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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STXBP5L
Full Name:
Syntaxin-binding protein 5-like
Alias:
Giant larvae protein; Lethal; STB5L; Tomosyn-2
Type:
Cytoplasm, Plasma membrane, Integral membrane protein
Mass (Da):
131887
Number AA:
1186
UniProt ID:
Q9Y2K9
International Prot ID:
IPI00032280
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
R
K
V
L
D
G
L
T
A
S
S
P
G
S
G
Site 2
S16
V
L
D
G
L
T
A
S
S
P
G
S
G
S
S
Site 3
S17
L
D
G
L
T
A
S
S
P
G
S
G
S
S
S
Site 4
S20
L
T
A
S
S
P
G
S
G
S
S
S
G
S
N
Site 5
S22
A
S
S
P
G
S
G
S
S
S
G
S
N
S
G
Site 6
S23
S
S
P
G
S
G
S
S
S
G
S
N
S
G
G
Site 7
S24
S
P
G
S
G
S
S
S
G
S
N
S
G
G
G
Site 8
S26
G
S
G
S
S
S
G
S
N
S
G
G
G
A
G
Site 9
S28
G
S
S
S
G
S
N
S
G
G
G
A
G
S
G
Site 10
S34
N
S
G
G
G
A
G
S
G
S
V
H
P
A
G
Site 11
S36
G
G
G
A
G
S
G
S
V
H
P
A
G
T
A
Site 12
T53
L
R
E
E
I
Q
E
T
L
T
S
E
Y
F
Q
Site 13
T55
E
E
I
Q
E
T
L
T
S
E
Y
F
Q
I
C
Site 14
Y58
Q
E
T
L
T
S
E
Y
F
Q
I
C
K
T
V
Site 15
Y105
G
R
P
G
V
D
C
Y
C
Q
H
E
S
G
A
Site 16
S130
E
G
A
L
V
S
A
S
S
D
D
T
L
H
L
Site 17
T134
V
S
A
S
S
D
D
T
L
H
L
W
N
L
R
Site 18
Y160
F
N
R
E
R
I
T
Y
C
H
L
P
F
Q
S
Site 19
Y171
P
F
Q
S
K
W
L
Y
V
G
T
E
R
G
N
Site 20
T174
S
K
W
L
Y
V
G
T
E
R
G
N
T
H
I
Site 21
T179
V
G
T
E
R
G
N
T
H
I
V
N
I
E
S
Site 22
S215
P
G
P
V
V
H
L
S
D
S
P
R
D
E
G
Site 23
S217
P
V
V
H
L
S
D
S
P
R
D
E
G
K
L
Site 24
S240
V
V
F
W
D
L
K
S
K
R
A
E
L
R
V
Site 25
Y248
K
R
A
E
L
R
V
Y
Y
D
E
A
I
H
S
Site 26
Y249
R
A
E
L
R
V
Y
Y
D
E
A
I
H
S
I
Site 27
S268
E
G
K
Q
F
M
C
S
H
S
D
G
S
L
T
Site 28
S270
K
Q
F
M
C
S
H
S
D
G
S
L
T
L
W
Site 29
S273
M
C
S
H
S
D
G
S
L
T
L
W
N
L
K
Site 30
T275
S
H
S
D
G
S
L
T
L
W
N
L
K
S
P
Site 31
S281
L
T
L
W
N
L
K
S
P
S
R
P
F
Q
T
Site 32
S283
L
W
N
L
K
S
P
S
R
P
F
Q
T
T
I
Site 33
T288
S
P
S
R
P
F
Q
T
T
I
P
H
G
K
S
Site 34
T289
P
S
R
P
F
Q
T
T
I
P
H
G
K
S
Q
Site 35
S295
T
T
I
P
H
G
K
S
Q
R
E
G
R
K
S
Site 36
S302
S
Q
R
E
G
R
K
S
E
S
C
K
P
I
L
Site 37
S304
R
E
G
R
K
S
E
S
C
K
P
I
L
K
V
Site 38
T315
I
L
K
V
E
Y
K
T
C
K
N
S
E
P
F
Site 39
S326
S
E
P
F
I
I
F
S
G
G
L
S
Y
D
K
Site 40
S330
I
I
F
S
G
G
L
S
Y
D
K
A
C
R
R
Site 41
S339
D
K
A
C
R
R
P
S
L
T
I
M
H
G
K
Site 42
T341
A
C
R
R
P
S
L
T
I
M
H
G
K
A
I
Site 43
T366
E
F
L
T
L
C
E
T
P
Y
P
N
E
F
Q
Site 44
Y368
L
T
L
C
E
T
P
Y
P
N
E
F
Q
E
P
Site 45
Y403
F
P
I
F
E
N
P
Y
P
M
D
I
H
E
S
Site 46
T413
D
I
H
E
S
P
V
T
C
T
A
Y
F
A
D
Site 47
Y417
S
P
V
T
C
T
A
Y
F
A
D
C
P
P
D
Site 48
S442
K
H
K
K
Q
G
Y
S
N
K
E
W
P
I
S
Site 49
S449
S
N
K
E
W
P
I
S
G
G
A
W
N
L
G
Site 50
S472
I
T
G
H
A
D
G
S
I
K
F
W
D
A
S
Site 51
T491
Q
M
L
Y
K
L
K
T
S
K
V
F
E
K
Q
Site 52
T506
K
V
G
E
G
K
Q
T
C
E
I
V
E
E
D
Site 53
Y561
S
L
E
V
R
L
Q
Y
D
V
E
D
I
I
T
Site 54
T568
Y
D
V
E
D
I
I
T
P
E
P
E
T
S
P
Site 55
T573
I
I
T
P
E
P
E
T
S
P
P
F
P
D
L
Site 56
S574
I
T
P
E
P
E
T
S
P
P
F
P
D
L
S
Site 57
S581
S
P
P
F
P
D
L
S
A
Q
L
P
S
S
R
Site 58
S586
D
L
S
A
Q
L
P
S
S
R
S
L
S
G
S
Site 59
S587
L
S
A
Q
L
P
S
S
R
S
L
S
G
S
T
Site 60
S589
A
Q
L
P
S
S
R
S
L
S
G
S
T
N
T
Site 61
S591
L
P
S
S
R
S
L
S
G
S
T
N
T
V
A
Site 62
S593
S
S
R
S
L
S
G
S
T
N
T
V
A
S
E
Site 63
T594
S
R
S
L
S
G
S
T
N
T
V
A
S
E
G
Site 64
T596
S
L
S
G
S
T
N
T
V
A
S
E
G
V
T
Site 65
S599
G
S
T
N
T
V
A
S
E
G
V
T
K
D
S
Site 66
S606
S
E
G
V
T
K
D
S
I
P
C
L
N
V
K
Site 67
Y623
P
V
R
M
P
P
G
Y
Q
A
E
L
V
I
Q
Site 68
S644
E
P
P
Q
Q
I
T
S
L
A
V
S
S
A
Y
Site 69
Y682
S
M
G
T
I
D
L
Y
R
S
S
D
L
Y
Q
Site 70
S685
T
I
D
L
Y
R
S
S
D
L
Y
Q
R
Q
P
Site 71
Y688
L
Y
R
S
S
D
L
Y
Q
R
Q
P
R
S
P
Site 72
S694
L
Y
Q
R
Q
P
R
S
P
R
K
N
K
Q
F
Site 73
Y715
M
R
G
L
S
N
F
Y
P
D
L
T
K
R
I
Site 74
T719
S
N
F
Y
P
D
L
T
K
R
I
R
T
S
Y
Site 75
T724
D
L
T
K
R
I
R
T
S
Y
Q
S
L
T
E
Site 76
S725
L
T
K
R
I
R
T
S
Y
Q
S
L
T
E
L
Site 77
Y726
T
K
R
I
R
T
S
Y
Q
S
L
T
E
L
N
Site 78
S728
R
I
R
T
S
Y
Q
S
L
T
E
L
N
D
S
Site 79
T730
R
T
S
Y
Q
S
L
T
E
L
N
D
S
P
V
Site 80
S735
S
L
T
E
L
N
D
S
P
V
P
L
E
L
E
Site 81
S746
L
E
L
E
R
C
K
S
P
T
S
D
H
V
N
Site 82
T748
L
E
R
C
K
S
P
T
S
D
H
V
N
G
H
Site 83
T757
D
H
V
N
G
H
C
T
S
P
T
S
Q
S
C
Site 84
S758
H
V
N
G
H
C
T
S
P
T
S
Q
S
C
S
Site 85
T760
N
G
H
C
T
S
P
T
S
Q
S
C
S
S
G
Site 86
S761
G
H
C
T
S
P
T
S
Q
S
C
S
S
G
K
Site 87
S763
C
T
S
P
T
S
Q
S
C
S
S
G
K
R
L
Site 88
S765
S
P
T
S
Q
S
C
S
S
G
K
R
L
S
S
Site 89
S766
P
T
S
Q
S
C
S
S
G
K
R
L
S
S
A
Site 90
S771
C
S
S
G
K
R
L
S
S
A
D
V
S
K
V
Site 91
S772
S
S
G
K
R
L
S
S
A
D
V
S
K
V
N
Site 92
S776
R
L
S
S
A
D
V
S
K
V
N
R
W
G
P
Site 93
T804
M
E
I
S
L
P
V
T
T
E
E
N
R
E
N
Site 94
S812
T
E
E
N
R
E
N
S
Y
N
R
S
R
S
S
Site 95
Y813
E
E
N
R
E
N
S
Y
N
R
S
R
S
S
S
Site 96
S816
R
E
N
S
Y
N
R
S
R
S
S
S
I
S
S
Site 97
S818
N
S
Y
N
R
S
R
S
S
S
I
S
S
I
D
Site 98
S819
S
Y
N
R
S
R
S
S
S
I
S
S
I
D
K
Site 99
S820
Y
N
R
S
R
S
S
S
I
S
S
I
D
K
D
Site 100
S822
R
S
R
S
S
S
I
S
S
I
D
K
D
S
K
Site 101
S823
S
R
S
S
S
I
S
S
I
D
K
D
S
K
E
Site 102
S828
I
S
S
I
D
K
D
S
K
E
A
I
T
A
L
Site 103
S840
T
A
L
Y
F
M
D
S
F
A
R
K
N
D
S
Site 104
S847
S
F
A
R
K
N
D
S
T
I
S
P
C
L
F
Site 105
S850
R
K
N
D
S
T
I
S
P
C
L
F
V
G
T
Site 106
T878
L
A
D
E
Q
R
F
T
E
P
V
M
V
L
P
Site 107
Y913
G
G
L
M
Q
P
P
Y
E
V
W
R
D
P
N
Site 108
S937
R
R
K
V
V
M
N
S
S
S
A
S
Q
E
I
Site 109
S938
R
K
V
V
M
N
S
S
S
A
S
Q
E
I
G
Site 110
S939
K
V
V
M
N
S
S
S
A
S
Q
E
I
G
D
Site 111
S941
V
M
N
S
S
S
A
S
Q
E
I
G
D
H
Q
Site 112
Y949
Q
E
I
G
D
H
Q
Y
T
I
I
C
S
E
K
Site 113
T950
E
I
G
D
H
Q
Y
T
I
I
C
S
E
K
Q
Site 114
S962
E
K
Q
A
K
V
F
S
L
P
S
Q
T
C
L
Site 115
Y970
L
P
S
Q
T
C
L
Y
V
H
N
I
T
E
T
Site 116
Y1019
R
P
M
L
D
V
N
Y
L
P
L
T
D
M
R
Site 117
T1023
D
V
N
Y
L
P
L
T
D
M
R
I
A
R
T
Site 118
Y1041
T
N
E
G
Q
A
L
Y
L
V
S
P
T
E
I
Site 119
T1052
P
T
E
I
Q
R
L
T
Y
S
Q
E
M
C
D
Site 120
Y1053
T
E
I
Q
R
L
T
Y
S
Q
E
M
C
D
N
Site 121
S1054
E
I
Q
R
L
T
Y
S
Q
E
M
C
D
N
L
Site 122
T1070
D
M
L
G
D
L
F
T
P
I
E
T
P
E
A
Site 123
T1074
D
L
F
T
P
I
E
T
P
E
A
Q
N
R
G
Site 124
T1093
L
F
G
G
S
G
Q
T
F
D
R
E
E
L
F
Site 125
S1104
E
E
L
F
G
E
A
S
A
G
K
A
S
R
S
Site 126
S1111
S
A
G
K
A
S
R
S
L
A
Q
H
I
P
G
Site 127
S1121
Q
H
I
P
G
P
G
S
I
E
G
M
K
G
A
Site 128
T1157
L
G
E
L
E
E
K
T
A
G
M
M
T
S
A
Site 129
S1163
K
T
A
G
M
M
T
S
A
E
A
F
S
K
H
Site 130
S1168
M
T
S
A
E
A
F
S
K
H
A
H
E
L
M
Site 131
Y1178
A
H
E
L
M
L
K
Y
K
D
K
K
W
Y
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation