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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RUVBL2
Full Name:
RuvB-like 2
Alias:
48-kDa TATA box-binding protein-interacting protein; 48-kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP51; ECP-51; INO80 complex subunit J; INO80J; Repressing pontin 52; Reptin; Reptin 52; Reptin52; RUVB2; Rvb2; RVB2; TAP54-beta; TIH2; TIP48; TIP49b; TIP60-associated protein 54-beta
Type:
EC 3.6.1.-; Helicase
Mass (Da):
51157
Number AA:
463
UniProt ID:
Q9Y230
International Prot ID:
IPI00009104
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035267
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003684
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
GO:0043968
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
T
V
T
A
T
T
K
V
P
E
Site 2
T17
V
P
E
I
R
D
V
T
R
I
E
R
I
G
A
Site 3
S26
I
E
R
I
G
A
H
S
H
I
R
G
L
G
L
Site 4
S43
A
L
E
P
R
Q
A
S
Q
G
M
V
G
Q
L
Site 5
T81
L
I
A
G
Q
P
G
T
G
K
T
A
I
A
M
Site 6
S110
I
A
G
S
E
I
F
S
L
E
M
S
K
T
E
Site 7
S114
E
I
F
S
L
E
M
S
K
T
E
A
L
T
Q
Site 8
T116
F
S
L
E
M
S
K
T
E
A
L
T
Q
A
F
Site 9
S126
L
T
Q
A
F
R
R
S
I
G
V
R
I
K
E
Site 10
T135
G
V
R
I
K
E
E
T
E
I
I
E
G
E
V
Site 11
T152
I
Q
I
D
R
P
A
T
G
T
G
S
K
V
G
Site 12
T154
I
D
R
P
A
T
G
T
G
S
K
V
G
K
L
Site 13
S156
R
P
A
T
G
T
G
S
K
V
G
K
L
T
L
Site 14
T165
V
G
K
L
T
L
K
T
T
E
M
E
T
I
Y
Site 15
Y172
T
T
E
M
E
T
I
Y
D
L
G
T
K
M
I
Site 16
T176
E
T
I
Y
D
L
G
T
K
M
I
E
S
L
T
Site 17
S181
L
G
T
K
M
I
E
S
L
T
K
D
K
V
Q
Site 18
S203
D
K
A
T
G
K
I
S
K
L
G
R
S
F
T
Site 19
S208
K
I
S
K
L
G
R
S
F
T
R
A
R
D
Y
Site 20
T210
S
K
L
G
R
S
F
T
R
A
R
D
Y
D
A
Site 21
Y215
S
F
T
R
A
R
D
Y
D
A
M
G
S
Q
T
Site 22
S220
R
D
Y
D
A
M
G
S
Q
T
K
F
V
Q
C
Site 23
T222
Y
D
A
M
G
S
Q
T
K
F
V
Q
C
P
D
Site 24
T241
K
R
K
E
V
V
H
T
V
S
L
H
E
I
D
Site 25
S270
G
D
T
G
E
I
K
S
E
V
R
E
Q
I
N
Site 26
T333
M
A
T
N
R
G
I
T
R
I
R
G
T
S
Y
Site 27
T338
G
I
T
R
I
R
G
T
S
Y
Q
S
P
H
G
Site 28
S339
I
T
R
I
R
G
T
S
Y
Q
S
P
H
G
I
Site 29
Y340
T
R
I
R
G
T
S
Y
Q
S
P
H
G
I
P
Site 30
S342
I
R
G
T
S
Y
Q
S
P
H
G
I
P
I
D
Site 31
S358
L
D
R
L
L
I
V
S
T
T
P
Y
S
E
K
Site 32
T359
D
R
L
L
I
V
S
T
T
P
Y
S
E
K
D
Site 33
T360
R
L
L
I
V
S
T
T
P
Y
S
E
K
D
T
Site 34
Y362
L
I
V
S
T
T
P
Y
S
E
K
D
T
K
Q
Site 35
S363
I
V
S
T
T
P
Y
S
E
K
D
T
K
Q
I
Site 36
T367
T
P
Y
S
E
K
D
T
K
Q
I
L
R
I
R
Site 37
T388
E
M
S
E
D
A
Y
T
V
L
T
R
I
G
L
Site 38
T419
V
C
R
K
R
K
G
T
E
V
Q
V
D
D
I
Site 39
Y430
V
D
D
I
K
R
V
Y
S
L
F
L
D
E
S
Site 40
S431
D
D
I
K
R
V
Y
S
L
F
L
D
E
S
R
Site 41
S437
Y
S
L
F
L
D
E
S
R
S
T
Q
Y
M
K
Site 42
S439
L
F
L
D
E
S
R
S
T
Q
Y
M
K
E
Y
Site 43
T440
F
L
D
E
S
R
S
T
Q
Y
M
K
E
Y
Q
Site 44
Y446
S
T
Q
Y
M
K
E
Y
Q
D
A
F
L
F
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation