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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLEC1
Full Name:
Deleted in lung and esophageal cancer protein 1
Alias:
DLC1
Type:
Tumour suppressor protein
Mass (Da):
195783
Number AA:
1755
UniProt ID:
Q9Y238
International Prot ID:
IPI00164104
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
T
R
S
S
K
T
R
R
S
L
A
Site 2
T8
M
E
T
R
S
S
K
T
R
R
S
L
A
S
R
Site 3
S11
R
S
S
K
T
R
R
S
L
A
S
R
T
N
E
Site 4
S14
K
T
R
R
S
L
A
S
R
T
N
E
C
Q
G
Site 5
T22
R
T
N
E
C
Q
G
T
M
W
A
P
T
S
P
Site 6
T27
Q
G
T
M
W
A
P
T
S
P
P
A
G
S
S
Site 7
S28
G
T
M
W
A
P
T
S
P
P
A
G
S
S
S
Site 8
S33
P
T
S
P
P
A
G
S
S
S
P
S
Q
P
T
Site 9
S34
T
S
P
P
A
G
S
S
S
P
S
Q
P
T
W
Site 10
S35
S
P
P
A
G
S
S
S
P
S
Q
P
T
W
K
Site 11
S37
P
A
G
S
S
S
P
S
Q
P
T
W
K
S
S
Site 12
T40
S
S
S
P
S
Q
P
T
W
K
S
S
L
Y
S
Site 13
S43
P
S
Q
P
T
W
K
S
S
L
Y
S
S
L
A
Site 14
S44
S
Q
P
T
W
K
S
S
L
Y
S
S
L
A
Y
Site 15
Y46
P
T
W
K
S
S
L
Y
S
S
L
A
Y
S
E
Site 16
S47
T
W
K
S
S
L
Y
S
S
L
A
Y
S
E
A
Site 17
S48
W
K
S
S
L
Y
S
S
L
A
Y
S
E
A
F
Site 18
S52
L
Y
S
S
L
A
Y
S
E
A
F
H
Y
S
F
Site 19
Y57
A
Y
S
E
A
F
H
Y
S
F
A
A
R
P
R
Site 20
S58
Y
S
E
A
F
H
Y
S
F
A
A
R
P
R
R
Site 21
T67
A
A
R
P
R
R
L
T
Q
L
A
L
A
Q
R
Site 22
S85
Q
L
L
R
L
R
P
S
S
L
R
T
Q
D
I
Site 23
S86
L
L
R
L
R
P
S
S
L
R
T
Q
D
I
S
Site 24
T89
L
R
P
S
S
L
R
T
Q
D
I
S
H
L
L
Site 25
S116
I
G
D
E
V
S
A
S
L
I
K
A
R
G
S
Site 26
S123
S
L
I
K
A
R
G
S
E
N
E
R
H
E
E
Site 27
Y142
L
Q
Q
I
R
E
L
Y
K
Q
R
L
D
E
F
Site 28
T157
E
M
L
E
R
H
I
T
Q
A
Q
A
R
A
I
Site 29
S172
A
E
N
E
R
V
M
S
Q
A
G
V
Q
D
L
Site 30
S190
V
R
L
P
P
V
K
S
V
S
R
W
C
I
D
Site 31
S208
L
R
K
H
H
L
I
S
P
E
D
Y
Y
T
D
Site 32
Y212
H
L
I
S
P
E
D
Y
Y
T
D
T
V
P
F
Site 33
Y213
L
I
S
P
E
D
Y
Y
T
D
T
V
P
F
H
Site 34
T214
I
S
P
E
D
Y
Y
T
D
T
V
P
F
H
S
Site 35
T216
P
E
D
Y
Y
T
D
T
V
P
F
H
S
A
P
Site 36
S221
T
D
T
V
P
F
H
S
A
P
K
G
I
S
L
Site 37
S227
H
S
A
P
K
G
I
S
L
P
G
C
S
K
L
Site 38
T235
L
P
G
C
S
K
L
T
F
S
C
E
K
R
S
Site 39
S237
G
C
S
K
L
T
F
S
C
E
K
R
S
V
Q
Site 40
S242
T
F
S
C
E
K
R
S
V
Q
K
K
E
L
N
Site 41
S255
L
N
K
K
L
E
D
S
C
R
K
K
L
A
E
Site 42
T270
F
E
D
E
L
D
H
T
V
D
S
L
T
W
N
Site 43
S273
E
L
D
H
T
V
D
S
L
T
W
N
L
T
P
Site 44
T275
D
H
T
V
D
S
L
T
W
N
L
T
P
K
A
Site 45
T279
D
S
L
T
W
N
L
T
P
K
A
K
E
R
T
Site 46
S294
R
E
P
L
K
K
A
S
Q
P
R
N
K
N
W
Site 47
S322
L
L
L
A
R
M
E
S
R
N
H
F
L
K
N
Site 48
T337
P
R
F
F
P
P
N
T
R
Y
G
G
K
S
L
Site 49
Y339
F
F
P
P
N
T
R
Y
G
G
K
S
L
V
F
Site 50
S343
N
T
R
Y
G
G
K
S
L
V
F
P
P
K
K
Site 51
S359
A
P
I
G
E
F
Q
S
T
E
P
E
Q
S
C
Site 52
T360
P
I
G
E
F
Q
S
T
E
P
E
Q
S
C
A
Site 53
S365
Q
S
T
E
P
E
Q
S
C
A
D
T
P
V
F
Site 54
T369
P
E
Q
S
C
A
D
T
P
V
F
L
A
K
P
Site 55
T401
I
A
L
Q
N
T
T
T
T
S
R
Y
L
R
V
Site 56
Y405
N
T
T
T
T
S
R
Y
L
R
V
L
P
P
S
Site 57
T516
R
F
C
I
M
P
K
T
S
W
P
P
L
S
F
Site 58
S562
E
V
L
F
S
P
K
S
L
G
K
A
E
Q
T
Site 59
S599
A
L
D
L
I
Y
I
S
G
E
K
S
Q
P
D
Site 60
S603
I
Y
I
S
G
E
K
S
Q
P
D
P
G
E
L
Site 61
T614
P
G
E
L
T
D
L
T
A
Q
H
F
I
R
F
Site 62
S628
F
E
P
E
N
L
R
S
T
A
R
K
Q
L
I
Site 63
T629
E
P
E
N
L
R
S
T
A
R
K
Q
L
I
I
Site 64
Y647
T
H
V
E
L
A
F
Y
W
Q
I
M
K
P
N
Site 65
T663
Q
P
L
M
P
G
E
T
F
S
M
D
S
I
K
Site 66
Y672
S
M
D
S
I
K
C
Y
P
D
K
E
T
A
F
Site 67
T677
K
C
Y
P
D
K
E
T
A
F
S
I
M
P
R
Site 68
S680
P
D
K
E
T
A
F
S
I
M
P
R
K
G
V
Site 69
S689
M
P
R
K
G
V
L
S
P
H
T
D
H
E
F
Site 70
T692
K
G
V
L
S
P
H
T
D
H
E
F
I
L
S
Site 71
S699
T
D
H
E
F
I
L
S
F
S
P
H
E
L
R
Site 72
S701
H
E
F
I
L
S
F
S
P
H
E
L
R
D
F
Site 73
S710
H
E
L
R
D
F
H
S
V
L
Q
M
V
L
E
Site 74
S724
E
E
V
P
E
P
V
S
S
E
A
E
S
L
G
Site 75
S725
E
V
P
E
P
V
S
S
E
A
E
S
L
G
H
Site 76
S729
P
V
S
S
E
A
E
S
L
G
H
S
S
Y
S
Site 77
S733
E
A
E
S
L
G
H
S
S
Y
S
V
D
D
V
Site 78
Y791
N
S
K
S
P
I
R
Y
L
W
G
K
I
S
D
Site 79
S814
G
T
G
V
I
E
P
S
E
V
G
D
F
E
L
Site 80
T824
G
D
F
E
L
N
F
T
G
G
V
P
G
P
T
Site 81
S844
C
E
I
E
D
S
P
S
P
V
V
L
H
I
E
Site 82
S880
L
G
Q
K
A
T
N
S
I
Q
I
R
N
V
S
Site 83
S887
S
I
Q
I
R
N
V
S
Q
L
P
A
T
W
R
Site 84
T892
N
V
S
Q
L
P
A
T
W
R
M
K
E
S
P
Site 85
S898
A
T
W
R
M
K
E
S
P
V
S
L
Q
E
R
Site 86
S901
R
M
K
E
S
P
V
S
L
Q
E
R
P
E
D
Site 87
S910
Q
E
R
P
E
D
V
S
P
F
D
I
E
P
S
Site 88
S917
S
P
F
D
I
E
P
S
S
G
Q
L
H
S
L
Site 89
S918
P
F
D
I
E
P
S
S
G
Q
L
H
S
L
G
Site 90
S923
P
S
S
G
Q
L
H
S
L
G
E
C
R
V
D
Site 91
T932
G
E
C
R
V
D
I
T
L
E
A
L
H
C
Q
Site 92
Y960
A
W
S
Y
L
P
V
Y
A
E
V
Q
K
P
H
Site 93
Y969
E
V
Q
K
P
H
V
Y
L
Q
S
S
Q
V
E
Site 94
S973
P
H
V
Y
L
Q
S
S
Q
V
E
V
R
N
L
Site 95
Y981
Q
V
E
V
R
N
L
Y
L
G
V
P
T
K
T
Site 96
S1067
K
P
L
V
L
G
I
S
G
K
P
Q
G
L
Q
Site 97
T1078
Q
G
L
Q
V
A
I
T
I
S
K
E
S
S
D
Site 98
S1080
L
Q
V
A
I
T
I
S
K
E
S
S
D
C
S
Site 99
S1084
I
T
I
S
K
E
S
S
D
C
S
T
E
Q
W
Site 100
S1087
S
K
E
S
S
D
C
S
T
E
Q
W
P
G
H
Site 101
T1088
K
E
S
S
D
C
S
T
E
Q
W
P
G
H
P
Site 102
S1104
E
L
R
L
D
F
G
S
A
V
P
L
R
T
R
Site 103
T1113
V
P
L
R
T
R
V
T
R
Q
L
I
L
T
N
Site 104
T1119
V
T
R
Q
L
I
L
T
N
R
S
P
I
R
T
Site 105
S1122
Q
L
I
L
T
N
R
S
P
I
R
T
R
F
S
Site 106
T1126
T
N
R
S
P
I
R
T
R
F
S
L
K
F
E
Site 107
S1129
S
P
I
R
T
R
F
S
L
K
F
E
Y
F
G
Site 108
Y1134
R
F
S
L
K
F
E
Y
F
G
S
P
Q
N
S
Site 109
S1137
L
K
F
E
Y
F
G
S
P
Q
N
S
L
S
K
Site 110
S1141
Y
F
G
S
P
Q
N
S
L
S
K
K
T
S
L
Site 111
S1143
G
S
P
Q
N
S
L
S
K
K
T
S
L
P
N
Site 112
S1147
N
S
L
S
K
K
T
S
L
P
N
M
P
P
A
Site 113
T1158
M
P
P
A
L
L
K
T
V
R
M
Q
E
H
L
Site 114
S1176
E
Q
L
D
F
M
E
S
M
L
S
H
G
K
G
Site 115
S1179
D
F
M
E
S
M
L
S
H
G
K
G
A
A
F
Site 116
T1247
C
P
I
S
S
L
R
T
T
S
Y
T
I
D
Q
Site 117
T1248
P
I
S
S
L
R
T
T
S
Y
T
I
D
Q
A
Site 118
S1249
I
S
S
L
R
T
T
S
Y
T
I
D
Q
A
Q
Site 119
Y1250
S
S
L
R
T
T
S
Y
T
I
D
Q
A
Q
K
Site 120
T1251
S
L
R
T
T
S
Y
T
I
D
Q
A
Q
K
E
Site 121
T1265
E
P
A
M
R
F
G
T
Q
V
S
G
G
D
T
Site 122
T1272
T
Q
V
S
G
G
D
T
V
T
R
T
L
R
L
Site 123
T1274
V
S
G
G
D
T
V
T
R
T
L
R
L
N
N
Site 124
T1276
G
G
D
T
V
T
R
T
L
R
L
N
N
S
S
Site 125
S1282
R
T
L
R
L
N
N
S
S
P
C
D
I
R
L
Site 126
S1283
T
L
R
L
N
N
S
S
P
C
D
I
R
L
D
Site 127
T1293
D
I
R
L
D
W
E
T
Y
V
P
E
D
K
E
Site 128
Y1294
I
R
L
D
W
E
T
Y
V
P
E
D
K
E
D
Site 129
S1338
E
G
G
C
L
L
W
S
P
G
P
S
S
S
S
Site 130
S1342
L
L
W
S
P
G
P
S
S
S
S
E
F
S
H
Site 131
S1343
L
W
S
P
G
P
S
S
S
S
E
F
S
H
E
Site 132
S1344
W
S
P
G
P
S
S
S
S
E
F
S
H
E
T
Site 133
S1345
S
P
G
P
S
S
S
S
E
F
S
H
E
T
D
Site 134
S1348
P
S
S
S
S
E
F
S
H
E
T
D
S
S
V
Site 135
T1351
S
S
E
F
S
H
E
T
D
S
S
V
E
G
S
Site 136
S1353
E
F
S
H
E
T
D
S
S
V
E
G
S
S
S
Site 137
S1354
F
S
H
E
T
D
S
S
V
E
G
S
S
S
A
Site 138
S1358
T
D
S
S
V
E
G
S
S
S
A
S
N
R
V
Site 139
S1360
S
S
V
E
G
S
S
S
A
S
N
R
V
A
Q
Site 140
S1362
V
E
G
S
S
S
A
S
N
R
V
A
Q
K
L
Site 141
S1382
Q
A
H
E
G
V
P
S
G
H
L
Y
C
I
S
Site 142
Y1386
G
V
P
S
G
H
L
Y
C
I
S
P
K
Q
V
Site 143
S1431
G
Y
A
L
G
F
M
S
L
D
S
K
V
E
R
Site 144
S1434
L
G
F
M
S
L
D
S
K
V
E
R
E
I
P
Site 145
S1461
P
L
K
L
D
L
H
S
Y
V
R
P
A
Q
L
Site 146
Y1462
L
K
L
D
L
H
S
Y
V
R
P
A
Q
L
S
Site 147
S1469
Y
V
R
P
A
Q
L
S
V
E
L
D
Y
G
G
Site 148
Y1474
Q
L
S
V
E
L
D
Y
G
G
S
M
E
F
Q
Site 149
S1498
Q
P
C
S
G
V
L
S
E
L
V
T
T
H
H
Site 150
T1511
H
H
L
K
L
T
N
T
T
E
I
P
H
Y
F
Site 151
Y1517
N
T
T
E
I
P
H
Y
F
R
L
M
V
S
R
Site 152
S1523
H
Y
F
R
L
M
V
S
R
P
F
S
V
S
Q
Site 153
S1527
L
M
V
S
R
P
F
S
V
S
Q
D
G
A
S
Site 154
S1529
V
S
R
P
F
S
V
S
Q
D
G
A
S
Q
D
Site 155
S1534
S
V
S
Q
D
G
A
S
Q
D
H
R
A
P
G
Site 156
S1554
E
C
E
E
E
T
A
S
A
D
K
Q
L
V
L
Site 157
S1581
S
L
S
L
E
L
L
S
Y
Q
K
L
P
A
D
Site 158
Y1582
L
S
L
E
L
L
S
Y
Q
K
L
P
A
D
Q
Site 159
T1590
Q
K
L
P
A
D
Q
T
L
P
G
V
D
I
Q
Site 160
S1601
V
D
I
Q
Q
S
A
S
G
E
R
E
M
V
F
Site 161
T1609
G
E
R
E
M
V
F
T
Q
N
L
L
L
E
Y
Site 162
S1640
P
E
L
Q
L
S
T
S
W
V
D
F
G
T
C
Site 163
S1650
D
F
G
T
C
F
V
S
Q
Q
R
V
R
E
V
Site 164
Y1658
Q
Q
R
V
R
E
V
Y
L
M
N
L
S
G
C
Site 165
Y1668
N
L
S
G
C
R
S
Y
W
T
M
L
M
G
Q
Site 166
S1691
A
F
R
V
S
P
N
S
G
L
L
E
A
R
S
Site 167
S1698
S
G
L
L
E
A
R
S
A
N
A
P
P
T
S
Site 168
S1717
V
F
F
T
A
R
S
S
E
L
Y
E
S
T
M
Site 169
Y1720
T
A
R
S
S
E
L
Y
E
S
T
M
V
V
E
Site 170
S1722
R
S
S
E
L
Y
E
S
T
M
V
V
E
G
V
Site 171
S1734
E
G
V
L
G
E
K
S
C
T
L
R
L
R
G
Site 172
T1736
V
L
G
E
K
S
C
T
L
R
L
R
G
Q
G
Site 173
S1744
L
R
L
R
G
Q
G
S
Y
D
E
R
Y
M
L
Site 174
Y1745
R
L
R
G
Q
G
S
Y
D
E
R
Y
M
L
P
Site 175
Y1749
Q
G
S
Y
D
E
R
Y
M
L
P
H
Q
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation