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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FOXA2
Full Name:
Hepatocyte nuclear factor 3-beta
Alias:
Forkhead box A2; Forkhead box protein A2; Hepatic nuclear factor-3-beta; Hepatocyte nuclear factor 3, beta; HNF3B; HNF-3B; TCF3B
Type:
Transcription factor
Mass (Da):
48288
Number AA:
457
UniProt ID:
Q9Y261
International Prot ID:
IPI00031773
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0010551
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
M
E
G
H
E
P
S
D
W
S
S
Y
Y
A
Site 2
S17
H
E
P
S
D
W
S
S
Y
Y
A
E
P
E
G
Site 3
Y18
E
P
S
D
W
S
S
Y
Y
A
E
P
E
G
Y
Site 4
Y19
P
S
D
W
S
S
Y
Y
A
E
P
E
G
Y
S
Site 5
Y25
Y
Y
A
E
P
E
G
Y
S
S
V
S
N
M
N
Site 6
S27
A
E
P
E
G
Y
S
S
V
S
N
M
N
A
G
Site 7
S29
P
E
G
Y
S
S
V
S
N
M
N
A
G
L
G
Site 8
Y43
G
M
N
G
M
N
T
Y
M
S
M
S
A
A
A
Site 9
S55
A
A
A
M
G
S
G
S
G
N
M
S
A
G
S
Site 10
S59
G
S
G
S
G
N
M
S
A
G
S
M
N
M
S
Site 11
S62
S
G
N
M
S
A
G
S
M
N
M
S
S
Y
V
Site 12
Y68
G
S
M
N
M
S
S
Y
V
G
A
G
M
S
P
Site 13
S107
A
G
M
G
P
H
L
S
P
S
L
S
P
L
G
Site 14
S109
M
G
P
H
L
S
P
S
L
S
P
L
G
G
Q
Site 15
S111
P
H
L
S
P
S
L
S
P
L
G
G
Q
A
A
Site 16
Y137
M
N
S
M
S
P
M
Y
G
Q
A
G
L
S
R
Site 17
S143
M
Y
G
Q
A
G
L
S
R
A
R
D
P
K
T
Site 18
T150
S
R
A
R
D
P
K
T
Y
R
R
S
Y
T
H
Site 19
Y151
R
A
R
D
P
K
T
Y
R
R
S
Y
T
H
A
Site 20
S154
D
P
K
T
Y
R
R
S
Y
T
H
A
K
P
P
Site 21
Y155
P
K
T
Y
R
R
S
Y
T
H
A
K
P
P
Y
Site 22
T156
K
T
Y
R
R
S
Y
T
H
A
K
P
P
Y
S
Site 23
Y162
Y
T
H
A
K
P
P
Y
S
Y
I
S
L
I
T
Site 24
S163
T
H
A
K
P
P
Y
S
Y
I
S
L
I
T
M
Site 25
T181
Q
S
P
N
K
M
L
T
L
S
E
I
Y
Q
W
Site 26
S212
N
S
I
R
H
S
L
S
F
N
D
C
F
L
K
Site 27
S223
C
F
L
K
V
P
R
S
P
D
K
P
G
K
G
Site 28
S231
P
D
K
P
G
K
G
S
F
W
T
L
H
P
D
Site 29
T234
P
G
K
G
S
F
W
T
L
H
P
D
S
G
N
Site 30
Y248
N
M
F
E
N
G
C
Y
L
R
R
Q
K
R
F
Site 31
S283
A
A
A
G
A
Q
A
S
Q
A
Q
L
G
E
A
Site 32
S295
G
E
A
A
G
P
A
S
E
T
P
A
G
T
E
Site 33
T297
A
A
G
P
A
S
E
T
P
A
G
T
E
S
P
Site 34
T301
A
S
E
T
P
A
G
T
E
S
P
H
S
S
A
Site 35
S303
E
T
P
A
G
T
E
S
P
H
S
S
A
S
P
Site 36
S306
A
G
T
E
S
P
H
S
S
A
S
P
C
Q
E
Site 37
S307
G
T
E
S
P
H
S
S
A
S
P
C
Q
E
H
Site 38
S309
E
S
P
H
S
S
A
S
P
C
Q
E
H
K
R
Site 39
S331
G
T
P
A
A
A
L
S
P
P
E
P
A
P
S
Site 40
S338
S
P
P
E
P
A
P
S
P
G
Q
Q
Q
Q
A
Site 41
S384
S
I
N
N
L
M
S
S
E
Q
Q
H
H
H
S
Site 42
Y405
H
K
M
D
L
K
A
Y
E
Q
V
M
H
Y
P
Site 43
Y411
A
Y
E
Q
V
M
H
Y
P
G
Y
G
S
P
M
Site 44
Y414
Q
V
M
H
Y
P
G
Y
G
S
P
M
P
G
S
Site 45
S416
M
H
Y
P
G
Y
G
S
P
M
P
G
S
L
A
Site 46
T431
M
G
P
V
T
N
K
T
G
L
D
A
S
P
L
Site 47
S436
N
K
T
G
L
D
A
S
P
L
A
A
D
T
S
Site 48
T442
A
S
P
L
A
A
D
T
S
Y
Y
Q
G
V
Y
Site 49
S443
S
P
L
A
A
D
T
S
Y
Y
Q
G
V
Y
S
Site 50
Y444
P
L
A
A
D
T
S
Y
Y
Q
G
V
Y
S
R
Site 51
Y445
L
A
A
D
T
S
Y
Y
Q
G
V
Y
S
R
P
Site 52
Y449
T
S
Y
Y
Q
G
V
Y
S
R
P
I
M
N
S
Site 53
S450
S
Y
Y
Q
G
V
Y
S
R
P
I
M
N
S
S
Site 54
S457
S
R
P
I
M
N
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation