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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN8A
Full Name:
Sodium channel protein type 8 subunit alpha
Alias:
CerIII; MED; NaCh6; Nav1.6; PN4; Sodium channel protein type VIII alpha subunit; Sodium channel protein type VIII subunit alpha; Sodium channel, voltage gated, type VIII, alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.6
Type:
Channel, sodium
Mass (Da):
225280
Number AA:
1980
UniProt ID:
Q9UQD0
International Prot ID:
IPI00183041
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
A
P
P
G
P
D
S
F
K
P
F
T
P
E
Site 2
T18
P
D
S
F
K
P
F
T
P
E
S
L
A
N
I
Site 3
S21
F
K
P
F
T
P
E
S
L
A
N
I
E
R
R
Site 4
S32
I
E
R
R
I
A
E
S
K
L
K
K
P
P
K
Site 5
S43
K
P
P
K
A
D
G
S
H
R
E
D
D
E
D
Site 6
S51
H
R
E
D
D
E
D
S
K
P
K
P
N
S
D
Site 7
S57
D
S
K
P
K
P
N
S
D
L
E
A
G
K
S
Site 8
S64
S
D
L
E
A
G
K
S
L
P
F
I
Y
G
D
Site 9
Y87
P
L
E
D
F
D
P
Y
Y
L
T
Q
K
T
F
Site 10
Y88
L
E
D
F
D
P
Y
Y
L
T
Q
K
T
F
V
Site 11
T93
P
Y
Y
L
T
Q
K
T
F
V
V
L
N
R
G
Site 12
Y163
D
W
S
K
N
V
E
Y
T
F
T
G
I
Y
T
Site 13
T164
W
S
K
N
V
E
Y
T
F
T
G
I
Y
T
F
Site 14
T166
K
N
V
E
Y
T
F
T
G
I
Y
T
F
E
S
Site 15
Y169
E
Y
T
F
T
G
I
Y
T
F
E
S
L
V
K
Site 16
Y292
P
I
N
F
N
E
S
Y
L
E
N
G
T
K
G
Site 17
Y305
K
G
F
D
W
E
E
Y
I
N
N
K
T
N
F
Site 18
Y313
I
N
N
K
T
N
F
Y
T
V
P
G
M
L
E
Site 19
T314
N
N
K
T
N
F
Y
T
V
P
G
M
L
E
P
Site 20
S327
E
P
L
L
C
G
N
S
S
D
A
G
Q
C
P
Site 21
S328
P
L
L
C
G
N
S
S
D
A
G
Q
C
P
E
Site 22
Y337
A
G
Q
C
P
E
G
Y
Q
C
M
K
A
G
R
Site 23
Y348
K
A
G
R
N
P
N
Y
G
Y
T
S
F
D
T
Site 24
Y350
G
R
N
P
N
Y
G
Y
T
S
F
D
T
F
S
Site 25
T368
L
A
L
F
R
L
M
T
Q
D
Y
W
E
N
L
Site 26
Y371
F
R
L
M
T
Q
D
Y
W
E
N
L
Y
Q
L
Site 27
S473
E
G
E
E
G
G
G
S
P
R
S
S
S
E
I
Site 28
S476
E
G
G
G
S
P
R
S
S
S
E
I
S
K
L
Site 29
S477
G
G
G
S
P
R
S
S
S
E
I
S
K
L
S
Site 30
S478
G
G
S
P
R
S
S
S
E
I
S
K
L
S
S
Site 31
S481
P
R
S
S
S
E
I
S
K
L
S
S
K
S
A
Site 32
S484
S
S
E
I
S
K
L
S
S
K
S
A
K
E
R
Site 33
S485
S
E
I
S
K
L
S
S
K
S
A
K
E
R
R
Site 34
S504
K
R
K
Q
K
E
L
S
E
G
E
E
K
G
D
Site 35
S518
D
P
E
K
V
F
K
S
E
S
E
D
G
M
R
Site 36
S520
E
K
V
F
K
S
E
S
E
D
G
M
R
R
K
Site 37
S541
N
R
I
G
R
K
F
S
I
M
N
Q
S
L
L
Site 38
S546
K
F
S
I
M
N
Q
S
L
L
S
I
P
G
S
Site 39
S549
I
M
N
Q
S
L
L
S
I
P
G
S
P
F
L
Site 40
S553
S
L
L
S
I
P
G
S
P
F
L
S
R
H
N
Site 41
S557
I
P
G
S
P
F
L
S
R
H
N
S
K
S
S
Site 42
S561
P
F
L
S
R
H
N
S
K
S
S
I
F
S
F
Site 43
S563
L
S
R
H
N
S
K
S
S
I
F
S
F
R
G
Site 44
S564
S
R
H
N
S
K
S
S
I
F
S
F
R
G
P
Site 45
S567
N
S
K
S
S
I
F
S
F
R
G
P
G
R
F
Site 46
S579
G
R
F
R
D
P
G
S
E
N
E
F
A
D
D
Site 47
S589
E
F
A
D
D
E
H
S
T
V
E
E
S
E
G
Site 48
T590
F
A
D
D
E
H
S
T
V
E
E
S
E
G
R
Site 49
S594
E
H
S
T
V
E
E
S
E
G
R
R
D
S
L
Site 50
S600
E
S
E
G
R
R
D
S
L
F
I
P
I
R
A
Site 51
S612
I
R
A
R
E
R
R
S
S
Y
S
G
Y
S
G
Site 52
S613
R
A
R
E
R
R
S
S
Y
S
G
Y
S
G
Y
Site 53
Y614
A
R
E
R
R
S
S
Y
S
G
Y
S
G
Y
S
Site 54
S615
R
E
R
R
S
S
Y
S
G
Y
S
G
Y
S
Q
Site 55
Y617
R
R
S
S
Y
S
G
Y
S
G
Y
S
Q
G
S
Site 56
S618
R
S
S
Y
S
G
Y
S
G
Y
S
Q
G
S
R
Site 57
Y620
S
Y
S
G
Y
S
G
Y
S
Q
G
S
R
S
S
Site 58
S621
Y
S
G
Y
S
G
Y
S
Q
G
S
R
S
S
R
Site 59
S624
Y
S
G
Y
S
Q
G
S
R
S
S
R
I
F
P
Site 60
S626
G
Y
S
Q
G
S
R
S
S
R
I
F
P
S
L
Site 61
S627
Y
S
Q
G
S
R
S
S
R
I
F
P
S
L
R
Site 62
S632
R
S
S
R
I
F
P
S
L
R
R
S
V
K
R
Site 63
S636
I
F
P
S
L
R
R
S
V
K
R
N
S
T
V
Site 64
S641
R
R
S
V
K
R
N
S
T
V
D
C
N
G
V
Site 65
T642
R
S
V
K
R
N
S
T
V
D
C
N
G
V
V
Site 66
S680
I
K
K
K
G
P
G
S
L
L
V
S
M
D
Q
Site 67
Y691
S
M
D
Q
L
A
S
Y
G
R
K
D
R
I
N
Site 68
S699
G
R
K
D
R
I
N
S
I
M
S
V
V
T
N
Site 69
S715
L
V
E
E
L
E
E
S
Q
R
K
C
P
P
C
Site 70
T778
A
M
E
H
H
P
M
T
P
Q
F
E
H
V
L
Site 71
Y810
K
L
I
A
M
D
P
Y
Y
Y
F
Q
E
G
W
Site 72
Y811
L
I
A
M
D
P
Y
Y
Y
F
Q
E
G
W
N
Site 73
S1000
E
M
N
N
L
Q
I
S
V
I
R
I
K
K
G
Site 74
Y1038
V
K
P
L
D
E
L
Y
E
K
K
A
N
C
I
Site 75
S1068
K
N
G
N
G
T
T
S
G
I
G
S
S
V
E
Site 76
S1073
T
T
S
G
I
G
S
S
V
E
K
Y
I
I
D
Site 77
Y1077
I
G
S
S
V
E
K
Y
I
I
D
E
D
H
M
Site 78
T1110
S
D
F
E
N
L
N
T
E
D
V
S
S
E
S
Site 79
S1114
N
L
N
T
E
D
V
S
S
E
S
D
P
E
G
Site 80
S1115
L
N
T
E
D
V
S
S
E
S
D
P
E
G
S
Site 81
S1117
T
E
D
V
S
S
E
S
D
P
E
G
S
K
D
Site 82
T1129
S
K
D
K
L
D
D
T
S
S
S
E
G
S
T
Site 83
S1130
K
D
K
L
D
D
T
S
S
S
E
G
S
T
I
Site 84
S1131
D
K
L
D
D
T
S
S
S
E
G
S
T
I
D
Site 85
S1132
K
L
D
D
T
S
S
S
E
G
S
T
I
D
I
Site 86
S1135
D
T
S
S
S
E
G
S
T
I
D
I
K
P
E
Site 87
T1136
T
S
S
S
E
G
S
T
I
D
I
K
P
E
V
Site 88
Y1154
P
V
E
Q
P
E
E
Y
L
D
P
D
A
C
F
Site 89
Y1221
A
L
A
F
E
D
I
Y
I
E
Q
R
K
T
I
Site 90
T1227
I
Y
I
E
Q
R
K
T
I
R
T
I
L
E
Y
Site 91
T1230
E
Q
R
K
T
I
R
T
I
L
E
Y
A
D
K
Site 92
T1240
E
Y
A
D
K
V
F
T
Y
I
F
I
L
E
M
Site 93
S1308
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 94
Y1353
V
N
L
F
A
G
K
Y
H
Y
C
F
N
E
T
Site 95
Y1355
L
F
A
G
K
Y
H
Y
C
F
N
E
T
S
E
Site 96
T1374
I
E
D
V
N
N
K
T
E
C
E
K
L
M
E
Site 97
Y1420
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
K
Site 98
Y1434
K
P
D
E
Q
P
K
Y
E
D
N
I
Y
M
Y
Site 99
T1482
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 100
Y1488
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 101
T1545
T
M
M
V
E
T
D
T
Q
S
K
Q
M
E
N
Site 102
S1722
L
N
R
P
P
D
C
S
L
D
K
E
H
P
G
Site 103
S1730
L
D
K
E
H
P
G
S
G
F
K
G
D
C
G
Site 104
S1776
F
S
V
A
T
E
E
S
A
D
P
L
S
E
D
Site 105
S1781
E
E
S
A
D
P
L
S
E
D
D
F
E
T
F
Site 106
T1787
L
S
E
D
D
F
E
T
F
Y
E
I
W
E
K
Site 107
Y1789
E
D
D
F
E
T
F
Y
E
I
W
E
K
F
D
Site 108
T1800
E
K
F
D
P
D
A
T
Q
F
I
E
Y
C
K
Site 109
S1859
T
K
R
V
L
G
D
S
G
E
L
D
I
L
R
Site 110
S1876
M
E
E
R
F
V
A
S
N
P
S
K
V
S
Y
Site 111
S1879
R
F
V
A
S
N
P
S
K
V
S
Y
E
P
I
Site 112
S1882
A
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
Site 113
Y1883
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
L
Site 114
T1888
V
S
Y
E
P
I
T
T
T
L
R
R
K
Q
E
Site 115
T1889
S
Y
E
P
I
T
T
T
L
R
R
K
Q
E
E
Site 116
Y1906
A
V
V
L
Q
R
A
Y
R
G
H
L
A
R
R
Site 117
T1920
R
G
F
I
C
K
K
T
T
S
N
K
L
E
N
Site 118
S1922
F
I
C
K
K
T
T
S
N
K
L
E
N
G
G
Site 119
T1930
N
K
L
E
N
G
G
T
H
R
E
K
K
E
S
Site 120
S1937
T
H
R
E
K
K
E
S
T
P
S
T
A
S
L
Site 121
T1938
H
R
E
K
K
E
S
T
P
S
T
A
S
L
P
Site 122
S1940
E
K
K
E
S
T
P
S
T
A
S
L
P
S
Y
Site 123
T1941
K
K
E
S
T
P
S
T
A
S
L
P
S
Y
D
Site 124
S1943
E
S
T
P
S
T
A
S
L
P
S
Y
D
S
V
Site 125
S1946
P
S
T
A
S
L
P
S
Y
D
S
V
T
K
P
Site 126
Y1947
S
T
A
S
L
P
S
Y
D
S
V
T
K
P
E
Site 127
S1949
A
S
L
P
S
Y
D
S
V
T
K
P
E
K
E
Site 128
T1951
L
P
S
Y
D
S
V
T
K
P
E
K
E
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation