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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NISCH
Full Name:
Nischarin
Alias:
I-1; I-1 receptor; I-1 receptor candidate protein; Imidazoline receptor; Imidazoline receptor 1; Imidazoline receptor antisera selected; Imidazoline receptor antisera-selected protein; Imidazoline receptor candidate; Imidazoline-1 receptor; Imidazoline-1 receptor candidate protein; IRAS; KIAA0975
Type:
Receptor, misc.
Mass (Da):
166643
Number AA:
1504
UniProt ID:
Q9Y2I1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005769
GO:0005886
GO:0055037
Uniprot
OncoNet
Molecular Function:
GO:0035091
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
T
A
R
T
F
G
P
E
R
E
A
Site 2
T45
T
D
G
S
H
E
W
T
V
K
H
R
Y
S
D
Site 3
S83
I
I
G
K
N
S
R
S
L
V
E
K
R
E
K
Site 4
Y95
R
E
K
D
L
E
V
Y
L
Q
K
L
L
A
A
Site 5
T175
C
A
S
G
D
A
K
T
D
L
G
H
I
L
D
Site 6
Y189
D
F
T
C
R
L
K
Y
L
K
V
S
G
T
E
Site 7
T195
K
Y
L
K
V
S
G
T
E
G
P
F
G
T
S
Site 8
S263
E
V
L
V
P
E
A
S
E
F
D
E
W
E
P
Site 9
T273
D
E
W
E
P
E
G
T
T
L
E
G
P
V
T
Site 10
T290
I
P
T
W
Q
A
L
T
T
L
D
L
S
H
N
Site 11
T291
P
T
W
Q
A
L
T
T
L
D
L
S
H
N
S
Site 12
S298
T
L
D
L
S
H
N
S
I
S
E
I
D
E
S
Site 13
S300
D
L
S
H
N
S
I
S
E
I
D
E
S
V
K
Site 14
S340
N
L
V
H
L
D
L
S
Y
N
K
L
S
S
L
Site 15
Y341
L
V
H
L
D
L
S
Y
N
K
L
S
S
L
E
Site 16
S346
L
S
Y
N
K
L
S
S
L
E
G
L
H
T
K
Site 17
T352
S
S
L
E
G
L
H
T
K
L
G
N
I
K
T
Site 18
S371
G
N
L
L
E
S
L
S
G
L
H
K
L
Y
S
Site 19
S378
S
G
L
H
K
L
Y
S
L
V
N
L
D
L
R
Site 20
S397
E
Q
M
E
E
V
R
S
I
G
S
L
P
C
L
Site 21
S400
E
E
V
R
S
I
G
S
L
P
C
L
E
H
V
Site 22
S415
S
L
L
N
N
P
L
S
I
I
P
D
Y
R
T
Site 23
Y420
P
L
S
I
I
P
D
Y
R
T
K
V
L
A
Q
Site 24
S433
A
Q
F
G
E
R
A
S
E
V
C
L
D
D
T
Site 25
T440
S
E
V
C
L
D
D
T
V
T
T
E
K
E
L
Site 26
T442
V
C
L
D
D
T
V
T
T
E
K
E
L
D
T
Site 27
T449
T
T
E
K
E
L
D
T
V
E
V
L
K
A
I
Site 28
S464
Q
K
A
K
E
V
K
S
K
L
S
N
P
E
K
Site 29
S467
K
E
V
K
S
K
L
S
N
P
E
K
K
G
G
Site 30
S477
E
K
K
G
G
E
D
S
R
L
S
A
A
P
C
Site 31
S480
G
G
E
D
S
R
L
S
A
A
P
C
I
R
P
Site 32
S488
A
A
P
C
I
R
P
S
S
S
P
P
T
V
A
Site 33
S489
A
P
C
I
R
P
S
S
S
P
P
T
V
A
P
Site 34
S490
P
C
I
R
P
S
S
S
P
P
T
V
A
P
A
Site 35
T493
R
P
S
S
S
P
P
T
V
A
P
A
S
A
S
Site 36
S521
V
Q
E
E
A
L
A
S
S
L
S
S
T
D
S
Site 37
S522
Q
E
E
A
L
A
S
S
L
S
S
T
D
S
L
Site 38
S524
E
A
L
A
S
S
L
S
S
T
D
S
L
T
P
Site 39
S525
A
L
A
S
S
L
S
S
T
D
S
L
T
P
E
Site 40
T526
L
A
S
S
L
S
S
T
D
S
L
T
P
E
H
Site 41
S528
S
S
L
S
S
T
D
S
L
T
P
E
H
Q
P
Site 42
T530
L
S
S
T
D
S
L
T
P
E
H
Q
P
I
A
Site 43
S541
Q
P
I
A
Q
G
C
S
D
S
L
E
S
I
P
Site 44
S543
I
A
Q
G
C
S
D
S
L
E
S
I
P
A
G
Site 45
S546
G
C
S
D
S
L
E
S
I
P
A
G
Q
A
A
Site 46
S568
P
G
A
V
G
G
A
S
P
E
H
A
E
P
E
Site 47
S607
Q
D
F
I
Q
R
L
S
T
L
I
R
Q
A
I
Site 48
T608
D
F
I
Q
R
L
S
T
L
I
R
Q
A
I
E
Site 49
Y654
E
D
V
A
E
N
R
Y
F
E
M
G
P
P
D
Site 50
S746
F
E
I
P
H
Q
E
S
R
G
S
S
Q
H
I
Site 51
S749
P
H
Q
E
S
R
G
S
S
Q
H
I
L
S
S
Site 52
S750
H
Q
E
S
R
G
S
S
Q
H
I
L
S
S
L
Site 53
T790
K
V
R
H
S
E
N
T
L
F
I
I
S
D
A
Site 54
S795
E
N
T
L
F
I
I
S
D
A
A
N
L
H
E
Site 55
S827
C
S
P
I
L
Y
G
S
H
T
S
L
Q
E
F
Site 56
S830
I
L
Y
G
S
H
T
S
L
Q
E
F
L
R
Q
Site 57
Y859
S
Q
G
C
F
P
V
Y
L
V
Y
S
D
K
R
Site 58
Y875
V
Q
T
A
A
G
D
Y
S
G
N
I
E
W
A
Site 59
S876
Q
T
A
A
G
D
Y
S
G
N
I
E
W
A
S
Site 60
S883
S
G
N
I
E
W
A
S
C
T
L
C
S
A
V
Site 61
T885
N
I
E
W
A
S
C
T
L
C
S
A
V
R
R
Site 62
S898
R
R
S
C
C
A
P
S
E
A
V
K
S
A
A
Site 63
S940
H
N
C
R
N
R
N
S
F
K
L
S
R
V
P
Site 64
S944
N
R
N
S
F
K
L
S
R
V
P
L
S
T
V
Site 65
T956
S
T
V
L
L
D
P
T
R
S
C
T
Q
P
R
Site 66
T960
L
D
P
T
R
S
C
T
Q
P
R
G
A
F
A
Site 67
Y998
K
F
H
F
L
R
V
Y
N
Q
L
R
A
S
L
Site 68
S1004
V
Y
N
Q
L
R
A
S
L
Q
D
L
K
T
V
Site 69
T1016
K
T
V
V
I
A
K
T
P
G
T
G
G
S
P
Site 70
S1022
K
T
P
G
T
G
G
S
P
Q
G
S
F
A
D
Site 71
S1026
T
G
G
S
P
Q
G
S
F
A
D
G
Q
P
A
Site 72
S1038
Q
P
A
E
R
R
A
S
N
D
Q
R
P
Q
E
Site 73
S1069
A
P
A
A
A
S
A
S
G
P
A
K
T
P
A
Site 74
T1074
S
A
S
G
P
A
K
T
P
A
P
A
E
A
S
Site 75
S1083
A
P
A
E
A
S
T
S
A
L
V
P
E
E
T
Site 76
T1090
S
A
L
V
P
E
E
T
P
V
E
A
P
A
P
Site 77
Y1106
P
A
E
A
P
A
Q
Y
P
S
E
H
L
I
Q
Site 78
S1116
E
H
L
I
Q
A
T
S
E
E
N
Q
I
P
S
Site 79
S1123
S
E
E
N
Q
I
P
S
H
L
P
A
C
P
S
Site 80
Y1198
L
H
D
G
L
R
R
Y
F
S
E
P
L
Q
D
Site 81
S1200
D
G
L
R
R
Y
F
S
E
P
L
Q
D
F
W
Site 82
T1247
F
D
Q
H
F
R
L
T
G
S
T
P
M
Q
V
Site 83
Y1263
T
C
L
T
R
D
S
Y
L
T
H
C
F
L
Q
Site 84
T1265
L
T
R
D
S
Y
L
T
H
C
F
L
Q
H
L
Site 85
S1277
Q
H
L
M
V
V
L
S
S
L
E
R
T
P
S
Site 86
T1282
V
L
S
S
L
E
R
T
P
S
P
E
P
V
D
Site 87
S1284
S
S
L
E
R
T
P
S
P
E
P
V
D
K
D
Site 88
Y1293
E
P
V
D
K
D
F
Y
S
E
F
G
N
K
T
Site 89
S1294
P
V
D
K
D
F
Y
S
E
F
G
N
K
T
T
Site 90
Y1307
T
T
G
K
M
E
N
Y
E
L
I
H
S
S
R
Site 91
S1312
E
N
Y
E
L
I
H
S
S
R
V
K
F
T
Y
Site 92
Y1319
S
S
R
V
K
F
T
Y
P
S
E
E
E
I
G
Site 93
S1321
R
V
K
F
T
Y
P
S
E
E
E
I
G
D
L
Site 94
T1329
E
E
E
I
G
D
L
T
F
T
V
A
Q
K
M
Site 95
T1372
R
G
P
L
R
P
K
T
L
L
L
T
S
S
E
Site 96
Y1390
L
D
E
D
C
V
H
Y
P
L
P
E
F
A
K
Site 97
Y1405
E
P
P
Q
R
D
R
Y
R
L
D
D
G
R
R
Site 98
Y1423
L
D
R
V
L
M
G
Y
Q
T
Y
P
Q
A
L
Site 99
S1445
Q
G
H
D
L
M
G
S
V
T
L
D
H
F
G
Site 100
S1462
P
G
G
P
A
R
A
S
Q
G
R
E
V
Q
W
Site 101
S1484
E
S
R
E
K
L
I
S
L
L
A
R
Q
W
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation