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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC5
Full Name:
Histone deacetylase 5
Alias:
Antigen NY-CO-9; FLJ90614; HD5; Histone deacetylase mHDA1; KIAA0600; NY-CO-9
Type:
Hydrolase; EC 3.5.1.98
Mass (Da):
121992
Number AA:
1122
UniProt ID:
Q9UQL6
International Prot ID:
IPI00217801
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000118
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0016566
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0030183
GO:0014898
GO:0032869
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
N
S
P
N
E
S
D
G
M
Site 2
S7
_
M
N
S
P
N
E
S
D
G
M
S
G
R
E
Site 3
S11
P
N
E
S
D
G
M
S
G
R
E
P
S
L
E
Site 4
S16
G
M
S
G
R
E
P
S
L
E
I
L
P
R
T
Site 5
S45
L
P
R
A
M
P
S
S
M
G
G
G
G
G
G
Site 6
S53
M
G
G
G
G
G
G
S
P
S
P
V
E
L
R
Site 7
S55
G
G
G
G
G
S
P
S
P
V
E
L
R
G
A
Site 8
S66
L
R
G
A
L
V
G
S
V
D
P
T
L
R
E
Site 9
T70
L
V
G
S
V
D
P
T
L
R
E
Q
Q
L
Q
Site 10
T106
Q
K
Q
H
D
H
L
T
R
Q
H
E
V
Q
L
Site 11
S173
I
L
R
N
K
E
K
S
K
E
S
A
I
A
S
Site 12
S180
S
K
E
S
A
I
A
S
T
E
V
K
L
R
L
Site 13
T181
K
E
S
A
I
A
S
T
E
V
K
L
R
L
Q
Site 14
S193
R
L
Q
E
F
L
L
S
K
S
K
E
P
T
P
Site 15
S195
Q
E
F
L
L
S
K
S
K
E
P
T
P
G
G
Site 16
T199
L
S
K
S
K
E
P
T
P
G
G
L
N
H
S
Site 17
S206
T
P
G
G
L
N
H
S
L
P
Q
H
P
K
C
Site 18
S220
C
W
G
A
H
H
A
S
L
D
Q
S
S
P
P
Site 19
S224
H
H
A
S
L
D
Q
S
S
P
P
Q
S
G
P
Site 20
S225
H
A
S
L
D
Q
S
S
P
P
Q
S
G
P
P
Site 21
S229
D
Q
S
S
P
P
Q
S
G
P
P
G
T
P
P
Site 22
T234
P
Q
S
G
P
P
G
T
P
P
S
Y
K
L
P
Site 23
S237
G
P
P
G
T
P
P
S
Y
K
L
P
L
P
G
Site 24
Y238
P
P
G
T
P
P
S
Y
K
L
P
L
P
G
P
Site 25
S248
P
L
P
G
P
Y
D
S
R
D
D
F
P
L
R
Site 26
T257
D
D
F
P
L
R
K
T
A
S
E
P
N
L
K
Site 27
S259
F
P
L
R
K
T
A
S
E
P
N
L
K
V
R
Site 28
S278
Q
K
V
A
E
R
R
S
S
P
L
L
R
R
K
Site 29
S279
K
V
A
E
R
R
S
S
P
L
L
R
R
K
D
Site 30
T288
L
L
R
R
K
D
G
T
V
I
S
T
F
K
K
Site 31
S291
R
K
D
G
T
V
I
S
T
F
K
K
R
A
V
Site 32
T292
K
D
G
T
V
I
S
T
F
K
K
R
A
V
E
Site 33
T301
K
K
R
A
V
E
I
T
G
A
G
P
G
A
S
Site 34
S308
T
G
A
G
P
G
A
S
S
V
C
N
S
A
P
Site 35
S309
G
A
G
P
G
A
S
S
V
C
N
S
A
P
G
Site 36
S313
G
A
S
S
V
C
N
S
A
P
G
S
G
P
S
Site 37
S317
V
C
N
S
A
P
G
S
G
P
S
S
P
N
S
Site 38
S320
S
A
P
G
S
G
P
S
S
P
N
S
S
H
S
Site 39
S321
A
P
G
S
G
P
S
S
P
N
S
S
H
S
T
Site 40
S324
S
G
P
S
S
P
N
S
S
H
S
T
I
A
E
Site 41
S325
G
P
S
S
P
N
S
S
H
S
T
I
A
E
N
Site 42
S327
S
S
P
N
S
S
H
S
T
I
A
E
N
G
F
Site 43
T328
S
P
N
S
S
H
S
T
I
A
E
N
G
F
T
Site 44
T335
T
I
A
E
N
G
F
T
G
S
V
P
N
I
P
Site 45
S337
A
E
N
G
F
T
G
S
V
P
N
I
P
T
E
Site 46
S356
H
R
A
L
P
L
D
S
S
P
N
Q
F
S
L
Site 47
S357
R
A
L
P
L
D
S
S
P
N
Q
F
S
L
Y
Site 48
S362
D
S
S
P
N
Q
F
S
L
Y
T
S
P
S
L
Site 49
Y364
S
P
N
Q
F
S
L
Y
T
S
P
S
L
P
N
Site 50
S366
N
Q
F
S
L
Y
T
S
P
S
L
P
N
I
S
Site 51
S368
F
S
L
Y
T
S
P
S
L
P
N
I
S
L
G
Site 52
S385
A
T
V
T
V
T
N
S
H
L
T
A
S
P
K
Site 53
T388
T
V
T
N
S
H
L
T
A
S
P
K
L
S
T
Site 54
S390
T
N
S
H
L
T
A
S
P
K
L
S
T
Q
Q
Site 55
S394
L
T
A
S
P
K
L
S
T
Q
Q
E
A
E
R
Site 56
S406
A
E
R
Q
A
L
Q
S
L
R
Q
G
G
T
L
Site 57
T412
Q
S
L
R
Q
G
G
T
L
T
G
K
F
M
S
Site 58
T414
L
R
Q
G
G
T
L
T
G
K
F
M
S
T
S
Site 59
S437
V
A
L
E
G
D
G
S
P
H
G
H
A
S
L
Site 60
S469
A
V
P
L
H
G
Q
S
P
L
V
T
G
E
R
Site 61
T473
H
G
Q
S
P
L
V
T
G
E
R
V
A
T
S
Site 62
T479
V
T
G
E
R
V
A
T
S
M
R
T
V
G
K
Site 63
S480
T
G
E
R
V
A
T
S
M
R
T
V
G
K
L
Site 64
T483
R
V
A
T
S
M
R
T
V
G
K
L
P
R
H
Site 65
S494
L
P
R
H
R
P
L
S
R
T
Q
S
S
P
L
Site 66
T496
R
H
R
P
L
S
R
T
Q
S
S
P
L
P
Q
Site 67
S498
R
P
L
S
R
T
Q
S
S
P
L
P
Q
S
P
Site 68
S499
R
P
L
S
R
T
Q
S
S
P
L
P
Q
S
P
Site 69
S504
Q
S
S
P
L
P
Q
S
P
Q
A
L
Q
Q
L
Site 70
T536
L
Q
L
G
K
I
L
T
K
T
G
E
L
P
R
Site 71
T538
L
G
K
I
L
T
K
T
G
E
L
P
R
Q
P
Site 72
T546
G
E
L
P
R
Q
P
T
T
H
P
E
E
T
E
Site 73
T547
G
E
L
P
R
Q
P
T
T
H
P
E
E
T
E
Site 74
T557
E
E
T
E
E
E
L
T
E
Q
Q
E
V
L
L
Site 75
T570
L
L
G
E
G
A
L
T
M
P
R
E
G
S
T
Site 76
S576
L
T
M
P
R
E
G
S
T
E
S
E
S
T
Q
Site 77
T577
T
M
P
R
E
G
S
T
E
S
E
S
T
Q
E
Site 78
S579
P
R
E
G
S
T
E
S
E
S
T
Q
E
D
L
Site 79
S581
E
G
S
T
E
S
E
S
T
Q
E
D
L
E
E
Site 80
T582
G
S
T
E
S
E
S
T
Q
E
D
L
E
E
E
Site 81
S611
V
K
D
E
E
G
E
S
G
A
E
E
G
P
D
Site 82
S631
A
G
Y
K
K
L
F
S
D
A
Q
P
L
Q
P
Site 83
S647
Q
V
Y
Q
A
P
L
S
L
A
T
V
P
H
Q
Site 84
S661
Q
A
L
G
R
T
Q
S
S
P
A
A
P
G
G
Site 85
S662
A
L
G
R
T
Q
S
S
P
A
A
P
G
G
M
Site 86
S671
A
A
P
G
G
M
K
S
P
P
D
Q
P
V
K
Site 87
Y687
L
F
T
T
G
V
V
Y
D
T
F
M
L
K
H
Site 88
S713
E
H
A
G
R
I
Q
S
I
W
S
R
L
Q
E
Site 89
S725
L
Q
E
T
G
L
L
S
K
C
E
R
I
R
G
Site 90
T736
R
I
R
G
R
K
A
T
L
D
E
I
Q
T
V
Site 91
T742
A
T
L
D
E
I
Q
T
V
H
S
E
Y
H
T
Site 92
T749
T
V
H
S
E
Y
H
T
L
L
Y
G
T
S
P
Site 93
Y752
S
E
Y
H
T
L
L
Y
G
T
S
P
L
N
R
Site 94
S755
H
T
L
L
Y
G
T
S
P
L
N
R
Q
K
L
Site 95
S764
L
N
R
Q
K
L
D
S
K
K
L
L
G
P
I
Site 96
Y776
G
P
I
S
Q
K
M
Y
A
V
L
P
C
G
G
Site 97
S798
V
W
N
E
M
H
S
S
S
A
V
R
M
A
V
Site 98
S799
W
N
E
M
H
S
S
S
A
V
R
M
A
V
G
Site 99
Y882
N
G
T
Q
Q
A
F
Y
N
D
P
S
V
L
Y
Site 100
S886
Q
A
F
Y
N
D
P
S
V
L
Y
I
S
L
H
Site 101
Y889
Y
N
D
P
S
V
L
Y
I
S
L
H
R
Y
D
Site 102
S891
D
P
S
V
L
Y
I
S
L
H
R
Y
D
N
G
Site 103
Y895
L
Y
I
S
L
H
R
Y
D
N
G
N
F
F
P
Site 104
S904
N
G
N
F
F
P
G
S
G
A
P
E
E
V
G
Site 105
S971
D
A
V
E
G
H
L
S
P
L
G
G
Y
S
V
Site 106
T1009
L
E
G
G
H
D
L
T
A
I
C
D
A
S
E
Site 107
S1071
F
A
A
G
L
G
R
S
L
R
E
A
Q
A
G
Site 108
S1108
A
A
A
A
R
E
H
S
P
R
P
A
E
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation