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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEKK2
Full Name:
Mitogen-activated protein kinase kinase kinase 2
Alias:
EC 2.7.11.25; Kinase MEKK2; M3K2; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2B
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25;
STE
group; STE11 family
Mass (Da):
69741
Number AA:
619
UniProt ID:
Q9Y2U5
International Prot ID:
IPI00513803
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007257
GO:0006468
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
MAPK/ERK kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2 pan-specific antibody AB-NK108-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK108-3#MAPK/ERK kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2 pan-specific antibody AB-NK108-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK108-4#MAPK/ERK kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2 pan-specific antibody AB-NK108-5#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK108-5#MAPK/ERK kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2 S239 phosphosite-specific antibody AB-PK700#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK700#MAPK/ERK kinase kinase 2 / Mitogen-activated protein kinase kinase kinase 2 (S39-E45, human) peptide - Powder PE-01AXT99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AXT99#MAPK/ERK kinase kinase 2 / Mitogen-activated protein kinase kinase kinase 2 (L119-P132, human) peptide - Powder PE-01AXU90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AXU90#MAPK/ERK kinase kinase 2 / Mitogen-activated protein kinase kinase kinase 2 (K602-V616, human) peptide - Powder PE-01AXV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AXV99#MAPK/ERK kinase kinase 2 / Mitogen-activated protein kinase kinase kinase 2 (R236-D242, human) pS239 phosphopeptide - Powder PE-04ANX90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANX90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
D
Q
Q
A
L
N
S
I
M
Q
D
L
A
V
Site 2
S26
K
A
S
R
P
A
L
S
L
Q
E
T
R
K
A
Site 3
T30
P
A
L
S
L
Q
E
T
R
K
A
K
S
S
S
Site 4
S35
Q
E
T
R
K
A
K
S
S
S
P
K
K
Q
N
Site 5
S36
E
T
R
K
A
K
S
S
S
P
K
K
Q
N
D
Site 6
S37
T
R
K
A
K
S
S
S
P
K
K
Q
N
D
V
Site 7
S70
V
K
L
E
D
L
R
S
K
A
K
I
A
F
G
Site 8
Y84
G
Q
S
M
D
L
H
Y
T
N
N
E
L
V
I
Site 9
T94
N
E
L
V
I
P
L
T
T
Q
D
D
L
D
K
Site 10
S109
A
V
E
L
L
D
R
S
I
H
M
K
S
L
K
Site 11
T128
I
N
G
S
T
Q
A
T
N
L
E
P
L
P
S
Site 12
S135
T
N
L
E
P
L
P
S
L
E
D
L
D
N
T
Site 13
T142
S
L
E
D
L
D
N
T
V
F
G
A
E
R
K
Site 14
S153
A
E
R
K
K
R
L
S
I
I
G
P
T
S
R
Site 15
T158
R
L
S
I
I
G
P
T
S
R
D
R
S
S
P
Site 16
S159
L
S
I
I
G
P
T
S
R
D
R
S
S
P
P
Site 17
S163
G
P
T
S
R
D
R
S
S
P
P
P
G
Y
I
Site 18
S164
P
T
S
R
D
R
S
S
P
P
P
G
Y
I
P
Site 19
Y169
R
S
S
P
P
P
G
Y
I
P
D
E
L
H
Q
Site 20
S182
H
Q
V
A
R
N
G
S
F
T
S
I
N
S
E
Site 21
T184
V
A
R
N
G
S
F
T
S
I
N
S
E
G
E
Site 22
S185
A
R
N
G
S
F
T
S
I
N
S
E
G
E
F
Site 23
S196
E
G
E
F
I
P
E
S
M
D
Q
M
L
D
P
Site 24
S205
D
Q
M
L
D
P
L
S
L
S
S
P
E
N
S
Site 25
S207
M
L
D
P
L
S
L
S
S
P
E
N
S
G
S
Site 26
S208
L
D
P
L
S
L
S
S
P
E
N
S
G
S
G
Site 27
S212
S
L
S
S
P
E
N
S
G
S
G
S
C
P
S
Site 28
S214
S
S
P
E
N
S
G
S
G
S
C
P
S
L
D
Site 29
S216
P
E
N
S
G
S
G
S
C
P
S
L
D
S
P
Site 30
S219
S
G
S
G
S
C
P
S
L
D
S
P
L
D
G
Site 31
S222
G
S
C
P
S
L
D
S
P
L
D
G
E
S
Y
Site 32
S228
D
S
P
L
D
G
E
S
Y
P
K
S
R
M
P
Site 33
Y229
S
P
L
D
G
E
S
Y
P
K
S
R
M
P
R
Site 34
S232
D
G
E
S
Y
P
K
S
R
M
P
R
A
Q
S
Site 35
S239
S
R
M
P
R
A
Q
S
Y
P
D
N
H
Q
E
MAPK/ERK kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2 S239 phosphosite-specific antibody AB-PK700#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK700#MAPK/ERK kinase kinase 2 / Mitogen-activated protein kinase kinase kinase 2 (R236-D242, human) pS239 phosphopeptide - Powder PE-04ANX90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANX90
Site 36
Y240
R
M
P
R
A
Q
S
Y
P
D
N
H
Q
E
F
Site 37
S248
P
D
N
H
Q
E
F
S
D
Y
D
N
P
I
F
Site 38
Y250
N
H
Q
E
F
S
D
Y
D
N
P
I
F
E
K
Site 39
T263
E
K
F
G
K
G
G
T
Y
P
R
R
Y
H
V
Site 40
Y264
K
F
G
K
G
G
T
Y
P
R
R
Y
H
V
S
Site 41
Y268
G
G
T
Y
P
R
R
Y
H
V
S
Y
H
H
Q
Site 42
Y272
P
R
R
Y
H
V
S
Y
H
H
Q
E
Y
N
D
Site 43
T283
E
Y
N
D
G
R
K
T
F
P
R
A
R
R
T
Site 44
T290
T
F
P
R
A
R
R
T
Q
G
T
S
L
R
S
Site 45
T293
R
A
R
R
T
Q
G
T
S
L
R
S
P
V
S
Site 46
S294
A
R
R
T
Q
G
T
S
L
R
S
P
V
S
F
Site 47
S297
T
Q
G
T
S
L
R
S
P
V
S
F
S
P
T
Site 48
S300
T
S
L
R
S
P
V
S
F
S
P
T
D
H
S
Site 49
S302
L
R
S
P
V
S
F
S
P
T
D
H
S
L
S
Site 50
T304
S
P
V
S
F
S
P
T
D
H
S
L
S
T
S
Site 51
S307
S
F
S
P
T
D
H
S
L
S
T
S
S
G
S
Site 52
S309
S
P
T
D
H
S
L
S
T
S
S
G
S
S
I
Site 53
T310
P
T
D
H
S
L
S
T
S
S
G
S
S
I
F
Site 54
S311
T
D
H
S
L
S
T
S
S
G
S
S
I
F
T
Site 55
S312
D
H
S
L
S
T
S
S
G
S
S
I
F
T
P
Site 56
S314
S
L
S
T
S
S
G
S
S
I
F
T
P
E
Y
Site 57
S315
L
S
T
S
S
G
S
S
I
F
T
P
E
Y
D
Site 58
T318
S
S
G
S
S
I
F
T
P
E
Y
D
D
S
R
Site 59
Y321
S
S
I
F
T
P
E
Y
D
D
S
R
I
R
R
Site 60
S324
F
T
P
E
Y
D
D
S
R
I
R
R
R
G
S
Site 61
S331
S
R
I
R
R
R
G
S
D
I
D
N
P
T
L
Site 62
T337
G
S
D
I
D
N
P
T
L
T
V
M
D
I
S
Site 63
T339
D
I
D
N
P
T
L
T
V
M
D
I
S
P
P
Site 64
S344
T
L
T
V
M
D
I
S
P
P
S
R
S
P
R
Site 65
S347
V
M
D
I
S
P
P
S
R
S
P
R
A
P
T
Site 66
S349
D
I
S
P
P
S
R
S
P
R
A
P
T
N
W
Site 67
T354
S
R
S
P
R
A
P
T
N
W
R
L
G
K
L
Site 68
Y371
Q
G
A
F
G
R
V
Y
L
C
Y
D
V
D
T
Site 69
Y374
F
G
R
V
Y
L
C
Y
D
V
D
T
G
R
E
Site 70
T378
Y
L
C
Y
D
V
D
T
G
R
E
L
A
V
K
Site 71
S393
Q
V
Q
F
D
P
D
S
P
E
T
S
K
E
V
Site 72
S397
D
P
D
S
P
E
T
S
K
E
V
N
A
L
E
Site 73
Y421
L
H
E
R
I
V
Q
Y
Y
G
C
L
R
D
P
Site 74
Y422
H
E
R
I
V
Q
Y
Y
G
C
L
R
D
P
Q
Site 75
T432
L
R
D
P
Q
E
K
T
L
S
I
F
M
E
Y
Site 76
S434
D
P
Q
E
K
T
L
S
I
F
M
E
Y
M
P
Site 77
Y439
T
L
S
I
F
M
E
Y
M
P
G
G
S
I
K
Site 78
T456
L
K
A
Y
G
A
L
T
E
N
V
T
R
K
Y
Site 79
Y463
T
E
N
V
T
R
K
Y
T
R
Q
I
L
E
G
Site 80
T464
E
N
V
T
R
K
Y
T
R
Q
I
L
E
G
V
Site 81
S493
G
A
N
I
L
R
D
S
T
G
N
V
K
L
G
Site 82
T494
A
N
I
L
R
D
S
T
G
N
V
K
L
G
D
Site 83
S505
K
L
G
D
F
G
A
S
K
R
L
Q
T
I
C
Site 84
T510
G
A
S
K
R
L
Q
T
I
C
L
S
G
T
G
Site 85
S514
R
L
Q
T
I
C
L
S
G
T
G
M
K
S
V
Site 86
S520
L
S
G
T
G
M
K
S
V
T
G
T
P
Y
W
Site 87
T522
G
T
G
M
K
S
V
T
G
T
P
Y
W
M
S
Site 88
T524
G
M
K
S
V
T
G
T
P
Y
W
M
S
P
E
Site 89
Y526
K
S
V
T
G
T
P
Y
W
M
S
P
E
V
I
Site 90
S529
T
G
T
P
Y
W
M
S
P
E
V
I
S
G
E
Site 91
Y538
E
V
I
S
G
E
G
Y
G
R
K
A
D
I
W
Site 92
T556
C
T
V
V
E
M
L
T
E
K
P
P
W
A
E
Site 93
S587
P
K
L
P
P
H
V
S
D
Y
T
R
D
F
L
Site 94
Y589
L
P
P
H
V
S
D
Y
T
R
D
F
L
K
R
Site 95
T590
P
P
H
V
S
D
Y
T
R
D
F
L
K
R
I
Site 96
S606
V
E
A
K
L
R
P
S
A
D
E
L
L
R
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation