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Updated November 2019
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Protein Info
Short Name:
THRAP3
Full Name:
Thyroid hormone receptor-associated protein 3
Alias:
T150; Thyroid hormone receptor associated protein 3; Thyroid hormone receptor associated protein 3 (TRAP150); Thyroid hormone receptor-associated protein complex 150 kDa component; TR150; TRAP150
Type:
Transcription, coactivator/corepressor
Mass (Da):
108666
Number AA:
955
UniProt ID:
Q9Y2W1
International Prot ID:
IPI00104050
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016455
GO:0030374
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045944
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
K
T
N
K
S
K
S
Site 2
S7
_
M
S
K
T
N
K
S
K
S
G
S
R
S
S
Site 3
S9
S
K
T
N
K
S
K
S
G
S
R
S
S
R
S
Site 4
S11
T
N
K
S
K
S
G
S
R
S
S
R
S
R
S
Site 5
S13
K
S
K
S
G
S
R
S
S
R
S
R
S
A
S
Site 6
S14
S
K
S
G
S
R
S
S
R
S
R
S
A
S
R
Site 7
S16
S
G
S
R
S
S
R
S
R
S
A
S
R
S
R
Site 8
S18
S
R
S
S
R
S
R
S
A
S
R
S
R
S
R
Site 9
S20
S
S
R
S
R
S
A
S
R
S
R
S
R
S
F
Site 10
S22
R
S
R
S
A
S
R
S
R
S
R
S
F
S
K
Site 11
S24
R
S
A
S
R
S
R
S
R
S
F
S
K
S
R
Site 12
S26
A
S
R
S
R
S
R
S
F
S
K
S
R
S
R
Site 13
S28
R
S
R
S
R
S
F
S
K
S
R
S
R
S
R
Site 14
S30
R
S
R
S
F
S
K
S
R
S
R
S
R
S
L
Site 15
S32
R
S
F
S
K
S
R
S
R
S
R
S
L
S
R
Site 16
S34
F
S
K
S
R
S
R
S
R
S
L
S
R
S
R
Site 17
S36
K
S
R
S
R
S
R
S
L
S
R
S
R
K
R
Site 18
S38
R
S
R
S
R
S
L
S
R
S
R
K
R
R
L
Site 19
S40
R
S
R
S
L
S
R
S
R
K
R
R
L
S
S
Site 20
S46
R
S
R
K
R
R
L
S
S
R
S
R
S
R
S
Site 21
S47
S
R
K
R
R
L
S
S
R
S
R
S
R
S
Y
Site 22
S49
K
R
R
L
S
S
R
S
R
S
R
S
Y
S
P
Site 23
S51
R
L
S
S
R
S
R
S
R
S
Y
S
P
A
H
Site 24
S53
S
S
R
S
R
S
R
S
Y
S
P
A
H
N
R
Site 25
Y54
S
R
S
R
S
R
S
Y
S
P
A
H
N
R
E
Site 26
S55
R
S
R
S
R
S
Y
S
P
A
H
N
R
E
R
Site 27
Y68
E
R
N
H
P
R
V
Y
Q
N
R
D
F
R
G
Site 28
Y80
F
R
G
H
N
R
G
Y
R
R
P
Y
Y
F
R
Site 29
Y84
N
R
G
Y
R
R
P
Y
Y
F
R
G
R
N
R
Site 30
Y85
R
G
Y
R
R
P
Y
Y
F
R
G
R
N
R
G
Site 31
Y94
R
G
R
N
R
G
F
Y
P
W
G
Q
Y
N
R
Site 32
Y99
G
F
Y
P
W
G
Q
Y
N
R
G
G
Y
G
N
Site 33
Y104
G
Q
Y
N
R
G
G
Y
G
N
Y
R
S
N
W
Site 34
Y107
N
R
G
G
Y
G
N
Y
R
S
N
W
Q
N
Y
Site 35
Y114
Y
R
S
N
W
Q
N
Y
R
Q
A
Y
S
P
R
Site 36
Y118
W
Q
N
Y
R
Q
A
Y
S
P
R
R
G
R
S
Site 37
S119
Q
N
Y
R
Q
A
Y
S
P
R
R
G
R
S
R
Site 38
S125
Y
S
P
R
R
G
R
S
R
S
R
S
P
K
R
Site 39
S127
P
R
R
G
R
S
R
S
R
S
P
K
R
R
S
Site 40
S129
R
G
R
S
R
S
R
S
P
K
R
R
S
P
S
Site 41
S134
S
R
S
P
K
R
R
S
P
S
P
R
S
R
S
Site 42
S136
S
P
K
R
R
S
P
S
P
R
S
R
S
H
S
Site 43
S139
R
R
S
P
S
P
R
S
R
S
H
S
R
N
S
Site 44
S141
S
P
S
P
R
S
R
S
H
S
R
N
S
D
K
Site 45
S143
S
P
R
S
R
S
H
S
R
N
S
D
K
S
S
Site 46
S146
S
R
S
H
S
R
N
S
D
K
S
S
S
D
R
Site 47
S149
H
S
R
N
S
D
K
S
S
S
D
R
S
R
R
Site 48
S150
S
R
N
S
D
K
S
S
S
D
R
S
R
R
S
Site 49
S151
R
N
S
D
K
S
S
S
D
R
S
R
R
S
S
Site 50
S154
D
K
S
S
S
D
R
S
R
R
S
S
S
S
R
Site 51
S157
S
S
D
R
S
R
R
S
S
S
S
R
S
S
S
Site 52
S158
S
D
R
S
R
R
S
S
S
S
R
S
S
S
N
Site 53
S159
D
R
S
R
R
S
S
S
S
R
S
S
S
N
H
Site 54
S160
R
S
R
R
S
S
S
S
R
S
S
S
N
H
S
Site 55
S162
R
R
S
S
S
S
R
S
S
S
N
H
S
R
V
Site 56
S163
R
S
S
S
S
R
S
S
S
N
H
S
R
V
E
Site 57
S164
S
S
S
S
R
S
S
S
N
H
S
R
V
E
S
Site 58
S167
S
R
S
S
S
N
H
S
R
V
E
S
S
K
R
Site 59
S171
S
N
H
S
R
V
E
S
S
K
R
K
S
A
K
Site 60
S172
N
H
S
R
V
E
S
S
K
R
K
S
A
K
E
Site 61
S176
V
E
S
S
K
R
K
S
A
K
E
K
K
S
S
Site 62
S182
K
S
A
K
E
K
K
S
S
S
K
D
S
R
P
Site 63
S183
S
A
K
E
K
K
S
S
S
K
D
S
R
P
S
Site 64
S184
A
K
E
K
K
S
S
S
K
D
S
R
P
S
Q
Site 65
S187
K
K
S
S
S
K
D
S
R
P
S
Q
A
A
G
Site 66
S190
S
S
K
D
S
R
P
S
Q
A
A
G
D
N
Q
Site 67
T205
G
D
E
A
K
E
Q
T
F
S
G
G
T
S
Q
Site 68
S207
E
A
K
E
Q
T
F
S
G
G
T
S
Q
D
T
Site 69
T210
E
Q
T
F
S
G
G
T
S
Q
D
T
K
A
S
Site 70
S211
Q
T
F
S
G
G
T
S
Q
D
T
K
A
S
E
Site 71
T214
S
G
G
T
S
Q
D
T
K
A
S
E
S
S
K
Site 72
S217
T
S
Q
D
T
K
A
S
E
S
S
K
P
W
P
Site 73
T227
S
K
P
W
P
D
A
T
Y
G
T
G
S
A
S
Site 74
Y228
K
P
W
P
D
A
T
Y
G
T
G
S
A
S
R
Site 75
T230
W
P
D
A
T
Y
G
T
G
S
A
S
R
A
S
Site 76
S232
D
A
T
Y
G
T
G
S
A
S
R
A
S
A
V
Site 77
S234
T
Y
G
T
G
S
A
S
R
A
S
A
V
S
E
Site 78
S237
T
G
S
A
S
R
A
S
A
V
S
E
L
S
P
Site 79
S240
A
S
R
A
S
A
V
S
E
L
S
P
R
E
R
Site 80
S243
A
S
A
V
S
E
L
S
P
R
E
R
S
P
A
Site 81
S248
E
L
S
P
R
E
R
S
P
A
L
K
S
P
L
Site 82
S253
E
R
S
P
A
L
K
S
P
L
Q
S
V
V
V
Site 83
S257
A
L
K
S
P
L
Q
S
V
V
V
R
R
R
S
Site 84
S264
S
V
V
V
R
R
R
S
P
R
P
S
P
V
P
Site 85
S268
R
R
R
S
P
R
P
S
P
V
P
K
P
S
P
Site 86
S274
P
S
P
V
P
K
P
S
P
P
L
S
S
T
S
Site 87
S278
P
K
P
S
P
P
L
S
S
T
S
Q
M
G
S
Site 88
S279
K
P
S
P
P
L
S
S
T
S
Q
M
G
S
T
Site 89
T280
P
S
P
P
L
S
S
T
S
Q
M
G
S
T
L
Site 90
S281
S
P
P
L
S
S
T
S
Q
M
G
S
T
L
P
Site 91
S285
S
S
T
S
Q
M
G
S
T
L
P
S
G
A
G
Site 92
T286
S
T
S
Q
M
G
S
T
L
P
S
G
A
G
Y
Site 93
S289
Q
M
G
S
T
L
P
S
G
A
G
Y
Q
S
G
Site 94
Y293
T
L
P
S
G
A
G
Y
Q
S
G
T
H
Q
G
Site 95
S295
P
S
G
A
G
Y
Q
S
G
T
H
Q
G
Q
F
Site 96
T297
G
A
G
Y
Q
S
G
T
H
Q
G
Q
F
D
H
Site 97
S306
Q
G
Q
F
D
H
G
S
G
S
L
S
P
S
K
Site 98
S308
Q
F
D
H
G
S
G
S
L
S
P
S
K
K
S
Site 99
S310
D
H
G
S
G
S
L
S
P
S
K
K
S
P
V
Site 100
S312
G
S
G
S
L
S
P
S
K
K
S
P
V
G
K
Site 101
S315
S
L
S
P
S
K
K
S
P
V
G
K
S
P
P
Site 102
S320
K
K
S
P
V
G
K
S
P
P
S
T
G
S
T
Site 103
S323
P
V
G
K
S
P
P
S
T
G
S
T
Y
G
S
Site 104
T324
V
G
K
S
P
P
S
T
G
S
T
Y
G
S
S
Site 105
S326
K
S
P
P
S
T
G
S
T
Y
G
S
S
Q
K
Site 106
T327
S
P
P
S
T
G
S
T
Y
G
S
S
Q
K
E
Site 107
Y328
P
P
S
T
G
S
T
Y
G
S
S
Q
K
E
E
Site 108
S330
S
T
G
S
T
Y
G
S
S
Q
K
E
E
S
A
Site 109
S331
T
G
S
T
Y
G
S
S
Q
K
E
E
S
A
A
Site 110
S336
G
S
S
Q
K
E
E
S
A
A
S
G
G
A
A
Site 111
S339
Q
K
E
E
S
A
A
S
G
G
A
A
Y
T
K
Site 112
Y344
A
A
S
G
G
A
A
Y
T
K
R
Y
L
E
E
Site 113
T354
R
Y
L
E
E
Q
K
T
E
N
G
K
D
K
E
Site 114
T365
K
D
K
E
Q
K
Q
T
N
T
D
K
E
K
I
Site 115
T367
K
E
Q
K
Q
T
N
T
D
K
E
K
I
K
E
Site 116
S377
E
K
I
K
E
K
G
S
F
S
D
T
G
L
G
Site 117
S379
I
K
E
K
G
S
F
S
D
T
G
L
G
D
G
Site 118
T381
E
K
G
S
F
S
D
T
G
L
G
D
G
K
M
Site 119
S390
L
G
D
G
K
M
K
S
D
S
F
A
P
K
T
Site 120
S392
D
G
K
M
K
S
D
S
F
A
P
K
T
D
S
Site 121
T397
S
D
S
F
A
P
K
T
D
S
E
K
P
F
R
Site 122
S399
S
F
A
P
K
T
D
S
E
K
P
F
R
G
S
Site 123
S406
S
E
K
P
F
R
G
S
Q
S
P
K
R
Y
K
Site 124
S408
K
P
F
R
G
S
Q
S
P
K
R
Y
K
L
R
Site 125
Y412
G
S
Q
S
P
K
R
Y
K
L
R
D
D
F
E
Site 126
S444
K
A
K
G
R
K
E
S
E
F
D
D
E
P
K
Site 127
S468
K
N
Q
E
E
E
K
S
G
K
W
E
G
L
V
Site 128
Y476
G
K
W
E
G
L
V
Y
A
P
P
G
K
E
K
Site 129
T487
G
K
E
K
Q
R
K
T
E
E
L
E
E
E
S
Site 130
S494
T
E
E
L
E
E
E
S
F
P
E
R
S
K
K
Site 131
S508
K
E
D
R
G
K
R
S
E
G
G
H
R
G
F
Site 132
T524
P
E
K
N
F
R
V
T
A
Y
K
A
V
Q
E
Site 133
S533
Y
K
A
V
Q
E
K
S
S
S
P
P
P
R
K
Site 134
S534
K
A
V
Q
E
K
S
S
S
P
P
P
R
K
T
Site 135
S535
A
V
Q
E
K
S
S
S
P
P
P
R
K
T
S
Site 136
T541
S
S
P
P
P
R
K
T
S
E
S
R
D
K
L
Site 137
S542
S
P
P
P
R
K
T
S
E
S
R
D
K
L
G
Site 138
S544
P
P
R
K
T
S
E
S
R
D
K
L
G
A
K
Site 139
T556
G
A
K
G
D
F
P
T
G
K
S
S
F
S
I
Site 140
S559
G
D
F
P
T
G
K
S
S
F
S
I
T
R
E
Site 141
S560
D
F
P
T
G
K
S
S
F
S
I
T
R
E
A
Site 142
S562
P
T
G
K
S
S
F
S
I
T
R
E
A
Q
V
Site 143
T564
G
K
S
S
F
S
I
T
R
E
A
Q
V
N
V
Site 144
S575
Q
V
N
V
R
M
D
S
F
D
E
D
L
A
R
Site 145
S584
D
E
D
L
A
R
P
S
G
L
L
A
Q
E
R
Site 146
S600
L
C
R
D
L
V
H
S
N
K
K
E
Q
E
F
Site 147
S609
K
K
E
Q
E
F
R
S
I
F
Q
H
I
Q
S
Site 148
S616
S
I
F
Q
H
I
Q
S
A
Q
S
Q
R
S
P
Site 149
S619
Q
H
I
Q
S
A
Q
S
Q
R
S
P
S
E
L
Site 150
S622
Q
S
A
Q
S
Q
R
S
P
S
E
L
F
A
Q
Site 151
S624
A
Q
S
Q
R
S
P
S
E
L
F
A
Q
H
I
Site 152
S645
V
K
E
H
H
F
G
S
S
G
M
T
L
H
E
Site 153
T649
H
F
G
S
S
G
M
T
L
H
E
R
F
T
K
Site 154
T655
M
T
L
H
E
R
F
T
K
Y
L
K
R
G
T
Site 155
Y657
L
H
E
R
F
T
K
Y
L
K
R
G
T
E
Q
Site 156
T662
T
K
Y
L
K
R
G
T
E
Q
E
A
A
K
N
Site 157
S672
E
A
A
K
N
K
K
S
P
E
I
H
R
R
I
Site 158
S682
I
H
R
R
I
D
I
S
P
S
T
F
R
K
H
Site 159
S684
R
R
I
D
I
S
P
S
T
F
R
K
H
G
L
Site 160
T685
R
I
D
I
S
P
S
T
F
R
K
H
G
L
A
Site 161
S698
L
A
H
D
E
M
K
S
P
R
E
P
G
Y
K
Site 162
Y704
K
S
P
R
E
P
G
Y
K
A
E
G
K
Y
K
Site 163
Y710
G
Y
K
A
E
G
K
Y
K
D
D
P
V
D
L
Site 164
S737
R
D
L
K
R
G
K
S
R
E
S
V
D
S
R
Site 165
S740
K
R
G
K
S
R
E
S
V
D
S
R
D
S
S
Site 166
S743
K
S
R
E
S
V
D
S
R
D
S
S
H
S
R
Site 167
S746
E
S
V
D
S
R
D
S
S
H
S
R
E
R
S
Site 168
S747
S
V
D
S
R
D
S
S
H
S
R
E
R
S
A
Site 169
S749
D
S
R
D
S
S
H
S
R
E
R
S
A
E
K
Site 170
S753
S
S
H
S
R
E
R
S
A
E
K
T
E
K
T
Site 171
T757
R
E
R
S
A
E
K
T
E
K
T
H
K
G
S
Site 172
T760
S
A
E
K
T
E
K
T
H
K
G
S
K
K
Q
Site 173
S777
H
R
R
A
R
D
R
S
R
S
S
S
S
S
S
Site 174
S779
R
A
R
D
R
S
R
S
S
S
S
S
S
Q
S
Site 175
S780
A
R
D
R
S
R
S
S
S
S
S
S
Q
S
S
Site 176
S781
R
D
R
S
R
S
S
S
S
S
S
Q
S
S
H
Site 177
S782
D
R
S
R
S
S
S
S
S
S
Q
S
S
H
S
Site 178
S783
R
S
R
S
S
S
S
S
S
Q
S
S
H
S
Y
Site 179
S784
S
R
S
S
S
S
S
S
Q
S
S
H
S
Y
K
Site 180
S786
S
S
S
S
S
S
Q
S
S
H
S
Y
K
A
E
Site 181
S787
S
S
S
S
S
Q
S
S
H
S
Y
K
A
E
E
Site 182
S789
S
S
S
Q
S
S
H
S
Y
K
A
E
E
Y
T
Site 183
S805
E
T
E
E
R
E
E
S
T
T
G
F
D
K
S
Site 184
T806
T
E
E
R
E
E
S
T
T
G
F
D
K
S
R
Site 185
T807
E
E
R
E
E
S
T
T
G
F
D
K
S
R
L
Site 186
S812
S
T
T
G
F
D
K
S
R
L
G
T
K
D
F
Site 187
T816
F
D
K
S
R
L
G
T
K
D
F
V
G
P
S
Site 188
S823
T
K
D
F
V
G
P
S
E
R
G
G
G
R
A
Site 189
T833
G
G
G
R
A
R
G
T
F
Q
F
R
A
R
G
Site 190
Y848
R
G
W
G
R
G
N
Y
S
G
N
N
N
N
N
Site 191
S856
S
G
N
N
N
N
N
S
N
N
D
F
Q
K
R
Site 192
Y873
E
E
E
W
D
P
E
Y
T
P
K
S
K
K
Y
Site 193
T874
E
E
W
D
P
E
Y
T
P
K
S
K
K
Y
Y
Site 194
S877
D
P
E
Y
T
P
K
S
K
K
Y
Y
L
H
D
Site 195
Y881
T
P
K
S
K
K
Y
Y
L
H
D
D
R
E
G
Site 196
S891
D
D
R
E
G
E
G
S
D
K
W
V
S
R
G
Site 197
S896
E
G
S
D
K
W
V
S
R
G
R
G
R
G
A
Site 198
S916
G
R
F
M
F
R
K
S
S
T
S
P
K
W
A
Site 199
S917
R
F
M
F
R
K
S
S
T
S
P
K
W
A
H
Site 200
T918
F
M
F
R
K
S
S
T
S
P
K
W
A
H
D
Site 201
S919
M
F
R
K
S
S
T
S
P
K
W
A
H
D
K
Site 202
S928
K
W
A
H
D
K
F
S
G
E
E
G
E
I
E
Site 203
S939
G
E
I
E
D
D
E
S
G
T
E
N
R
E
E
Site 204
T941
I
E
D
D
E
S
G
T
E
N
R
E
E
K
D
Site 205
T953
E
K
D
N
I
Q
P
T
T
E
_
_
_
_
_
Site 206
T954
K
D
N
I
Q
P
T
T
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation