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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAN2B2
Full Name:
Alias:
Mannosidase alpha class 2B member 2
Type:
Mass (Da):
113979
Number AA:
1009
UniProt ID:
Q9Y2E5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
R
P
P
G
V
Q
S
A
G
P
I
R
A
F
Site 2
S35
R
A
F
V
V
P
H
S
H
M
D
V
G
W
V
Site 3
Y52
V
Q
E
S
M
R
A
Y
A
A
N
V
Y
T
S
Site 4
Y94
V
A
S
D
Q
Q
K
Y
Q
V
R
Q
L
L
E
Site 5
Y137
T
E
G
H
G
F
L
Y
E
T
F
G
I
R
P
Site 6
T139
G
H
G
F
L
Y
E
T
F
G
I
R
P
Q
F
Site 7
Y178
H
L
G
S
R
I
D
Y
D
L
K
A
A
M
Q
Site 8
S197
L
Q
F
V
W
R
G
S
P
S
L
S
E
R
Q
Site 9
S199
F
V
W
R
G
S
P
S
L
S
E
R
Q
E
I
Site 10
S201
W
R
G
S
P
S
L
S
E
R
Q
E
I
F
T
Site 11
T208
S
E
R
Q
E
I
F
T
H
I
M
D
Q
Y
S
Site 12
Y247
K
P
P
P
D
G
V
Y
P
N
M
S
E
P
V
Site 13
S251
D
G
V
Y
P
N
M
S
E
P
V
T
P
A
N
Site 14
T255
P
N
M
S
E
P
V
T
P
A
N
I
N
L
Y
Site 15
T338
A
L
H
A
L
N
V
T
W
R
V
R
D
H
H
Site 16
Y362
F
Q
A
W
T
G
F
Y
T
S
R
S
S
L
K
Site 17
T363
Q
A
W
T
G
F
Y
T
S
R
S
S
L
K
G
Site 18
S364
A
W
T
G
F
Y
T
S
R
S
S
L
K
G
L
Site 19
S366
T
G
F
Y
T
S
R
S
S
L
K
G
L
A
R
Site 20
S367
G
F
Y
T
S
R
S
S
L
K
G
L
A
R
R
Site 21
S376
K
G
L
A
R
R
A
S
A
L
L
Y
A
G
E
Site 22
Y380
R
R
A
S
A
L
L
Y
A
G
E
S
M
F
T
Site 23
Y389
G
E
S
M
F
T
R
Y
L
W
P
A
P
R
G
Site 24
T401
P
R
G
H
L
D
P
T
W
A
L
Q
Q
L
Q
Site 25
T424
V
Q
H
H
D
A
I
T
G
T
E
S
P
K
V
Site 26
T426
H
H
D
A
I
T
G
T
E
S
P
K
V
R
D
Site 27
S428
D
A
I
T
G
T
E
S
P
K
V
R
D
M
Y
Site 28
Y435
S
P
K
V
R
D
M
Y
A
T
H
L
A
S
G
Site 29
T437
K
V
R
D
M
Y
A
T
H
L
A
S
G
M
L
Site 30
S467
P
Q
A
P
M
A
A
S
S
D
A
G
P
A
G
Site 31
S468
Q
A
P
M
A
A
S
S
D
A
G
P
A
G
H
Site 32
T503
G
F
P
G
V
R
V
T
D
E
A
G
H
P
V
Site 33
S512
E
A
G
H
P
V
P
S
Q
I
Q
N
S
T
E
Site 34
T518
P
S
Q
I
Q
N
S
T
E
T
P
S
A
Y
D
Site 35
T520
Q
I
Q
N
S
T
E
T
P
S
A
Y
D
L
L
Site 36
S536
L
T
T
I
P
G
L
S
Y
R
H
Y
S
I
R
Site 37
Y540
P
G
L
S
Y
R
H
Y
S
I
R
P
T
A
G
Site 38
S541
G
L
S
Y
R
H
Y
S
I
R
P
T
A
G
A
Site 39
T545
R
H
Y
S
I
R
P
T
A
G
A
Q
E
G
T
Site 40
T558
G
T
Q
E
P
A
A
T
V
A
S
T
L
Q
F
Site 41
T562
P
A
A
T
V
A
S
T
L
Q
F
G
R
R
L
Site 42
T573
G
R
R
L
R
R
R
T
S
H
A
G
R
Y
L
Site 43
S574
R
R
L
R
R
R
T
S
H
A
G
R
Y
L
V
Site 44
Y579
R
T
S
H
A
G
R
Y
L
V
P
V
A
N
D
Site 45
S607
H
S
I
W
E
R
Q
S
N
R
T
V
R
V
T
Site 46
T610
W
E
R
Q
S
N
R
T
V
R
V
T
Q
E
F
Site 47
T614
S
N
R
T
V
R
V
T
Q
E
F
L
E
Y
H
Site 48
Y620
V
T
Q
E
F
L
E
Y
H
V
N
G
D
V
K
Site 49
S632
D
V
K
Q
G
P
I
S
D
N
Y
L
F
T
P
Site 50
Y635
Q
G
P
I
S
D
N
Y
L
F
T
P
G
K
A
Site 51
Y666
L
V
T
E
I
R
Q
Y
F
Y
R
N
M
T
A
Site 52
Y676
R
N
M
T
A
Q
N
Y
T
Y
A
I
R
S
R
Site 53
Y678
M
T
A
Q
N
Y
T
Y
A
I
R
S
R
L
T
Site 54
T685
Y
A
I
R
S
R
L
T
H
V
P
Q
G
H
D
Site 55
Y704
C
H
R
I
E
Q
E
Y
Q
A
G
P
L
E
L
Site 56
S720
R
E
A
V
L
R
T
S
T
N
L
N
S
Q
Q
Site 57
T721
E
A
V
L
R
T
S
T
N
L
N
S
Q
Q
V
Site 58
S725
R
T
S
T
N
L
N
S
Q
Q
V
I
Y
S
D
Site 59
Y730
L
N
S
Q
Q
V
I
Y
S
D
N
N
G
Y
Q
Site 60
Y743
Y
Q
M
Q
R
R
P
Y
V
S
Y
V
N
N
S
Site 61
S745
M
Q
R
R
P
Y
V
S
Y
V
N
N
S
I
A
Site 62
Y746
Q
R
R
P
Y
V
S
Y
V
N
N
S
I
A
R
Site 63
Y755
N
N
S
I
A
R
N
Y
Y
P
M
V
Q
S
A
Site 64
Y756
N
S
I
A
R
N
Y
Y
P
M
V
Q
S
A
F
Site 65
S769
A
F
M
E
D
G
K
S
R
L
V
L
L
S
E
Site 66
S775
K
S
R
L
V
L
L
S
E
R
A
H
G
I
S
Site 67
S782
S
E
R
A
H
G
I
S
S
Q
G
N
G
Q
V
Site 68
S783
E
R
A
H
G
I
S
S
Q
G
N
G
Q
V
E
Site 69
Y807
N
F
D
W
D
L
G
Y
N
L
T
L
N
D
T
Site 70
T810
W
D
L
G
Y
N
L
T
L
N
D
T
S
V
V
Site 71
T831
L
L
G
S
W
S
L
T
T
A
L
R
Q
R
S
Site 72
S838
T
T
A
L
R
Q
R
S
A
L
A
L
Q
H
R
Site 73
T870
P
Q
Q
Q
E
A
V
T
L
P
P
N
L
H
L
Site 74
S881
N
L
H
L
Q
I
L
S
I
P
G
W
R
Y
S
Site 75
Y887
L
S
I
P
G
W
R
Y
S
S
N
H
T
E
H
Site 76
S888
S
I
P
G
W
R
Y
S
S
N
H
T
E
H
S
Site 77
S889
I
P
G
W
R
Y
S
S
N
H
T
E
H
S
Q
Site 78
T892
W
R
Y
S
S
N
H
T
E
H
S
Q
N
L
R
Site 79
S895
S
S
N
H
T
E
H
S
Q
N
L
R
K
G
H
Site 80
Y918
R
R
V
L
L
R
L
Y
H
L
Y
E
V
G
E
Site 81
T956
A
V
E
E
R
S
L
T
G
T
W
D
L
S
M
Site 82
T958
E
E
R
S
L
T
G
T
W
D
L
S
M
L
H
Site 83
S968
L
S
M
L
H
R
W
S
W
R
T
G
P
G
R
Site 84
T971
L
H
R
W
S
W
R
T
G
P
G
R
H
R
G
Site 85
T980
P
G
R
H
R
G
D
T
T
S
P
S
R
P
P
Site 86
T981
G
R
H
R
G
D
T
T
S
P
S
R
P
P
G
Site 87
S982
R
H
R
G
D
T
T
S
P
S
R
P
P
G
G
Site 88
S984
R
G
D
T
T
S
P
S
R
P
P
G
G
P
I
Site 89
T993
P
P
G
G
P
I
I
T
V
H
P
K
E
I
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation