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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLGAP4
Full Name:
ISOFORM 1 OF DISKS LARGE-ASSOCIATED PROTEIN 4.
Alias:
DAP4; DAP-4; Discs, large-associated protein 4; Disks large-associated protein 4; DLGP4; KIAA0964; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP4
Type:
Adaptor/scaffold; Membrane protein, peripheral
Mass (Da):
108012
Number AA:
992
UniProt ID:
Q9Y2H0
International Prot ID:
IPI00007138
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
G
L
G
D
S
R
P
R
H
L
S
D
Site 2
S13
D
S
R
P
R
H
L
S
D
S
L
D
P
P
H
Site 3
S15
R
P
R
H
L
S
D
S
L
D
P
P
H
E
P
Site 4
Y32
A
G
T
D
R
N
P
Y
L
L
S
P
T
E
A
Site 5
S35
D
R
N
P
Y
L
L
S
P
T
E
A
F
A
R
Site 6
T51
A
R
F
P
G
Q
N
T
L
P
G
D
G
L
F
Site 7
S68
N
N
Q
L
P
P
P
S
S
T
F
P
R
I
H
Site 8
S69
N
Q
L
P
P
P
S
S
T
F
P
R
I
H
Y
Site 9
T70
Q
L
P
P
P
S
S
T
F
P
R
I
H
Y
N
Site 10
Y76
S
T
F
P
R
I
H
Y
N
S
H
F
E
V
P
Site 11
S78
F
P
R
I
H
Y
N
S
H
F
E
V
P
E
E
Site 12
S86
H
F
E
V
P
E
E
S
P
F
P
S
H
A
Q
Site 13
S90
P
E
E
S
P
F
P
S
H
A
Q
A
T
K
I
Site 14
S120
P
I
H
R
D
G
F
S
T
L
Q
F
P
R
G
Site 15
T121
I
H
R
D
G
F
S
T
L
Q
F
P
R
G
E
Site 16
S135
E
A
K
A
R
G
E
S
P
G
R
I
R
H
L
Site 17
S145
R
I
R
H
L
V
H
S
V
Q
R
L
F
F
T
Site 18
T152
S
V
Q
R
L
F
F
T
K
A
P
S
L
E
G
Site 19
S156
L
F
F
T
K
A
P
S
L
E
G
T
A
G
K
Site 20
T160
K
A
P
S
L
E
G
T
A
G
K
V
G
G
N
Site 21
S169
G
K
V
G
G
N
G
S
K
K
G
G
M
E
D
Site 22
S184
G
K
G
R
R
A
K
S
K
E
R
A
K
A
G
Site 23
S197
A
G
E
P
K
R
R
S
R
S
N
I
S
G
W
Site 24
S199
E
P
K
R
R
S
R
S
N
I
S
G
W
W
S
Site 25
S202
R
R
S
R
S
N
I
S
G
W
W
S
S
D
D
Site 26
S206
S
N
I
S
G
W
W
S
S
D
D
N
L
D
G
Site 27
S207
N
I
S
G
W
W
S
S
D
D
N
L
D
G
E
Site 28
S220
G
E
A
G
A
F
R
S
S
G
P
A
S
G
L
Site 29
S221
E
A
G
A
F
R
S
S
G
P
A
S
G
L
M
Site 30
S225
F
R
S
S
G
P
A
S
G
L
M
T
L
G
R
Site 31
T229
G
P
A
S
G
L
M
T
L
G
R
Q
A
E
R
Site 32
S237
L
G
R
Q
A
E
R
S
Q
P
R
Y
F
M
H
Site 33
Y241
A
E
R
S
Q
P
R
Y
F
M
H
A
Y
N
T
Site 34
T257
S
G
H
M
L
K
T
T
K
N
N
T
T
E
L
Site 35
T265
K
N
N
T
T
E
L
T
A
P
P
P
P
P
A
Site 36
T286
S
L
G
V
G
T
D
T
N
Y
V
K
R
G
S
Site 37
Y288
G
V
G
T
D
T
N
Y
V
K
R
G
S
W
S
Site 38
S293
T
N
Y
V
K
R
G
S
W
S
T
L
T
L
S
Site 39
S295
Y
V
K
R
G
S
W
S
T
L
T
L
S
H
A
Site 40
T296
V
K
R
G
S
W
S
T
L
T
L
S
H
A
H
Site 41
T298
R
G
S
W
S
T
L
T
L
S
H
A
H
E
V
Site 42
T312
V
C
Q
K
T
S
A
T
L
D
K
S
L
L
K
Site 43
S316
T
S
A
T
L
D
K
S
L
L
K
S
K
S
C
Site 44
S320
L
D
K
S
L
L
K
S
K
S
C
H
Q
G
L
Site 45
S322
K
S
L
L
K
S
K
S
C
H
Q
G
L
A
Y
Site 46
Y329
S
C
H
Q
G
L
A
Y
H
Y
L
Q
V
P
G
Site 47
Y331
H
Q
G
L
A
Y
H
Y
L
Q
V
P
G
G
G
Site 48
S342
P
G
G
G
G
E
W
S
T
T
L
L
S
P
R
Site 49
T343
G
G
G
G
E
W
S
T
T
L
L
S
P
R
E
Site 50
T344
G
G
G
E
W
S
T
T
L
L
S
P
R
E
T
Site 51
S347
E
W
S
T
T
L
L
S
P
R
E
T
D
A
A
Site 52
T351
T
L
L
S
P
R
E
T
D
A
A
A
E
G
P
Site 53
S366
I
P
C
R
R
M
R
S
G
S
Y
I
K
A
M
Site 54
S368
C
R
R
M
R
S
G
S
Y
I
K
A
M
G
D
Site 55
Y369
R
R
M
R
S
G
S
Y
I
K
A
M
G
D
E
Site 56
S378
K
A
M
G
D
E
D
S
D
E
S
G
G
S
P
Site 57
S381
G
D
E
D
S
D
E
S
G
G
S
P
K
P
S
Site 58
S384
D
S
D
E
S
G
G
S
P
K
P
S
P
K
T
Site 59
S388
S
G
G
S
P
K
P
S
P
K
T
A
A
R
R
Site 60
T391
S
P
K
P
S
P
K
T
A
A
R
R
Q
S
Y
Site 61
S397
K
T
A
A
R
R
Q
S
Y
L
R
A
T
Q
Q
Site 62
Y398
T
A
A
R
R
Q
S
Y
L
R
A
T
Q
Q
S
Site 63
T402
R
Q
S
Y
L
R
A
T
Q
Q
S
L
G
E
Q
Site 64
S405
Y
L
R
A
T
Q
Q
S
L
G
E
Q
S
N
P
Site 65
S410
Q
Q
S
L
G
E
Q
S
N
P
R
R
S
L
D
Site 66
S415
E
Q
S
N
P
R
R
S
L
D
R
L
D
S
V
Site 67
S421
R
S
L
D
R
L
D
S
V
D
M
L
L
P
S
Site 68
S428
S
V
D
M
L
L
P
S
K
C
P
S
W
E
E
Site 69
S432
L
L
P
S
K
C
P
S
W
E
E
D
Y
T
P
Site 70
Y437
C
P
S
W
E
E
D
Y
T
P
V
S
D
S
L
Site 71
T438
P
S
W
E
E
D
Y
T
P
V
S
D
S
L
N
Site 72
S441
E
E
D
Y
T
P
V
S
D
S
L
N
D
S
S
Site 73
S443
D
Y
T
P
V
S
D
S
L
N
D
S
S
C
I
Site 74
S447
V
S
D
S
L
N
D
S
S
C
I
S
Q
I
F
Site 75
S448
S
D
S
L
N
D
S
S
C
I
S
Q
I
F
G
Site 76
S451
L
N
D
S
S
C
I
S
Q
I
F
G
Q
A
S
Site 77
S476
Q
V
R
E
A
E
L
S
D
Q
Y
E
A
A
C
Site 78
Y479
E
A
E
L
S
D
Q
Y
E
A
A
C
E
S
A
Site 79
S488
A
A
C
E
S
A
C
S
E
A
E
S
T
A
A
Site 80
S492
S
A
C
S
E
A
E
S
T
A
A
E
T
L
D
Site 81
T493
A
C
S
E
A
E
S
T
A
A
E
T
L
D
L
Site 82
S504
T
L
D
L
P
L
P
S
Y
F
R
S
R
S
H
Site 83
Y505
L
D
L
P
L
P
S
Y
F
R
S
R
S
H
S
Site 84
S508
P
L
P
S
Y
F
R
S
R
S
H
S
Y
L
R
Site 85
S510
P
S
Y
F
R
S
R
S
H
S
Y
L
R
A
I
Site 86
S512
Y
F
R
S
R
S
H
S
Y
L
R
A
I
Q
A
Site 87
Y513
F
R
S
R
S
H
S
Y
L
R
A
I
Q
A
G
Site 88
S522
R
A
I
Q
A
G
C
S
Q
E
E
D
S
V
S
Site 89
S527
G
C
S
Q
E
E
D
S
V
S
L
Q
S
L
S
Site 90
S529
S
Q
E
E
D
S
V
S
L
Q
S
L
S
P
P
Site 91
S532
E
D
S
V
S
L
Q
S
L
S
P
P
P
S
T
Site 92
S534
S
V
S
L
Q
S
L
S
P
P
P
S
T
G
S
Site 93
S538
Q
S
L
S
P
P
P
S
T
G
S
L
S
N
S
Site 94
T539
S
L
S
P
P
P
S
T
G
S
L
S
N
S
R
Site 95
S541
S
P
P
P
S
T
G
S
L
S
N
S
R
T
L
Site 96
S543
P
P
S
T
G
S
L
S
N
S
R
T
L
P
S
Site 97
S545
S
T
G
S
L
S
N
S
R
T
L
P
S
S
S
Site 98
T547
G
S
L
S
N
S
R
T
L
P
S
S
S
C
L
Site 99
S550
S
N
S
R
T
L
P
S
S
S
C
L
V
A
Y
Site 100
S551
N
S
R
T
L
P
S
S
S
C
L
V
A
Y
K
Site 101
S552
S
R
T
L
P
S
S
S
C
L
V
A
Y
K
K
Site 102
Y557
S
S
S
C
L
V
A
Y
K
K
T
P
P
P
V
Site 103
T560
C
L
V
A
Y
K
K
T
P
P
P
V
P
P
R
Site 104
T568
P
P
P
V
P
P
R
T
T
S
K
P
F
I
S
Site 105
T569
P
P
V
P
P
R
T
T
S
K
P
F
I
S
V
Site 106
S570
P
V
P
P
R
T
T
S
K
P
F
I
S
V
T
Site 107
S575
T
T
S
K
P
F
I
S
V
T
V
Q
S
S
T
Site 108
T577
S
K
P
F
I
S
V
T
V
Q
S
S
T
E
S
Site 109
S580
F
I
S
V
T
V
Q
S
S
T
E
S
A
Q
D
Site 110
S581
I
S
V
T
V
Q
S
S
T
E
S
A
Q
D
T
Site 111
S584
T
V
Q
S
S
T
E
S
A
Q
D
T
Y
L
D
Site 112
T588
S
T
E
S
A
Q
D
T
Y
L
D
S
Q
D
H
Site 113
Y589
T
E
S
A
Q
D
T
Y
L
D
S
Q
D
H
K
Site 114
S592
A
Q
D
T
Y
L
D
S
Q
D
H
K
S
E
V
Site 115
S597
L
D
S
Q
D
H
K
S
E
V
T
S
Q
S
G
Site 116
S601
D
H
K
S
E
V
T
S
Q
S
G
L
S
N
S
Site 117
S603
K
S
E
V
T
S
Q
S
G
L
S
N
S
S
D
Site 118
S606
V
T
S
Q
S
G
L
S
N
S
S
D
S
L
D
Site 119
S608
S
Q
S
G
L
S
N
S
S
D
S
L
D
S
S
Site 120
S609
Q
S
G
L
S
N
S
S
D
S
L
D
S
S
T
Site 121
S611
G
L
S
N
S
S
D
S
L
D
S
S
T
R
P
Site 122
S614
N
S
S
D
S
L
D
S
S
T
R
P
P
S
V
Site 123
S615
S
S
D
S
L
D
S
S
T
R
P
P
S
V
T
Site 124
T616
S
D
S
L
D
S
S
T
R
P
P
S
V
T
R
Site 125
S620
D
S
S
T
R
P
P
S
V
T
R
G
G
V
A
Site 126
T622
S
T
R
P
P
S
V
T
R
G
G
V
A
P
A
Site 127
S644
P
K
H
A
A
L
K
S
E
Q
G
T
L
T
S
Site 128
T648
A
L
K
S
E
Q
G
T
L
T
S
S
E
S
H
Site 129
T650
K
S
E
Q
G
T
L
T
S
S
E
S
H
P
E
Site 130
S651
S
E
Q
G
T
L
T
S
S
E
S
H
P
E
A
Site 131
S652
E
Q
G
T
L
T
S
S
E
S
H
P
E
A
A
Site 132
S654
G
T
L
T
S
S
E
S
H
P
E
A
A
P
K
Site 133
S665
A
A
P
K
R
K
L
S
S
I
G
I
Q
V
D
Site 134
S666
A
P
K
R
K
L
S
S
I
G
I
Q
V
D
C
Site 135
S683
P
V
P
K
E
E
P
S
P
A
T
K
F
Q
S
Site 136
S701
Q
V
E
D
D
W
R
S
S
V
P
S
H
S
M
Site 137
S702
V
E
D
D
W
R
S
S
V
P
S
H
S
M
S
Site 138
S705
D
W
R
S
S
V
P
S
H
S
M
S
S
R
R
Site 139
S707
R
S
S
V
P
S
H
S
M
S
S
R
R
D
T
Site 140
S709
S
V
P
S
H
S
M
S
S
R
R
D
T
D
S
Site 141
S710
V
P
S
H
S
M
S
S
R
R
D
T
D
S
D
Site 142
T714
S
M
S
S
R
R
D
T
D
S
D
T
Q
D
A
Site 143
S716
S
S
R
R
D
T
D
S
D
T
Q
D
A
N
D
Site 144
T718
R
R
D
T
D
S
D
T
Q
D
A
N
D
S
S
Site 145
S724
D
T
Q
D
A
N
D
S
S
C
K
S
S
E
R
Site 146
S725
T
Q
D
A
N
D
S
S
C
K
S
S
E
R
S
Site 147
S728
A
N
D
S
S
C
K
S
S
E
R
S
L
P
D
Site 148
S729
N
D
S
S
C
K
S
S
E
R
S
L
P
D
C
Site 149
S732
S
C
K
S
S
E
R
S
L
P
D
C
T
P
H
Site 150
T737
E
R
S
L
P
D
C
T
P
H
P
N
S
I
S
Site 151
S742
D
C
T
P
H
P
N
S
I
S
I
D
A
G
P
Site 152
S744
T
P
H
P
N
S
I
S
I
D
A
G
P
R
Q
Site 153
S763
A
Q
I
K
R
N
L
S
Y
G
D
N
S
D
P
Site 154
Y764
Q
I
K
R
N
L
S
Y
G
D
N
S
D
P
A
Site 155
S768
N
L
S
Y
G
D
N
S
D
P
A
L
E
A
S
Site 156
S775
S
D
P
A
L
E
A
S
S
L
P
P
P
D
P
Site 157
S776
D
P
A
L
E
A
S
S
L
P
P
P
D
P
W
Site 158
T786
P
P
D
P
W
L
E
T
S
S
S
S
P
A
E
Site 159
S787
P
D
P
W
L
E
T
S
S
S
S
P
A
E
P
Site 160
S788
D
P
W
L
E
T
S
S
S
S
P
A
E
P
A
Site 161
S789
P
W
L
E
T
S
S
S
S
P
A
E
P
A
Q
Site 162
S790
W
L
E
T
S
S
S
S
P
A
E
P
A
Q
P
Site 163
Y805
G
A
C
R
R
D
G
Y
W
F
L
K
L
L
Q
Site 164
T815
L
K
L
L
Q
A
E
T
E
R
L
E
G
W
C
Site 165
S835
E
T
K
E
N
N
L
S
E
E
V
L
G
K
V
Site 166
S854
G
S
A
Q
L
L
M
S
Q
K
F
Q
Q
F
R
Site 167
T877
P
D
A
N
P
R
P
T
A
Q
D
L
A
G
F
Site 168
Y903
S
M
K
F
D
E
L
Y
H
L
K
A
N
S
W
Site 169
T915
N
S
W
Q
L
V
E
T
P
E
K
R
K
E
E
Site 170
S936
V
P
K
K
P
A
K
S
K
P
A
V
S
R
D
Site 171
S941
A
K
S
K
P
A
V
S
R
D
K
A
S
D
A
Site 172
S968
L
A
A
K
R
A
A
S
V
R
Q
N
S
A
T
Site 173
S973
A
A
S
V
R
Q
N
S
A
T
E
S
A
D
S
Site 174
T975
S
V
R
Q
N
S
A
T
E
S
A
D
S
I
E
Site 175
S977
R
Q
N
S
A
T
E
S
A
D
S
I
E
I
Y
Site 176
S980
S
A
T
E
S
A
D
S
I
E
I
Y
V
P
E
Site 177
Y984
S
A
D
S
I
E
I
Y
V
P
E
A
Q
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation