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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRS85
Full Name:
Syntaxin-binding protein 5-like
Alias:
HsT2706; KIAA1012
Type:
Golgi apparatus protein
Mass (Da):
160941
Number AA:
1435
UniProt ID:
Q9Y2L5
International Prot ID:
IPI00007253
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005801
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006888
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
Q
C
V
Q
S
V
Q
E
L
I
P
D
Site 2
T32
S
D
E
A
E
R
L
T
R
L
N
H
L
S
F
Site 3
S38
L
T
R
L
N
H
L
S
F
A
E
L
L
K
P
Site 4
S47
A
E
L
L
K
P
F
S
R
L
T
S
E
V
H
Site 5
T50
L
K
P
F
S
R
L
T
S
E
V
H
M
R
D
Site 6
S51
K
P
F
S
R
L
T
S
E
V
H
M
R
D
P
Site 7
S73
K
N
L
K
I
A
V
S
N
I
V
T
Q
P
P
Site 8
S94
K
L
L
N
D
V
V
S
G
S
Q
P
A
E
G
Site 9
T119
Y
D
L
N
I
S
A
T
T
P
W
F
E
S
Y
Site 10
T120
D
L
N
I
S
A
T
T
P
W
F
E
S
Y
R
Site 11
Y126
T
T
P
W
F
E
S
Y
R
E
T
F
L
Q
S
Site 12
T129
W
F
E
S
Y
R
E
T
F
L
Q
S
M
P
A
Site 13
S133
Y
R
E
T
F
L
Q
S
M
P
A
S
D
H
E
Site 14
S137
F
L
Q
S
M
P
A
S
D
H
E
F
L
N
H
Site 15
S155
C
M
L
V
A
S
S
S
E
A
E
P
V
E
Q
Site 16
S167
V
E
Q
F
S
K
L
S
Q
E
Q
H
R
I
Q
Site 17
Y179
R
I
Q
H
N
S
D
Y
S
Y
P
K
W
F
I
Site 18
Y181
Q
H
N
S
D
Y
S
Y
P
K
W
F
I
P
N
Site 19
S200
Y
V
L
L
H
D
V
S
A
G
D
E
Q
R
A
Site 20
S209
G
D
E
Q
R
A
E
S
I
Y
E
E
M
K
Q
Site 21
Y211
E
Q
R
A
E
S
I
Y
E
E
M
K
Q
K
Y
Site 22
Y218
Y
E
E
M
K
Q
K
Y
G
T
Q
G
C
Y
L
Site 23
Y224
K
Y
G
T
Q
G
C
Y
L
L
K
I
N
S
R
Site 24
S230
C
Y
L
L
K
I
N
S
R
T
S
N
R
A
S
Site 25
S233
L
K
I
N
S
R
T
S
N
R
A
S
D
E
Q
Site 26
S237
S
R
T
S
N
R
A
S
D
E
Q
I
P
D
P
Site 27
S246
E
Q
I
P
D
P
W
S
Q
Y
L
Q
K
N
S
Site 28
Y248
I
P
D
P
W
S
Q
Y
L
Q
K
N
S
I
Q
Site 29
Y260
S
I
Q
N
Q
E
S
Y
E
D
G
P
C
T
I
Site 30
T266
S
Y
E
D
G
P
C
T
I
T
S
N
K
N
S
Site 31
S269
D
G
P
C
T
I
T
S
N
K
N
S
D
N
N
Site 32
S273
T
I
T
S
N
K
N
S
D
N
N
L
L
S
L
Site 33
S279
N
S
D
N
N
L
L
S
L
D
G
L
D
N
E
Site 34
S305
H
P
L
Q
L
E
Q
S
S
D
P
S
N
S
I
Site 35
S306
P
L
Q
L
E
Q
S
S
D
P
S
N
S
I
D
Site 36
S309
L
E
Q
S
S
D
P
S
N
S
I
D
G
P
D
Site 37
S311
Q
S
S
D
P
S
N
S
I
D
G
P
D
H
L
Site 38
S320
D
G
P
D
H
L
R
S
A
S
S
L
H
E
T
Site 39
S322
P
D
H
L
R
S
A
S
S
L
H
E
T
K
K
Site 40
S323
D
H
L
R
S
A
S
S
L
H
E
T
K
K
G
Site 41
T327
S
A
S
S
L
H
E
T
K
K
G
N
T
G
I
Site 42
T343
H
G
A
C
L
T
L
T
D
H
D
R
I
R
Q
Site 43
T356
R
Q
F
I
Q
E
F
T
F
R
G
L
L
P
H
Site 44
T367
L
L
P
H
I
E
K
T
I
R
Q
L
N
D
Q
Site 45
S382
L
I
S
R
K
G
L
S
R
S
L
F
S
A
T
Site 46
S384
S
R
K
G
L
S
R
S
L
F
S
A
T
K
K
Site 47
S387
G
L
S
R
S
L
F
S
A
T
K
K
W
F
S
Site 48
T389
S
R
S
L
F
S
A
T
K
K
W
F
S
G
S
Site 49
S394
S
A
T
K
K
W
F
S
G
S
K
V
P
E
K
Site 50
S396
T
K
K
W
F
S
G
S
K
V
P
E
K
S
I
Site 51
S402
G
S
K
V
P
E
K
S
I
N
D
L
K
N
T
Site 52
Y414
K
N
T
S
G
L
L
Y
P
P
E
A
P
E
L
Site 53
Y440
V
Q
H
Y
D
L
A
Y
S
C
Y
H
T
A
K
Site 54
Y480
Q
P
G
A
P
R
P
Y
P
A
H
Y
M
D
T
Site 55
S515
L
S
A
E
L
L
K
S
Q
S
K
Y
S
E
A
Site 56
S517
A
E
L
L
K
S
Q
S
K
Y
S
E
A
A
A
Site 57
Y519
L
L
K
S
Q
S
K
Y
S
E
A
A
A
L
L
Site 58
S520
L
K
S
Q
S
K
Y
S
E
A
A
A
L
L
I
Site 59
T530
A
A
L
L
I
R
L
T
S
E
D
S
D
L
R
Site 60
S531
A
L
L
I
R
L
T
S
E
D
S
D
L
R
S
Site 61
S534
I
R
L
T
S
E
D
S
D
L
R
S
A
L
L
Site 62
S538
S
E
D
S
D
L
R
S
A
L
L
L
E
Q
A
Site 63
Y560
K
S
P
M
V
R
K
Y
A
F
H
M
I
L
A
Site 64
S572
I
L
A
G
H
R
F
S
K
A
G
Q
K
K
H
Site 65
Y584
K
K
H
A
L
R
C
Y
C
Q
A
M
Q
V
Y
Site 66
S597
V
Y
K
G
K
G
W
S
L
A
E
D
H
I
N
Site 67
S611
N
F
T
I
G
R
Q
S
Y
T
L
R
Q
L
D
Site 68
Y612
F
T
I
G
R
Q
S
Y
T
L
R
Q
L
D
N
Site 69
T613
T
I
G
R
Q
S
Y
T
L
R
Q
L
D
N
A
Site 70
S635
L
I
N
E
S
K
Q
S
A
A
Q
Q
G
A
F
Site 71
Y646
Q
G
A
F
L
R
E
Y
L
Y
V
Y
K
N
V
Site 72
Y648
A
F
L
R
E
Y
L
Y
V
Y
K
N
V
S
Q
Site 73
Y650
L
R
E
Y
L
Y
V
Y
K
N
V
S
Q
L
S
Site 74
S654
L
Y
V
Y
K
N
V
S
Q
L
S
P
D
G
P
Site 75
S657
Y
K
N
V
S
Q
L
S
P
D
G
P
L
P
Q
Site 76
Y669
L
P
Q
L
P
L
P
Y
I
N
S
S
A
T
R
Site 77
T675
P
Y
I
N
S
S
A
T
R
V
F
F
G
H
D
Site 78
Y702
H
V
S
L
D
Q
E
Y
D
S
E
S
S
Q
Q
Site 79
S704
S
L
D
Q
E
Y
D
S
E
S
S
Q
Q
W
R
Site 80
S706
D
Q
E
Y
D
S
E
S
S
Q
Q
W
R
E
L
Site 81
Y735
S
N
F
H
P
T
Q
Y
C
L
N
S
Y
S
D
Site 82
S739
P
T
Q
Y
C
L
N
S
Y
S
D
N
S
R
F
Site 83
S741
Q
Y
C
L
N
S
Y
S
D
N
S
R
F
P
L
Site 84
S744
L
N
S
Y
S
D
N
S
R
F
P
L
A
V
V
Site 85
S786
K
F
H
P
K
D
F
S
G
K
D
N
E
E
V
Site 86
T798
E
E
V
K
Q
L
V
T
S
E
P
E
M
I
G
Site 87
S819
F
L
I
N
G
E
E
S
K
V
A
R
L
K
L
Site 88
Y841
L
H
I
L
G
V
V
Y
N
L
G
T
I
Q
G
Site 89
T851
G
T
I
Q
G
S
M
T
V
D
G
I
G
A
L
Site 90
T863
G
A
L
P
G
C
H
T
G
K
Y
S
L
S
M
Site 91
Y866
P
G
C
H
T
G
K
Y
S
L
S
M
S
V
R
Site 92
S867
G
C
H
T
G
K
Y
S
L
S
M
S
V
R
G
Site 93
S869
H
T
G
K
Y
S
L
S
M
S
V
R
G
K
Q
Site 94
S871
G
K
Y
S
L
S
M
S
V
R
G
K
Q
D
L
Site 95
T888
Q
G
P
R
L
N
N
T
K
E
E
K
T
S
V
Site 96
S894
N
T
K
E
E
K
T
S
V
K
Y
G
P
D
R
Site 97
T959
S
K
R
P
E
F
F
T
F
G
G
N
T
A
V
Site 98
T968
G
G
N
T
A
V
L
T
P
L
S
P
S
A
S
Site 99
S971
T
A
V
L
T
P
L
S
P
S
A
S
E
N
C
Site 100
S973
V
L
T
P
L
S
P
S
A
S
E
N
C
S
A
Site 101
S975
T
P
L
S
P
S
A
S
E
N
C
S
A
Y
K
Site 102
S979
P
S
A
S
E
N
C
S
A
Y
K
T
V
V
T
Site 103
T983
E
N
C
S
A
Y
K
T
V
V
T
D
A
T
S
Site 104
Y1053
E
I
N
F
L
F
Y
Y
E
S
V
K
K
Q
P
Site 105
T1070
R
H
R
I
L
R
H
T
A
I
I
C
T
S
R
Site 106
T1084
R
S
L
N
V
R
A
T
V
C
R
S
N
S
L
Site 107
S1090
A
T
V
C
R
S
N
S
L
E
N
E
E
G
R
Site 108
T1112
V
D
V
E
N
T
N
T
S
E
A
G
V
K
E
Site 109
S1126
E
F
H
I
V
Q
V
S
S
S
S
K
H
W
K
Site 110
S1127
F
H
I
V
Q
V
S
S
S
S
K
H
W
K
L
Site 111
S1137
K
H
W
K
L
Q
K
S
V
N
L
S
E
N
K
Site 112
S1141
L
Q
K
S
V
N
L
S
E
N
K
D
A
K
L
Site 113
T1170
C
E
K
E
E
A
A
T
Q
S
S
E
K
Y
T
Site 114
T1177
T
Q
S
S
E
K
Y
T
F
A
D
I
I
F
G
Site 115
S1190
F
G
N
E
Q
I
I
S
S
A
S
P
C
A
D
Site 116
Y1200
S
P
C
A
D
F
F
Y
R
S
L
S
S
E
L
Site 117
S1202
C
A
D
F
F
Y
R
S
L
S
S
E
L
K
K
Site 118
S1204
D
F
F
Y
R
S
L
S
S
E
L
K
K
P
Q
Site 119
T1223
V
H
T
E
K
Q
S
T
E
D
A
V
R
L
I
Site 120
Y1275
I
G
K
E
A
F
S
Y
P
Q
K
Q
E
P
P
Site 121
T1296
F
F
R
P
E
N
I
T
V
S
S
R
P
S
V
Site 122
S1298
R
P
E
N
I
T
V
S
S
R
P
S
V
E
Q
Site 123
S1302
I
T
V
S
S
R
P
S
V
E
Q
L
S
S
L
Site 124
S1307
R
P
S
V
E
Q
L
S
S
L
I
K
T
S
L
Site 125
S1308
P
S
V
E
Q
L
S
S
L
I
K
T
S
L
H
Site 126
T1312
Q
L
S
S
L
I
K
T
S
L
H
Y
P
E
S
Site 127
S1313
L
S
S
L
I
K
T
S
L
H
Y
P
E
S
F
Site 128
Y1316
L
I
K
T
S
L
H
Y
P
E
S
F
N
H
P
Site 129
T1356
I
V
D
L
R
H
K
T
T
S
P
E
A
L
E
Site 130
S1358
D
L
R
H
K
T
T
S
P
E
A
L
E
I
H
Site 131
S1367
E
A
L
E
I
H
G
S
F
T
W
L
G
Q
T
Site 132
S1382
Q
Y
K
L
Q
L
K
S
Q
E
I
H
S
L
Q
Site 133
S1387
L
K
S
Q
E
I
H
S
L
Q
L
K
A
C
F
Site 134
T1416
A
K
L
S
D
Q
V
T
V
F
E
T
S
Q
Q
Site 135
S1421
Q
V
T
V
F
E
T
S
Q
Q
N
S
M
P
A
Site 136
S1433
M
P
A
L
I
I
I
S
N
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation