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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INPP5F
Full Name:
Phosphatidylinositide phosphatase SAC2
Alias:
EC 3.1.3.-; HSAC2; Inositol polyphosphate-5-phosphatase F; KIAA0966; Sac domain-containing inositol phosphatase 2; SAC2
Type:
EC 3.1.3.-; Phosphatase, lipid
Mass (Da):
128407
Number AA:
1132
UniProt ID:
Q9Y2H2
International Prot ID:
IPI00480159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
L
F
Q
A
K
D
H
Y
I
L
Q
Q
G
E
R
Site 2
S22
G
E
R
A
L
W
C
S
R
R
D
G
G
L
Q
Site 3
S123
K
P
E
K
I
I
P
S
P
D
D
S
K
F
L
Site 4
S127
I
I
P
S
P
D
D
S
K
F
L
L
K
T
F
Site 5
T133
D
S
K
F
L
L
K
T
F
T
H
I
K
S
N
Site 6
T135
K
F
L
L
K
T
F
T
H
I
K
S
N
V
S
Site 7
S139
K
T
F
T
H
I
K
S
N
V
S
A
P
N
K
Site 8
Y177
F
M
D
S
E
S
F
Y
Y
S
L
T
Y
D
L
Site 9
Y178
M
D
S
E
S
F
Y
Y
S
L
T
Y
D
L
T
Site 10
S179
D
S
E
S
F
Y
Y
S
L
T
Y
D
L
T
N
Site 11
T181
E
S
F
Y
Y
S
L
T
Y
D
L
T
N
S
V
Site 12
T185
Y
S
L
T
Y
D
L
T
N
S
V
Q
R
Q
S
Site 13
S187
L
T
Y
D
L
T
N
S
V
Q
R
Q
S
T
G
Site 14
S192
T
N
S
V
Q
R
Q
S
T
G
E
R
D
G
R
Site 15
T193
N
S
V
Q
R
Q
S
T
G
E
R
D
G
R
P
Site 16
Y214
D
R
F
F
W
N
K
Y
M
I
Q
D
L
T
E
Site 17
T220
K
Y
M
I
Q
D
L
T
E
I
G
T
P
D
V
Site 18
T224
Q
D
L
T
E
I
G
T
P
D
V
D
F
W
I
Site 19
S252
V
V
N
Y
T
E
S
S
D
D
E
K
S
S
P
Site 20
S257
E
S
S
D
D
E
K
S
S
P
E
T
P
P
Q
Site 21
S258
S
S
D
D
E
K
S
S
P
E
T
P
P
Q
E
Site 22
T261
D
E
K
S
S
P
E
T
P
P
Q
E
S
T
C
Site 23
S282
R
F
L
V
A
L
I
S
R
R
S
R
H
R
A
Site 24
S285
V
A
L
I
S
R
R
S
R
H
R
A
G
M
R
Site 25
Y293
R
H
R
A
G
M
R
Y
K
R
R
G
V
D
K
Site 26
Y307
K
N
G
N
V
A
N
Y
V
E
T
E
Q
L
I
Site 27
T320
L
I
H
V
H
N
H
T
L
S
F
V
Q
T
R
Site 28
S322
H
V
H
N
H
T
L
S
F
V
Q
T
R
G
S
Site 29
S329
S
F
V
Q
T
R
G
S
V
P
V
F
W
S
Q
Site 30
S350
P
R
P
R
L
D
R
S
E
K
E
T
V
A
Y
Site 31
T354
L
D
R
S
E
K
E
T
V
A
Y
F
C
A
H
Site 32
Y357
S
E
K
E
T
V
A
Y
F
C
A
H
F
E
E
Site 33
Y391
E
K
I
I
G
D
A
Y
L
K
Q
V
L
L
F
Site 34
Y405
F
N
N
S
H
L
T
Y
V
S
F
D
F
H
E
Site 35
T424
M
K
F
E
N
V
Q
T
L
T
D
A
I
Y
D
Site 36
Y430
Q
T
L
T
D
A
I
Y
D
I
I
L
D
M
K
Site 37
S513
A
N
N
G
D
S
I
S
R
Q
Y
A
G
T
A
Site 38
Y516
G
D
S
I
S
R
Q
Y
A
G
T
A
A
L
K
Site 39
T519
I
S
R
Q
Y
A
G
T
A
A
L
K
G
D
F
Site 40
T527
A
A
L
K
G
D
F
T
R
T
G
E
R
K
L
Site 41
T529
L
K
G
D
F
T
R
T
G
E
R
K
L
A
G
Site 42
Y548
G
V
N
S
A
N
R
Y
Y
L
N
R
F
K
D
Site 43
Y549
V
N
S
A
N
R
Y
Y
L
N
R
F
K
D
A
Site 44
Y557
L
N
R
F
K
D
A
Y
R
Q
A
V
I
D
L
Site 45
Y575
I
P
V
T
E
D
L
Y
S
I
F
T
K
E
K
Site 46
S576
P
V
T
E
D
L
Y
S
I
F
T
K
E
K
E
Site 47
S594
L
H
K
E
N
Q
R
S
H
Q
E
L
I
S
Q
Site 48
S600
R
S
H
Q
E
L
I
S
Q
L
L
Q
S
Y
M
Site 49
T634
D
P
S
L
I
D
A
T
H
R
D
V
D
V
L
Site 50
Y649
L
L
L
S
N
S
A
Y
Y
V
A
Y
Y
D
D
Site 51
Y650
L
L
S
N
S
A
Y
Y
V
A
Y
Y
D
D
E
Site 52
Y654
S
A
Y
Y
V
A
Y
Y
D
D
E
V
D
K
V
Site 53
Y664
E
V
D
K
V
N
Q
Y
Q
R
L
S
L
E
N
Site 54
S668
V
N
Q
Y
Q
R
L
S
L
E
N
L
E
K
I
Site 55
Y696
F
S
C
M
R
L
H
Y
R
Y
K
E
A
S
G
Site 56
Y698
C
M
R
L
H
Y
R
Y
K
E
A
S
G
Y
F
Site 57
Y704
R
Y
K
E
A
S
G
Y
F
H
T
L
R
A
V
Site 58
T707
E
A
S
G
Y
F
H
T
L
R
A
V
M
R
N
Site 59
T722
P
E
E
D
G
K
D
T
L
Q
C
I
A
E
M
Site 60
S739
I
T
K
Q
A
M
G
S
D
L
P
I
I
E
K
Site 61
S752
E
K
K
L
E
R
K
S
S
K
P
H
E
D
I
Site 62
S753
K
K
L
E
R
K
S
S
K
P
H
E
D
I
I
Site 63
S764
E
D
I
I
G
I
R
S
Q
N
Q
G
S
L
A
Site 64
S779
Q
G
K
N
F
L
M
S
K
F
S
S
L
N
Q
Site 65
S783
F
L
M
S
K
F
S
S
L
N
Q
K
V
K
Q
Site 66
S793
Q
K
V
K
Q
T
K
S
N
V
N
I
G
N
L
Site 67
S827
L
K
V
N
L
W
K
S
D
S
S
L
E
T
M
Site 68
S829
V
N
L
W
K
S
D
S
S
L
E
T
M
E
N
Site 69
S830
N
L
W
K
S
D
S
S
L
E
T
M
E
N
T
Site 70
T833
K
S
D
S
S
L
E
T
M
E
N
T
G
V
M
Site 71
S852
A
E
S
D
G
D
M
S
S
D
N
D
S
Y
H
Site 72
S853
E
S
D
G
D
M
S
S
D
N
D
S
Y
H
S
Site 73
S857
D
M
S
S
D
N
D
S
Y
H
S
D
E
F
L
Site 74
Y858
M
S
S
D
N
D
S
Y
H
S
D
E
F
L
T
Site 75
S860
S
D
N
D
S
Y
H
S
D
E
F
L
T
N
S
Site 76
T865
Y
H
S
D
E
F
L
T
N
S
K
S
D
E
D
Site 77
S867
S
D
E
F
L
T
N
S
K
S
D
E
D
R
Q
Site 78
S869
E
F
L
T
N
S
K
S
D
E
D
R
Q
L
A
Site 79
S878
E
D
R
Q
L
A
N
S
L
E
S
V
G
P
I
Site 80
Y887
E
S
V
G
P
I
D
Y
V
L
P
S
C
G
I
Site 81
S903
A
S
A
P
R
L
G
S
R
S
Q
S
L
S
S
Site 82
S905
A
P
R
L
G
S
R
S
Q
S
L
S
S
T
D
Site 83
S907
R
L
G
S
R
S
Q
S
L
S
S
T
D
S
S
Site 84
S909
G
S
R
S
Q
S
L
S
S
T
D
S
S
V
H
Site 85
S910
S
R
S
Q
S
L
S
S
T
D
S
S
V
H
A
Site 86
T911
R
S
Q
S
L
S
S
T
D
S
S
V
H
A
P
Site 87
S913
Q
S
L
S
S
T
D
S
S
V
H
A
P
S
E
Site 88
S914
S
L
S
S
T
D
S
S
V
H
A
P
S
E
I
Site 89
S919
D
S
S
V
H
A
P
S
E
I
T
V
A
H
G
Site 90
S927
E
I
T
V
A
H
G
S
G
L
G
K
G
Q
E
Site 91
S935
G
L
G
K
G
Q
E
S
P
L
K
K
S
P
S
Site 92
S940
Q
E
S
P
L
K
K
S
P
S
A
G
D
V
H
Site 93
S942
S
P
L
K
K
S
P
S
A
G
D
V
H
I
L
Site 94
Y959
F
A
K
P
M
D
I
Y
C
H
R
F
V
Q
D
Site 95
S975
Q
N
K
V
T
H
L
S
E
T
R
S
V
S
Q
Site 96
T977
K
V
T
H
L
S
E
T
R
S
V
S
Q
Q
A
Site 97
S979
T
H
L
S
E
T
R
S
V
S
Q
Q
A
S
Q
Site 98
S981
L
S
E
T
R
S
V
S
Q
Q
A
S
Q
E
R
Site 99
S985
R
S
V
S
Q
Q
A
S
Q
E
R
N
Q
M
T
Site 100
S996
N
Q
M
T
N
Q
V
S
N
E
T
Q
S
E
S
Site 101
S1003
S
N
E
T
Q
S
E
S
T
E
Q
T
P
S
R
Site 102
T1007
Q
S
E
S
T
E
Q
T
P
S
R
P
S
Q
L
Site 103
S1009
E
S
T
E
Q
T
P
S
R
P
S
Q
L
D
V
Site 104
S1012
E
Q
T
P
S
R
P
S
Q
L
D
V
S
L
S
Site 105
S1017
R
P
S
Q
L
D
V
S
L
S
A
T
G
P
Q
Site 106
S1033
L
S
V
E
P
A
H
S
V
A
S
Q
K
T
P
Site 107
T1039
H
S
V
A
S
Q
K
T
P
T
S
A
S
S
M
Site 108
S1042
A
S
Q
K
T
P
T
S
A
S
S
M
L
E
L
Site 109
T1056
L
E
T
G
L
H
V
T
P
S
P
S
E
S
S
Site 110
S1058
T
G
L
H
V
T
P
S
P
S
E
S
S
S
S
Site 111
S1060
L
H
V
T
P
S
P
S
E
S
S
S
S
R
A
Site 112
S1062
V
T
P
S
P
S
E
S
S
S
S
R
A
V
S
Site 113
S1063
T
P
S
P
S
E
S
S
S
S
R
A
V
S
P
Site 114
S1064
P
S
P
S
E
S
S
S
S
R
A
V
S
P
F
Site 115
S1065
S
P
S
E
S
S
S
S
R
A
V
S
P
F
A
Site 116
S1069
S
S
S
S
R
A
V
S
P
F
A
K
I
R
S
Site 117
S1098
H
G
I
N
F
A
V
S
K
V
Q
K
S
P
P
Site 118
S1103
A
V
S
K
V
Q
K
S
P
P
E
P
E
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation