PhosphoNET

           
Protein Info 
   
Short Name:  MAST1
Full Name:  Microtubule-associated serine,threonine-protein kinase 1
Alias:  EC 2.7.11.1; KIAA0973; Microtubule associated serine/threonine kinase 1; SAST
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; MAST family
Mass (Da):  170677
Number AA:  1570
UniProt ID:  Q9Y2H9
International Prot ID:  IPI00027883
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005856  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0000287  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0007010  GO:0006468  GO:0007243 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S10DSLWTALSNFSMPSF
Site 2S13WTALSNFSMPSFPGG
Site 3S21MPSFPGGSMFRRTKS
Site 4T26GGSMFRRTKSCRTSN
Site 5S28SMFRRTKSCRTSNRK
Site 6T31RRTKSCRTSNRKSLI
Site 7S32RTKSCRTSNRKSLIL
Site 8S36CRTSNRKSLILTSTS
Site 9T40NRKSLILTSTSPTLP
Site 10S41RKSLILTSTSPTLPR
Site 11T42KSLILTSTSPTLPRP
Site 12S43SLILTSTSPTLPRPH
Site 13T45ILTSTSPTLPRPHSP
Site 14S51PTLPRPHSPLPGHLG
Site 15S59PLPGHLGSSPLDSPR
Site 16S60LPGHLGSSPLDSPRN
Site 17S64LGSSPLDSPRNFSPN
Site 18S69LDSPRNFSPNTPAHF
Site 19T72PRNFSPNTPAHFSFA
Site 20S77PNTPAHFSFASSRRA
Site 21S80PAHFSFASSRRADGR
Site 22S81AHFSFASSRRADGRR
Site 23S90RADGRRWSLASLPSS
Site 24S93GRRWSLASLPSSGYG
Site 25S97SLASLPSSGYGTNTP
Site 26Y99ASLPSSGYGTNTPSS
Site 27T101LPSSGYGTNTPSSTV
Site 28T103SSGYGTNTPSSTVSS
Site 29S105GYGTNTPSSTVSSSC
Site 30S106YGTNTPSSTVSSSCS
Site 31T107GTNTPSSTVSSSCSS
Site 32S109NTPSSTVSSSCSSQE
Site 33S110TPSSTVSSSCSSQER
Site 34S111PSSTVSSSCSSQERL
Site 35S113STVSSSCSSQERLHQ
Site 36S114TVSSSCSSQERLHQL
Site 37Y123ERLHQLPYQPTVDEL
Site 38T126HQLPYQPTVDELHFL
Site 39S134VDELHFLSKHFGSTE
Site 40S139FLSKHFGSTESITDE
Site 41T140LSKHFGSTESITDED
Site 42S142KHFGSTESITDEDGG
Site 43T144FGSTESITDEDGGRR
Site 44S152DEDGGRRSPAVRPRS
Site 45S159SPAVRPRSRSLSPGR
Site 46S161AVRPRSRSLSPGRSP
Site 47S163RPRSRSLSPGRSPSS
Site 48S167RSLSPGRSPSSYDNE
Site 49S169LSPGRSPSSYDNEIV
Site 50S170SPGRSPSSYDNEIVM
Site 51Y171PGRSPSSYDNEIVMM
Site 52Y182IVMMNHVYKERFPKA
Site 53T201EEKLRDFTRAYEPDS
Site 54Y204LRDFTRAYEPDSVLP
Site 55S208TRAYEPDSVLPLADG
Site 56T233ELARDCLTKSRDGLI
Site 57S235ARDCLTKSRDGLITT
Site 58T241KSRDGLITTVYFYEL
Site 59T242SRDGLITTVYFYELQ
Site 60Y244DGLITTVYFYELQEN
Site 61Y260EKLLQDAYERSESLE
Site 62S265DAYERSESLEVAFVT
Site 63S283KKLLIIISRPARLLE
Site 64T318KEGHLVKTDIPRYII
Site 65Y323VKTDIPRYIIRQLGL
Site 66T331IIRQLGLTRDPFPDV
Site 67S346VHLEEQDSGGSNTPE
Site 68S349EEQDSGGSNTPEQDD
Site 69T351QDSGGSNTPEQDDLS
Site 70S358TPEQDDLSEGRSSKA
Site 71S362DDLSEGRSSKAKKPP
Site 72S363DLSEGRSSKAKKPPG
Site 73T376PGENDFDTIKLISNG
Site 74Y389NGAYGAVYLVRHRDT
Site 75T396YLVRHRDTRQRFAMK
Site 76Y487ETVLALEYLHNYGIV
Site 77Y491ALEYLHNYGIVHRDL
Site 78T514SMGHIKLTDFGLSKM
Site 79Y531MSLTTNLYEGHIEKD
Site 80T550LDKQVCGTPEYIAPE
Site 81Y564EVILRQGYGKPVDWW
Site 82T591CVPFFGDTPEELFGQ
Site 83T615EGDEALPTEAQLLIS
Site 84T653FFRDLDWTGLLRQKA
Site 85S668EFIPHLESEDDTSYF
Site 86T672HLESEDDTSYFDTRS
Site 87S673LESEDDTSYFDTRSD
Site 88Y674ESEDDTSYFDTRSDR
Site 89T677DDTSYFDTRSDRYHH
Site 90Y682FDTRSDRYHHVNSYD
Site 91S687DRYHHVNSYDEDDTT
Site 92Y688RYHHVNSYDEDDTTE
Site 93T693NSYDEDDTTEEEPVE
Site 94T694SYDEDDTTEEEPVEI
Site 95S705PVEIRQFSSCSPRFS
Site 96S706VEIRQFSSCSPRFSK
Site 97S708IRQFSSCSPRFSKVY
Site 98S712SSCSPRFSKVYSSME
Site 99Y715SPRFSKVYSSMEQLS
Site 100S716PRFSKVYSSMEQLSQ
Site 101S717RFSKVYSSMEQLSQH
Site 102S722YSSMEQLSQHEPKTP
Site 103T728LSQHEPKTPVAAAGS
Site 104S736PVAAAGSSKREPSTK
Site 105S741GSSKREPSTKGPEEK
Site 106T742SSKREPSTKGPEEKV
Site 107T760REGLGGLTLREKTWR
Site 108T765GLTLREKTWRGGSPE
Site 109S770EKTWRGGSPEIKRFS
Site 110S777SPEIKRFSASEASFL
Site 111S779EIKRFSASEASFLEG
Site 112S782RFSASEASFLEGEAS
Site 113S789SFLEGEASPPLGARR
Site 114S799LGARRRFSALLEPSR
Site 115S808LLEPSRFSAPQEDED
Site 116S826LRRPPRPSSDPAGSL
Site 117S827RRPPRPSSDPAGSLD
Site 118S832PSSDPAGSLDARAPK
Site 119S849TQGEGTSSAGDSEAT
Site 120S853GTSSAGDSEATDRPR
Site 121T856SAGDSEATDRPRPGD
Site 122S868PGDLCPPSKDGDASG
Site 123S874PSKDGDASGPRATND
Site 124T879DASGPRATNDLVLRR
Site 125S893RARHQQMSGDVAVEK
Site 126S903VAVEKRPSRTGGKVI
Site 127S930PAVDPHGSSPLASPM
Site 128S931AVDPHGSSPLASPMS
Site 129S935HGSSPLASPMSPRSL
Site 130S938SPLASPMSPRSLSSN
Site 131S941ASPMSPRSLSSNPSS
Site 132S943PMSPRSLSSNPSSRD
Site 133S944MSPRSLSSNPSSRDS
Site 134S947RSLSSNPSSRDSSPS
Site 135S948SLSSNPSSRDSSPSR
Site 136S951SNPSSRDSSPSRDYS
Site 137S952NPSSRDSSPSRDYSP
Site 138S954SSRDSSPSRDYSPAV
Site 139Y957DSSPSRDYSPAVSGL
Site 140S958SSPSRDYSPAVSGLR
Site 141S962RDYSPAVSGLRSPIT
Site 142S966PAVSGLRSPITIQRS
Site 143T969SGLRSPITIQRSGKK
Site 144S973SPITIQRSGKKYGFT
Site 145Y977IQRSGKKYGFTLRAI
Site 146T980SGKKYGFTLRAIRVY
Site 147Y987TLRAIRVYMGDTDVY
Site 148Y994YMGDTDVYSVHHIVW
Site 149T1050SGNKVAVTTTPFENT
Site 150T1052NKVAVTTTPFENTSI
Site 151S1058TTPFENTSIRIGPAR
Site 152S1067RIGPARRSSYKAKMA
Site 153S1068IGPARRSSYKAKMAR
Site 154Y1069GPARRSSYKAKMARR
Site 155S1081ARRNKRPSAKEGQES
Site 156S1088SAKEGQESKKRSSLF
Site 157S1092GQESKKRSSLFRKIT
Site 158S1093QESKKRSSLFRKITK
Site 159T1099SSLFRKITKQSNLLH
Site 160S1102FRKITKQSNLLHTSR
Site 161T1107KQSNLLHTSRSLSSL
Site 162S1108QSNLLHTSRSLSSLN
Site 163S1110NLLHTSRSLSSLNRS
Site 164S1112LHTSRSLSSLNRSLS
Site 165S1113HTSRSLSSLNRSLSS
Site 166S1117SLSSLNRSLSSSDSL
Site 167S1119SSLNRSLSSSDSLPG
Site 168S1120SLNRSLSSSDSLPGS
Site 169S1121LNRSLSSSDSLPGSP
Site 170S1123RSLSSSDSLPGSPTH
Site 171S1127SSDSLPGSPTHGLPA
Site 172S1136THGLPARSPTHSYRS
Site 173T1138GLPARSPTHSYRSTP
Site 174S1140PARSPTHSYRSTPDS
Site 175S1143SPTHSYRSTPDSAYL
Site 176T1144PTHSYRSTPDSAYLG
Site 177S1147SYRSTPDSAYLGASS
Site 178Y1149RSTPDSAYLGASSQS
Site 179S1153DSAYLGASSQSSSPA
Site 180S1154SAYLGASSQSSSPAS
Site 181S1156YLGASSQSSSPASST
Site 182S1157LGASSQSSSPASSTP
Site 183S1158GASSQSSSPASSTPN
Site 184S1161SQSSSPASSTPNSPA
Site 185S1162QSSSPASSTPNSPAS
Site 186T1163SSSPASSTPNSPASS
Site 187S1166PASSTPNSPASSASH
Site 188S1169STPNSPASSASHHIR
Site 189S1170TPNSPASSASHHIRP
Site 190S1172NSPASSASHHIRPST
Site 191S1178ASHHIRPSTLHGLSP
Site 192T1179SHHIRPSTLHGLSPK
Site 193S1184PSTLHGLSPKLHRQY
Site 194Y1191SPKLHRQYRSARCKS
Site 195S1193KLHRQYRSARCKSAG
Site 196S1198YRSARCKSAGNIPLS
Site 197S1205SAGNIPLSPLAHTPS
Site 198T1210PLSPLAHTPSPTQAS
Site 199S1212SPLAHTPSPTQASPP
Site 200T1214LAHTPSPTQASPPPL
Site 201S1217TPSPTQASPPPLPGH
Site 202T1225PPPLPGHTVGSSHTT
Site 203S1228LPGHTVGSSHTTQSF
Site 204S1229PGHTVGSSHTTQSFP
Site 205T1232TVGSSHTTQSFPAKL
Site 206S1234GSSHTTQSFPAKLHS
Site 207S1241SFPAKLHSSPPVVRP
Site 208S1242FPAKLHSSPPVVRPR
Site 209S1252VVRPRPKSAEPPRSP
Site 210S1258KSAEPPRSPLLKRVQ
Site 211S1266PLLKRVQSAEKLGAS
Site 212S1273SAEKLGASLSADKKG
Site 213S1275EKLGASLSADKKGAL
Site 214S1286KGALRKHSLEVGHPD
Site 215S1306HGELALHSLAESDGE
Site 216S1310ALHSLAESDGETPPV
Site 217T1314LAESDGETPPVEGLG
Site 218S1336RRLGRQESPLSLGAD
Site 219S1339GRQESPLSLGADPLL
Site 220S1351PLLPEGASRPPVSSK
Site 221S1356GASRPPVSSKEKESP
Site 222S1357ASRPPVSSKEKESPG
Site 223S1362VSSKEKESPGGAEAC
Site 224T1370PGGAEACTPPRATTP
Site 225T1375ACTPPRATTPGGRTL
Site 226T1376CTPPRATTPGGRTLE
Site 227T1389LERDVGCTRHQSVQT
Site 228S1393VGCTRHQSVQTEDGT
Site 229S1413AVAKAALSPVQEHET
Site 230T1420SPVQEHETGRRSSSG
Site 231S1424EHETGRRSSSGEAGT
Site 232S1425HETGRRSSSGEAGTP
Site 233S1426ETGRRSSSGEAGTPL
Site 234T1431SSSGEAGTPLVPIVV
Site 235S1457PQPLGADSKGLQEPA
Site 236S1469EPAPLAPSVPEAPRG
Site 237T1490EVVEERTTLSGPRSK
Site 238S1492VEERTTLSGPRSKPA
Site 239S1496TTLSGPRSKPASPKL
Site 240S1500GPRSKPASPKLSPEP
Site 241S1504KPASPKLSPEPQTPS
Site 242T1509KLSPEPQTPSLAPAK
Site 243S1511SPEPQTPSLAPAKCS
Site 244S1521PAKCSAPSSAVTPVP
Site 245S1522AKCSAPSSAVTPVPP
Site 246S1535PPASLLGSGTKPQVG
Site 247T1558AVPPAGLTKKGVSSP
Site 248S1563GLTKKGVSSPAPPGP
Site 249S1564LTKKGVSSPAPPGP_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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