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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIP2C
Full Name:
Disco-interacting protein 2 homologue C
Alias:
DIP2 disco-interacting protein 2C
Type:
Nucleus protein
Mass (Da):
170767
Number AA:
1556
UniProt ID:
Q9Y2E4
International Prot ID:
IPI00032087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
A
E
L
E
L
E
L
S
E
G
D
I
T
Q
K
Site 2
T32
E
L
S
E
G
D
I
T
Q
K
G
Y
E
K
K
Site 3
S41
K
G
Y
E
K
K
R
S
K
L
I
G
A
Y
L
Site 4
Y47
R
S
K
L
I
G
A
Y
L
P
Q
P
P
R
V
Site 5
T67
Q
E
R
R
A
P
V
T
P
S
S
A
S
R
Y
Site 6
S69
R
R
A
P
V
T
P
S
S
A
S
R
Y
H
R
Site 7
S70
R
A
P
V
T
P
S
S
A
S
R
Y
H
R
R
Site 8
S72
P
V
T
P
S
S
A
S
R
Y
H
R
R
R
S
Site 9
Y74
T
P
S
S
A
S
R
Y
H
R
R
R
S
S
G
Site 10
S79
S
R
Y
H
R
R
R
S
S
G
S
R
D
E
R
Site 11
S80
R
Y
H
R
R
R
S
S
G
S
R
D
E
R
Y
Site 12
S82
H
R
R
R
S
S
G
S
R
D
E
R
Y
R
S
Site 13
Y87
S
G
S
R
D
E
R
Y
R
S
D
V
H
T
E
Site 14
S89
S
R
D
E
R
Y
R
S
D
V
H
T
E
A
V
Site 15
T93
R
Y
R
S
D
V
H
T
E
A
V
Q
A
A
L
Site 16
S114
K
M
A
V
P
M
P
S
K
R
R
S
L
V
V
Site 17
S118
P
M
P
S
K
R
R
S
L
V
V
Q
T
S
M
Site 18
S124
R
S
L
V
V
Q
T
S
M
D
A
Y
T
P
P
Site 19
Y128
V
Q
T
S
M
D
A
Y
T
P
P
D
T
S
S
Site 20
T129
Q
T
S
M
D
A
Y
T
P
P
D
T
S
S
G
Site 21
T133
D
A
Y
T
P
P
D
T
S
S
G
S
E
D
E
Site 22
S135
Y
T
P
P
D
T
S
S
G
S
E
D
E
G
S
Site 23
S137
P
P
D
T
S
S
G
S
E
D
E
G
S
V
Q
Site 24
S142
S
G
S
E
D
E
G
S
V
Q
G
D
S
Q
G
Site 25
S147
E
G
S
V
Q
G
D
S
Q
G
T
P
T
S
S
Site 26
T150
V
Q
G
D
S
Q
G
T
P
T
S
S
Q
G
S
Site 27
T152
G
D
S
Q
G
T
P
T
S
S
Q
G
S
I
N
Site 28
S153
D
S
Q
G
T
P
T
S
S
Q
G
S
I
N
M
Site 29
S154
S
Q
G
T
P
T
S
S
Q
G
S
I
N
M
E
Site 30
S157
T
P
T
S
S
Q
G
S
I
N
M
E
H
W
I
Site 31
S171
I
S
Q
A
I
H
G
S
T
T
S
T
T
S
S
Site 32
T172
S
Q
A
I
H
G
S
T
T
S
T
T
S
S
S
Site 33
T173
Q
A
I
H
G
S
T
T
S
T
T
S
S
S
S
Site 34
S174
A
I
H
G
S
T
T
S
T
T
S
S
S
S
T
Site 35
T175
I
H
G
S
T
T
S
T
T
S
S
S
S
T
Q
Site 36
T176
H
G
S
T
T
S
T
T
S
S
S
S
T
Q
S
Site 37
S177
G
S
T
T
S
T
T
S
S
S
S
T
Q
S
G
Site 38
S178
S
T
T
S
T
T
S
S
S
S
T
Q
S
G
G
Site 39
S179
T
T
S
T
T
S
S
S
S
T
Q
S
G
G
S
Site 40
S180
T
S
T
T
S
S
S
S
T
Q
S
G
G
S
G
Site 41
T181
S
T
T
S
S
S
S
T
Q
S
G
G
S
G
A
Site 42
S183
T
S
S
S
S
T
Q
S
G
G
S
G
A
A
H
Site 43
T211
H
S
A
P
P
D
V
T
T
Y
T
S
E
H
S
Site 44
T212
S
A
P
P
D
V
T
T
Y
T
S
E
H
S
I
Site 45
Y213
A
P
P
D
V
T
T
Y
T
S
E
H
S
I
Q
Site 46
T214
P
P
D
V
T
T
Y
T
S
E
H
S
I
Q
V
Site 47
T228
V
E
R
P
Q
G
S
T
G
S
R
T
A
P
K
Site 48
T232
Q
G
S
T
G
S
R
T
A
P
K
Y
G
N
A
Site 49
Y236
G
S
R
T
A
P
K
Y
G
N
A
E
L
M
E
Site 50
T244
G
N
A
E
L
M
E
T
G
D
G
V
P
V
S
Site 51
S251
T
G
D
G
V
P
V
S
S
R
V
S
A
K
I
Site 52
S252
G
D
G
V
P
V
S
S
R
V
S
A
K
I
Q
Site 53
T264
K
I
Q
Q
L
V
N
T
L
K
R
P
K
R
P
Site 54
T314
G
E
Q
L
G
V
V
T
N
W
P
P
S
L
E
Site 55
S319
V
V
T
N
W
P
P
S
L
E
A
A
L
Q
R
Site 56
T329
A
A
L
Q
R
W
G
T
I
S
P
K
A
P
C
Site 57
S331
L
Q
R
W
G
T
I
S
P
K
A
P
C
L
T
Site 58
T338
S
P
K
A
P
C
L
T
T
M
D
T
N
G
K
Site 59
T342
P
C
L
T
T
M
D
T
N
G
K
P
L
Y
I
Site 60
Y348
D
T
N
G
K
P
L
Y
I
L
T
Y
G
K
L
Site 61
T351
G
K
P
L
Y
I
L
T
Y
G
K
L
W
T
R
Site 62
T418
V
P
I
E
V
P
L
T
R
K
D
A
G
S
Q
Site 63
S424
L
T
R
K
D
A
G
S
Q
Q
I
G
F
L
L
Site 64
S452
C
H
K
G
L
P
K
S
P
T
G
E
I
P
Q
Site 65
T454
K
G
L
P
K
S
P
T
G
E
I
P
Q
F
K
Site 66
T471
P
K
L
L
W
F
V
T
E
S
K
H
L
S
K
Site 67
S473
L
L
W
F
V
T
E
S
K
H
L
S
K
P
P
Site 68
S477
V
T
E
S
K
H
L
S
K
P
P
R
D
W
F
Site 69
Y496
D
A
N
N
D
T
A
Y
I
E
Y
K
T
C
K
Site 70
T501
T
A
Y
I
E
Y
K
T
C
K
D
G
S
V
L
Site 71
S555
L
W
H
G
I
L
T
S
V
M
N
M
M
H
V
Site 72
Y567
M
H
V
I
S
I
P
Y
S
L
M
K
V
N
P
Site 73
S576
L
M
K
V
N
P
L
S
W
I
Q
K
V
C
Q
Site 74
S612
D
Q
R
D
I
N
L
S
S
L
R
M
L
I
V
Site 75
S613
Q
R
D
I
N
L
S
S
L
R
M
L
I
V
A
Site 76
S627
A
D
G
A
N
P
W
S
I
S
S
C
D
A
F
Site 77
S629
G
A
N
P
W
S
I
S
S
C
D
A
F
L
N
Site 78
S640
A
F
L
N
V
F
Q
S
K
G
L
R
Q
E
V
Site 79
T659
A
S
S
P
E
A
L
T
V
A
I
R
R
P
T
Site 80
T666
T
V
A
I
R
R
P
T
D
D
S
N
Q
P
P
Site 81
S669
I
R
R
P
T
D
D
S
N
Q
P
P
G
R
G
Site 82
S679
P
P
G
R
G
V
L
S
M
H
G
L
T
Y
G
Site 83
S697
V
D
S
E
E
K
L
S
V
L
T
V
Q
D
V
Site 84
Y745
V
A
T
G
T
S
Y
Y
G
L
S
G
M
T
K
Site 85
S748
G
T
S
Y
Y
G
L
S
G
M
T
K
N
T
F
Site 86
S763
E
V
F
P
M
T
S
S
G
A
P
I
S
E
Y
Site 87
S768
T
S
S
G
A
P
I
S
E
Y
P
F
I
R
T
Site 88
Y770
S
G
A
P
I
S
E
Y
P
F
I
R
T
G
L
Site 89
S800
M
D
G
L
M
V
V
S
G
R
R
H
N
A
D
Site 90
S850
V
A
E
Q
R
P
D
S
T
E
E
D
S
F
Q
Site 91
T851
A
E
Q
R
P
D
S
T
E
E
D
S
F
Q
W
Site 92
S855
P
D
S
T
E
E
D
S
F
Q
W
M
S
R
V
Site 93
T888
P
A
N
T
L
P
K
T
P
L
G
G
I
H
L
Site 94
T898
G
G
I
H
L
S
E
T
K
Q
L
F
L
E
G
Site 95
S945
V
M
V
G
N
L
V
S
G
K
R
I
A
Q
A
Site 96
S953
G
K
R
I
A
Q
A
S
G
R
D
L
G
Q
I
Site 97
T982
V
L
Q
W
R
A
Q
T
T
P
D
H
I
L
Y
Site 98
T983
L
Q
W
R
A
Q
T
T
P
D
H
I
L
Y
T
Site 99
Y989
T
T
P
D
H
I
L
Y
T
L
L
N
C
R
G
Site 100
T1056
Y
A
G
C
V
P
I
T
V
R
P
P
H
P
Q
Site 101
T1133
C
K
P
C
N
P
D
T
L
A
Y
L
D
F
S
Site 102
S1202
S
V
Y
S
G
H
Q
S
I
L
I
P
P
S
E
Site 103
S1208
Q
S
I
L
I
P
P
S
E
L
E
T
N
P
A
Site 104
S1245
L
C
T
K
G
L
G
S
Q
T
E
S
L
K
A
Site 105
S1249
G
L
G
S
Q
T
E
S
L
K
A
R
G
L
D
Site 106
S1258
K
A
R
G
L
D
L
S
R
V
R
T
C
V
V
Site 107
T1276
E
R
P
R
I
A
L
T
Q
S
F
S
K
L
F
Site 108
S1278
P
R
I
A
L
T
Q
S
F
S
K
L
F
K
D
Site 109
S1296
H
P
R
A
V
S
T
S
F
G
C
R
V
N
L
Site 110
T1316
G
T
S
G
P
D
P
T
T
V
Y
V
D
M
R
Site 111
T1317
T
S
G
P
D
P
T
T
V
Y
V
D
M
R
A
Site 112
Y1319
G
P
D
P
T
T
V
Y
V
D
M
R
A
L
R
Site 113
S1337
V
R
L
V
E
R
G
S
P
H
S
L
P
L
M
Site 114
S1340
V
E
R
G
S
P
H
S
L
P
L
M
E
S
G
Site 115
T1362
I
I
I
A
N
P
E
T
K
G
P
L
G
D
S
Site 116
S1369
T
K
G
P
L
G
D
S
H
L
G
E
I
W
V
Site 117
Y1385
S
A
H
N
A
S
G
Y
F
T
I
Y
G
D
E
Site 118
T1387
H
N
A
S
G
Y
F
T
I
Y
G
D
E
S
L
Site 119
Y1389
A
S
G
Y
F
T
I
Y
G
D
E
S
L
Q
S
Site 120
S1396
Y
G
D
E
S
L
Q
S
D
H
F
N
S
R
L
Site 121
S1404
D
H
F
N
S
R
L
S
F
G
D
T
Q
T
I
Site 122
T1408
S
R
L
S
F
G
D
T
Q
T
I
W
A
R
T
Site 123
T1410
L
S
F
G
D
T
Q
T
I
W
A
R
T
G
Y
Site 124
Y1417
T
I
W
A
R
T
G
Y
L
G
F
L
R
R
T
Site 125
T1424
Y
L
G
F
L
R
R
T
E
L
T
D
A
N
G
Site 126
T1427
F
L
R
R
T
E
L
T
D
A
N
G
E
R
H
Site 127
Y1438
G
E
R
H
D
A
L
Y
V
V
G
A
L
D
E
Site 128
T1461
Y
H
P
I
D
I
E
T
S
V
I
R
A
H
K
Site 129
S1462
H
P
I
D
I
E
T
S
V
I
R
A
H
K
S
Site 130
Y1551
A
D
Q
L
D
P
I
Y
V
A
Y
N
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation