KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
AKAP2
Full Name:
A-kinase anchor protein 2
Alias:
AKA2; AKAP-2; AKAP-KL; KIAA0920; PALM2-AKAP2; PRKA2; Protein kinase A anchoring protein 2; Protein kinase A-anchoring protein 2
Type:
Adaptor/scaffold
Mass (Da):
94661
Number AA:
859
UniProt ID:
Q9Y2D5
International Prot ID:
IPI00032064
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
K
S
V
P
G
I
T
S
T
P
H
P
M
D
H
Site 2
T19
S
V
P
G
I
T
S
T
P
H
P
M
D
H
P
Site 3
S27
P
H
P
M
D
H
P
S
A
F
Y
S
P
P
H
Site 4
Y30
M
D
H
P
S
A
F
Y
S
P
P
H
N
G
L
Site 5
S31
D
H
P
S
A
F
Y
S
P
P
H
N
G
L
L
Site 6
T39
P
P
H
N
G
L
L
T
D
H
H
E
S
L
D
Site 7
S44
L
L
T
D
H
H
E
S
L
D
N
D
V
A
R
Site 8
T72
C
D
S
A
V
D
G
T
Y
N
G
T
S
S
P
Site 9
Y73
D
S
A
V
D
G
T
Y
N
G
T
S
S
P
E
Site 10
T76
V
D
G
T
Y
N
G
T
S
S
P
E
P
G
A
Site 11
S77
D
G
T
Y
N
G
T
S
S
P
E
P
G
A
V
Site 12
S78
G
T
Y
N
G
T
S
S
P
E
P
G
A
V
V
Site 13
S108
E
P
T
E
R
T
A
S
R
Q
A
P
P
H
I
Site 14
S118
A
P
P
H
I
E
L
S
N
S
S
P
D
P
M
Site 15
S120
P
H
I
E
L
S
N
S
S
P
D
P
M
A
E
Site 16
S121
H
I
E
L
S
N
S
S
P
D
P
M
A
E
A
Site 17
T131
P
M
A
E
A
E
R
T
N
G
H
S
P
S
Q
Site 18
S135
A
E
R
T
N
G
H
S
P
S
Q
P
R
D
A
Site 19
S137
R
T
N
G
H
S
P
S
Q
P
R
D
A
L
G
Site 20
S146
P
R
D
A
L
G
D
S
L
Q
V
P
V
S
P
Site 21
S152
D
S
L
Q
V
P
V
S
P
S
S
T
T
S
S
Site 22
S154
L
Q
V
P
V
S
P
S
S
T
T
S
S
R
C
Site 23
S155
Q
V
P
V
S
P
S
S
T
T
S
S
R
C
S
Site 24
T156
V
P
V
S
P
S
S
T
T
S
S
R
C
S
S
Site 25
T157
P
V
S
P
S
S
T
T
S
S
R
C
S
S
R
Site 26
S158
V
S
P
S
S
T
T
S
S
R
C
S
S
R
D
Site 27
S159
S
P
S
S
T
T
S
S
R
C
S
S
R
D
G
Site 28
S162
S
T
T
S
S
R
C
S
S
R
D
G
E
F
T
Site 29
S163
T
T
S
S
R
C
S
S
R
D
G
E
F
T
L
Site 30
T169
S
S
R
D
G
E
F
T
L
T
T
L
K
K
E
Site 31
T171
R
D
G
E
F
T
L
T
T
L
K
K
E
A
K
Site 32
Y204
D
E
H
E
K
E
Q
Y
C
I
R
K
V
R
P
Site 33
S212
C
I
R
K
V
R
P
S
E
E
M
L
E
L
E
Site 34
S228
E
R
R
E
L
I
R
S
Q
A
V
K
K
N
P
Site 35
T249
W
N
P
P
Q
E
K
T
I
E
E
Q
L
D
E
Site 36
S261
L
D
E
E
H
L
E
S
H
K
K
Y
K
E
R
Site 37
Y265
H
L
E
S
H
K
K
Y
K
E
R
K
E
R
R
Site 38
S293
Q
Q
Q
Q
Q
P
P
S
Q
L
C
T
A
P
A
Site 39
T297
Q
P
P
S
Q
L
C
T
A
P
A
S
S
H
E
Site 40
S301
Q
L
C
T
A
P
A
S
S
H
E
R
A
S
M
Site 41
S302
L
C
T
A
P
A
S
S
H
E
R
A
S
M
I
Site 42
S307
A
S
S
H
E
R
A
S
M
I
D
K
A
K
E
Site 43
T318
K
A
K
E
D
I
V
T
E
Q
I
D
F
S
A
Site 44
S336
Q
F
Q
L
M
E
N
S
R
Q
A
V
A
K
G
Site 45
T346
A
V
A
K
G
Q
S
T
P
R
L
F
S
I
K
Site 46
S351
Q
S
T
P
R
L
F
S
I
K
P
F
Y
R
P
Site 47
S361
P
F
Y
R
P
L
G
S
V
N
S
D
K
P
L
Site 48
S364
R
P
L
G
S
V
N
S
D
K
P
L
T
N
P
Site 49
T369
V
N
S
D
K
P
L
T
N
P
R
P
P
S
V
Site 50
S375
L
T
N
P
R
P
P
S
V
G
G
P
P
E
D
Site 51
S383
D
S
L
Q
V
P
V
S
P
S
S
T
T
S
S
Site 52
S386
P
P
E
D
S
G
A
S
A
A
K
G
Q
K
S
Site 53
S393
S
A
A
K
G
Q
K
S
P
G
A
L
E
T
P
Site 54
T399
K
S
P
G
A
L
E
T
P
S
A
A
G
S
Q
Site 55
S401
P
G
A
L
E
T
P
S
A
A
G
S
Q
G
N
Site 56
S405
E
T
P
S
A
A
G
S
Q
G
N
T
A
S
Q
Site 57
T409
A
A
G
S
Q
G
N
T
A
S
Q
G
K
E
G
Site 58
S411
G
S
Q
G
N
T
A
S
Q
G
K
E
G
P
Y
Site 59
Y418
S
Q
G
K
E
G
P
Y
S
E
P
S
K
R
G
Site 60
S419
Q
G
K
E
G
P
Y
S
E
P
S
K
R
G
P
Site 61
S422
E
G
P
Y
S
E
P
S
K
R
G
P
L
S
K
Site 62
S428
P
S
K
R
G
P
L
S
K
L
W
A
E
D
G
Site 63
T445
T
S
A
R
A
V
L
T
V
V
K
D
D
D
H
Site 64
S459
H
G
I
L
D
Q
F
S
R
S
V
N
V
S
L
Site 65
S461
I
L
D
Q
F
S
R
S
V
N
V
S
L
T
Q
Site 66
S465
F
S
R
S
V
N
V
S
L
T
Q
E
E
L
D
Site 67
T467
R
S
V
N
V
S
L
T
Q
E
E
L
D
S
G
Site 68
S473
L
T
Q
E
E
L
D
S
G
L
D
E
L
S
V
Site 69
S479
D
S
G
L
D
E
L
S
V
R
S
Q
D
T
T
Site 70
T486
S
V
R
S
Q
D
T
T
V
L
E
T
L
S
N
Site 71
S492
T
T
V
L
E
T
L
S
N
D
F
S
M
D
N
Site 72
S496
E
T
L
S
N
D
F
S
M
D
N
I
S
D
S
Site 73
S501
D
F
S
M
D
N
I
S
D
S
G
A
S
N
E
Site 74
S503
S
M
D
N
I
S
D
S
G
A
S
N
E
T
T
Site 75
T510
S
G
A
S
N
E
T
T
N
A
L
Q
E
N
S
Site 76
S517
T
N
A
L
Q
E
N
S
L
A
D
F
S
L
P
Site 77
S522
E
N
S
L
A
D
F
S
L
P
Q
T
P
Q
T
Site 78
T526
A
D
F
S
L
P
Q
T
P
Q
T
D
N
P
S
Site 79
T529
S
L
P
Q
T
P
Q
T
D
N
P
S
E
G
R
Site 80
S533
T
P
Q
T
D
N
P
S
E
G
R
G
E
G
V
Site 81
S541
E
G
R
G
E
G
V
S
K
S
F
S
D
H
G
Site 82
S543
R
G
E
G
V
S
K
S
F
S
D
H
G
F
Y
Site 83
S545
E
G
V
S
K
S
F
S
D
H
G
F
Y
S
P
Site 84
Y550
S
F
S
D
H
G
F
Y
S
P
S
S
T
L
G
Site 85
S551
F
S
D
H
G
F
Y
S
P
S
S
T
L
G
D
Site 86
S553
D
H
G
F
Y
S
P
S
S
T
L
G
D
S
P
Site 87
S554
H
G
F
Y
S
P
S
S
T
L
G
D
S
P
L
Site 88
T555
G
F
Y
S
P
S
S
T
L
G
D
S
P
L
V
Site 89
S559
P
S
S
T
L
G
D
S
P
L
V
D
D
P
L
Site 90
T593
V
D
K
A
V
S
K
T
S
R
D
G
A
E
Q
Site 91
S617
P
P
E
D
S
G
A
S
A
A
K
G
Q
K
S
Site 92
S622
F
G
S
E
K
P
Q
S
M
F
E
P
P
Q
V
Site 93
S631
F
E
P
P
Q
V
S
S
P
V
Q
E
K
R
D
Site 94
S666
P
L
P
A
V
Q
P
S
G
P
I
N
M
E
E
Site 95
T674
G
P
I
N
M
E
E
T
R
P
E
G
S
Y
F
Site 96
S679
E
E
T
R
P
E
G
S
Y
F
S
K
Y
S
E
Site 97
Y680
E
T
R
P
E
G
S
Y
F
S
K
Y
S
E
A
Site 98
Y684
E
G
S
Y
F
S
K
Y
S
E
A
A
E
L
R
Site 99
S685
G
S
Y
F
S
K
Y
S
E
A
A
E
L
R
S
Site 100
T693
E
A
A
E
L
R
S
T
A
S
L
L
A
T
Q
Site 101
S695
A
E
L
R
S
T
A
S
L
L
A
T
Q
E
S
Site 102
T699
S
T
A
S
L
L
A
T
Q
E
S
D
V
M
V
Site 103
S702
S
L
L
A
T
Q
E
S
D
V
M
V
G
P
F
Site 104
S713
V
G
P
F
K
L
R
S
R
K
Q
R
T
L
S
Site 105
T718
L
R
S
R
K
Q
R
T
L
S
M
I
E
E
E
Site 106
S720
S
R
K
Q
R
T
L
S
M
I
E
E
E
I
R
Site 107
S745
R
Q
R
Q
V
L
Q
S
T
Q
S
P
R
T
K
Site 108
T746
Q
R
Q
V
L
Q
S
T
Q
S
P
R
T
K
N
Site 109
S748
Q
V
L
Q
S
T
Q
S
P
R
T
K
N
A
P
Site 110
S756
P
R
T
K
N
A
P
S
L
P
S
R
T
C
Y
Site 111
S759
K
N
A
P
S
L
P
S
R
T
C
Y
K
T
A
Site 112
Y763
S
L
P
S
R
T
C
Y
K
T
A
P
G
K
I
Site 113
T765
P
S
R
T
C
Y
K
T
A
P
G
K
I
E
K
Site 114
S778
E
K
V
K
P
P
P
S
P
T
T
E
G
P
S
Site 115
T781
K
P
P
P
S
P
T
T
E
G
P
S
L
Q
P
Site 116
S785
S
P
T
T
E
G
P
S
L
Q
P
D
L
A
P
Site 117
T798
A
P
E
E
A
A
G
T
Q
R
P
K
N
L
M
Site 118
Y812
M
Q
T
L
M
E
D
Y
E
T
H
K
S
K
R
Site 119
T814
T
L
M
E
D
Y
E
T
H
K
S
K
R
R
E
Site 120
S817
E
D
Y
E
T
H
K
S
K
R
R
E
R
M
D
Site 121
S826
R
R
E
R
M
D
D
S
S
V
L
E
A
T
R
Site 122
S827
R
E
R
M
D
D
S
S
V
L
E
A
T
R
V
Site 123
S839
T
R
V
N
R
R
K
S
A
L
A
L
R
W
E
Site 124
Y850
L
R
W
E
A
G
I
Y
A
N
Q
E
E
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation