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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENTPD4
Full Name:
Ectonucleoside triphosphate diphosphohydrolase 4
Alias:
EC 3.6.1.6; ENP4; ENTP4; KIAA0392; LALP70; LYSAL1; Lysosomal apyrase-like protein of 70 kDa; NTPDase4; Uridine-diphosphatase
Type:
Hydrolase, Nucleotides - purine metabolism, Nucleotides - pyrimidine metabolism
Mass (Da):
70255
Number AA:
616
UniProt ID:
Q9Y227
International Prot ID:
IPI00031718
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0030173
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0000287
GO:0045134
PhosphoSite+
KinaseNET
Biological Process:
GO:0006256
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
S
V
L
A
A
A
V
S
L
L
Y
F
S
V
V
Site 2
Y48
A
A
A
V
S
L
L
Y
F
S
V
V
I
I
R
Site 3
Y58
V
V
I
I
R
N
K
Y
G
R
L
T
R
D
K
Site 4
T62
R
N
K
Y
G
R
L
T
R
D
K
K
F
Q
R
Site 5
Y70
R
D
K
K
F
Q
R
Y
L
A
R
V
T
D
I
Site 6
T75
Q
R
Y
L
A
R
V
T
D
I
E
A
T
D
T
Site 7
T82
T
D
I
E
A
T
D
T
N
N
P
N
V
N
Y
Site 8
Y105
S
G
S
R
V
F
V
Y
C
W
P
R
H
N
G
Site 9
S140
M
K
I
K
P
G
I
S
E
F
A
T
S
P
E
Site 10
T144
P
G
I
S
E
F
A
T
S
P
E
K
V
S
D
Site 11
S145
G
I
S
E
F
A
T
S
P
E
K
V
S
D
Y
Site 12
S150
A
T
S
P
E
K
V
S
D
Y
I
S
P
L
L
Site 13
Y152
S
P
E
K
V
S
D
Y
I
S
P
L
L
N
F
Site 14
T172
P
R
A
K
H
K
E
T
P
L
Y
I
L
C
T
Site 15
Y175
K
H
K
E
T
P
L
Y
I
L
C
T
A
G
M
Site 16
S188
G
M
R
I
L
P
E
S
Q
Q
K
A
I
L
E
Site 17
Y225
S
G
K
Q
E
G
V
Y
A
W
I
G
I
N
F
Site 18
Y281
G
V
S
T
Q
I
A
Y
E
V
P
K
T
V
S
Site 19
T286
I
A
Y
E
V
P
K
T
V
S
F
A
S
S
Q
Site 20
S288
Y
E
V
P
K
T
V
S
F
A
S
S
Q
Q
E
Site 21
S292
K
T
V
S
F
A
S
S
Q
Q
E
E
V
A
K
Site 22
Y337
G
N
A
A
R
Q
R
Y
E
D
R
I
F
A
N
Site 23
T345
E
D
R
I
F
A
N
T
I
Q
K
N
R
L
L
Site 24
T359
L
G
K
Q
T
G
L
T
P
D
M
P
Y
L
D
Site 25
Y385
Q
Q
N
G
Q
T
I
Y
L
R
G
T
G
D
F
Site 26
T389
Q
T
I
Y
L
R
G
T
G
D
F
D
L
C
R
Site 27
S412
K
T
N
E
T
Q
T
S
L
N
G
V
Y
Q
P
Site 28
Y417
Q
T
S
L
N
G
V
Y
Q
P
P
I
H
F
Q
Site 29
Y436
Y
G
F
S
E
F
Y
Y
C
T
E
D
V
L
R
Site 30
Y448
V
L
R
M
G
G
D
Y
N
A
A
K
F
T
K
Site 31
Y460
F
T
K
A
A
K
D
Y
C
A
T
K
W
S
I
Site 32
Y477
E
R
F
D
R
G
L
Y
A
S
H
A
D
L
H
Site 33
S479
F
D
R
G
L
Y
A
S
H
A
D
L
H
R
L
Site 34
Y488
A
D
L
H
R
L
K
Y
Q
C
F
K
S
A
W
Site 35
S505
E
V
F
H
R
G
F
S
F
P
V
N
Y
K
S
Site 36
S512
S
F
P
V
N
Y
K
S
L
K
T
A
L
Q
V
Site 37
T527
Y
D
K
E
V
Q
W
T
L
G
A
I
L
Y
R
Site 38
T553
E
A
F
R
A
S
H
T
H
W
R
G
V
S
F
Site 39
T592
L
R
R
I
H
R
R
T
P
R
S
S
S
A
A
Site 40
S595
I
H
R
R
T
P
R
S
S
S
A
A
A
L
W
Site 41
S596
H
R
R
T
P
R
S
S
S
A
A
A
L
W
M
Site 42
S597
R
R
T
P
R
S
S
S
A
A
A
L
W
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation