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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP8A1
Full Name:
Probable phospholipid-transporting ATPase IA
Alias:
AT8A1; ATPase class I type 8A member 1; ATPase, aminophospholipid transporter (APLT) class I, type 8A, member 1; ATPIA; Chromaffin granule ATPase II
Type:
Hydrolase; Transporter; EC 3.6.3.1
Mass (Da):
131369
Number AA:
1164
UniProt ID:
Q9Y2Q0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0019829
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015917
GO:0015914
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
P
T
M
R
R
T
V
S
E
I
R
S
R
Site 2
S9
P
T
M
R
R
T
V
S
E
I
R
S
R
A
E
Site 3
S13
R
T
V
S
E
I
R
S
R
A
E
G
Y
E
K
Site 4
T21
R
A
E
G
Y
E
K
T
D
D
V
S
E
K
T
Site 5
S25
Y
E
K
T
D
D
V
S
E
K
T
S
L
A
D
Site 6
T28
T
D
D
V
S
E
K
T
S
L
A
D
Q
E
E
Site 7
S29
D
D
V
S
E
K
T
S
L
A
D
Q
E
E
V
Site 8
T38
A
D
Q
E
E
V
R
T
I
F
I
N
Q
P
Q
Site 9
Y70
T
F
L
P
R
F
L
Y
S
Q
F
R
R
A
A
Site 10
S71
F
L
P
R
F
L
Y
S
Q
F
R
R
A
A
N
Site 11
S94
L
Q
Q
I
P
D
V
S
P
T
G
R
Y
T
T
Site 12
T96
Q
I
P
D
V
S
P
T
G
R
Y
T
T
L
V
Site 13
S171
H
L
P
A
D
L
I
S
L
S
S
S
E
P
Q
Site 14
S173
P
A
D
L
I
S
L
S
S
S
E
P
Q
A
M
Site 15
S175
D
L
I
S
L
S
S
S
E
P
Q
A
M
C
Y
Site 16
Y182
S
E
P
Q
A
M
C
Y
I
E
T
S
N
L
D
Site 17
S211
S
D
I
K
D
V
D
S
L
M
R
I
S
G
R
Site 18
S216
V
D
S
L
M
R
I
S
G
R
I
E
C
E
S
Site 19
S223
S
G
R
I
E
C
E
S
P
N
R
H
L
Y
D
Site 20
Y229
E
S
P
N
R
H
L
Y
D
F
V
G
N
I
R
Site 21
T242
I
R
L
D
G
H
G
T
V
P
L
G
A
D
Q
Site 22
Y269
W
V
H
G
I
V
V
Y
T
G
H
D
T
K
L
Site 23
T270
V
H
G
I
V
V
Y
T
G
H
D
T
K
L
M
Site 24
T274
V
V
Y
T
G
H
D
T
K
L
M
Q
N
S
T
Site 25
S280
D
T
K
L
M
Q
N
S
T
S
P
P
L
K
L
Site 26
T281
T
K
L
M
Q
N
S
T
S
P
P
L
K
L
S
Site 27
S282
K
L
M
Q
N
S
T
S
P
P
L
K
L
S
N
Site 28
S288
T
S
P
P
L
K
L
S
N
V
E
R
I
T
N
Site 29
T294
L
S
N
V
E
R
I
T
N
V
Q
I
L
I
L
Site 30
S309
F
C
I
L
I
A
M
S
L
V
C
S
V
G
S
Site 31
S324
A
I
W
N
R
R
H
S
G
K
D
W
Y
L
N
Site 32
Y329
R
H
S
G
K
D
W
Y
L
N
L
N
Y
G
G
Site 33
Y334
D
W
Y
L
N
L
N
Y
G
G
A
S
N
F
G
Site 34
Y382
N
W
D
L
D
M
H
Y
E
P
T
D
T
A
A
Site 35
T387
M
H
Y
E
P
T
D
T
A
A
M
A
R
T
S
Site 36
S394
T
A
A
M
A
R
T
S
N
L
N
E
E
L
G
Site 37
Y405
E
E
L
G
Q
V
K
Y
I
F
S
D
K
T
G
Site 38
S408
G
Q
V
K
Y
I
F
S
D
K
T
G
T
L
T
Site 39
T411
K
Y
I
F
S
D
K
T
G
T
L
T
C
N
V
Site 40
T415
S
D
K
T
G
T
L
T
C
N
V
M
Q
F
K
Site 41
Y431
C
T
I
A
G
V
A
Y
G
H
V
P
E
P
E
Site 42
Y440
H
V
P
E
P
E
D
Y
G
C
S
P
D
E
W
Site 43
S443
E
P
E
D
Y
G
C
S
P
D
E
W
Q
N
S
Site 44
S450
S
P
D
E
W
Q
N
S
Q
F
G
D
E
K
T
Site 45
T457
S
Q
F
G
D
E
K
T
F
S
D
S
S
L
L
Site 46
S459
F
G
D
E
K
T
F
S
D
S
S
L
L
E
N
Site 47
S462
E
K
T
F
S
D
S
S
L
L
E
N
L
Q
N
Site 48
Y501
R
E
G
D
K
I
I
Y
Q
A
A
S
P
D
E
Site 49
T523
K
Q
L
N
F
V
F
T
G
R
T
P
D
S
V
Site 50
S534
P
D
S
V
I
I
D
S
L
G
Q
E
E
R
Y
Site 51
S551
L
N
V
L
E
F
T
S
A
R
K
R
M
S
V
Site 52
S557
T
S
A
R
K
R
M
S
V
I
V
R
T
P
S
Site 53
T562
R
M
S
V
I
V
R
T
P
S
G
K
L
R
L
Site 54
Y570
P
S
G
K
L
R
L
Y
C
K
G
A
D
T
V
Site 55
Y579
K
G
A
D
T
V
I
Y
D
R
L
A
E
T
S
Site 56
S586
Y
D
R
L
A
E
T
S
K
Y
K
E
I
T
L
Site 57
Y588
R
L
A
E
T
S
K
Y
K
E
I
T
L
K
H
Site 58
T601
K
H
L
E
Q
F
A
T
E
G
L
R
T
L
C
Site 59
S617
A
V
A
E
I
S
E
S
D
F
Q
E
W
R
A
Site 60
Y626
F
Q
E
W
R
A
V
Y
Q
R
A
S
T
S
V
Site 61
S630
R
A
V
Y
Q
R
A
S
T
S
V
Q
N
R
L
Site 62
T631
A
V
Y
Q
R
A
S
T
S
V
Q
N
R
L
L
Site 63
S632
V
Y
Q
R
A
S
T
S
V
Q
N
R
L
L
K
Site 64
S643
R
L
L
K
L
E
E
S
Y
E
L
I
E
K
N
Site 65
T673
Q
V
P
E
T
I
E
T
L
M
K
A
D
I
K
Site 66
S715
M
I
V
I
N
E
G
S
L
D
G
T
R
E
T
Site 67
T719
N
E
G
S
L
D
G
T
R
E
T
L
S
R
H
Site 68
T722
S
L
D
G
T
R
E
T
L
S
R
H
C
T
T
Site 69
S724
D
G
T
R
E
T
L
S
R
H
C
T
T
L
G
Site 70
T728
E
T
L
S
R
H
C
T
T
L
G
D
A
L
R
Site 71
T754
K
T
L
K
Y
A
L
T
F
G
V
R
Q
Y
F
Site 72
S782
R
V
S
P
L
Q
K
S
E
V
V
E
M
V
K
Site 73
S807
G
D
G
A
N
D
V
S
M
I
Q
T
A
H
V
Site 74
T811
N
D
V
S
M
I
Q
T
A
H
V
G
V
G
I
Site 75
S829
E
G
L
Q
A
A
N
S
S
D
Y
S
I
A
Q
Site 76
S830
G
L
Q
A
A
N
S
S
D
Y
S
I
A
Q
F
Site 77
Y832
Q
A
A
N
S
S
D
Y
S
I
A
Q
F
K
Y
Site 78
S833
A
A
N
S
S
D
Y
S
I
A
Q
F
K
Y
L
Site 79
Y839
Y
S
I
A
Q
F
K
Y
L
K
N
L
L
M
I
Site 80
S914
T
L
G
I
F
E
R
S
C
R
K
E
N
M
L
Site 81
Y923
R
K
E
N
M
L
K
Y
P
E
L
Y
K
T
S
Site 82
T929
K
Y
P
E
L
Y
K
T
S
Q
N
A
L
D
F
Site 83
S975
A
F
G
N
G
K
T
S
D
Y
L
L
L
G
N
Site 84
Y977
G
N
G
K
T
S
D
Y
L
L
L
G
N
F
V
Site 85
Y1002
K
A
G
L
E
T
S
Y
W
T
W
F
S
H
I
Site 86
T1079
I
K
R
T
A
F
K
T
L
V
D
E
V
Q
E
Site 87
S1091
V
Q
E
L
E
A
K
S
Q
D
P
G
A
V
V
Site 88
Y1122
K
K
N
H
V
N
L
Y
R
S
E
S
L
Q
Q
Site 89
S1126
V
N
L
Y
R
S
E
S
L
Q
Q
N
L
L
H
Site 90
S1138
L
L
H
G
Y
A
F
S
Q
D
E
N
G
I
V
Site 91
S1146
Q
D
E
N
G
I
V
S
Q
S
E
V
I
R
A
Site 92
S1148
E
N
G
I
V
S
Q
S
E
V
I
R
A
Y
D
Site 93
Y1154
Q
S
E
V
I
R
A
Y
D
T
T
K
Q
R
P
Site 94
T1157
V
I
R
A
Y
D
T
T
K
Q
R
P
D
E
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation