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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
exonuclease 1
Full Name:
Exonuclease 1
Alias:
Exo1; ExoI; HEX1; Rad2 nuclease family member, of S. cerevisiae exonuclease 1
Type:
EC 3.1.-.-; Hydrolase
Mass (Da):
94103
Number AA:
846
UniProt ID:
Q9UQ84
International Prot ID:
IPI00219173
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051908
GO:0048256
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007126
GO:0006298
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
E
P
I
H
V
R
K
Y
K
G
Q
V
V
A
V
Site 2
T52
K
L
A
K
G
E
P
T
D
R
Y
V
G
F
C
Site 3
Y55
K
G
E
P
T
D
R
Y
V
G
F
C
M
K
F
Site 4
S68
K
F
V
N
M
L
L
S
H
G
I
K
P
I
L
Site 5
S91
S
K
K
E
V
E
R
S
R
R
E
R
R
Q
A
Site 6
S113
L
L
R
E
G
K
V
S
E
A
R
E
C
F
T
Site 7
T126
F
T
R
S
I
N
I
T
H
A
M
A
H
K
V
Site 8
T211
R
Q
L
G
D
V
F
T
E
E
K
F
R
Y
M
Site 9
Y271
N
I
T
V
P
E
D
Y
I
N
G
F
I
R
A
Site 10
T309
E
D
D
V
D
P
E
T
L
S
Y
A
G
Q
Y
Site 11
S311
D
V
D
P
E
T
L
S
Y
A
G
Q
Y
V
D
Site 12
Y312
V
D
P
E
T
L
S
Y
A
G
Q
Y
V
D
D
Site 13
T334
L
G
N
K
D
I
N
T
F
E
Q
I
D
D
Y
Site 14
Y341
T
F
E
Q
I
D
D
Y
N
P
D
T
A
M
P
Site 15
T345
I
D
D
Y
N
P
D
T
A
M
P
A
H
S
R
Site 16
S351
D
T
A
M
P
A
H
S
R
S
H
S
W
D
D
Site 17
S353
A
M
P
A
H
S
R
S
H
S
W
D
D
K
T
Site 18
S355
P
A
H
S
R
S
H
S
W
D
D
K
T
C
Q
Site 19
T360
S
H
S
W
D
D
K
T
C
Q
K
S
A
N
V
Site 20
Y375
S
S
I
W
H
R
N
Y
S
P
R
P
E
S
G
Site 21
S376
S
I
W
H
R
N
Y
S
P
R
P
E
S
G
T
Site 22
S381
N
Y
S
P
R
P
E
S
G
T
V
S
D
A
P
Site 23
T383
S
P
R
P
E
S
G
T
V
S
D
A
P
Q
L
Site 24
S385
R
P
E
S
G
T
V
S
D
A
P
Q
L
K
E
Site 25
S395
P
Q
L
K
E
N
P
S
T
V
G
V
E
R
V
Site 26
T396
Q
L
K
E
N
P
S
T
V
G
V
E
R
V
I
Site 27
S414
G
L
N
L
P
R
K
S
S
I
V
K
R
P
R
Site 28
S415
L
N
L
P
R
K
S
S
I
V
K
R
P
R
S
Site 29
S422
S
I
V
K
R
P
R
S
A
E
L
S
E
D
D
Site 30
S426
R
P
R
S
A
E
L
S
E
D
D
L
L
S
Q
Site 31
S432
L
S
E
D
D
L
L
S
Q
Y
S
L
S
F
T
Site 32
Y434
E
D
D
L
L
S
Q
Y
S
L
S
F
T
K
K
Site 33
S435
D
D
L
L
S
Q
Y
S
L
S
F
T
K
K
T
Site 34
S437
L
L
S
Q
Y
S
L
S
F
T
K
K
T
K
K
Site 35
T439
S
Q
Y
S
L
S
F
T
K
K
T
K
K
N
S
Site 36
T442
S
L
S
F
T
K
K
T
K
K
N
S
S
E
G
Site 37
S446
T
K
K
T
K
K
N
S
S
E
G
N
K
S
L
Site 38
S447
K
K
T
K
K
N
S
S
E
G
N
K
S
L
S
Site 39
S452
N
S
S
E
G
N
K
S
L
S
F
S
E
V
F
Site 40
S454
S
E
G
N
K
S
L
S
F
S
E
V
F
V
P
Site 41
S456
G
N
K
S
L
S
F
S
E
V
F
V
P
D
L
Site 42
T468
P
D
L
V
N
G
P
T
N
K
K
S
V
S
T
Site 43
S472
N
G
P
T
N
K
K
S
V
S
T
P
P
R
T
Site 44
S474
P
T
N
K
K
S
V
S
T
P
P
R
T
R
N
Site 45
T475
T
N
K
K
S
V
S
T
P
P
R
T
R
N
K
Site 46
T479
S
V
S
T
P
P
R
T
R
N
K
F
A
T
F
Site 47
T485
R
T
R
N
K
F
A
T
F
L
Q
R
K
N
E
Site 48
S494
L
Q
R
K
N
E
E
S
G
A
V
V
V
P
G
Site 49
T502
G
A
V
V
V
P
G
T
R
S
R
F
F
C
S
Site 50
S510
R
S
R
F
F
C
S
S
D
S
T
D
C
V
S
Site 51
S512
R
F
F
C
S
S
D
S
T
D
C
V
S
N
K
Site 52
T513
F
F
C
S
S
D
S
T
D
C
V
S
N
K
V
Site 53
S517
S
D
S
T
D
C
V
S
N
K
V
S
I
Q
P
Site 54
S521
D
C
V
S
N
K
V
S
I
Q
P
L
D
E
T
Site 55
T528
S
I
Q
P
L
D
E
T
A
V
T
D
K
E
N
Site 56
T531
P
L
D
E
T
A
V
T
D
K
E
N
N
L
H
Site 57
S540
K
E
N
N
L
H
E
S
E
Y
G
D
Q
E
G
Site 58
Y542
N
N
L
H
E
S
E
Y
G
D
Q
E
G
K
R
Site 59
T553
E
G
K
R
L
V
D
T
D
V
A
R
N
S
S
Site 60
S559
D
T
D
V
A
R
N
S
S
D
D
I
P
N
N
Site 61
S560
T
D
V
A
R
N
S
S
D
D
I
P
N
N
H
Site 62
T578
D
H
I
P
D
K
A
T
V
F
T
D
E
E
S
Site 63
T581
P
D
K
A
T
V
F
T
D
E
E
S
Y
S
F
Site 64
S585
T
V
F
T
D
E
E
S
Y
S
F
E
S
S
K
Site 65
S587
F
T
D
E
E
S
Y
S
F
E
S
S
K
F
T
Site 66
S591
E
S
Y
S
F
E
S
S
K
F
T
R
T
I
S
Site 67
T594
S
F
E
S
S
K
F
T
R
T
I
S
P
P
T
Site 68
T596
E
S
S
K
F
T
R
T
I
S
P
P
T
L
G
Site 69
S598
S
K
F
T
R
T
I
S
P
P
T
L
G
T
L
Site 70
S607
P
T
L
G
T
L
R
S
C
F
S
W
S
G
G
Site 71
S610
G
T
L
R
S
C
F
S
W
S
G
G
L
G
D
Site 72
S612
L
R
S
C
F
S
W
S
G
G
L
G
D
F
S
Site 73
S619
S
G
G
L
G
D
F
S
R
T
P
S
P
S
P
Site 74
T621
G
L
G
D
F
S
R
T
P
S
P
S
P
S
T
Site 75
S623
G
D
F
S
R
T
P
S
P
S
P
S
T
A
L
Site 76
S625
F
S
R
T
P
S
P
S
P
S
T
A
L
Q
Q
Site 77
S627
R
T
P
S
P
S
P
S
T
A
L
Q
Q
F
R
Site 78
S637
L
Q
Q
F
R
R
K
S
D
S
P
T
S
L
P
Site 79
S639
Q
F
R
R
K
S
D
S
P
T
S
L
P
E
N
Site 80
T641
R
R
K
S
D
S
P
T
S
L
P
E
N
N
M
Site 81
S642
R
K
S
D
S
P
T
S
L
P
E
N
N
M
S
Site 82
S649
S
L
P
E
N
N
M
S
D
V
S
Q
L
K
S
Site 83
S652
E
N
N
M
S
D
V
S
Q
L
K
S
E
E
S
Site 84
S656
S
D
V
S
Q
L
K
S
E
E
S
S
D
D
E
Site 85
S659
S
Q
L
K
S
E
E
S
S
D
D
E
S
H
P
Site 86
S660
Q
L
K
S
E
E
S
S
D
D
E
S
H
P
L
Site 87
S664
E
E
S
S
D
D
E
S
H
P
L
R
E
E
A
Site 88
S673
P
L
R
E
E
A
C
S
S
Q
S
Q
E
S
G
Site 89
S674
L
R
E
E
A
C
S
S
Q
S
Q
E
S
G
E
Site 90
S676
E
E
A
C
S
S
Q
S
Q
E
S
G
E
F
S
Site 91
S679
C
S
S
Q
S
Q
E
S
G
E
F
S
L
Q
S
Site 92
S683
S
Q
E
S
G
E
F
S
L
Q
S
S
N
A
S
Site 93
S686
S
G
E
F
S
L
Q
S
S
N
A
S
K
L
S
Site 94
S687
G
E
F
S
L
Q
S
S
N
A
S
K
L
S
Q
Site 95
S690
S
L
Q
S
S
N
A
S
K
L
S
Q
C
S
S
Site 96
S693
S
S
N
A
S
K
L
S
Q
C
S
S
K
D
S
Site 97
S696
A
S
K
L
S
Q
C
S
S
K
D
S
D
S
E
Site 98
S697
S
K
L
S
Q
C
S
S
K
D
S
D
S
E
E
Site 99
S700
S
Q
C
S
S
K
D
S
D
S
E
E
S
D
C
Site 100
S702
C
S
S
K
D
S
D
S
E
E
S
D
C
N
I
Site 101
S705
K
D
S
D
S
E
E
S
D
C
N
I
K
L
L
Site 102
S714
C
N
I
K
L
L
D
S
Q
S
D
Q
T
S
K
Site 103
S716
I
K
L
L
D
S
Q
S
D
Q
T
S
K
L
R
Site 104
S720
D
S
Q
S
D
Q
T
S
K
L
R
L
S
H
F
Site 105
S725
Q
T
S
K
L
R
L
S
H
F
S
K
K
D
T
Site 106
S728
K
L
R
L
S
H
F
S
K
K
D
T
P
L
R
Site 107
T732
S
H
F
S
K
K
D
T
P
L
R
N
K
V
P
Site 108
Y742
R
N
K
V
P
G
L
Y
K
S
S
S
A
D
S
Site 109
S744
K
V
P
G
L
Y
K
S
S
S
A
D
S
L
S
Site 110
S745
V
P
G
L
Y
K
S
S
S
A
D
S
L
S
T
Site 111
S746
P
G
L
Y
K
S
S
S
A
D
S
L
S
T
T
Site 112
S749
Y
K
S
S
S
A
D
S
L
S
T
T
K
I
K
Site 113
S751
S
S
S
A
D
S
L
S
T
T
K
I
K
P
L
Site 114
T752
S
S
A
D
S
L
S
T
T
K
I
K
P
L
G
Site 115
T753
S
A
D
S
L
S
T
T
K
I
K
P
L
G
P
Site 116
S764
P
L
G
P
A
R
A
S
G
L
S
K
K
P
A
Site 117
S767
P
A
R
A
S
G
L
S
K
K
P
A
S
I
Q
Site 118
S772
G
L
S
K
K
P
A
S
I
Q
K
R
K
H
H
Site 119
S804
N
F
G
F
K
K
D
S
E
K
L
P
P
C
K
Site 120
S815
P
P
C
K
K
P
L
S
P
V
R
D
N
I
Q
Site 121
T824
V
R
D
N
I
Q
L
T
P
E
A
E
E
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation