KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RIMS2
Full Name:
Regulating synaptic membrane exocytosis protein 2
Alias:
KIAA0751; OBOE; Rab3-interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis 2; RIM2
Type:
Plasma membrane, Synapse, Cell junction protein
Mass (Da):
160403
Number AA:
1411
UniProt ID:
Q9UQ26
International Prot ID:
IPI00005698
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0045202
Uniprot
OncoNet
Molecular Function:
GO:0017137
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
A
P
I
P
A
A
S
Q
P
P
L
Q
P
E
Site 2
S30
Q
P
E
M
P
D
L
S
H
L
T
E
E
E
R
Site 3
T60
E
E
H
K
P
Q
L
T
Q
W
F
P
F
S
G
Site 4
S66
L
T
Q
W
F
P
F
S
G
I
T
E
L
V
N
Site 5
T69
W
F
P
F
S
G
I
T
E
L
V
N
N
V
L
Site 6
T122
E
Q
K
G
D
A
P
T
C
G
I
C
H
K
T
Site 7
T129
T
C
G
I
C
H
K
T
K
F
A
D
G
C
G
Site 8
S140
D
G
C
G
H
N
C
S
Y
C
Q
T
K
F
C
Site 9
S155
A
R
C
G
G
R
V
S
L
R
S
N
K
V
M
Site 10
T176
R
K
Q
Q
E
I
L
T
K
S
G
A
W
F
Y
Site 11
S178
Q
Q
E
I
L
T
K
S
G
A
W
F
Y
N
S
Site 12
Y183
T
K
S
G
A
W
F
Y
N
S
G
S
N
T
P
Site 13
S185
S
G
A
W
F
Y
N
S
G
S
N
T
P
Q
Q
Site 14
T189
F
Y
N
S
G
S
N
T
P
Q
Q
P
D
Q
K
Site 15
S224
Q
T
Q
F
Q
G
P
S
G
D
L
S
V
P
A
Site 16
S228
Q
G
P
S
G
D
L
S
V
P
A
V
E
K
S
Site 17
S235
S
V
P
A
V
E
K
S
R
S
H
G
L
T
R
Site 18
S237
P
A
V
E
K
S
R
S
H
G
L
T
R
Q
H
Site 19
T241
K
S
R
S
H
G
L
T
R
Q
H
S
I
K
N
Site 20
S245
H
G
L
T
R
Q
H
S
I
K
N
G
S
G
V
Site 21
S258
G
V
K
H
H
I
A
S
D
I
A
S
D
R
K
Site 22
S262
H
I
A
S
D
I
A
S
D
R
K
R
S
P
S
Site 23
S267
I
A
S
D
R
K
R
S
P
S
V
S
R
D
Q
Site 24
S269
S
D
R
K
R
S
P
S
V
S
R
D
Q
N
R
Site 25
S271
R
K
R
S
P
S
V
S
R
D
Q
N
R
R
Y
Site 26
Y278
S
R
D
Q
N
R
R
Y
D
Q
R
E
E
R
E
Site 27
Y287
Q
R
E
E
R
E
E
Y
S
Q
Y
A
T
S
D
Site 28
S288
R
E
E
R
E
E
Y
S
Q
Y
A
T
S
D
T
Site 29
Y290
E
R
E
E
Y
S
Q
Y
A
T
S
D
T
A
M
Site 30
T292
E
E
Y
S
Q
Y
A
T
S
D
T
A
M
P
R
Site 31
S293
E
Y
S
Q
Y
A
T
S
D
T
A
M
P
R
S
Site 32
T295
S
Q
Y
A
T
S
D
T
A
M
P
R
S
P
S
Site 33
S300
S
D
T
A
M
P
R
S
P
S
D
Y
A
D
R
Site 34
S302
T
A
M
P
R
S
P
S
D
Y
A
D
R
R
S
Site 35
Y304
M
P
R
S
P
S
D
Y
A
D
R
R
S
Q
H
Site 36
S309
S
D
Y
A
D
R
R
S
Q
H
E
P
Q
F
Y
Site 37
Y316
S
Q
H
E
P
Q
F
Y
E
D
S
D
H
L
S
Site 38
S319
E
P
Q
F
Y
E
D
S
D
H
L
S
Y
R
D
Site 39
S323
Y
E
D
S
D
H
L
S
Y
R
D
S
N
R
R
Site 40
S327
D
H
L
S
Y
R
D
S
N
R
R
S
H
R
H
Site 41
S331
Y
R
D
S
N
R
R
S
H
R
H
S
K
E
Y
Site 42
S335
N
R
R
S
H
R
H
S
K
E
Y
I
V
D
D
Site 43
Y338
S
H
R
H
S
K
E
Y
I
V
D
D
E
D
V
Site 44
S347
V
D
D
E
D
V
E
S
R
D
E
Y
E
R
Q
Site 45
Y351
D
V
E
S
R
D
E
Y
E
R
Q
R
R
E
E
Site 46
Y360
R
Q
R
R
E
E
E
Y
Q
S
R
Y
R
S
D
Site 47
S362
R
R
E
E
E
Y
Q
S
R
Y
R
S
D
P
N
Site 48
S366
E
Y
Q
S
R
Y
R
S
D
P
N
L
A
R
Y
Site 49
Y373
S
D
P
N
L
A
R
Y
P
V
K
P
Q
P
Y
Site 50
S400
A
R
H
E
R
R
H
S
D
V
S
L
A
N
A
Site 51
S403
E
R
R
H
S
D
V
S
L
A
N
A
D
L
E
Site 52
S412
A
N
A
D
L
E
D
S
R
I
S
M
L
R
M
Site 53
S415
D
L
E
D
S
R
I
S
M
L
R
M
D
R
P
Site 54
S423
M
L
R
M
D
R
P
S
R
Q
R
S
I
S
E
Site 55
S427
D
R
P
S
R
Q
R
S
I
S
E
R
R
A
A
Site 56
S429
P
S
R
Q
R
S
I
S
E
R
R
A
A
M
E
Site 57
S440
A
A
M
E
N
Q
R
S
Y
S
M
E
R
T
R
Site 58
Y441
A
M
E
N
Q
R
S
Y
S
M
E
R
T
R
E
Site 59
S442
M
E
N
Q
R
S
Y
S
M
E
R
T
R
E
A
Site 60
T446
R
S
Y
S
M
E
R
T
R
E
A
Q
G
P
S
Site 61
S453
T
R
E
A
Q
G
P
S
S
Y
A
Q
R
T
T
Site 62
S454
R
E
A
Q
G
P
S
S
Y
A
Q
R
T
T
N
Site 63
Y455
E
A
Q
G
P
S
S
Y
A
Q
R
T
T
N
H
Site 64
T459
P
S
S
Y
A
Q
R
T
T
N
H
S
P
P
T
Site 65
T460
S
S
Y
A
Q
R
T
T
N
H
S
P
P
T
P
Site 66
S463
A
Q
R
T
T
N
H
S
P
P
T
P
R
R
S
Site 67
T466
T
T
N
H
S
P
P
T
P
R
R
S
P
L
P
Site 68
S470
S
P
P
T
P
R
R
S
P
L
P
I
D
R
P
Site 69
T482
D
R
P
D
L
R
R
T
D
S
L
R
K
Q
H
Site 70
S484
P
D
L
R
R
T
D
S
L
R
K
Q
H
H
L
Site 71
S494
K
Q
H
H
L
D
P
S
S
A
V
R
K
T
K
Site 72
S495
Q
H
H
L
D
P
S
S
A
V
R
K
T
K
R
Site 73
T500
P
S
S
A
V
R
K
T
K
R
E
K
M
E
T
Site 74
T507
T
K
R
E
K
M
E
T
M
L
R
N
D
S
L
Site 75
S513
E
T
M
L
R
N
D
S
L
S
S
D
Q
S
E
Site 76
S515
M
L
R
N
D
S
L
S
S
D
Q
S
E
S
V
Site 77
S516
L
R
N
D
S
L
S
S
D
Q
S
E
S
V
R
Site 78
S519
D
S
L
S
S
D
Q
S
E
S
V
R
P
P
P
Site 79
S521
L
S
S
D
Q
S
E
S
V
R
P
P
P
P
K
Site 80
S532
P
P
P
K
P
H
K
S
K
K
G
G
K
M
R
Site 81
S542
G
G
K
M
R
Q
I
S
L
S
S
S
E
E
E
Site 82
S544
K
M
R
Q
I
S
L
S
S
S
E
E
E
L
A
Site 83
S546
R
Q
I
S
L
S
S
S
E
E
E
L
A
S
T
Site 84
S552
S
S
E
E
E
L
A
S
T
P
E
Y
T
S
C
Site 85
T553
S
E
E
E
L
A
S
T
P
E
Y
T
S
C
D
Site 86
Y556
E
L
A
S
T
P
E
Y
T
S
C
D
D
V
E
Site 87
T557
L
A
S
T
P
E
Y
T
S
C
D
D
V
E
I
Site 88
S566
C
D
D
V
E
I
E
S
E
S
V
S
E
K
G
Site 89
S568
D
V
E
I
E
S
E
S
V
S
E
K
G
D
S
Site 90
S570
E
I
E
S
E
S
V
S
E
K
G
D
S
Q
K
Site 91
S575
S
V
S
E
K
G
D
S
Q
K
G
K
R
K
T
Site 92
T582
S
Q
K
G
K
R
K
T
S
E
Q
A
V
L
S
Site 93
S583
Q
K
G
K
R
K
T
S
E
Q
A
V
L
S
D
Site 94
S589
T
S
E
Q
A
V
L
S
D
S
N
T
R
S
E
Site 95
S591
E
Q
A
V
L
S
D
S
N
T
R
S
E
R
Q
Site 96
T593
A
V
L
S
D
S
N
T
R
S
E
R
Q
K
E
Site 97
S595
L
S
D
S
N
T
R
S
E
R
Q
K
E
M
M
Site 98
Y603
E
R
Q
K
E
M
M
Y
F
G
G
H
S
L
E
Site 99
S623
S
E
P
Q
I
K
D
S
G
V
D
T
C
S
S
Site 100
T627
I
K
D
S
G
V
D
T
C
S
S
T
T
L
N
Site 101
S629
D
S
G
V
D
T
C
S
S
T
T
L
N
E
E
Site 102
S630
S
G
V
D
T
C
S
S
T
T
L
N
E
E
H
Site 103
S638
T
T
L
N
E
E
H
S
H
S
D
K
H
P
V
Site 104
S640
L
N
E
E
H
S
H
S
D
K
H
P
V
T
W
Site 105
T646
H
S
D
K
H
P
V
T
W
Q
P
S
K
D
G
Site 106
S670
N
K
R
L
K
D
G
S
V
P
R
D
S
G
A
Site 107
S675
D
G
S
V
P
R
D
S
G
A
M
L
G
L
K
Site 108
T689
K
V
V
G
G
K
M
T
E
S
G
R
L
C
A
Site 109
S691
V
G
G
K
M
T
E
S
G
R
L
C
A
F
I
Site 110
T699
G
R
L
C
A
F
I
T
K
V
K
K
G
S
L
Site 111
S705
I
T
K
V
K
K
G
S
L
A
D
T
V
G
H
Site 112
T709
K
K
G
S
L
A
D
T
V
G
H
L
R
P
G
Site 113
T731
G
R
L
L
Q
G
A
T
F
E
E
V
Y
N
I
Site 114
Y736
G
A
T
F
E
E
V
Y
N
I
I
L
E
S
K
Site 115
S765
D
I
P
R
I
P
D
S
T
H
A
Q
L
E
S
Site 116
T766
I
P
R
I
P
D
S
T
H
A
Q
L
E
S
S
Site 117
S772
S
T
H
A
Q
L
E
S
S
S
S
S
F
E
S
Site 118
S773
T
H
A
Q
L
E
S
S
S
S
S
F
E
S
Q
Site 119
S774
H
A
Q
L
E
S
S
S
S
S
F
E
S
Q
K
Site 120
S775
A
Q
L
E
S
S
S
S
S
F
E
S
Q
K
M
Site 121
S776
Q
L
E
S
S
S
S
S
F
E
S
Q
K
M
D
Site 122
S779
S
S
S
S
S
F
E
S
Q
K
M
D
R
P
S
Site 123
S786
S
Q
K
M
D
R
P
S
I
S
V
T
S
P
M
Site 124
S788
K
M
D
R
P
S
I
S
V
T
S
P
M
S
P
Site 125
T790
D
R
P
S
I
S
V
T
S
P
M
S
P
G
M
Site 126
S791
R
P
S
I
S
V
T
S
P
M
S
P
G
M
L
Site 127
S806
R
D
V
P
Q
F
L
S
G
Q
L
S
I
K
L
Site 128
S810
Q
F
L
S
G
Q
L
S
I
K
L
W
F
D
K
Site 129
T825
V
G
H
Q
L
I
V
T
I
L
G
A
K
D
L
Site 130
S834
L
G
A
K
D
L
P
S
R
E
D
G
R
P
R
Site 131
Y844
D
G
R
P
R
N
P
Y
V
K
I
Y
F
L
P
Site 132
Y848
R
N
P
Y
V
K
I
Y
F
L
P
D
R
S
D
Site 133
S854
I
Y
F
L
P
D
R
S
D
K
N
K
R
R
T
Site 134
T861
S
D
K
N
K
R
R
T
K
T
V
K
K
T
L
Site 135
T863
K
N
K
R
R
T
K
T
V
K
K
T
L
E
P
Site 136
T867
R
T
K
T
V
K
K
T
L
E
P
K
W
N
Q
Site 137
S879
W
N
Q
T
F
I
Y
S
P
V
H
R
R
E
F
Site 138
T894
R
E
R
M
L
E
I
T
L
W
D
Q
A
R
V
Site 139
S906
A
R
V
R
E
E
E
S
E
F
L
G
E
I
L
Site 140
T918
E
I
L
I
E
L
E
T
A
L
L
D
D
E
P
Site 141
Y928
L
D
D
E
P
H
W
Y
K
L
Q
T
H
D
V
Site 142
T932
P
H
W
Y
K
L
Q
T
H
D
V
S
S
L
P
Site 143
S936
K
L
Q
T
H
D
V
S
S
L
P
L
P
H
P
Site 144
S937
L
Q
T
H
D
V
S
S
L
P
L
P
H
P
S
Site 145
S944
S
L
P
L
P
H
P
S
P
Y
M
P
R
R
Q
Site 146
S956
R
R
Q
L
H
G
E
S
P
T
R
R
L
Q
R
Site 147
S964
P
T
R
R
L
Q
R
S
K
R
I
S
D
S
E
Site 148
S968
L
Q
R
S
K
R
I
S
D
S
E
V
S
D
Y
Site 149
S970
R
S
K
R
I
S
D
S
E
V
S
D
Y
D
C
Site 150
Y975
S
D
S
E
V
S
D
Y
D
C
D
D
G
I
G
Site 151
Y987
G
I
G
V
V
S
D
Y
R
H
D
G
R
D
L
Site 152
S996
H
D
G
R
D
L
Q
S
S
T
L
S
V
P
E
Site 153
S997
D
G
R
D
L
Q
S
S
T
L
S
V
P
E
Q
Site 154
T998
G
R
D
L
Q
S
S
T
L
S
V
P
E
Q
V
Site 155
S1000
D
L
Q
S
S
T
L
S
V
P
E
Q
V
M
S
Site 156
S1007
S
V
P
E
Q
V
M
S
S
N
H
C
S
P
S
Site 157
S1008
V
P
E
Q
V
M
S
S
N
H
C
S
P
S
G
Site 158
S1012
V
M
S
S
N
H
C
S
P
S
G
S
P
H
R
Site 159
S1014
S
S
N
H
C
S
P
S
G
S
P
H
R
V
D
Site 160
S1016
N
H
C
S
P
S
G
S
P
H
R
V
D
V
I
Site 161
T1026
R
V
D
V
I
G
R
T
R
S
W
S
P
S
V
Site 162
S1028
D
V
I
G
R
T
R
S
W
S
P
S
V
P
P
Site 163
S1030
I
G
R
T
R
S
W
S
P
S
V
P
P
P
Q
Site 164
S1032
R
T
R
S
W
S
P
S
V
P
P
P
Q
S
R
Site 165
S1038
P
S
V
P
P
P
Q
S
R
N
V
E
Q
G
L
Site 166
T1048
V
E
Q
G
L
R
G
T
R
T
M
T
G
H
Y
Site 167
T1050
Q
G
L
R
G
T
R
T
M
T
G
H
Y
N
T
Site 168
T1052
L
R
G
T
R
T
M
T
G
H
Y
N
T
I
S
Site 169
Y1055
T
R
T
M
T
G
H
Y
N
T
I
S
R
M
D
Site 170
T1057
T
M
T
G
H
Y
N
T
I
S
R
M
D
R
H
Site 171
Y1071
H
R
V
M
D
D
H
Y
S
P
D
R
D
R
D
Site 172
S1072
R
V
M
D
D
H
Y
S
P
D
R
D
R
D
C
Site 173
Y1087
E
A
A
D
R
Q
P
Y
H
R
S
R
S
T
E
Site 174
S1092
Q
P
Y
H
R
S
R
S
T
E
Q
R
P
L
L
Site 175
T1093
P
Y
H
R
S
R
S
T
E
Q
R
P
L
L
E
Site 176
T1102
Q
R
P
L
L
E
R
T
T
T
R
S
R
S
T
Site 177
T1103
R
P
L
L
E
R
T
T
T
R
S
R
S
T
E
Site 178
T1104
P
L
L
E
R
T
T
T
R
S
R
S
T
E
R
Site 179
S1106
L
E
R
T
T
T
R
S
R
S
T
E
R
P
D
Site 180
S1108
R
T
T
T
R
S
R
S
T
E
R
P
D
T
N
Site 181
T1109
T
T
T
R
S
R
S
T
E
R
P
D
T
N
L
Site 182
T1114
R
S
T
E
R
P
D
T
N
L
M
R
S
M
P
Site 183
S1119
P
D
T
N
L
M
R
S
M
P
S
L
M
T
G
Site 184
S1122
N
L
M
R
S
M
P
S
L
M
T
G
R
S
A
Site 185
T1125
R
S
M
P
S
L
M
T
G
R
S
A
P
P
S
Site 186
S1128
P
S
L
M
T
G
R
S
A
P
P
S
P
A
L
Site 187
S1132
T
G
R
S
A
P
P
S
P
A
L
S
R
S
H
Site 188
S1136
A
P
P
S
P
A
L
S
R
S
H
P
R
T
G
Site 189
S1138
P
S
P
A
L
S
R
S
H
P
R
T
G
S
V
Site 190
T1142
L
S
R
S
H
P
R
T
G
S
V
Q
T
S
P
Site 191
S1144
R
S
H
P
R
T
G
S
V
Q
T
S
P
S
S
Site 192
T1147
P
R
T
G
S
V
Q
T
S
P
S
S
T
P
V
Site 193
S1148
R
T
G
S
V
Q
T
S
P
S
S
T
P
V
A
Site 194
S1150
G
S
V
Q
T
S
P
S
S
T
P
V
A
G
R
Site 195
S1151
S
V
Q
T
S
P
S
S
T
P
V
A
G
R
R
Site 196
T1152
V
Q
T
S
P
S
S
T
P
V
A
G
R
R
G
Site 197
T1170
P
Q
L
P
P
K
G
T
L
D
R
K
A
G
G
Site 198
S1182
A
G
G
K
K
L
R
S
T
V
Q
R
S
T
E
Site 199
T1183
G
G
K
K
L
R
S
T
V
Q
R
S
T
E
T
Site 200
S1187
L
R
S
T
V
Q
R
S
T
E
T
G
L
A
V
Site 201
T1188
R
S
T
V
Q
R
S
T
E
T
G
L
A
V
E
Site 202
S1205
N
W
M
T
R
Q
A
S
R
E
S
T
D
G
S
Site 203
S1208
T
R
Q
A
S
R
E
S
T
D
G
S
M
N
S
Site 204
T1209
R
Q
A
S
R
E
S
T
D
G
S
M
N
S
Y
Site 205
S1212
S
R
E
S
T
D
G
S
M
N
S
Y
S
S
E
Site 206
S1215
S
T
D
G
S
M
N
S
Y
S
S
E
G
N
L
Site 207
Y1216
T
D
G
S
M
N
S
Y
S
S
E
G
N
L
I
Site 208
S1217
D
G
S
M
N
S
Y
S
S
E
G
N
L
I
F
Site 209
S1218
G
S
M
N
S
Y
S
S
E
G
N
L
I
F
P
Site 210
S1231
F
P
G
V
R
L
A
S
D
S
Q
F
S
D
F
Site 211
S1233
G
V
R
L
A
S
D
S
Q
F
S
D
F
L
D
Site 212
T1255
V
G
R
Q
T
L
A
T
P
A
M
G
D
I
Q
Site 213
T1290
V
V
K
P
G
S
K
T
L
P
A
P
Y
V
K
Site 214
T1318
K
T
K
V
A
R
K
T
L
E
P
L
Y
Q
Q
Site 215
Y1323
R
K
T
L
E
P
L
Y
Q
Q
L
L
S
F
E
Site 216
S1328
P
L
Y
Q
Q
L
L
S
F
E
E
S
P
Q
G
Site 217
S1332
Q
L
L
S
F
E
E
S
P
Q
G
K
V
L
Q
Site 218
Y1346
Q
I
I
V
W
G
D
Y
G
R
M
D
H
K
S
Site 219
T1387
P
S
S
L
V
D
P
T
L
A
P
L
T
R
R
Site 220
T1392
D
P
T
L
A
P
L
T
R
R
A
S
Q
S
S
Site 221
S1396
A
P
L
T
R
R
A
S
Q
S
S
L
E
S
S
Site 222
S1398
L
T
R
R
A
S
Q
S
S
L
E
S
S
T
G
Site 223
S1399
T
R
R
A
S
Q
S
S
L
E
S
S
T
G
P
Site 224
S1402
A
S
Q
S
S
L
E
S
S
T
G
P
S
Y
S
Site 225
S1403
S
Q
S
S
L
E
S
S
T
G
P
S
Y
S
R
Site 226
T1404
Q
S
S
L
E
S
S
T
G
P
S
Y
S
R
S
Site 227
S1407
L
E
S
S
T
G
P
S
Y
S
R
S
_
_
_
Site 228
Y1408
E
S
S
T
G
P
S
Y
S
R
S
_
_
_
_
Site 229
S1409
S
S
T
G
P
S
Y
S
R
S
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation