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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AXIN2
Full Name:
Axin-2
Alias:
Axil; Axin 2; Axin-like protein; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC126582
Type:
Intracellular, Cytoplasm, Nucleus protein
Mass (Da):
93558
Number AA:
843
UniProt ID:
Q9Y2T1
International Prot ID:
IPI00294274
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
V
T
C
L
P
D
P
S
S
S
F
R
E
D
A
Site 2
S15
T
C
L
P
D
P
S
S
S
F
R
E
D
A
P
Site 3
S16
C
L
P
D
P
S
S
S
F
R
E
D
A
P
R
Site 4
T33
V
P
G
E
E
G
E
T
P
P
C
Q
P
G
V
Site 5
T46
G
V
G
K
G
Q
V
T
K
P
M
S
V
S
S
Site 6
S50
G
Q
V
T
K
P
M
S
V
S
S
N
T
R
R
Site 7
S53
T
K
P
M
S
V
S
S
N
T
R
R
N
E
D
Site 8
S70
G
E
P
E
G
R
A
S
P
D
S
P
L
T
R
Site 9
S73
E
G
R
A
S
P
D
S
P
L
T
R
W
T
K
Site 10
T76
A
S
P
D
S
P
L
T
R
W
T
K
S
L
H
Site 11
T79
D
S
P
L
T
R
W
T
K
S
L
H
S
L
L
Site 12
S81
P
L
T
R
W
T
K
S
L
H
S
L
L
G
D
Site 13
S84
R
W
T
K
S
L
H
S
L
L
G
D
Q
D
G
Site 14
Y93
L
G
D
Q
D
G
A
Y
L
F
R
T
F
L
E
Site 15
T97
D
G
A
Y
L
F
R
T
F
L
E
R
E
K
C
Site 16
T127
M
N
L
K
D
T
K
T
L
R
V
A
K
A
I
Site 17
Y135
L
R
V
A
K
A
I
Y
K
R
Y
I
E
N
N
Site 18
Y138
A
K
A
I
Y
K
R
Y
I
E
N
N
S
I
V
Site 19
S143
K
R
Y
I
E
N
N
S
I
V
S
K
Q
L
K
Site 20
T155
Q
L
K
P
A
T
K
T
Y
I
R
D
G
I
K
Site 21
Y156
L
K
P
A
T
K
T
Y
I
R
D
G
I
K
K
Site 22
S180
Q
A
Q
T
E
I
Q
S
V
M
E
E
N
A
Y
Site 23
Y187
S
V
M
E
E
N
A
Y
Q
M
F
L
T
S
D
Site 24
Y199
T
S
D
I
Y
L
E
Y
V
R
S
G
G
E
N
Site 25
S202
I
Y
L
E
Y
V
R
S
G
G
E
N
T
A
Y
Site 26
T207
V
R
S
G
G
E
N
T
A
Y
M
S
N
G
G
Site 27
Y209
S
G
G
E
N
T
A
Y
M
S
N
G
G
L
G
Site 28
S211
G
E
N
T
A
Y
M
S
N
G
G
L
G
S
L
Site 29
T258
S
S
K
T
L
R
A
T
A
S
V
R
S
T
E
Site 30
S260
K
T
L
R
A
T
A
S
V
R
S
T
E
T
V
Site 31
T264
A
T
A
S
V
R
S
T
E
T
V
D
S
G
Y
Site 32
T266
A
S
V
R
S
T
E
T
V
D
S
G
Y
R
S
Site 33
S269
R
S
T
E
T
V
D
S
G
Y
R
S
F
K
R
Site 34
Y271
T
E
T
V
D
S
G
Y
R
S
F
K
R
S
D
Site 35
S273
T
V
D
S
G
Y
R
S
F
K
R
S
D
P
V
Site 36
S277
G
Y
R
S
F
K
R
S
D
P
V
N
P
Y
H
Site 37
Y283
R
S
D
P
V
N
P
Y
H
I
G
S
G
Y
V
Site 38
S296
Y
V
F
A
P
A
T
S
A
N
D
S
E
I
S
Site 39
S300
P
A
T
S
A
N
D
S
E
I
S
S
D
A
L
Site 40
S304
A
N
D
S
E
I
S
S
D
A
L
T
D
D
S
Site 41
T308
E
I
S
S
D
A
L
T
D
D
S
M
S
M
T
Site 42
S311
S
D
A
L
T
D
D
S
M
S
M
T
D
S
S
Site 43
S313
A
L
T
D
D
S
M
S
M
T
D
S
S
V
D
Site 44
T315
T
D
D
S
M
S
M
T
D
S
S
V
D
G
I
Site 45
S317
D
S
M
S
M
T
D
S
S
V
D
G
I
P
P
Site 46
S318
S
M
S
M
T
D
S
S
V
D
G
I
P
P
Y
Site 47
Y325
S
V
D
G
I
P
P
Y
R
V
G
S
K
K
Q
Site 48
S329
I
P
P
Y
R
V
G
S
K
K
Q
L
Q
R
E
Site 49
S340
L
Q
R
E
M
H
R
S
V
K
A
N
G
Q
V
Site 50
S348
V
K
A
N
G
Q
V
S
L
P
H
F
P
R
T
Site 51
T355
S
L
P
H
F
P
R
T
H
R
L
P
K
E
M
Site 52
T363
H
R
L
P
K
E
M
T
P
V
E
P
A
T
F
Site 53
S390
L
E
L
E
S
R
H
S
L
E
E
R
L
Q
Q
Site 54
S407
E
D
E
E
R
E
G
S
E
L
T
L
N
S
R
Site 55
T419
N
S
R
E
G
A
P
T
Q
H
P
L
S
L
L
Site 56
S424
A
P
T
Q
H
P
L
S
L
L
P
S
G
S
Y
Site 57
S428
H
P
L
S
L
L
P
S
G
S
Y
E
E
D
P
Site 58
S430
L
S
L
L
P
S
G
S
Y
E
E
D
P
Q
T
Site 59
T437
S
Y
E
E
D
P
Q
T
I
L
D
D
H
L
S
Site 60
S444
T
I
L
D
D
H
L
S
R
V
L
K
T
P
G
Site 61
T449
H
L
S
R
V
L
K
T
P
G
C
Q
S
P
G
Site 62
S454
L
K
T
P
G
C
Q
S
P
G
V
G
R
Y
S
Site 63
Y460
Q
S
P
G
V
G
R
Y
S
P
R
S
R
S
P
Site 64
S461
S
P
G
V
G
R
Y
S
P
R
S
R
S
P
D
Site 65
S464
V
G
R
Y
S
P
R
S
R
S
P
D
H
H
H
Site 66
S466
R
Y
S
P
R
S
R
S
P
D
H
H
H
H
H
Site 67
Y477
H
H
H
H
H
S
Q
Y
H
S
L
L
P
P
G
Site 68
S479
H
H
H
S
Q
Y
H
S
L
L
P
P
G
G
K
Site 69
T507
L
G
G
K
G
F
V
T
K
Q
T
T
K
H
V
Site 70
T536
E
E
I
E
A
E
A
T
Q
R
V
H
C
F
C
Site 71
Y549
F
C
P
G
G
S
E
Y
Y
C
Y
S
K
C
K
Site 72
Y552
G
G
S
E
Y
Y
C
Y
S
K
C
K
S
H
S
Site 73
S557
Y
C
Y
S
K
C
K
S
H
S
K
A
P
E
T
Site 74
S559
Y
S
K
C
K
S
H
S
K
A
P
E
T
M
P
Site 75
T564
S
H
S
K
A
P
E
T
M
P
S
E
Q
F
G
Site 76
S567
K
A
P
E
T
M
P
S
E
Q
F
G
G
S
R
Site 77
S573
P
S
E
Q
F
G
G
S
R
G
S
T
L
P
K
Site 78
S576
Q
F
G
G
S
R
G
S
T
L
P
K
R
N
G
Site 79
T577
F
G
G
S
R
G
S
T
L
P
K
R
N
G
K
Site 80
T586
P
K
R
N
G
K
G
T
E
P
G
L
A
L
P
Site 81
S630
M
L
E
S
E
R
Q
S
K
P
K
P
H
S
A
Site 82
S636
Q
S
K
P
K
P
H
S
A
Q
S
T
K
K
A
Site 83
T640
K
P
H
S
A
Q
S
T
K
K
A
Y
P
L
E
Site 84
Y644
A
Q
S
T
K
K
A
Y
P
L
E
S
A
R
S
Site 85
S648
K
K
A
Y
P
L
E
S
A
R
S
S
P
G
E
Site 86
S651
Y
P
L
E
S
A
R
S
S
P
G
E
R
A
S
Site 87
S652
P
L
E
S
A
R
S
S
P
G
E
R
A
S
R
Site 88
S658
S
S
P
G
E
R
A
S
R
H
H
L
W
G
G
Site 89
T672
G
N
S
G
H
P
R
T
T
P
R
A
H
L
F
Site 90
T673
N
S
G
H
P
R
T
T
P
R
A
H
L
F
T
Site 91
T680
T
P
R
A
H
L
F
T
Q
D
P
A
M
P
P
Site 92
T689
D
P
A
M
P
P
L
T
P
P
N
T
L
A
Q
Site 93
T693
P
P
L
T
P
P
N
T
L
A
Q
L
E
E
A
Site 94
S708
C
R
R
L
A
E
V
S
K
P
P
K
Q
R
C
Site 95
S727
Q
Q
R
D
R
N
H
S
A
T
V
Q
T
G
A
Site 96
T729
R
D
R
N
H
S
A
T
V
Q
T
G
A
T
P
Site 97
T735
A
T
V
Q
T
G
A
T
P
F
S
N
P
S
L
Site 98
S738
Q
T
G
A
T
P
F
S
N
P
S
L
A
P
E
Site 99
S741
A
T
P
F
S
N
P
S
L
A
P
E
D
H
K
Site 100
Y777
F
C
G
E
E
I
P
Y
R
R
M
L
K
A
Q
Site 101
S785
R
R
M
L
K
A
Q
S
L
T
L
G
H
F
K
Site 102
S796
G
H
F
K
E
Q
L
S
K
K
G
N
Y
R
Y
Site 103
Y803
S
K
K
G
N
Y
R
Y
Y
F
K
K
A
S
D
Site 104
Y804
K
K
G
N
Y
R
Y
Y
F
K
K
A
S
D
E
Site 105
S809
R
Y
Y
F
K
K
A
S
D
E
F
A
C
G
A
Site 106
T826
E
E
I
W
E
D
E
T
V
L
P
M
Y
E
G
Site 107
Y831
D
E
T
V
L
P
M
Y
E
G
R
I
L
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation