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Updated November 2019
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Protein Info
Short Name:
SHANK2
Full Name:
SH3 and multiple ankyrin repeat domains protein 2
Alias:
Cortactin-binding protein 1; Cortbp1; Cttnbp1; Proline-rich synapse-associated protein 1; Prosap1; Sh3 and multiple ankyrin repeat domains 2; Shan2; Shank; Shank2; Spank-3
Type:
Adaptor/scaffold
Mass (Da):
158822
Number AA:
1470
UniProt ID:
Q9UPX8
International Prot ID:
IPI00107633
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0014069
Uniprot
OncoNet
Molecular Function:
GO:0030160
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
SH3 and multiple ankyrin repeat domains protein 2 pan-specific antibody AB-NN318-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN318-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
P
F
R
E
A
P
A
Y
S
N
R
R
R
R
P
Site 2
S22
F
R
E
A
P
A
Y
S
N
R
R
R
R
P
P
Site 3
T31
R
R
R
R
P
P
N
T
L
A
A
P
R
V
L
Site 4
S41
A
P
R
V
L
L
R
S
N
S
D
N
N
L
N
Site 5
S43
R
V
L
L
R
S
N
S
D
N
N
L
N
A
S
Site 6
S58
A
P
D
W
A
V
C
S
T
A
T
S
H
R
S
Site 7
T61
W
A
V
C
S
T
A
T
S
H
R
S
L
S
P
Site 8
S62
A
V
C
S
T
A
T
S
H
R
S
L
S
P
Q
Site 9
S65
S
T
A
T
S
H
R
S
L
S
P
Q
L
L
Q
Site 10
S67
A
T
S
H
R
S
L
S
P
Q
L
L
Q
Q
M
Site 11
S87
G
A
A
K
T
I
G
S
Y
V
P
G
P
R
S
Site 12
Y88
A
A
K
T
I
G
S
Y
V
P
G
P
R
S
R
Site 13
S94
S
Y
V
P
G
P
R
S
R
S
P
S
L
N
R
Site 14
S96
V
P
G
P
R
S
R
S
P
S
L
N
R
L
G
Site 15
S98
G
P
R
S
R
S
P
S
L
N
R
L
G
G
A
Site 16
S130
A
L
G
A
N
K
D
S
L
S
A
F
E
Y
P
Site 17
S132
G
A
N
K
D
S
L
S
A
F
E
Y
P
G
P
Site 18
Y136
D
S
L
S
A
F
E
Y
P
G
P
K
R
K
L
Site 19
Y144
P
G
P
K
R
K
L
Y
S
A
V
P
G
R
L
Site 20
S178
G
D
R
V
K
V
L
S
I
G
E
G
G
F
W
Site 21
S211
V
Q
C
K
P
R
D
S
Q
A
E
T
R
A
D
Site 22
T215
P
R
D
S
Q
A
E
T
R
A
D
R
S
K
K
Site 23
S220
A
E
T
R
A
D
R
S
K
K
L
F
R
H
Y
Site 24
Y227
S
K
K
L
F
R
H
Y
T
V
G
S
Y
D
S
Site 25
T228
K
K
L
F
R
H
Y
T
V
G
S
Y
D
S
F
Site 26
S231
F
R
H
Y
T
V
G
S
Y
D
S
F
D
T
S
Site 27
Y232
R
H
Y
T
V
G
S
Y
D
S
F
D
T
S
S
Site 28
S234
Y
T
V
G
S
Y
D
S
F
D
T
S
S
D
C
Site 29
T237
G
S
Y
D
S
F
D
T
S
S
D
C
I
I
E
Site 30
S238
S
Y
D
S
F
D
T
S
S
D
C
I
I
E
E
Site 31
S239
Y
D
S
F
D
T
S
S
D
C
I
I
E
E
K
Site 32
T247
D
C
I
I
E
E
K
T
V
V
L
Q
K
K
D
Site 33
T269
L
R
G
A
K
A
D
T
P
I
E
E
F
T
P
Site 34
T275
D
T
P
I
E
E
F
T
P
T
P
A
F
P
A
Site 35
T277
P
I
E
E
F
T
P
T
P
A
F
P
A
L
Q
Site 36
Y285
P
A
F
P
A
L
Q
Y
L
E
S
V
D
E
G
Site 37
S288
P
A
L
Q
Y
L
E
S
V
D
E
G
G
V
A
Site 38
T349
R
N
L
D
P
D
D
T
A
R
K
K
A
P
P
Site 39
T363
P
P
P
K
R
A
P
T
T
A
L
T
L
R
S
Site 40
T367
R
A
P
T
T
A
L
T
L
R
S
K
S
M
T
Site 41
S370
T
T
A
L
T
L
R
S
K
S
M
T
S
E
L
Site 42
S372
A
L
T
L
R
S
K
S
M
T
S
E
L
E
E
Site 43
T374
T
L
R
S
K
S
M
T
S
E
L
E
E
L
V
Site 44
S385
E
E
L
V
D
K
A
S
V
R
K
K
K
D
K
Site 45
S400
P
E
E
I
V
P
A
S
K
P
S
R
A
A
E
Site 46
T417
A
V
E
P
R
V
A
T
I
K
Q
R
P
S
S
Site 47
S423
A
T
I
K
Q
R
P
S
S
R
C
F
P
A
G
Site 48
S424
T
I
K
Q
R
P
S
S
R
C
F
P
A
G
S
Site 49
S431
S
R
C
F
P
A
G
S
D
M
N
S
V
Y
E
Site 50
S435
P
A
G
S
D
M
N
S
V
Y
E
R
Q
G
I
Site 51
Y437
G
S
D
M
N
S
V
Y
E
R
Q
G
I
A
V
Site 52
T446
R
Q
G
I
A
V
M
T
P
T
V
P
G
S
P
Site 53
T448
G
I
A
V
M
T
P
T
V
P
G
S
P
K
A
Site 54
S452
M
T
P
T
V
P
G
S
P
K
A
P
F
L
G
Site 55
T464
F
L
G
I
P
R
G
T
M
R
R
Q
K
S
I
Site 56
S470
G
T
M
R
R
Q
K
S
I
D
S
R
I
F
L
Site 57
S473
R
R
Q
K
S
I
D
S
R
I
F
L
S
G
I
Site 58
S478
I
D
S
R
I
F
L
S
G
I
T
E
E
E
R
Site 59
T481
R
I
F
L
S
G
I
T
E
E
E
R
Q
F
L
Site 60
T496
A
P
P
M
L
K
F
T
R
S
L
S
M
P
D
Site 61
S498
P
M
L
K
F
T
R
S
L
S
M
P
D
T
S
Site 62
S500
L
K
F
T
R
S
L
S
M
P
D
T
S
E
D
Site 63
T504
R
S
L
S
M
P
D
T
S
E
D
I
P
P
P
Site 64
S505
S
L
S
M
P
D
T
S
E
D
I
P
P
P
P
Site 65
S514
D
I
P
P
P
P
Q
S
V
P
P
S
P
P
P
Site 66
S518
P
P
Q
S
V
P
P
S
P
P
P
P
S
P
T
Site 67
S523
P
P
S
P
P
P
P
S
P
T
T
Y
N
C
P
Site 68
T525
S
P
P
P
P
S
P
T
T
Y
N
C
P
K
S
Site 69
T526
P
P
P
P
S
P
T
T
Y
N
C
P
K
S
P
Site 70
Y527
P
P
P
S
P
T
T
Y
N
C
P
K
S
P
T
Site 71
S532
T
T
Y
N
C
P
K
S
P
T
P
R
V
Y
G
Site 72
T534
Y
N
C
P
K
S
P
T
P
R
V
Y
G
T
I
Site 73
Y538
K
S
P
T
P
R
V
Y
G
T
I
K
P
A
F
Site 74
S554
Q
N
S
A
A
K
V
S
P
A
T
R
S
D
T
Site 75
S559
K
V
S
P
A
T
R
S
D
T
V
A
T
M
M
Site 76
T561
S
P
A
T
R
S
D
T
V
A
T
M
M
R
E
Site 77
Y572
M
M
R
E
K
G
M
Y
F
R
R
E
L
D
R
Site 78
Y580
F
R
R
E
L
D
R
Y
S
L
D
S
E
D
L
Site 79
S581
R
R
E
L
D
R
Y
S
L
D
S
E
D
L
Y
Site 80
S584
L
D
R
Y
S
L
D
S
E
D
L
Y
S
R
N
Site 81
Y588
S
L
D
S
E
D
L
Y
S
R
N
A
G
P
Q
Site 82
S589
L
D
S
E
D
L
Y
S
R
N
A
G
P
Q
A
Site 83
Y610
G
Q
M
P
E
N
P
Y
S
E
V
G
K
I
A
Site 84
S611
Q
M
P
E
N
P
Y
S
E
V
G
K
I
A
S
Site 85
Y622
K
I
A
S
K
A
V
Y
V
P
A
K
P
A
R
Site 86
S643
K
Q
S
N
V
E
D
S
P
E
K
T
C
S
I
Site 87
T647
V
E
D
S
P
E
K
T
C
S
I
P
I
P
T
Site 88
S649
D
S
P
E
K
T
C
S
I
P
I
P
T
I
I
Site 89
S661
T
I
I
V
K
E
P
S
T
S
S
S
G
K
S
Site 90
T662
I
I
V
K
E
P
S
T
S
S
S
G
K
S
S
Site 91
S663
I
V
K
E
P
S
T
S
S
S
G
K
S
S
Q
Site 92
S664
V
K
E
P
S
T
S
S
S
G
K
S
S
Q
G
Site 93
S665
K
E
P
S
T
S
S
S
G
K
S
S
Q
G
S
Site 94
S668
S
T
S
S
S
G
K
S
S
Q
G
S
S
M
E
Site 95
S669
T
S
S
S
G
K
S
S
Q
G
S
S
M
E
I
Site 96
S672
S
G
K
S
S
Q
G
S
S
M
E
I
D
P
Q
Site 97
S673
G
K
S
S
Q
G
S
S
M
E
I
D
P
Q
A
Site 98
S685
P
Q
A
P
E
P
P
S
Q
L
R
P
D
E
S
Site 99
S692
S
Q
L
R
P
D
E
S
L
T
V
S
S
P
F
Site 100
T694
L
R
P
D
E
S
L
T
V
S
S
P
F
A
A
Site 101
S720
R
L
E
A
R
R
N
S
P
A
F
L
S
T
D
Site 102
S725
R
N
S
P
A
F
L
S
T
D
L
G
D
E
D
Site 103
T726
N
S
P
A
F
L
S
T
D
L
G
D
E
D
V
Site 104
T742
L
G
P
P
A
P
R
T
R
P
S
M
F
P
E
Site 105
S745
P
A
P
R
T
R
P
S
M
F
P
E
E
G
D
Site 106
S758
G
D
F
A
D
E
D
S
A
E
Q
L
S
S
P
Site 107
S763
E
D
S
A
E
Q
L
S
S
P
M
P
S
A
T
Site 108
S764
D
S
A
E
Q
L
S
S
P
M
P
S
A
T
P
Site 109
S768
Q
L
S
S
P
M
P
S
A
T
P
R
E
P
E
Site 110
T770
S
S
P
M
P
S
A
T
P
R
E
P
E
N
H
Site 111
S796
E
A
G
R
P
L
N
S
T
S
K
A
Q
G
P
Site 112
T797
A
G
R
P
L
N
S
T
S
K
A
Q
G
P
E
Site 113
S798
G
R
P
L
N
S
T
S
K
A
Q
G
P
E
S
Site 114
S805
S
K
A
Q
G
P
E
S
S
P
A
V
P
S
A
Site 115
S806
K
A
Q
G
P
E
S
S
P
A
V
P
S
A
S
Site 116
S811
E
S
S
P
A
V
P
S
A
S
S
G
T
A
G
Site 117
S813
S
P
A
V
P
S
A
S
S
G
T
A
G
P
G
Site 118
S814
P
A
V
P
S
A
S
S
G
T
A
G
P
G
N
Site 119
Y822
G
T
A
G
P
G
N
Y
V
H
P
L
T
G
R
Site 120
T827
G
N
Y
V
H
P
L
T
G
R
L
L
D
P
S
Site 121
S842
S
P
L
A
L
A
L
S
A
R
D
R
A
M
K
Site 122
S851
R
D
R
A
M
K
E
S
Q
Q
G
P
K
G
E
Site 123
Y869
A
D
L
N
K
P
L
Y
I
D
T
K
M
R
P
Site 124
T872
N
K
P
L
Y
I
D
T
K
M
R
P
S
L
D
Site 125
S877
I
D
T
K
M
R
P
S
L
D
A
G
F
P
T
Site 126
T884
S
L
D
A
G
F
P
T
V
T
R
Q
N
T
R
Site 127
T890
P
T
V
T
R
Q
N
T
R
G
P
L
R
R
Q
Site 128
T899
G
P
L
R
R
Q
E
T
E
N
K
Y
E
T
D
Site 129
Y903
R
Q
E
T
E
N
K
Y
E
T
D
L
G
R
D
Site 130
S927
L
I
D
I
M
D
T
S
Q
Q
K
S
A
G
L
Site 131
S931
M
D
T
S
Q
Q
K
S
A
G
L
L
M
V
H
Site 132
S964
E
V
E
M
K
P
D
S
S
P
S
E
V
P
E
Site 133
S965
V
E
M
K
P
D
S
S
P
S
E
V
P
E
G
Site 134
S967
M
K
P
D
S
S
P
S
E
V
P
E
G
V
S
Site 135
S983
T
E
G
A
L
Q
I
S
A
A
P
E
P
T
T
Site 136
T990
S
A
A
P
E
P
T
T
V
P
G
R
T
I
V
Site 137
S1001
R
T
I
V
A
V
G
S
M
E
E
A
V
I
L
Site 138
S1019
I
P
P
P
P
L
A
S
V
D
L
D
E
D
F
Site 139
S1041
P
P
L
E
F
A
N
S
F
D
I
P
D
D
R
Site 140
S1051
I
P
D
D
R
A
A
S
V
P
A
L
S
D
L
Site 141
S1056
A
A
S
V
P
A
L
S
D
L
V
K
Q
K
K
Site 142
S1064
D
L
V
K
Q
K
K
S
D
T
P
Q
S
P
S
Site 143
T1066
V
K
Q
K
K
S
D
T
P
Q
S
P
S
L
N
Site 144
S1069
K
K
S
D
T
P
Q
S
P
S
L
N
S
S
Q
Site 145
S1071
S
D
T
P
Q
S
P
S
L
N
S
S
Q
P
T
Site 146
S1074
P
Q
S
P
S
L
N
S
S
Q
P
T
N
S
A
Site 147
S1075
Q
S
P
S
L
N
S
S
Q
P
T
N
S
A
D
Site 148
T1078
S
L
N
S
S
Q
P
T
N
S
A
D
S
K
K
Site 149
S1080
N
S
S
Q
P
T
N
S
A
D
S
K
K
P
A
Site 150
S1083
Q
P
T
N
S
A
D
S
K
K
P
A
S
L
S
Site 151
S1088
A
D
S
K
K
P
A
S
L
S
N
C
L
P
A
Site 152
S1090
S
K
K
P
A
S
L
S
N
C
L
P
A
S
F
Site 153
S1096
L
S
N
C
L
P
A
S
F
L
P
P
P
E
S
Site 154
S1103
S
F
L
P
P
P
E
S
F
D
A
V
A
D
S
Site 155
S1110
S
F
D
A
V
A
D
S
G
I
E
E
V
D
S
Site 156
S1117
S
G
I
E
E
V
D
S
R
S
S
S
D
H
H
Site 157
S1119
I
E
E
V
D
S
R
S
S
S
D
H
H
L
E
Site 158
S1120
E
E
V
D
S
R
S
S
S
D
H
H
L
E
T
Site 159
S1121
E
V
D
S
R
S
S
S
D
H
H
L
E
T
T
Site 160
T1127
S
S
D
H
H
L
E
T
T
S
T
I
S
T
V
Site 161
T1128
S
D
H
H
L
E
T
T
S
T
I
S
T
V
S
Site 162
S1129
D
H
H
L
E
T
T
S
T
I
S
T
V
S
S
Site 163
T1130
H
H
L
E
T
T
S
T
I
S
T
V
S
S
I
Site 164
S1136
S
T
I
S
T
V
S
S
I
S
T
L
S
S
E
Site 165
T1139
S
T
V
S
S
I
S
T
L
S
S
E
G
G
E
Site 166
S1141
V
S
S
I
S
T
L
S
S
E
G
G
E
N
V
Site 167
S1142
S
S
I
S
T
L
S
S
E
G
G
E
N
V
D
Site 168
T1150
E
G
G
E
N
V
D
T
C
T
V
Y
A
D
G
Site 169
T1152
G
E
N
V
D
T
C
T
V
Y
A
D
G
Q
A
Site 170
Y1184
I
H
K
S
N
A
L
Y
Q
D
A
L
V
E
E
Site 171
S1209
A
P
P
P
P
P
G
S
A
Q
P
G
M
A
K
Site 172
S1223
K
V
L
Q
P
R
T
S
K
L
W
G
D
V
T
Site 173
T1230
S
K
L
W
G
D
V
T
E
I
K
S
P
I
L
Site 174
S1234
G
D
V
T
E
I
K
S
P
I
L
S
G
P
K
Site 175
S1250
N
V
I
S
E
L
N
S
I
L
Q
Q
M
N
R
Site 176
S1269
K
P
G
E
G
L
D
S
P
M
G
A
K
S
A
Site 177
S1275
D
S
P
M
G
A
K
S
A
S
L
A
P
R
S
Site 178
S1277
P
M
G
A
K
S
A
S
L
A
P
R
S
P
E
Site 179
S1282
S
A
S
L
A
P
R
S
P
E
I
M
S
T
I
Site 180
S1287
P
R
S
P
E
I
M
S
T
I
S
G
T
R
S
Site 181
T1288
R
S
P
E
I
M
S
T
I
S
G
T
R
S
T
Site 182
S1290
P
E
I
M
S
T
I
S
G
T
R
S
T
T
V
Site 183
T1295
T
I
S
G
T
R
S
T
T
V
T
F
T
V
R
Site 184
T1296
I
S
G
T
R
S
T
T
V
T
F
T
V
R
P
Site 185
T1298
G
T
R
S
T
T
V
T
F
T
V
R
P
G
T
Site 186
T1300
R
S
T
T
V
T
F
T
V
R
P
G
T
S
Q
Site 187
T1305
T
F
T
V
R
P
G
T
S
Q
P
I
T
L
Q
Site 188
S1306
F
T
V
R
P
G
T
S
Q
P
I
T
L
Q
S
Site 189
T1310
P
G
T
S
Q
P
I
T
L
Q
S
R
P
P
D
Site 190
S1313
S
Q
P
I
T
L
Q
S
R
P
P
D
Y
E
S
Site 191
Y1318
L
Q
S
R
P
P
D
Y
E
S
R
T
S
G
T
Site 192
S1320
S
R
P
P
D
Y
E
S
R
T
S
G
T
R
R
Site 193
S1323
P
D
Y
E
S
R
T
S
G
T
R
R
A
P
S
Site 194
S1330
S
G
T
R
R
A
P
S
P
V
V
S
P
T
E
Site 195
S1334
R
A
P
S
P
V
V
S
P
T
E
M
N
K
E
Site 196
T1336
P
S
P
V
V
S
P
T
E
M
N
K
E
T
L
Site 197
S1348
E
T
L
P
A
P
L
S
A
A
T
A
S
P
S
Site 198
S1353
P
L
S
A
A
T
A
S
P
S
P
A
L
S
D
Site 199
S1363
P
A
L
S
D
V
F
S
L
P
S
Q
P
P
S
Site 200
S1366
S
D
V
F
S
L
P
S
Q
P
P
S
G
D
L
Site 201
S1370
S
L
P
S
Q
P
P
S
G
D
L
F
G
L
N
Site 202
S1382
G
L
N
P
A
G
R
S
R
S
P
S
P
S
I
Site 203
S1384
N
P
A
G
R
S
R
S
P
S
P
S
I
L
Q
Site 204
S1386
A
G
R
S
R
S
P
S
P
S
I
L
Q
Q
P
Site 205
S1388
R
S
R
S
P
S
P
S
I
L
Q
Q
P
I
S
Site 206
S1395
S
I
L
Q
Q
P
I
S
N
K
P
F
T
T
K
Site 207
T1400
P
I
S
N
K
P
F
T
T
K
P
V
H
L
W
Site 208
S1418
D
V
A
D
W
L
E
S
L
N
L
G
E
H
K
Site 209
S1436
M
D
N
E
I
D
G
S
H
L
P
N
L
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation