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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH4
Full Name:
Alias:
Brain-specific eag-like channel 2;Ether-a-go-go-like potassium channel 1;Voltage-gated potassium channel subunit Kv12.3
Type:
Mass (Da):
111693
Number AA:
1017
UniProt ID:
Q9UQ05
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
Q
N
T
F
L
D
T
I
A
T
R
F
D
G
Site 2
T53
S
D
G
F
C
E
L
T
G
Y
G
R
T
E
V
Site 3
Y55
G
F
C
E
L
T
G
Y
G
R
T
E
V
M
Q
Site 4
Y71
T
C
S
C
R
F
L
Y
G
P
E
T
S
E
P
Site 5
T75
R
F
L
Y
G
P
E
T
S
E
P
A
L
Q
R
Site 6
Y100
H
R
A
E
I
C
F
Y
R
K
D
G
S
A
F
Site 7
S105
C
F
Y
R
K
D
G
S
A
F
W
C
L
L
D
Site 8
T134
L
F
S
F
K
D
I
T
Q
S
G
S
P
G
L
Site 9
S136
S
F
K
D
I
T
Q
S
G
S
P
G
L
G
P
Site 10
S138
K
D
I
T
Q
S
G
S
P
G
L
G
P
Q
G
Site 11
S150
P
Q
G
G
R
G
D
S
N
H
E
N
S
L
G
Site 12
S155
G
D
S
N
H
E
N
S
L
G
R
R
G
A
T
Site 13
T162
S
L
G
R
R
G
A
T
W
K
F
R
S
A
R
Site 14
S167
G
A
T
W
K
F
R
S
A
R
R
R
S
R
T
Site 15
S172
F
R
S
A
R
R
R
S
R
T
V
L
H
R
L
Site 16
T174
S
A
R
R
R
S
R
T
V
L
H
R
L
T
G
Site 17
T180
R
T
V
L
H
R
L
T
G
H
F
G
R
R
G
Site 18
S203
N
V
F
E
P
K
P
S
V
P
E
Y
K
V
A
Site 19
Y207
P
K
P
S
V
P
E
Y
K
V
A
S
V
G
G
Site 20
T256
C
F
S
G
D
D
D
T
P
I
T
S
R
H
T
Site 21
T259
G
D
D
D
T
P
I
T
S
R
H
T
L
V
S
Site 22
T284
D
I
I
L
N
F
R
T
T
Y
V
S
Q
S
G
Site 23
T285
I
I
L
N
F
R
T
T
Y
V
S
Q
S
G
Q
Site 24
Y286
I
L
N
F
R
T
T
Y
V
S
Q
S
G
Q
V
Site 25
S288
N
F
R
T
T
Y
V
S
Q
S
G
Q
V
I
S
Site 26
S295
S
Q
S
G
Q
V
I
S
A
P
R
S
I
G
L
Site 27
Y412
G
K
R
L
E
V
P
Y
V
N
G
S
V
G
G
Site 28
S416
E
V
P
Y
V
N
G
S
V
G
G
P
S
R
R
Site 29
S421
N
G
S
V
G
G
P
S
R
R
S
A
Y
I
A
Site 30
Y426
G
P
S
R
R
S
A
Y
I
A
A
L
Y
F
T
Site 31
Y482
T
A
I
I
Q
R
M
Y
S
R
R
S
L
Y
H
Site 32
S483
A
I
I
Q
R
M
Y
S
R
R
S
L
Y
H
S
Site 33
S486
Q
R
M
Y
S
R
R
S
L
Y
H
S
R
M
K
Site 34
Y488
M
Y
S
R
R
S
L
Y
H
S
R
M
K
D
L
Site 35
S490
S
R
R
S
L
Y
H
S
R
M
K
D
L
K
D
Site 36
Y515
L
K
Q
R
M
L
E
Y
F
Q
T
T
W
A
V
Site 37
Y582
S
F
C
A
P
G
E
Y
L
L
R
R
G
D
A
Site 38
Y595
D
A
L
Q
A
H
Y
Y
V
C
S
G
S
L
E
Site 39
S658
Y
C
G
L
Q
Q
L
S
S
R
G
L
A
E
V
Site 40
T685
A
G
L
P
R
D
L
T
F
N
L
R
Q
G
S
Site 41
S692
T
F
N
L
R
Q
G
S
D
T
S
G
L
S
R
Site 42
T694
N
L
R
Q
G
S
D
T
S
G
L
S
R
F
S
Site 43
S695
L
R
Q
G
S
D
T
S
G
L
S
R
F
S
R
Site 44
S698
G
S
D
T
S
G
L
S
R
F
S
R
S
P
R
Site 45
S701
T
S
G
L
S
R
F
S
R
S
P
R
L
S
Q
Site 46
S703
G
L
S
R
F
S
R
S
P
R
L
S
Q
P
R
Site 47
S707
F
S
R
S
P
R
L
S
Q
P
R
S
E
S
L
Site 48
S711
P
R
L
S
Q
P
R
S
E
S
L
G
S
S
S
Site 49
S713
L
S
Q
P
R
S
E
S
L
G
S
S
S
D
K
Site 50
S716
P
R
S
E
S
L
G
S
S
S
D
K
T
L
P
Site 51
S717
R
S
E
S
L
G
S
S
S
D
K
T
L
P
S
Site 52
S718
S
E
S
L
G
S
S
S
D
K
T
L
P
S
I
Site 53
T721
L
G
S
S
S
D
K
T
L
P
S
I
T
E
A
Site 54
S724
S
S
D
K
T
L
P
S
I
T
E
A
E
S
G
Site 55
S730
P
S
I
T
E
A
E
S
G
A
E
P
G
G
G
Site 56
S750
P
L
L
L
P
N
L
S
P
A
R
P
R
G
S
Site 57
S757
S
P
A
R
P
R
G
S
L
V
S
L
L
G
E
Site 58
S760
R
P
R
G
S
L
V
S
L
L
G
E
E
L
P
Site 59
S770
G
E
E
L
P
P
F
S
A
L
V
S
S
P
S
Site 60
S774
P
P
F
S
A
L
V
S
S
P
S
L
S
P
S
Site 61
S781
S
S
P
S
L
S
P
S
L
S
P
A
L
A
G
Site 62
S783
P
S
L
S
P
S
L
S
P
A
L
A
G
Q
G
Site 63
S792
A
L
A
G
Q
G
H
S
A
S
P
H
G
P
P
Site 64
S794
A
G
Q
G
H
S
A
S
P
H
G
P
P
R
C
Site 65
S802
P
H
G
P
P
R
C
S
A
A
W
K
P
P
Q
Site 66
S824
T
F
G
P
P
D
L
S
P
R
I
V
D
G
I
Site 67
S834
I
V
D
G
I
E
D
S
G
S
T
A
E
A
P
Site 68
S836
D
G
I
E
D
S
G
S
T
A
E
A
P
S
F
Site 69
S842
G
S
T
A
E
A
P
S
F
R
F
S
R
R
P
Site 70
S846
E
A
P
S
F
R
F
S
R
R
P
E
L
P
R
Site 71
S856
P
E
L
P
R
P
R
S
Q
A
P
P
T
G
T
Site 72
T861
P
R
S
Q
A
P
P
T
G
T
R
P
S
P
E
Site 73
S866
P
P
T
G
T
R
P
S
P
E
L
A
S
E
A
Site 74
S888
C
R
L
N
Q
E
I
S
R
L
N
Q
E
V
S
Site 75
S895
S
R
L
N
Q
E
V
S
Q
L
S
R
E
L
R
Site 76
T924
H
P
A
G
S
A
W
T
P
D
P
P
C
P
Q
Site 77
S938
Q
L
R
P
P
C
L
S
P
C
A
S
R
P
P
Site 78
S942
P
C
L
S
P
C
A
S
R
P
P
P
S
L
Q
Site 79
S947
C
A
S
R
P
P
P
S
L
Q
D
T
T
L
A
Site 80
T951
P
P
P
S
L
Q
D
T
T
L
A
E
V
H
C
Site 81
T952
P
P
S
L
Q
D
T
T
L
A
E
V
H
C
P
Site 82
Y982
R
P
S
I
L
P
P
Y
P
S
E
P
D
P
L
Site 83
S984
S
I
L
P
P
Y
P
S
E
P
D
P
L
G
P
Site 84
S992
E
P
D
P
L
G
P
S
P
V
P
E
A
S
P
Site 85
S998
P
S
P
V
P
E
A
S
P
P
T
P
S
L
L
Site 86
T1001
V
P
E
A
S
P
P
T
P
S
L
L
R
H
S
Site 87
S1003
E
A
S
P
P
T
P
S
L
L
R
H
S
F
Q
Site 88
S1008
T
P
S
L
L
R
H
S
F
Q
S
R
S
D
T
Site 89
S1011
L
L
R
H
S
F
Q
S
R
S
D
T
F
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation