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Updated November 2019
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Protein Info
Short Name:
R3HDM2
Full Name:
R3H domain-containing protein 2
Alias:
KIAA1002; R3H domain containing 2; R3h domain-containing protein 2; R3hd2
Type:
RNA binding protein
Mass (Da):
106999
Number AA:
976
UniProt ID:
Q9Y2K5
International Prot ID:
IPI00396041
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
V
N
K
N
K
F
I
S
K
T
P
S
K
E
E
Site 2
T35
K
N
K
F
I
S
K
T
P
S
K
E
E
I
E
Site 3
S37
K
F
I
S
K
T
P
S
K
E
E
I
E
K
E
Site 4
T48
I
E
K
E
C
E
D
T
S
L
R
Q
E
T
Q
Site 5
S49
E
K
E
C
E
D
T
S
L
R
Q
E
T
Q
R
Site 6
T54
D
T
S
L
R
Q
E
T
Q
R
R
T
S
N
H
Site 7
T58
R
Q
E
T
Q
R
R
T
S
N
H
G
H
A
R
Site 8
S59
Q
E
T
Q
R
R
T
S
N
H
G
H
A
R
K
Site 9
S70
H
A
R
K
R
A
K
S
N
S
K
L
K
L
V
Site 10
S72
R
K
R
A
K
S
N
S
K
L
K
L
V
R
S
Site 11
S79
S
K
L
K
L
V
R
S
L
A
V
C
E
E
S
Site 12
S86
S
L
A
V
C
E
E
S
S
T
P
F
A
D
G
Site 13
T88
A
V
C
E
E
S
S
T
P
F
A
D
G
P
L
Site 14
S116
S
D
K
E
E
E
K
S
T
K
D
V
S
E
K
Site 15
T117
D
K
E
E
E
K
S
T
K
D
V
S
E
K
E
Site 16
S139
K
I
P
R
K
M
L
S
R
D
S
S
Q
E
Y
Site 17
S142
R
K
M
L
S
R
D
S
S
Q
E
Y
T
D
S
Site 18
S143
K
M
L
S
R
D
S
S
Q
E
Y
T
D
S
T
Site 19
Y146
S
R
D
S
S
Q
E
Y
T
D
S
T
G
I
D
Site 20
T147
R
D
S
S
Q
E
Y
T
D
S
T
G
I
D
L
Site 21
S149
S
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
Site 22
T150
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
F
Site 23
T161
L
H
E
F
L
V
N
T
L
K
K
N
P
R
D
Site 24
Y199
K
F
P
Q
M
T
S
Y
H
R
M
L
L
H
R
Site 25
S230
A
V
I
I
N
K
T
S
N
T
R
I
P
E
Q
Site 26
S240
R
I
P
E
Q
R
F
S
E
H
I
K
D
E
K
Site 27
S263
I
L
K
R
D
D
A
S
M
D
R
D
D
N
Q
Site 28
T271
M
D
R
D
D
N
Q
T
G
Q
N
G
Y
L
N
Site 29
S283
Y
L
N
D
I
R
L
S
K
E
A
F
S
S
S
Site 30
S288
R
L
S
K
E
A
F
S
S
S
S
H
K
R
R
Site 31
S289
L
S
K
E
A
F
S
S
S
S
H
K
R
R
Q
Site 32
S290
S
K
E
A
F
S
S
S
S
H
K
R
R
Q
I
Site 33
S291
K
E
A
F
S
S
S
S
H
K
R
R
Q
I
F
Site 34
S306
R
G
N
R
E
G
L
S
R
T
S
S
S
R
Q
Site 35
S309
R
E
G
L
S
R
T
S
S
S
R
Q
S
S
T
Site 36
S310
E
G
L
S
R
T
S
S
S
R
Q
S
S
T
D
Site 37
S311
G
L
S
R
T
S
S
S
R
Q
S
S
T
D
S
Site 38
S314
R
T
S
S
S
R
Q
S
S
T
D
S
E
L
K
Site 39
S315
T
S
S
S
R
Q
S
S
T
D
S
E
L
K
S
Site 40
T316
S
S
S
R
Q
S
S
T
D
S
E
L
K
S
L
Site 41
S318
S
R
Q
S
S
T
D
S
E
L
K
S
L
E
P
Site 42
S322
S
T
D
S
E
L
K
S
L
E
P
R
P
W
S
Site 43
S329
S
L
E
P
R
P
W
S
S
T
D
S
D
G
S
Site 44
S330
L
E
P
R
P
W
S
S
T
D
S
D
G
S
V
Site 45
T331
E
P
R
P
W
S
S
T
D
S
D
G
S
V
R
Site 46
S333
R
P
W
S
S
T
D
S
D
G
S
V
R
S
M
Site 47
S336
S
S
T
D
S
D
G
S
V
R
S
M
R
P
P
Site 48
S339
D
S
D
G
S
V
R
S
M
R
P
P
V
T
K
Site 49
T345
R
S
M
R
P
P
V
T
K
A
S
S
F
S
G
Site 50
S348
R
P
P
V
T
K
A
S
S
F
S
G
I
S
I
Site 51
S349
P
P
V
T
K
A
S
S
F
S
G
I
S
I
L
Site 52
S351
V
T
K
A
S
S
F
S
G
I
S
I
L
T
R
Site 53
S361
S
I
L
T
R
G
D
S
I
G
S
S
K
G
G
Site 54
S364
T
R
G
D
S
I
G
S
S
K
G
G
S
A
G
Site 55
S365
R
G
D
S
I
G
S
S
K
G
G
S
A
G
R
Site 56
S369
I
G
S
S
K
G
G
S
A
G
R
I
S
R
P
Site 57
S374
G
G
S
A
G
R
I
S
R
P
G
M
A
L
G
Site 58
T390
P
E
V
C
N
Q
V
T
S
S
Q
S
V
R
G
Site 59
S394
N
Q
V
T
S
S
Q
S
V
R
G
L
L
P
C
Site 60
T420
Q
L
P
A
L
P
P
T
P
Q
Q
Q
P
P
L
Site 61
S433
P
L
N
N
H
M
I
S
Q
A
D
D
L
S
N
Site 62
S439
M
S
L
S
R
Q
G
S
T
E
A
A
D
P
S
Site 63
S446
S
N
P
F
G
Q
M
S
L
S
R
Q
G
S
T
Site 64
S448
P
F
G
Q
M
S
L
S
R
Q
G
S
T
E
A
Site 65
S452
M
S
L
S
R
Q
G
S
T
E
A
A
D
P
S
Site 66
T453
S
L
S
R
Q
G
S
T
E
A
A
D
P
S
A
Site 67
S459
S
T
E
A
A
D
P
S
A
A
L
F
Q
T
P
Site 68
T465
P
S
A
A
L
F
Q
T
P
L
I
S
Q
H
P
Site 69
S469
L
F
Q
T
P
L
I
S
Q
H
P
Q
Q
T
S
Site 70
S476
S
Q
H
P
Q
Q
T
S
F
I
M
A
S
T
G
Site 71
T488
S
T
G
Q
P
L
P
T
S
N
Y
S
T
S
S
Site 72
S489
T
G
Q
P
L
P
T
S
N
Y
S
T
S
S
H
Site 73
Y491
Q
P
L
P
T
S
N
Y
S
T
S
S
H
A
P
Site 74
S492
P
L
P
T
S
N
Y
S
T
S
S
H
A
P
P
Site 75
T493
L
P
T
S
N
Y
S
T
S
S
H
A
P
P
T
Site 76
S495
T
S
N
Y
S
T
S
S
H
A
P
P
T
Q
Q
Site 77
T500
T
S
S
H
A
P
P
T
Q
Q
V
L
P
P
Q
Site 78
Y509
Q
V
L
P
P
Q
G
Y
M
Q
P
P
Q
Q
I
Site 79
S519
P
P
Q
Q
I
Q
V
S
Y
Y
P
P
G
Q
Y
Site 80
Y520
P
Q
Q
I
Q
V
S
Y
Y
P
P
G
Q
Y
P
Site 81
Y521
Q
Q
I
Q
V
S
Y
Y
P
P
G
Q
Y
P
N
Site 82
Y526
S
Y
Y
P
P
G
Q
Y
P
N
S
N
Q
Q
Y
Site 83
S529
P
P
G
Q
Y
P
N
S
N
Q
Q
Y
R
P
L
Site 84
Y533
Y
P
N
S
N
Q
Q
Y
R
P
L
S
H
P
V
Site 85
S537
N
Q
Q
Y
R
P
L
S
H
P
V
A
Y
S
P
Site 86
S543
L
S
H
P
V
A
Y
S
P
Q
R
G
Q
Q
L
Site 87
S554
G
Q
Q
L
P
Q
P
S
Q
Q
P
G
L
Q
P
Site 88
Y571
P
N
Q
Q
Q
A
A
Y
Q
G
M
I
G
V
Q
Site 89
S587
P
Q
N
Q
G
L
L
S
S
Q
R
S
S
M
G
Site 90
S588
Q
N
Q
G
L
L
S
S
Q
R
S
S
M
G
G
Site 91
S591
G
L
L
S
S
Q
R
S
S
M
G
G
Q
M
Q
Site 92
S592
L
L
S
S
Q
R
S
S
M
G
G
Q
M
Q
G
Site 93
S609
V
Q
Y
T
P
L
P
S
Y
Q
V
P
V
G
S
Site 94
Y610
Q
Y
T
P
L
P
S
Y
Q
V
P
V
G
S
D
Site 95
S618
Q
V
P
V
G
S
D
S
Q
N
V
V
Q
P
P
Site 96
S663
P
A
Q
Q
N
G
T
S
P
S
V
G
F
L
Q
Site 97
S665
Q
Q
N
G
T
S
P
S
V
G
F
L
Q
P
P
Site 98
S674
G
F
L
Q
P
P
G
S
E
Q
Y
Q
M
P
Q
Site 99
Y677
Q
P
P
G
S
E
Q
Y
Q
M
P
Q
S
P
S
Site 100
S682
E
Q
Y
Q
M
P
Q
S
P
S
P
C
S
P
P
Site 101
S684
Y
Q
M
P
Q
S
P
S
P
C
S
P
P
Q
M
Site 102
S687
P
Q
S
P
S
P
C
S
P
P
Q
M
P
Q
Q
Site 103
Y695
P
P
Q
M
P
Q
Q
Y
S
G
V
S
P
S
G
Site 104
S696
P
Q
M
P
Q
Q
Y
S
G
V
S
P
S
G
P
Site 105
S699
P
Q
Q
Y
S
G
V
S
P
S
G
P
G
V
V
Site 106
Y746
G
Q
K
P
G
D
L
Y
S
P
D
S
S
P
Q
Site 107
S747
Q
K
P
G
D
L
Y
S
P
D
S
S
P
Q
A
Site 108
S750
G
D
L
Y
S
P
D
S
S
P
Q
A
N
T
Q
Site 109
S751
D
L
Y
S
P
D
S
S
P
Q
A
N
T
Q
M
Site 110
T756
D
S
S
P
Q
A
N
T
Q
M
S
S
S
P
V
Site 111
S759
P
Q
A
N
T
Q
M
S
S
S
P
V
T
S
P
Site 112
S760
Q
A
N
T
Q
M
S
S
S
P
V
T
S
P
T
Site 113
S761
A
N
T
Q
M
S
S
S
P
V
T
S
P
T
Q
Site 114
T764
Q
M
S
S
S
P
V
T
S
P
T
Q
S
P
A
Site 115
S765
M
S
S
S
P
V
T
S
P
T
Q
S
P
A
P
Site 116
T767
S
S
P
V
T
S
P
T
Q
S
P
A
P
S
P
Site 117
S769
P
V
T
S
P
T
Q
S
P
A
P
S
P
V
T
Site 118
S773
P
T
Q
S
P
A
P
S
P
V
T
S
L
S
S
Site 119
Y807
P
A
Q
G
D
G
R
Y
S
L
L
G
Q
P
L
Site 120
S808
A
Q
G
D
G
R
Y
S
L
L
G
Q
P
L
Q
Site 121
S829
P
P
L
L
H
G
Q
S
T
Y
T
V
H
Q
G
Site 122
Y831
L
L
H
G
Q
S
T
Y
T
V
H
Q
G
Q
S
Site 123
T832
L
H
G
Q
S
T
Y
T
V
H
Q
G
Q
S
G
Site 124
S853
G
K
R
Q
A
L
K
S
A
S
T
D
L
G
T
Site 125
S855
R
Q
A
L
K
S
A
S
T
D
L
G
T
A
D
Site 126
T856
Q
A
L
K
S
A
S
T
D
L
G
T
A
D
V
Site 127
S915
G
G
G
G
G
D
N
S
G
T
A
E
N
G
R
Site 128
T917
G
G
G
D
N
S
G
T
A
E
N
G
R
H
S
Site 129
S924
T
A
E
N
G
R
H
S
D
L
A
A
L
Y
T
Site 130
Y930
H
S
D
L
A
A
L
Y
T
I
V
A
V
F
P
Site 131
S946
P
L
A
A
Q
N
A
S
L
R
L
N
N
S
V
Site 132
S952
A
S
L
R
L
N
N
S
V
S
R
F
K
L
R
Site 133
S954
L
R
L
N
N
S
V
S
R
F
K
L
R
M
A
Site 134
Y965
L
R
M
A
K
K
N
Y
D
L
R
I
L
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation