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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Gab2
Full Name:
GRB2-associated-binding protein 2
Alias:
GABJ; Grb2-associated binder 2; GRB2-associated binding protein 2; KIAA0571; pp100
Type:
Adapter/scaffold protein
Mass (Da):
74458
Number AA:
676
UniProt ID:
Q9UQC2
International Prot ID:
IPI00186990
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030316
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
C
T
G
W
L
R
K
S
P
P
E
K
K
L
R
Site 2
Y25
P
E
K
K
L
R
R
Y
A
W
K
K
R
W
F
Site 3
S36
K
R
W
F
I
L
R
S
G
R
M
S
G
D
P
Site 4
S40
I
L
R
S
G
R
M
S
G
D
P
D
V
L
E
Site 5
Y48
G
D
P
D
V
L
E
Y
Y
K
N
D
H
S
K
Site 6
Y49
D
P
D
V
L
E
Y
Y
K
N
D
H
S
K
K
Site 7
S54
E
Y
Y
K
N
D
H
S
K
K
P
L
R
I
I
Site 8
T74
E
Q
V
D
A
G
L
T
F
N
K
K
E
L
Q
Site 9
S83
N
K
K
E
L
Q
D
S
F
V
F
D
I
K
T
Site 10
T90
S
F
V
F
D
I
K
T
S
E
R
T
F
Y
L
Site 11
Y96
K
T
S
E
R
T
F
Y
L
V
A
E
T
E
E
Site 12
T101
T
F
Y
L
V
A
E
T
E
E
D
M
N
K
W
Site 13
S124
G
F
N
Q
A
E
E
S
T
D
S
L
R
N
V
Site 14
S127
Q
A
E
E
S
T
D
S
L
R
N
V
S
S
A
Site 15
S132
T
D
S
L
R
N
V
S
S
A
G
H
G
P
R
Site 16
S133
D
S
L
R
N
V
S
S
A
G
H
G
P
R
S
Site 17
S140
S
A
G
H
G
P
R
S
S
P
A
E
L
S
S
Site 18
S141
A
G
H
G
P
R
S
S
P
A
E
L
S
S
S
Site 19
S146
R
S
S
P
A
E
L
S
S
S
S
Q
H
L
L
Site 20
S147
S
S
P
A
E
L
S
S
S
S
Q
H
L
L
R
Site 21
S148
S
P
A
E
L
S
S
S
S
Q
H
L
L
R
E
Site 22
S149
P
A
E
L
S
S
S
S
Q
H
L
L
R
E
R
Site 23
S158
H
L
L
R
E
R
K
S
S
A
P
S
H
S
S
Site 24
S159
L
L
R
E
R
K
S
S
A
P
S
H
S
S
Q
Site 25
S162
E
R
K
S
S
A
P
S
H
S
S
Q
P
T
L
Site 26
S164
K
S
S
A
P
S
H
S
S
Q
P
T
L
F
T
Site 27
S165
S
S
A
P
S
H
S
S
Q
P
T
L
F
T
F
Site 28
T168
P
S
H
S
S
Q
P
T
L
F
T
F
E
P
P
Site 29
T171
S
S
Q
P
T
L
F
T
F
E
P
P
V
S
N
Site 30
S177
F
T
F
E
P
P
V
S
N
H
M
Q
P
T
L
Site 31
T183
V
S
N
H
M
Q
P
T
L
S
T
S
A
P
Q
Site 32
S185
N
H
M
Q
P
T
L
S
T
S
A
P
Q
E
Y
Site 33
S187
M
Q
P
T
L
S
T
S
A
P
Q
E
Y
L
Y
Site 34
Y192
S
T
S
A
P
Q
E
Y
L
Y
L
H
Q
C
I
Site 35
Y194
S
A
P
Q
E
Y
L
Y
L
H
Q
C
I
S
R
Site 36
S200
L
Y
L
H
Q
C
I
S
R
R
A
E
N
A
R
Site 37
S208
R
R
A
E
N
A
R
S
A
S
F
S
Q
G
T
Site 38
S210
A
E
N
A
R
S
A
S
F
S
Q
G
T
R
A
Site 39
S212
N
A
R
S
A
S
F
S
Q
G
T
R
A
S
F
Site 40
S218
F
S
Q
G
T
R
A
S
F
L
M
R
S
D
T
Site 41
S223
R
A
S
F
L
M
R
S
D
T
A
V
Q
K
L
Site 42
T225
S
F
L
M
R
S
D
T
A
V
Q
K
L
A
Q
Site 43
Y249
S
G
Q
V
H
G
F
Y
S
L
P
K
P
S
R
Site 44
S250
G
Q
V
H
G
F
Y
S
L
P
K
P
S
R
H
Site 45
T259
P
K
P
S
R
H
N
T
E
F
R
D
S
T
Y
Site 46
S264
H
N
T
E
F
R
D
S
T
Y
D
L
P
R
S
Site 47
T265
N
T
E
F
R
D
S
T
Y
D
L
P
R
S
L
Site 48
Y266
T
E
F
R
D
S
T
Y
D
L
P
R
S
L
A
Site 49
S271
S
T
Y
D
L
P
R
S
L
A
S
H
G
H
T
Site 50
T278
S
L
A
S
H
G
H
T
K
G
S
L
T
G
S
Site 51
S281
S
H
G
H
T
K
G
S
L
T
G
S
E
T
D
Site 52
S285
T
K
G
S
L
T
G
S
E
T
D
N
E
D
V
Site 53
T287
G
S
L
T
G
S
E
T
D
N
E
D
V
Y
T
Site 54
Y293
E
T
D
N
E
D
V
Y
T
F
K
T
P
S
N
Site 55
T294
T
D
N
E
D
V
Y
T
F
K
T
P
S
N
T
Site 56
T297
E
D
V
Y
T
F
K
T
P
S
N
T
L
C
R
Site 57
S299
V
Y
T
F
K
T
P
S
N
T
L
C
R
E
F
Site 58
T301
T
F
K
T
P
S
N
T
L
C
R
E
F
G
D
Site 59
T319
D
N
M
D
V
P
A
T
P
L
S
A
Y
Q
I
Site 60
S322
D
V
P
A
T
P
L
S
A
Y
Q
I
P
R
T
Site 61
Y324
P
A
T
P
L
S
A
Y
Q
I
P
R
T
F
T
Site 62
T329
S
A
Y
Q
I
P
R
T
F
T
L
D
K
N
H
Site 63
T331
Y
Q
I
P
R
T
F
T
L
D
K
N
H
N
A
Site 64
T340
D
K
N
H
N
A
M
T
V
A
T
P
G
D
S
Site 65
S359
P
P
R
P
P
K
P
S
Q
A
E
T
P
R
W
Site 66
T363
P
K
P
S
Q
A
E
T
P
R
W
G
S
P
Q
Site 67
S368
A
E
T
P
R
W
G
S
P
Q
Q
R
P
P
I
Site 68
S376
P
Q
Q
R
P
P
I
S
E
N
S
R
S
V
A
Site 69
S381
P
I
S
E
N
S
R
S
V
A
A
T
I
P
R
Site 70
T385
N
S
R
S
V
A
A
T
I
P
R
R
N
T
L
Site 71
T391
A
T
I
P
R
R
N
T
L
P
A
M
D
N
S
Site 72
S398
T
L
P
A
M
D
N
S
R
L
H
R
A
S
S
Site 73
S404
N
S
R
L
H
R
A
S
S
C
E
T
Y
E
Y
Site 74
S405
S
R
L
H
R
A
S
S
C
E
T
Y
E
Y
P
Site 75
T408
H
R
A
S
S
C
E
T
Y
E
Y
P
Q
R
G
Site 76
Y409
R
A
S
S
C
E
T
Y
E
Y
P
Q
R
G
G
Site 77
Y411
S
S
C
E
T
Y
E
Y
P
Q
R
G
G
E
S
Site 78
S418
Y
P
Q
R
G
G
E
S
A
G
R
S
A
E
S
Site 79
S422
G
G
E
S
A
G
R
S
A
E
S
M
S
D
G
Site 80
S425
S
A
G
R
S
A
E
S
M
S
D
G
V
G
S
Site 81
S427
G
R
S
A
E
S
M
S
D
G
V
G
S
F
L
Site 82
S443
G
K
M
I
V
G
R
S
D
S
T
N
S
E
D
Site 83
S445
M
I
V
G
R
S
D
S
T
N
S
E
D
N
Y
Site 84
Y452
S
T
N
S
E
D
N
Y
V
P
M
N
P
G
S
Site 85
S459
Y
V
P
M
N
P
G
S
S
T
L
L
A
M
E
Site 86
S472
M
E
R
A
G
D
N
S
Q
S
V
Y
I
P
M
Site 87
S474
R
A
G
D
N
S
Q
S
V
Y
I
P
M
S
P
Site 88
Y476
G
D
N
S
Q
S
V
Y
I
P
M
S
P
G
A
Site 89
S480
Q
S
V
Y
I
P
M
S
P
G
A
H
H
F
D
Site 90
S488
P
G
A
H
H
F
D
S
L
G
Y
P
S
T
T
Site 91
Y491
H
H
F
D
S
L
G
Y
P
S
T
T
L
P
V
Site 92
S493
F
D
S
L
G
Y
P
S
T
T
L
P
V
H
R
Site 93
T494
D
S
L
G
Y
P
S
T
T
L
P
V
H
R
G
Site 94
T495
S
L
G
Y
P
S
T
T
L
P
V
H
R
G
P
Site 95
S503
L
P
V
H
R
G
P
S
R
G
S
E
I
Q
P
Site 96
S506
H
R
G
P
S
R
G
S
E
I
Q
P
P
P
V
Site 97
T526
P
D
R
K
A
K
P
T
P
L
D
L
R
N
N
Site 98
T534
P
L
D
L
R
N
N
T
V
I
D
E
L
P
F
Site 99
S543
I
D
E
L
P
F
K
S
P
I
T
K
S
W
S
Site 100
T546
L
P
F
K
S
P
I
T
K
S
W
S
R
A
N
Site 101
S548
F
K
S
P
I
T
K
S
W
S
R
A
N
H
T
Site 102
S550
S
P
I
T
K
S
W
S
R
A
N
H
T
F
N
Site 103
T555
S
W
S
R
A
N
H
T
F
N
S
S
S
S
Q
Site 104
S558
R
A
N
H
T
F
N
S
S
S
S
Q
Y
C
R
Site 105
S561
H
T
F
N
S
S
S
S
Q
Y
C
R
P
I
S
Site 106
Y563
F
N
S
S
S
S
Q
Y
C
R
P
I
S
T
Q
Site 107
S568
S
Q
Y
C
R
P
I
S
T
Q
S
I
T
S
T
Site 108
T569
Q
Y
C
R
P
I
S
T
Q
S
I
T
S
T
D
Site 109
S571
C
R
P
I
S
T
Q
S
I
T
S
T
D
S
G
Site 110
T573
P
I
S
T
Q
S
I
T
S
T
D
S
G
D
S
Site 111
T575
S
T
Q
S
I
T
S
T
D
S
G
D
S
E
E
Site 112
S577
Q
S
I
T
S
T
D
S
G
D
S
E
E
N
Y
Site 113
Y584
S
G
D
S
E
E
N
Y
V
P
M
Q
N
P
V
Site 114
S592
V
P
M
Q
N
P
V
S
A
S
P
V
P
S
G
Site 115
S594
M
Q
N
P
V
S
A
S
P
V
P
S
G
T
N
Site 116
S598
V
S
A
S
P
V
P
S
G
T
N
S
P
A
P
Site 117
T600
A
S
P
V
P
S
G
T
N
S
P
A
P
K
K
Site 118
S602
P
V
P
S
G
T
N
S
P
A
P
K
K
S
T
Site 119
S608
N
S
P
A
P
K
K
S
T
G
S
V
D
Y
L
Site 120
S611
A
P
K
K
S
T
G
S
V
D
Y
L
A
L
D
Site 121
Y614
K
S
T
G
S
V
D
Y
L
A
L
D
F
Q
P
Site 122
S622
L
A
L
D
F
Q
P
S
S
P
S
P
H
R
K
Site 123
S623
A
L
D
F
Q
P
S
S
P
S
P
H
R
K
P
Site 124
S625
D
F
Q
P
S
S
P
S
P
H
R
K
P
S
T
Site 125
S631
P
S
P
H
R
K
P
S
T
S
S
V
T
S
D
Site 126
T632
S
P
H
R
K
P
S
T
S
S
V
T
S
D
E
Site 127
S633
P
H
R
K
P
S
T
S
S
V
T
S
D
E
K
Site 128
S634
H
R
K
P
S
T
S
S
V
T
S
D
E
K
V
Site 129
T636
K
P
S
T
S
S
V
T
S
D
E
K
V
D
Y
Site 130
S637
P
S
T
S
S
V
T
S
D
E
K
V
D
Y
V
Site 131
Y643
T
S
D
E
K
V
D
Y
V
Q
V
D
K
E
K
Site 132
T662
Q
N
T
M
Q
E
W
T
D
V
R
Q
S
S
E
Site 133
S667
E
W
T
D
V
R
Q
S
S
E
P
S
K
G
A
Site 134
S668
W
T
D
V
R
Q
S
S
E
P
S
K
G
A
K
Site 135
S671
V
R
Q
S
S
E
P
S
K
G
A
K
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation