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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCML2
Full Name:
ISOFORM 1 OF SEX COMB ON MIDLEG-LIKE PROTEIN 2.
Alias:
Sex comb on midleg (Drosophila)-like 2; Sex comb on midleg-like 2; Sex comb on midleg-like 2 (Drosophila)
Type:
Mass (Da):
77257
Number AA:
700
UniProt ID:
Q9UQR0
International Prot ID:
IPI00328688
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
Q
T
V
N
E
D
S
M
D
V
K
K
E
N
Site 2
T20
K
K
E
N
Q
E
K
T
P
Q
S
S
T
S
S
Site 3
S23
N
Q
E
K
T
P
Q
S
S
T
S
S
V
Q
R
Site 4
S24
Q
E
K
T
P
Q
S
S
T
S
S
V
Q
R
D
Site 5
S27
T
P
Q
S
S
T
S
S
V
Q
R
D
D
F
H
Site 6
Y38
D
D
F
H
W
E
E
Y
L
K
E
T
G
S
I
Site 7
S44
E
Y
L
K
E
T
G
S
I
S
A
P
S
E
C
Site 8
S46
L
K
E
T
G
S
I
S
A
P
S
E
C
F
R
Site 9
S49
T
G
S
I
S
A
P
S
E
C
F
R
Q
S
Q
Site 10
S55
P
S
E
C
F
R
Q
S
Q
I
P
P
V
N
D
Site 11
T78
A
R
D
P
R
N
A
T
S
V
C
I
A
T
V
Site 12
S100
L
R
L
R
L
D
G
S
D
N
R
N
D
F
W
Site 13
S112
D
F
W
R
L
V
D
S
P
D
I
Q
P
V
G
Site 14
Y134
L
L
Q
P
P
L
G
Y
Q
M
N
T
S
S
W
Site 15
S156
L
N
G
S
E
M
A
S
A
T
L
F
K
K
E
Site 16
T205
K
G
D
E
V
H
I
T
F
D
G
W
S
G
A
Site 17
T233
P
A
G
W
C
R
L
T
G
D
V
L
Q
P
P
Site 18
T242
D
V
L
Q
P
P
G
T
S
V
P
I
V
K
N
Site 19
T253
I
V
K
N
I
A
K
T
E
S
S
P
S
E
A
Site 20
S255
K
N
I
A
K
T
E
S
S
P
S
E
A
S
Q
Site 21
S256
N
I
A
K
T
E
S
S
P
S
E
A
S
Q
H
Site 22
S258
A
K
T
E
S
S
P
S
E
A
S
Q
H
S
M
Site 23
S261
E
S
S
P
S
E
A
S
Q
H
S
M
Q
S
P
Site 24
S264
P
S
E
A
S
Q
H
S
M
Q
S
P
Q
K
T
Site 25
S267
A
S
Q
H
S
M
Q
S
P
Q
K
T
T
L
I
Site 26
T271
S
M
Q
S
P
Q
K
T
T
L
I
L
P
T
Q
Site 27
S283
P
T
Q
Q
V
R
R
S
S
R
I
K
P
P
G
Site 28
S284
T
Q
Q
V
R
R
S
S
R
I
K
P
P
G
P
Site 29
T292
R
I
K
P
P
G
P
T
A
V
P
K
R
S
S
Site 30
S298
P
T
A
V
P
K
R
S
S
S
V
K
N
I
T
Site 31
S299
T
A
V
P
K
R
S
S
S
V
K
N
I
T
P
Site 32
S300
A
V
P
K
R
S
S
S
V
K
N
I
T
P
R
Site 33
T305
S
S
S
V
K
N
I
T
P
R
K
K
G
P
N
Site 34
S313
P
R
K
K
G
P
N
S
G
K
K
E
K
P
L
Site 35
T326
P
L
P
V
I
C
S
T
S
A
A
S
L
K
S
Site 36
S330
I
C
S
T
S
A
A
S
L
K
S
L
T
R
D
Site 37
S333
T
S
A
A
S
L
K
S
L
T
R
D
R
G
M
Site 38
T335
A
A
S
L
K
S
L
T
R
D
R
G
M
L
Y
Site 39
Y342
T
R
D
R
G
M
L
Y
K
D
V
A
S
G
P
Site 40
T408
D
C
A
L
E
T
K
T
V
F
G
Y
L
K
P
Site 41
Y412
E
T
K
T
V
F
G
Y
L
K
P
D
N
R
G
Site 42
S426
G
G
E
V
I
T
A
S
F
D
G
E
T
H
S
Site 43
T431
T
A
S
F
D
G
E
T
H
S
I
Q
L
P
P
Site 44
S433
S
F
D
G
E
T
H
S
I
Q
L
P
P
V
N
Site 45
S463
L
Q
C
D
N
L
L
S
S
Q
P
F
S
S
S
Site 46
S464
Q
C
D
N
L
L
S
S
Q
P
F
S
S
S
R
Site 47
S468
L
L
S
S
Q
P
F
S
S
S
R
G
H
T
H
Site 48
S469
L
S
S
Q
P
F
S
S
S
R
G
H
T
H
S
Site 49
S470
S
S
Q
P
F
S
S
S
R
G
H
T
H
S
S
Site 50
T474
F
S
S
S
R
G
H
T
H
S
S
A
E
H
D
Site 51
S476
S
S
R
G
H
T
H
S
S
A
E
H
D
K
N
Site 52
T491
Q
S
A
K
E
D
V
T
E
R
Q
S
T
K
R
Site 53
S495
E
D
V
T
E
R
Q
S
T
K
R
S
P
Q
Q
Site 54
T496
D
V
T
E
R
Q
S
T
K
R
S
P
Q
Q
T
Site 55
S499
E
R
Q
S
T
K
R
S
P
Q
Q
T
V
P
Y
Site 56
T503
T
K
R
S
P
Q
Q
T
V
P
Y
V
V
P
L
Site 57
Y506
S
P
Q
Q
T
V
P
Y
V
V
P
L
S
P
K
Site 58
S511
V
P
Y
V
V
P
L
S
P
K
L
P
K
T
K
Site 59
T517
L
S
P
K
L
P
K
T
K
E
Y
A
S
E
G
Site 60
Y520
K
L
P
K
T
K
E
Y
A
S
E
G
E
P
L
Site 61
S522
P
K
T
K
E
Y
A
S
E
G
E
P
L
F
A
Site 62
S532
E
P
L
F
A
G
G
S
A
I
P
K
E
E
N
Site 63
S541
I
P
K
E
E
N
L
S
E
D
S
K
S
S
S
Site 64
S544
E
E
N
L
S
E
D
S
K
S
S
S
L
N
S
Site 65
S546
N
L
S
E
D
S
K
S
S
S
L
N
S
G
N
Site 66
S547
L
S
E
D
S
K
S
S
S
L
N
S
G
N
Y
Site 67
S548
S
E
D
S
K
S
S
S
L
N
S
G
N
Y
L
Site 68
S551
S
K
S
S
S
L
N
S
G
N
Y
L
N
P
A
Site 69
Y554
S
S
L
N
S
G
N
Y
L
N
P
A
C
R
N
Site 70
Y564
P
A
C
R
N
P
M
Y
I
H
T
S
V
S
Q
Site 71
T567
R
N
P
M
Y
I
H
T
S
V
S
Q
D
F
S
Site 72
S568
N
P
M
Y
I
H
T
S
V
S
Q
D
F
S
R
Site 73
S570
M
Y
I
H
T
S
V
S
Q
D
F
S
R
S
V
Site 74
S574
T
S
V
S
Q
D
F
S
R
S
V
P
G
T
T
Site 75
S576
V
S
Q
D
F
S
R
S
V
P
G
T
T
S
S
Site 76
T580
F
S
R
S
V
P
G
T
T
S
S
P
L
V
G
Site 77
T581
S
R
S
V
P
G
T
T
S
S
P
L
V
G
D
Site 78
S582
R
S
V
P
G
T
T
S
S
P
L
V
G
D
I
Site 79
S583
S
V
P
G
T
T
S
S
P
L
V
G
D
I
S
Site 80
S590
S
P
L
V
G
D
I
S
P
K
S
S
P
H
E
Site 81
S593
V
G
D
I
S
P
K
S
S
P
H
E
V
K
F
Site 82
S594
G
D
I
S
P
K
S
S
P
H
E
V
K
F
Q
Site 83
S606
K
F
Q
M
Q
R
K
S
E
A
P
S
Y
I
A
Site 84
S610
Q
R
K
S
E
A
P
S
Y
I
A
V
P
D
P
Site 85
Y611
R
K
S
E
A
P
S
Y
I
A
V
P
D
P
S
Site 86
S625
S
V
L
K
Q
G
F
S
K
D
P
S
T
W
S
Site 87
S629
Q
G
F
S
K
D
P
S
T
W
S
V
D
E
V
Site 88
T630
G
F
S
K
D
P
S
T
W
S
V
D
E
V
I
Site 89
S632
S
K
D
P
S
T
W
S
V
D
E
V
I
Q
F
Site 90
S670
K
A
L
F
L
L
K
S
D
V
M
M
K
Y
M
Site 91
Y676
K
S
D
V
M
M
K
Y
M
G
L
K
L
G
P
Site 92
Y690
P
A
L
K
L
C
Y
Y
I
E
K
L
K
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation