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Updated November 2019
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Protein Info
Short Name:
PLEKHA6
Full Name:
Pleckstrin homology domain-containing family A member 6
Alias:
KIAA0969; PEPP3; PEPP-3; Phosphoinositol 3-phosphate-binding protein 3; Phosphoinositol 3-phosphate-binding protein-3; PKHA6; Pleckstrin homology domain-containing protein A6; Pleckstriny domain containing, family A member 6
Type:
Lipid binding protein
Mass (Da):
117128
Number AA:
1048
UniProt ID:
Q9Y2H5
International Prot ID:
IPI00007248
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
T
G
G
K
R
P
A
T
T
N
S
D
I
P
N
Site 2
T13
G
G
K
R
P
A
T
T
N
S
D
I
P
N
H
Site 3
S15
K
R
P
A
T
T
N
S
D
I
P
N
H
N
M
Site 4
S32
E
V
P
P
E
R
P
S
V
R
A
T
R
T
A
Site 5
T36
E
R
P
S
V
R
A
T
R
T
A
R
K
A
V
Site 6
T38
P
S
V
R
A
T
R
T
A
R
K
A
V
A
F
Site 7
S51
A
F
G
K
R
S
H
S
M
K
R
N
P
N
A
Site 8
T61
R
N
P
N
A
P
V
T
K
A
G
W
L
F
K
Site 9
Y92
V
D
R
C
L
F
Y
Y
K
D
E
K
E
E
S
Site 10
S99
Y
K
D
E
K
E
E
S
I
L
G
S
I
P
L
Site 11
S121
V
Q
P
S
D
N
I
S
R
K
H
T
F
K
A
Site 12
T125
D
N
I
S
R
K
H
T
F
K
A
E
H
A
G
Site 13
Y136
E
H
A
G
V
R
T
Y
F
F
S
A
E
S
P
Site 14
S139
G
V
R
T
Y
F
F
S
A
E
S
P
E
E
Q
Site 15
S142
T
Y
F
F
S
A
E
S
P
E
E
Q
E
A
W
Site 16
S167
Q
I
P
P
A
Q
K
S
V
P
Q
A
V
R
H
Site 17
S175
V
P
Q
A
V
R
H
S
H
E
K
P
D
S
E
Site 18
S181
H
S
H
E
K
P
D
S
E
N
V
P
P
S
K
Site 19
S187
D
S
E
N
V
P
P
S
K
H
H
Q
Q
P
P
Site 20
S197
H
Q
Q
P
P
H
N
S
L
P
K
P
E
P
E
Site 21
S247
P
A
G
P
E
P
A
S
E
P
G
S
P
Y
P
Site 22
S251
E
P
A
S
E
P
G
S
P
Y
P
E
G
P
R
Site 23
Y253
A
S
E
P
G
S
P
Y
P
E
G
P
R
V
P
Site 24
Y274
A
Q
P
N
G
W
Q
Y
H
S
P
S
R
P
G
Site 25
S276
P
N
G
W
Q
Y
H
S
P
S
R
P
G
S
T
Site 26
S278
G
W
Q
Y
H
S
P
S
R
P
G
S
T
A
F
Site 27
S282
H
S
P
S
R
P
G
S
T
A
F
P
S
Q
D
Site 28
T283
S
P
S
R
P
G
S
T
A
F
P
S
Q
D
G
Site 29
S287
P
G
S
T
A
F
P
S
Q
D
G
E
T
G
G
Site 30
S298
E
T
G
G
H
R
R
S
F
P
P
R
T
N
P
Site 31
T303
R
R
S
F
P
P
R
T
N
P
D
K
I
A
Q
Site 32
S313
D
K
I
A
Q
R
K
S
S
M
N
Q
L
Q
Q
Site 33
S314
K
I
A
Q
R
K
S
S
M
N
Q
L
Q
Q
W
Site 34
S336
P
P
P
E
D
L
R
S
P
S
R
F
Y
P
V
Site 35
S338
P
E
D
L
R
S
P
S
R
F
Y
P
V
S
R
Site 36
Y341
L
R
S
P
S
R
F
Y
P
V
S
R
R
V
P
Site 37
S344
P
S
R
F
Y
P
V
S
R
R
V
P
E
Y
Y
Site 38
Y350
V
S
R
R
V
P
E
Y
Y
G
P
Y
S
S
Q
Site 39
Y351
S
R
R
V
P
E
Y
Y
G
P
Y
S
S
Q
Y
Site 40
S355
P
E
Y
Y
G
P
Y
S
S
Q
Y
P
D
D
Y
Site 41
Y358
Y
G
P
Y
S
S
Q
Y
P
D
D
Y
Q
Y
Y
Site 42
Y362
S
S
Q
Y
P
D
D
Y
Q
Y
Y
P
P
G
V
Site 43
Y364
Q
Y
P
D
D
Y
Q
Y
Y
P
P
G
V
R
P
Site 44
Y365
Y
P
D
D
Y
Q
Y
Y
P
P
G
V
R
P
E
Site 45
S373
P
P
G
V
R
P
E
S
I
C
S
M
P
A
Y
Site 46
S376
V
R
P
E
S
I
C
S
M
P
A
Y
D
R
I
Site 47
Y380
S
I
C
S
M
P
A
Y
D
R
I
S
P
P
W
Site 48
S384
M
P
A
Y
D
R
I
S
P
P
W
A
L
E
D
Site 49
Y404
R
N
G
G
G
P
A
Y
Q
L
R
E
W
K
E
Site 50
S414
R
E
W
K
E
P
A
S
Y
G
R
Q
D
A
T
Site 51
Y415
E
W
K
E
P
A
S
Y
G
R
Q
D
A
T
V
Site 52
T421
S
Y
G
R
Q
D
A
T
V
W
I
P
S
P
S
Site 53
S426
D
A
T
V
W
I
P
S
P
S
R
Q
P
V
Y
Site 54
Y433
S
P
S
R
Q
P
V
Y
Y
D
E
L
D
A
A
Site 55
Y434
P
S
R
Q
P
V
Y
Y
D
E
L
D
A
A
S
Site 56
S441
Y
D
E
L
D
A
A
S
S
S
L
R
R
L
S
Site 57
S442
D
E
L
D
A
A
S
S
S
L
R
R
L
S
L
Site 58
S443
E
L
D
A
A
S
S
S
L
R
R
L
S
L
Q
Site 59
S448
S
S
S
L
R
R
L
S
L
Q
P
R
S
H
S
Site 60
S453
R
L
S
L
Q
P
R
S
H
S
V
P
R
S
P
Site 61
S455
S
L
Q
P
R
S
H
S
V
P
R
S
P
S
Q
Site 62
S459
R
S
H
S
V
P
R
S
P
S
Q
G
S
Y
S
Site 63
S461
H
S
V
P
R
S
P
S
Q
G
S
Y
S
R
A
Site 64
S464
P
R
S
P
S
Q
G
S
Y
S
R
A
R
I
Y
Site 65
Y465
R
S
P
S
Q
G
S
Y
S
R
A
R
I
Y
S
Site 66
S466
S
P
S
Q
G
S
Y
S
R
A
R
I
Y
S
P
Site 67
Y471
S
Y
S
R
A
R
I
Y
S
P
V
R
S
P
S
Site 68
S472
Y
S
R
A
R
I
Y
S
P
V
R
S
P
S
A
Site 69
S476
R
I
Y
S
P
V
R
S
P
S
A
R
F
E
R
Site 70
S478
Y
S
P
V
R
S
P
S
A
R
F
E
R
L
P
Site 71
S488
F
E
R
L
P
P
R
S
E
D
I
Y
A
D
P
Site 72
Y492
P
P
R
S
E
D
I
Y
A
D
P
A
A
Y
V
Site 73
Y498
I
Y
A
D
P
A
A
Y
V
M
R
R
S
I
S
Site 74
S503
A
A
Y
V
M
R
R
S
I
S
S
P
K
V
P
Site 75
S505
Y
V
M
R
R
S
I
S
S
P
K
V
P
P
Y
Site 76
S506
V
M
R
R
S
I
S
S
P
K
V
P
P
Y
P
Site 77
Y512
S
S
P
K
V
P
P
Y
P
E
V
F
R
D
S
Site 78
S519
Y
P
E
V
F
R
D
S
L
H
T
Y
K
L
N
Site 79
Y523
F
R
D
S
L
H
T
Y
K
L
N
E
Q
D
T
Site 80
T530
Y
K
L
N
E
Q
D
T
D
K
L
L
G
K
L
Site 81
S560
Q
L
R
A
E
K
E
S
L
E
S
A
L
M
G
Site 82
S563
A
E
K
E
S
L
E
S
A
L
M
G
T
H
Q
Site 83
S577
Q
E
L
E
M
F
G
S
Q
P
A
Y
P
E
K
Site 84
Y581
M
F
G
S
Q
P
A
Y
P
E
K
L
R
H
K
Site 85
S591
K
L
R
H
K
K
D
S
L
Q
N
Q
L
I
N
Site 86
S613
A
T
T
A
L
T
N
S
T
I
E
Y
E
H
L
Site 87
Y617
L
T
N
S
T
I
E
Y
E
H
L
E
S
E
V
Site 88
S622
I
E
Y
E
H
L
E
S
E
V
S
A
L
H
D
Site 89
S625
E
H
L
E
S
E
V
S
A
L
H
D
D
L
W
Site 90
T639
W
E
Q
L
N
L
D
T
Q
N
E
V
L
N
R
Site 91
S668
G
L
R
K
N
N
P
S
R
G
T
D
T
A
K
Site 92
T671
K
N
N
P
S
R
G
T
D
T
A
K
H
R
G
Site 93
T673
N
P
S
R
G
T
D
T
A
K
H
R
G
G
L
Site 94
S683
H
R
G
G
L
G
P
S
A
T
Y
S
S
N
S
Site 95
T685
G
G
L
G
P
S
A
T
Y
S
S
N
S
P
A
Site 96
Y686
G
L
G
P
S
A
T
Y
S
S
N
S
P
A
S
Site 97
S687
L
G
P
S
A
T
Y
S
S
N
S
P
A
S
P
Site 98
S688
G
P
S
A
T
Y
S
S
N
S
P
A
S
P
L
Site 99
S690
S
A
T
Y
S
S
N
S
P
A
S
P
L
S
S
Site 100
S693
Y
S
S
N
S
P
A
S
P
L
S
S
A
S
L
Site 101
S696
N
S
P
A
S
P
L
S
S
A
S
L
T
S
P
Site 102
S697
S
P
A
S
P
L
S
S
A
S
L
T
S
P
L
Site 103
S699
A
S
P
L
S
S
A
S
L
T
S
P
L
S
P
Site 104
S702
L
S
S
A
S
L
T
S
P
L
S
P
F
S
L
Site 105
S705
A
S
L
T
S
P
L
S
P
F
S
L
V
S
G
Site 106
S708
T
S
P
L
S
P
F
S
L
V
S
G
S
Q
G
Site 107
S711
L
S
P
F
S
L
V
S
G
S
Q
G
S
P
T
Site 108
S713
P
F
S
L
V
S
G
S
Q
G
S
P
T
K
P
Site 109
S716
L
V
S
G
S
Q
G
S
P
T
K
P
G
S
N
Site 110
T718
S
G
S
Q
G
S
P
T
K
P
G
S
N
E
P
Site 111
S722
G
S
P
T
K
P
G
S
N
E
P
K
A
N
Y
Site 112
T739
S
K
K
D
P
H
Q
T
L
P
L
D
T
P
R
Site 113
T744
H
Q
T
L
P
L
D
T
P
R
D
I
S
L
V
Site 114
S749
L
D
T
P
R
D
I
S
L
V
P
T
R
Q
E
Site 115
T753
R
D
I
S
L
V
P
T
R
Q
E
V
E
A
E
Site 116
T775
V
G
V
V
P
P
R
T
K
S
P
T
D
D
E
Site 117
S777
V
V
P
P
R
T
K
S
P
T
D
D
E
V
T
Site 118
T779
P
P
R
T
K
S
P
T
D
D
E
V
T
P
S
Site 119
T784
S
P
T
D
D
E
V
T
P
S
A
V
V
R
R
Site 120
S786
T
D
D
E
V
T
P
S
A
V
V
R
R
N
A
Site 121
S794
A
V
V
R
R
N
A
S
G
L
T
N
G
L
S
Site 122
S801
S
G
L
T
N
G
L
S
S
Q
E
R
P
K
S
Site 123
S802
G
L
T
N
G
L
S
S
Q
E
R
P
K
S
A
Site 124
S808
S
S
Q
E
R
P
K
S
A
V
F
P
G
E
G
Site 125
S820
G
E
G
K
V
K
M
S
V
E
E
Q
I
D
R
Site 126
S833
D
R
M
R
R
H
Q
S
G
S
M
R
E
K
R
Site 127
S835
M
R
R
H
Q
S
G
S
M
R
E
K
R
R
S
Site 128
S842
S
M
R
E
K
R
R
S
L
Q
L
P
A
S
P
Site 129
S848
R
S
L
Q
L
P
A
S
P
A
P
D
P
S
P
Site 130
S854
A
S
P
A
P
D
P
S
P
R
P
A
Y
K
V
Site 131
Y859
D
P
S
P
R
P
A
Y
K
V
V
R
R
H
R
Site 132
S867
K
V
V
R
R
H
R
S
I
H
E
V
D
I
S
Site 133
S874
S
I
H
E
V
D
I
S
N
L
E
A
A
L
R
Site 134
Y890
E
E
P
G
G
H
A
Y
E
T
P
R
E
E
I
Site 135
T892
P
G
G
H
A
Y
E
T
P
R
E
E
I
A
R
Site 136
Y910
M
E
L
E
P
Q
H
Y
D
V
D
I
N
K
E
Site 137
S919
V
D
I
N
K
E
L
S
T
P
D
K
V
L
I
Site 138
T920
D
I
N
K
E
L
S
T
P
D
K
V
L
I
P
Site 139
Y930
K
V
L
I
P
E
R
Y
I
D
L
E
P
D
T
Site 140
T937
Y
I
D
L
E
P
D
T
P
L
S
P
E
E
L
Site 141
S940
L
E
P
D
T
P
L
S
P
E
E
L
K
E
K
Site 142
T956
K
K
V
E
R
I
K
T
L
I
A
K
S
S
M
Site 143
S961
I
K
T
L
I
A
K
S
S
M
Q
N
V
V
P
Site 144
S974
V
P
I
G
E
G
D
S
V
D
V
P
Q
D
S
Site 145
S981
S
V
D
V
P
Q
D
S
E
S
Q
L
Q
E
Q
Site 146
S983
D
V
P
Q
D
S
E
S
Q
L
Q
E
Q
E
K
Site 147
S1003
C
A
L
A
T
E
A
S
R
R
G
R
M
L
S
Site 148
S1010
S
R
R
G
R
M
L
S
V
Q
C
A
T
P
S
Site 149
T1015
M
L
S
V
Q
C
A
T
P
S
P
P
T
S
P
Site 150
S1017
S
V
Q
C
A
T
P
S
P
P
T
S
P
A
S
Site 151
T1020
C
A
T
P
S
P
P
T
S
P
A
S
P
A
P
Site 152
S1021
A
T
P
S
P
P
T
S
P
A
S
P
A
P
P
Site 153
S1024
S
P
P
T
S
P
A
S
P
A
P
P
A
N
P
Site 154
S1033
A
P
P
A
N
P
L
S
S
E
S
P
R
G
A
Site 155
S1034
P
P
A
N
P
L
S
S
E
S
P
R
G
A
D
Site 156
S1036
A
N
P
L
S
S
E
S
P
R
G
A
D
S
S
Site 157
S1043
S
P
R
G
A
D
S
S
Y
T
M
R
V
_
_
Site 158
Y1044
P
R
G
A
D
S
S
Y
T
M
R
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation