
Site 41
T313
E
H
L
E
D
Q
T
T
A
R
N
T
F
Q
E
Site 42
T317
D
Q
T
T
A
R
N
T
F
Q
E
E
G
S
G
Site 43
S334
D
V
P
A
W
L
K
S
L
R
L
H
K
Y
A
Site 44
Y340
K
S
L
R
L
H
K
Y
A
A
L
F
S
Q
M
Site 45
S389
E
R
Q
N
L
L
K
S
L
E
R
D
I
I
E
Site 46
S399
R
D
I
I
E
G
G
S
L
R
I
P
L
Q
E
Site 47
T413
E
L
H
Q
M
I
L
T
P
I
K
A
Y
S
S
Site 48
Y418
I
L
T
P
I
K
A
Y
S
S
P
S
T
T
P
Site 49
S419
L
T
P
I
K
A
Y
S
S
P
S
T
T
P
E
Site 50
S420
T
P
I
K
A
Y
S
S
P
S
T
T
P
E
A
Site 51
S422
I
K
A
Y
S
S
P
S
T
T
P
E
A
R
R
Site 52
T423
K
A
Y
S
S
P
S
T
T
P
E
A
R
R
R
Site 53
T424
A
Y
S
S
P
S
T
T
P
E
A
R
R
R
E
Site 54
S439
P
Q
A
P
R
Q
P
S
L
M
G
P
E
S
Q
Site 55
S445
P
S
L
M
G
P
E
S
Q
S
P
D
C
K
D
Site 56
S447
L
M
G
P
E
S
Q
S
P
D
C
K
D
G
A
Site 57
S468
A
T
P
S
A
G
A
S
G
G
L
Q
P
H
Q
Site 58
S478
L
Q
P
H
Q
L
S
S
C
D
G
E
L
A
V
Site 59
S519
R
P
D
E
E
N
I
S
S
Y
L
Q
L
I
D
Site 60
S520
P
D
E
E
N
I
S
S
Y
L
Q
L
I
D
K
Site 61
S544
T
Q
K
K
R
L
L
S
W
K
Q
Q
V
Q
K
Site 62
S555
Q
V
Q
K
L
F
R
S
F
P
R
K
T
L
L
Site 63
T560
F
R
S
F
P
R
K
T
L
L
D
I
S
G
Y
Site 64
S565
R
K
T
L
L
D
I
S
G
Y
R
Q
Q
R
N
Site 65
Y567
T
L
L
D
I
S
G
Y
R
Q
Q
R
N
R
G
Site 66
S578
R
N
R
G
F
G
Q
S
N
S
L
P
T
A
G
Site 67
S580
R
G
F
G
Q
S
N
S
L
P
T
A
G
S
V
Site 68
S586
N
S
L
P
T
A
G
S
V
G
G
G
M
G
R
Site 69
Y599
G
R
R
N
P
R
Q
Y
Q
I
P
S
R
N
V
Site 70
S617
R
L
G
L
L
G
T
S
G
F
V
S
S
N
Q
Site 71
S621
L
G
T
S
G
F
V
S
S
N
Q
R
N
T
T
Site 72
S622
G
T
S
G
F
V
S
S
N
Q
R
N
T
T
A
Site 73
T627
V
S
S
N
Q
R
N
T
T
A
T
P
T
I
M
Site 74
T628
S
S
N
Q
R
N
T
T
A
T
P
T
I
M
K
Site 75
T630
N
Q
R
N
T
T
A
T
P
T
I
M
K
Q
G
Site 76
S649
W
F
A
N
P
G
G
S
N
S
M
P
S
R
T
Site 77
S651
A
N
P
G
G
S
N
S
M
P
S
R
T
H
S
Site 78
S654
G
G
S
N
S
M
P
S
R
T
H
S
S
V
Q
Site 79
T656
S
N
S
M
P
S
R
T
H
S
S
V
Q
R
T
Site 80
S658
S
M
P
S
R
T
H
S
S
V
Q
R
T
R
S
Site 81
S659
M
P
S
R
T
H
S
S
V
Q
R
T
R
S
L
Site 82
T663
T
H
S
S
V
Q
R
T
R
S
L
P
V
H
T
Site 83
S665
S
S
V
Q
R
T
R
S
L
P
V
H
T
S
P
Site 84
S671
R
S
L
P
V
H
T
S
P
Q
N
M
L
M
F
Site 85
T688
P
E
F
Q
L
P
V
T
E
P
D
I
N
N
R
Site 86
S698
D
I
N
N
R
L
E
S
L
C
L
S
M
T
E
Site 87
T704
E
S
L
C
L
S
M
T
E
H
A
L
G
D
G
Site 88
S716
G
D
G
V
D
R
T
S
T
I
_
_
_
_
_
Site 89
T717
D
G
V
D
R
T
S
T
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation