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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXL11
Full Name:
JmjC domain-containing histone demethylation protein 1A
Alias:
CXXC8; DKFZP434M1735; FBL11; FBL7; F-box and leucine-rich repeat 11; F-box protein FBL11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; Fbxl11; FLJ00115; JHD1A; JHDM1A; Jumonji C domain-containing histone demethylase 1A; KIAA1004; LILINA; Lysine (K)-specific demethylase 2A; Lysine-specific demethylase 2A: JmjC domain-containing histone demethylation protein 1A: [Histone-H3]-lysine-36 demethylase 1A: F-box/LRR-repeat protein 11: F-box and leucine-rich repeat protein 11: F-box protein FBL7: F-box protein Lilina: CXXC-type zinc finger protein 8: Lysine-specific demethylase 2A: JmjC domain-containing histone demethylation protein 1A: [Histone-H3]-lysine-36 demethylase 1A: F-box/LRR-repeat protein 11: F-box and leucine-rich repeat protein 11: F-box protein FBL7: F-box protein Lilina: CXXC-type zinc finger protein 8
Type:
Oxidoreductase; EC 1.14.11.27; Demethylase
Mass (Da):
132793
Number AA:
1162
UniProt ID:
Q9Y2K7
International Prot ID:
IPI00166009
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0051864
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0019941
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
P
E
E
E
R
I
R
Y
S
Q
R
L
R
G
T
Site 2
S11
E
E
E
R
I
R
Y
S
Q
R
L
R
G
T
M
Site 3
T17
Y
S
Q
R
L
R
G
T
M
R
R
R
Y
E
D
Site 4
Y22
R
G
T
M
R
R
R
Y
E
D
D
G
I
S
D
Site 5
S28
R
Y
E
D
D
G
I
S
D
D
E
I
E
G
K
Site 6
T37
D
E
I
E
G
K
R
T
F
D
L
E
E
K
L
Site 7
T46
D
L
E
E
K
L
H
T
N
K
Y
N
A
N
F
Site 8
Y49
E
K
L
H
T
N
K
Y
N
A
N
F
V
T
F
Site 9
Y66
G
K
D
F
N
V
E
Y
I
Q
R
G
G
L
R
Site 10
T94
K
M
P
D
P
D
F
T
V
N
D
V
K
M
C
Site 11
Y130
M
A
Q
W
T
R
Y
Y
E
T
P
E
E
E
R
Site 12
T132
Q
W
T
R
Y
Y
E
T
P
E
E
E
R
E
K
Site 13
Y141
E
E
E
R
E
K
L
Y
N
V
I
S
L
E
F
Site 14
S145
E
K
L
Y
N
V
I
S
L
E
F
S
H
T
R
Site 15
S149
N
V
I
S
L
E
F
S
H
T
R
L
E
N
M
Site 16
T151
I
S
L
E
F
S
H
T
R
L
E
N
M
V
Q
Site 17
T162
N
M
V
Q
R
P
S
T
V
D
F
I
D
W
V
Site 18
S180
W
P
R
H
L
K
E
S
Q
T
E
S
T
N
A
Site 19
T182
R
H
L
K
E
S
Q
T
E
S
T
N
A
I
L
Site 20
S184
L
K
E
S
Q
T
E
S
T
N
A
I
L
E
M
Site 21
Y193
N
A
I
L
E
M
Q
Y
P
K
V
Q
K
Y
C
Site 22
Y199
Q
Y
P
K
V
Q
K
Y
C
L
M
S
V
R
G
Site 23
Y222
F
G
G
T
S
V
W
Y
H
I
H
Q
G
G
K
Site 24
Y244
T
A
H
N
L
E
L
Y
E
N
W
L
L
S
G
Site 25
Y274
R
I
E
L
K
Q
G
Y
T
F
V
I
P
S
G
Site 26
T318
I
Y
N
I
E
D
R
T
R
V
P
N
K
F
R
Site 27
Y342
Y
V
L
E
R
Y
V
Y
C
I
T
N
R
S
H
Site 28
S358
T
K
E
F
Q
K
E
S
L
S
M
D
L
E
L
Site 29
S360
E
F
Q
K
E
S
L
S
M
D
L
E
L
N
G
Site 30
S386
D
R
E
P
R
R
L
S
S
R
R
S
V
L
T
Site 31
S387
R
E
P
R
R
L
S
S
R
R
S
V
L
T
S
Site 32
S390
R
R
L
S
S
R
R
S
V
L
T
S
P
V
A
Site 33
T393
S
S
R
R
S
V
L
T
S
P
V
A
N
G
V
Site 34
S394
S
R
R
S
V
L
T
S
P
V
A
N
G
V
N
Site 35
Y404
A
N
G
V
N
L
D
Y
D
G
L
G
K
T
C
Site 36
T410
D
Y
D
G
L
G
K
T
C
R
S
L
P
S
L
Site 37
S413
G
L
G
K
T
C
R
S
L
P
S
L
K
K
T
Site 38
S416
K
T
C
R
S
L
P
S
L
K
K
T
L
A
G
Site 39
T420
S
L
P
S
L
K
K
T
L
A
G
D
S
S
S
Site 40
S425
K
K
T
L
A
G
D
S
S
S
D
C
S
R
G
Site 41
S426
K
T
L
A
G
D
S
S
S
D
C
S
R
G
S
Site 42
S427
T
L
A
G
D
S
S
S
D
C
S
R
G
S
H
Site 43
S430
G
D
S
S
S
D
C
S
R
G
S
H
N
G
Q
Site 44
S433
S
S
D
C
S
R
G
S
H
N
G
Q
V
W
D
Site 45
T454
K
D
R
Q
V
H
L
T
H
F
E
L
E
G
L
Site 46
T534
R
P
K
V
R
V
P
T
I
P
I
T
K
P
H
Site 47
T538
R
V
P
T
I
P
I
T
K
P
H
T
M
K
P
Site 48
T542
I
P
I
T
K
P
H
T
M
K
P
A
P
R
L
Site 49
T550
M
K
P
A
P
R
L
T
P
V
R
P
A
A
A
Site 50
S558
P
V
R
P
A
A
A
S
P
I
V
S
G
A
R
Site 51
S562
A
A
A
S
P
I
V
S
G
A
R
R
R
R
V
Site 52
T632
E
V
D
Q
N
E
E
T
Q
D
F
E
K
K
L
Site 53
Y676
C
W
E
C
P
K
C
Y
Q
E
D
S
S
E
K
Site 54
S681
K
C
Y
Q
E
D
S
S
E
K
A
Q
K
R
K
Site 55
S692
Q
K
R
K
M
E
E
S
D
E
E
A
V
Q
A
Site 56
S707
K
V
L
R
P
L
R
S
C
D
E
P
L
T
P
Site 57
T713
R
S
C
D
E
P
L
T
P
P
P
H
S
P
T
Site 58
S718
P
L
T
P
P
P
H
S
P
T
S
M
L
Q
L
Site 59
T720
T
P
P
P
H
S
P
T
S
M
L
Q
L
I
H
Site 60
S721
P
P
P
H
S
P
T
S
M
L
Q
L
I
H
D
Site 61
S731
Q
L
I
H
D
P
V
S
P
R
G
M
V
T
R
Site 62
T737
V
S
P
R
G
M
V
T
R
S
S
P
G
A
G
Site 63
S739
P
R
G
M
V
T
R
S
S
P
G
A
G
P
S
Site 64
S740
R
G
M
V
T
R
S
S
P
G
A
G
P
S
D
Site 65
S746
S
S
P
G
A
G
P
S
D
H
H
S
A
S
R
Site 66
S750
A
G
P
S
D
H
H
S
A
S
R
D
E
R
F
Site 67
S752
P
S
D
H
H
S
A
S
R
D
E
R
F
K
R
Site 68
T768
Q
L
L
R
L
Q
A
T
E
R
T
M
V
R
E
Site 69
S781
R
E
K
E
N
N
P
S
G
K
K
E
L
S
E
Site 70
S787
P
S
G
K
K
E
L
S
E
V
E
K
A
K
I
Site 71
S797
E
K
A
K
I
R
G
S
Y
L
T
V
T
L
Q
Site 72
Y798
K
A
K
I
R
G
S
Y
L
T
V
T
L
Q
R
Site 73
T800
K
I
R
G
S
Y
L
T
V
T
L
Q
R
P
T
Site 74
T802
R
G
S
Y
L
T
V
T
L
Q
R
P
T
K
E
Site 75
T807
T
V
T
L
Q
R
P
T
K
E
L
H
G
T
S
Site 76
T813
P
T
K
E
L
H
G
T
S
I
V
P
K
L
Q
Site 77
S814
T
K
E
L
H
G
T
S
I
V
P
K
L
Q
A
Site 78
T823
V
P
K
L
Q
A
I
T
A
S
S
A
N
L
R
Site 79
S825
K
L
Q
A
I
T
A
S
S
A
N
L
R
H
S
Site 80
S826
L
Q
A
I
T
A
S
S
A
N
L
R
H
S
P
Site 81
S832
S
S
A
N
L
R
H
S
P
R
V
L
V
Q
H
Site 82
T844
V
Q
H
C
P
A
R
T
P
Q
R
G
D
E
E
Site 83
S869
E
E
E
E
E
D
D
S
A
E
E
G
G
A
A
Site 84
S883
A
R
L
N
G
R
G
S
W
A
Q
D
G
D
E
Site 85
S906
M
S
V
F
R
Y
L
S
R
R
E
L
C
E
C
Site 86
T931
C
C
D
K
R
L
W
T
K
I
D
L
S
R
C
Site 87
S956
I
I
K
R
Q
P
V
S
L
D
L
S
W
T
N
Site 88
S960
Q
P
V
S
L
D
L
S
W
T
N
I
S
K
K
Site 89
T1024
P
Q
I
R
D
L
L
T
P
P
A
D
K
P
G
Site 90
S1036
K
P
G
Q
D
N
R
S
K
L
R
N
M
T
D
Site 91
T1042
R
S
K
L
R
N
M
T
D
F
R
L
A
G
L
Site 92
S1067
I
R
H
M
P
L
L
S
R
L
D
L
S
H
C
Site 93
S1072
L
L
S
R
L
D
L
S
H
C
S
H
L
T
D
Site 94
T1078
L
S
H
C
S
H
L
T
D
Q
S
S
N
L
L
Site 95
S1082
S
H
L
T
D
Q
S
S
N
L
L
T
A
V
G
Site 96
T1086
D
Q
S
S
N
L
L
T
A
V
G
S
S
T
R
Site 97
Y1094
A
V
G
S
S
T
R
Y
S
L
T
E
L
N
M
Site 98
S1095
V
G
S
S
T
R
Y
S
L
T
E
L
N
M
A
Site 99
Y1150
D
L
S
I
N
S
L
Y
C
L
S
D
E
K
L
Site 100
S1153
I
N
S
L
Y
C
L
S
D
E
K
L
I
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation