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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIS3
Full Name:
Alias:
Protein DIS3 homolog;Ribosomal RNA-processing protein 44
Type:
Mass (Da):
109003
Number AA:
958
UniProt ID:
Q9Y2L1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
L
K
S
K
T
F
L
K
K
T
R
A
Site 2
T11
S
K
T
F
L
K
K
T
R
A
G
G
V
M
K
Site 3
Y24
M
K
I
V
R
E
H
Y
L
R
D
D
I
G
C
Site 4
S57
P
Q
P
Q
D
P
A
S
S
V
C
P
Q
P
H
Site 5
S58
Q
P
Q
D
P
A
S
S
V
C
P
Q
P
H
Y
Site 6
Y65
S
V
C
P
Q
P
H
Y
L
L
P
D
T
N
V
Site 7
S102
L
Q
E
V
R
N
R
S
A
P
V
Y
K
R
I
Site 8
Y106
R
N
R
S
A
P
V
Y
K
R
I
R
D
V
T
Site 9
T113
Y
K
R
I
R
D
V
T
N
N
Q
E
K
H
F
Site 10
Y121
N
N
Q
E
K
H
F
Y
T
F
T
N
E
H
H
Site 11
T131
T
N
E
H
H
R
E
T
Y
V
E
Q
E
Q
G
Site 12
Y132
N
E
H
H
R
E
T
Y
V
E
Q
E
Q
G
E
Site 13
S164
N
E
H
L
K
K
M
S
A
D
N
Q
L
Q
V
Site 14
T175
Q
L
Q
V
I
F
I
T
N
D
R
R
N
K
E
Site 15
Y197
P
A
F
T
C
E
E
Y
V
K
S
L
T
A
N
Site 16
S200
T
C
E
E
Y
V
K
S
L
T
A
N
P
E
L
Site 17
T202
E
E
Y
V
K
S
L
T
A
N
P
E
L
I
D
Site 18
S215
I
D
R
L
A
C
L
S
E
E
G
N
E
I
E
Site 19
S229
E
S
G
K
I
I
F
S
E
H
L
P
L
S
K
Site 20
S235
F
S
E
H
L
P
L
S
K
L
Q
Q
G
I
K
Site 21
S243
K
L
Q
Q
G
I
K
S
G
T
Y
L
Q
G
T
Site 22
Y246
Q
G
I
K
S
G
T
Y
L
Q
G
T
F
R
A
Site 23
T250
S
G
T
Y
L
Q
G
T
F
R
A
S
R
E
N
Site 24
S254
L
Q
G
T
F
R
A
S
R
E
N
Y
L
E
A
Site 25
Y258
F
R
A
S
R
E
N
Y
L
E
A
T
V
W
I
Site 26
S300
A
V
E
L
L
P
K
S
Q
W
V
A
P
S
S
Site 27
S306
K
S
Q
W
V
A
P
S
S
V
V
L
H
D
E
Site 28
S307
S
Q
W
V
A
P
S
S
V
V
L
H
D
E
G
Site 29
T332
E
T
E
R
M
L
K
T
A
V
S
E
K
M
L
Site 30
S335
R
M
L
K
T
A
V
S
E
K
M
L
K
P
T
Site 31
Y356
I
K
R
N
W
R
P
Y
C
G
M
L
S
K
S
Site 32
S361
R
P
Y
C
G
M
L
S
K
S
D
I
K
E
S
Site 33
S363
Y
C
G
M
L
S
K
S
D
I
K
E
S
R
R
Site 34
S368
S
K
S
D
I
K
E
S
R
R
H
L
F
T
P
Site 35
T374
E
S
R
R
H
L
F
T
P
A
D
K
R
I
P
Site 36
T387
I
P
R
I
R
I
E
T
R
Q
A
S
T
L
E
Site 37
S391
R
I
E
T
R
Q
A
S
T
L
E
G
R
R
I
Site 38
Y411
G
W
P
R
N
S
R
Y
P
N
G
H
F
V
R
Site 39
S523
G
N
A
L
D
Q
E
S
A
R
R
G
T
T
V
Site 40
T528
Q
E
S
A
R
R
G
T
T
V
Y
L
C
E
K
Site 41
T529
E
S
A
R
R
G
T
T
V
Y
L
C
E
K
R
Site 42
Y531
A
R
R
G
T
T
V
Y
L
C
E
K
R
I
D
Site 43
T575
H
N
A
E
I
L
K
T
K
F
T
K
S
V
I
Site 44
T578
E
I
L
K
T
K
F
T
K
S
V
I
N
S
K
Site 45
S580
L
K
T
K
F
T
K
S
V
I
N
S
K
A
S
Site 46
S584
F
T
K
S
V
I
N
S
K
A
S
L
T
Y
A
Site 47
S587
S
V
I
N
S
K
A
S
L
T
Y
A
E
A
Q
Site 48
S599
E
A
Q
L
R
I
D
S
A
N
M
N
D
D
I
Site 49
T607
A
N
M
N
D
D
I
T
T
S
L
R
G
L
N
Site 50
T608
N
M
N
D
D
I
T
T
S
L
R
G
L
N
K
Site 51
S609
M
N
D
D
I
T
T
S
L
R
G
L
N
K
L
Site 52
T631
R
I
E
K
G
A
L
T
L
S
S
P
E
V
R
Site 53
S633
E
K
G
A
L
T
L
S
S
P
E
V
R
F
H
Site 54
S634
K
G
A
L
T
L
S
S
P
E
V
R
F
H
M
Site 55
S643
E
V
R
F
H
M
D
S
E
T
H
D
P
I
D
Site 56
T645
R
F
H
M
D
S
E
T
H
D
P
I
D
L
Q
Site 57
T659
Q
T
K
E
L
R
E
T
N
S
M
V
E
E
F
Site 58
S661
K
E
L
R
E
T
N
S
M
V
E
E
F
M
L
Site 59
S673
F
M
L
L
A
N
I
S
V
A
K
K
I
H
E
Site 60
S697
K
H
P
A
P
P
P
S
N
Y
E
I
L
V
K
Site 61
T715
S
R
N
L
E
I
K
T
D
T
A
K
S
L
A
Site 62
S720
I
K
T
D
T
A
K
S
L
A
E
S
L
D
Q
Site 63
S724
T
A
K
S
L
A
E
S
L
D
Q
A
E
S
P
Site 64
S730
E
S
L
D
Q
A
E
S
P
T
F
P
Y
L
N
Site 65
T732
L
D
Q
A
E
S
P
T
F
P
Y
L
N
T
L
Site 66
Y765
M
D
N
D
F
H
H
Y
G
L
A
S
P
I
Y
Site 67
T773
G
L
A
S
P
I
Y
T
H
F
T
S
P
I
R
Site 68
S777
P
I
Y
T
H
F
T
S
P
I
R
R
Y
A
D
Site 69
Y782
F
T
S
P
I
R
R
Y
A
D
V
I
V
H
R
Site 70
T800
V
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
Site 71
Y801
A
I
G
A
D
C
T
Y
P
E
L
T
D
K
H
Site 72
S831
A
Q
Y
A
Q
R
A
S
V
A
F
H
T
Q
L
Site 73
S842
H
T
Q
L
F
F
K
S
K
G
I
V
S
E
E
Site 74
T872
P
K
Y
G
L
E
G
T
V
F
F
E
E
K
D
Site 75
Y887
K
P
N
P
Q
L
I
Y
D
D
E
I
P
S
L
Site 76
T899
P
S
L
K
I
E
D
T
V
F
H
V
F
D
K
Site 77
S926
Q
H
Q
K
I
R
M
S
L
V
E
P
Q
I
P
Site 78
S936
E
P
Q
I
P
G
I
S
I
P
T
D
T
S
N
Site 79
S942
I
S
I
P
T
D
T
S
N
M
D
L
N
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation