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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL20
Full Name:
Alias:
Kelch-like ECT2-interacting protein;Kelch-like protein X
Type:
Mass (Da):
67955
Number AA:
609
UniProt ID:
Q9Y2M5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
K
P
M
R
R
C
T
N
I
R
P
G
E
T
Site 2
T22
G
E
T
G
M
D
V
T
S
R
C
T
L
G
D
Site 3
S23
E
T
G
M
D
V
T
S
R
C
T
L
G
D
P
Site 4
T26
M
D
V
T
S
R
C
T
L
G
D
P
N
K
L
Site 5
Y45
P
Q
P
A
R
M
P
Y
I
S
D
K
H
P
R
Site 6
S47
P
A
R
M
P
Y
I
S
D
K
H
P
R
Q
T
Site 7
T54
S
D
K
H
P
R
Q
T
L
E
V
I
N
L
L
Site 8
S104
F
T
G
E
L
A
E
S
R
Q
T
E
V
V
I
Site 9
T107
E
L
A
E
S
R
Q
T
E
V
V
I
R
D
I
Site 10
S168
L
K
R
Q
L
D
P
S
N
C
L
G
I
R
A
Site 11
T179
G
I
R
A
F
A
D
T
H
S
C
R
E
L
L
Site 12
S181
R
A
F
A
D
T
H
S
C
R
E
L
L
R
I
Site 13
T193
L
R
I
A
D
K
F
T
Q
H
N
F
Q
E
V
Site 14
S203
N
F
Q
E
V
M
E
S
E
E
F
M
L
L
P
Site 15
S219
N
Q
L
I
D
I
I
S
S
D
E
L
N
V
R
Site 16
S220
Q
L
I
D
I
I
S
S
D
E
L
N
V
R
S
Site 17
S279
G
S
D
P
L
I
K
S
D
E
E
C
R
D
L
Site 18
Y293
L
V
D
E
A
K
N
Y
L
L
L
P
Q
E
R
Site 19
T308
P
L
M
Q
G
P
R
T
R
P
R
K
P
I
R
Site 20
S334
C
S
G
D
A
I
S
S
V
E
R
Y
D
P
Q
Site 21
Y338
A
I
S
S
V
E
R
Y
D
P
Q
T
N
E
W
Site 22
T342
V
E
R
Y
D
P
Q
T
N
E
W
R
M
V
A
Site 23
S352
W
R
M
V
A
S
M
S
K
R
R
C
G
V
G
Site 24
S376
A
V
G
G
H
D
G
S
S
Y
L
N
S
V
E
Site 25
S377
V
G
G
H
D
G
S
S
Y
L
N
S
V
E
R
Site 26
Y378
G
G
H
D
G
S
S
Y
L
N
S
V
E
R
Y
Site 27
S381
D
G
S
S
Y
L
N
S
V
E
R
Y
D
P
K
Site 28
T389
V
E
R
Y
D
P
K
T
N
Q
W
S
S
D
V
Site 29
S394
P
K
T
N
Q
W
S
S
D
V
A
P
T
S
T
Site 30
S400
S
S
D
V
A
P
T
S
T
C
R
T
S
V
G
Site 31
T401
S
D
V
A
P
T
S
T
C
R
T
S
V
G
V
Site 32
T441
D
P
K
E
N
K
W
T
R
V
A
S
M
S
T
Site 33
S445
N
K
W
T
R
V
A
S
M
S
T
R
R
L
G
Site 34
S447
W
T
R
V
A
S
M
S
T
R
R
L
G
V
A
Site 35
S472
V
G
G
S
D
G
T
S
P
L
N
T
V
E
R
Site 36
T476
D
G
T
S
P
L
N
T
V
E
R
Y
N
P
Q
Site 37
T489
P
Q
E
N
R
W
H
T
I
A
P
M
G
T
R
Site 38
T495
H
T
I
A
P
M
G
T
R
R
K
H
L
G
C
Site 39
Y510
A
V
Y
Q
D
M
I
Y
A
V
G
G
R
D
D
Site 40
T518
A
V
G
G
R
D
D
T
T
E
L
S
S
A
E
Site 41
T519
V
G
G
R
D
D
T
T
E
L
S
S
A
E
R
Site 42
S522
R
D
D
T
T
E
L
S
S
A
E
R
Y
N
P
Site 43
Y527
E
L
S
S
A
E
R
Y
N
P
R
T
N
Q
W
Site 44
T531
A
E
R
Y
N
P
R
T
N
Q
W
S
P
V
V
Site 45
S535
N
P
R
T
N
Q
W
S
P
V
V
A
M
T
S
Site 46
T541
W
S
P
V
V
A
M
T
S
R
R
S
G
V
G
Site 47
S542
S
P
V
V
A
M
T
S
R
R
S
G
V
G
L
Site 48
T570
D
G
T
T
Y
L
K
T
I
E
V
F
D
P
D
Site 49
Y584
D
A
N
T
W
R
L
Y
G
G
M
N
Y
R
R
Site 50
Y589
R
L
Y
G
G
M
N
Y
R
R
L
G
G
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation