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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GNE
Full Name:
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Alias:
UDP-GlcNAc-2-epimerase/ManAc kinase
Type:
Mass (Da):
79257
Number AA:
722
UniProt ID:
Q9Y223
International Prot ID:
IPI00023162
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000271
GO:0005975
GO:0005976
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
K
L
R
V
C
V
A
T
C
N
R
A
D
Y
S
Site 2
Y22
A
T
C
N
R
A
D
Y
S
K
L
A
P
I
M
Site 3
Y54
G
S
H
L
I
D
D
Y
G
N
T
Y
R
M
I
Site 4
T74
D
I
N
T
R
L
H
T
I
V
R
G
E
D
E
Site 5
T141
E
G
G
E
V
S
G
T
I
D
D
S
I
R
H
Site 6
S145
V
S
G
T
I
D
D
S
I
R
H
A
I
T
K
Site 7
S170
S
A
E
Q
H
L
I
S
M
C
E
D
H
D
R
Site 8
S191
P
S
Y
D
K
L
L
S
A
K
N
K
D
Y
M
Site 9
Y197
L
S
A
K
N
K
D
Y
M
S
I
I
R
M
W
Site 10
S199
A
K
N
K
D
Y
M
S
I
I
R
M
W
L
G
Site 11
S211
W
L
G
D
D
V
K
S
K
D
Y
I
V
A
L
Site 12
Y214
D
D
V
K
S
K
D
Y
I
V
A
L
Q
H
P
Site 13
S258
F
P
N
I
D
A
G
S
K
E
M
V
R
V
M
Site 14
T327
T
R
Q
I
G
R
E
T
G
E
N
V
L
H
V
Site 15
T339
L
H
V
R
D
A
D
T
Q
D
K
I
L
Q
A
Site 16
Y355
H
L
Q
F
G
K
Q
Y
P
C
S
K
I
Y
G
Site 17
S397
P
P
V
K
E
N
I
S
Q
D
I
D
H
I
L
Site 18
Y434
K
G
E
I
V
K
K
Y
T
Q
F
N
P
K
T
Site 19
T441
Y
T
Q
F
N
P
K
T
Y
E
E
R
I
N
L
Site 20
T502
W
N
S
V
D
L
R
T
P
L
S
D
T
L
H
Site 21
S592
G
C
I
E
A
Y
A
S
G
M
A
L
Q
R
E
Site 22
S640
L
G
N
A
K
A
Q
S
I
L
R
T
A
G
T
Site 23
Y716
A
A
S
M
V
L
D
Y
T
T
R
R
I
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation