PhosphoNET

           
Protein Info 
   
Short Name:  AKT3
Full Name:  RAC-gamma serine/threonine-protein kinase
Alias:  Akt3; EC 2.7.11.1; Kinase Akt3; PKB gamma; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B, gamma; RAC-gamma; RAC-gamma serine,threonine protein kinase; RAC-gamma serine/threonine protein kinase; RAC-PK-gamma; STK-2; V-akt murine thymoma viral oncogene 3
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family
Mass (Da):  55775
Number AA:  479
UniProt ID:  Q9Y243
International Prot ID:  IPI00031747
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0019898   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0006468  GO:0007165   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y18WVQKRGEYIKNWRPR
Site 2Y26IKNWRPRYFLLKTDG
Site 3T31PRYFLLKTDGSFIGY
Site 4S34FLLKTDGSFIGYKEK
Site 5Y38TDGSFIGYKEKPQDV
Site 6Y49PQDVDLPYPLNNFSV
Site 7T64AKCQLMKTERPKPNT
Site 8T71TERPKPNTFIIRCLQ
Site 9T80IIRCLQWTTVIERTF
Site 10T81IRCLQWTTVIERTFH
Site 11T91ERTFHVDTPEEREEW
Site 12S120 EEERMNCSPTSQIDN
Site 13S123RMNCSPTSQIDNIGE
Site 14S136GEEEMDASTTHHKRK
Site 15T144TTHHKRKTMNDFDYL
Site 16Y150KTMNDFDYLKLLGKG
Site 17Y173REKASGKYYAMKILK
Site 18Y174EKASGKYYAMKILKK
Site 19T193AKDEVAHTLTESRVL
Site 20T195DEVAHTLTESRVLKN
Site 21S197VAHTLTESRVLKNTR
Site 22T203ESRVLKNTRHPFLTS
Site 23T209NTRHPFLTSLKYSFQ
Site 24S210TRHPFLTSLKYSFQT
Site 25Y213PFLTSLKYSFQTKDR
Site 26S214FLTSLKYSFQTKDRL
Site 27S238GELFFHLSRERVFSE
Site 28S244LSRERVFSEDRTRFY
Site 29T248RVFSEDRTRFYGAEI
Site 30Y251SEDRTRFYGAEIVSA
Site 31S264SALDYLHSGKIVYRD
Site 32Y269LHSGKIVYRDLKLEN
Site 33T298GLCKEGITDAATMKT
Site 34T302EGITDAATMKTFCGT
Site 35T305 TDAATMKTFCGTPEY
Site 36T309TMKTFCGTPEYLAPE
Site 37Y312TFCGTPEYLAPEVLE
Site 38Y323EVLEDNDYGRAVDWW
Site 39Y347MCGRLPFYNQDHEKL
Site 40T368EDIKFPRTLSSDAKS
Site 41S370IKFPRTLSSDAKSLL
Site 42S371KFPRTLSSDAKSLLS
Site 43Y414GVNWQDVYDKKLVPP
Site 44S428PFKPQVTSETDTRYF
Site 45T432QVTSETDTRYFDEEF
Site 46Y434TSETDTRYFDEEFTA
Site 47T440RYFDEEFTAQTITIT
Site 48T445EFTAQTITITPPEKY
Site 49T447 TAQTITITPPEKYDE
Site 50Y452TITPPEKYDEDGMDC
Site 51S472 RPHFPQFSYSASGRE
Site 52Y473PHFPQFSYSASGRE_
Site 53S474HFPQFSYSASGRE__
Site 54S476PQFSYSASGRE____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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