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Updated November 2019
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Protein Info
Short Name:
ZNF281
Full Name:
Zinc finger protein 281
Alias:
GC-box-binding zinc finger protein 1; GZP1; Transcription factor ZBP-99; ZBP99; ZBP-99; Zinc finger DNA binding protein 99; Zinc finger DNA-binding protein 99; ZN281; ZNP-99; ZNP-99 transcription factor
Type:
Transcription protein
Mass (Da):
96915
Number AA:
895
UniProt ID:
Q9Y2X9
International Prot ID:
IPI00032563
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000428
GO:0005622
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003702
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006139
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
I
G
S
G
F
L
S
G
G
G
G
T
G
S
Site 2
S16
S
G
G
G
G
T
G
S
S
G
G
S
G
S
G
Site 3
S17
G
G
G
G
T
G
S
S
G
G
S
G
S
G
G
Site 4
S20
G
T
G
S
S
G
G
S
G
S
G
G
G
G
S
Site 5
S22
G
S
S
G
G
S
G
S
G
G
G
G
S
G
G
Site 6
S27
S
G
S
G
G
G
G
S
G
G
G
G
G
G
G
Site 7
S35
G
G
G
G
G
G
G
S
S
G
R
R
A
E
M
Site 8
S36
G
G
G
G
G
G
S
S
G
R
R
A
E
M
E
Site 9
T45
R
R
A
E
M
E
P
T
F
P
Q
G
M
V
M
Site 10
T61
N
H
R
L
P
P
V
T
S
F
T
R
P
A
G
Site 11
S62
H
R
L
P
P
V
T
S
F
T
R
P
A
G
S
Site 12
S69
S
F
T
R
P
A
G
S
A
A
P
P
P
Q
C
Site 13
S79
P
P
P
Q
C
V
L
S
S
S
T
S
A
A
P
Site 14
S80
P
P
Q
C
V
L
S
S
S
T
S
A
A
P
A
Site 15
T99
P
P
P
A
P
D
M
T
F
K
K
E
P
A
A
Site 16
S107
F
K
K
E
P
A
A
S
A
A
A
F
P
S
Q
Site 17
S113
A
S
A
A
A
F
P
S
Q
R
T
S
W
G
F
Site 18
T116
A
A
F
P
S
Q
R
T
S
W
G
F
L
Q
S
Site 19
S117
A
F
P
S
Q
R
T
S
W
G
F
L
Q
S
L
Site 20
S123
T
S
W
G
F
L
Q
S
L
V
S
I
K
Q
E
Site 21
S126
G
F
L
Q
S
L
V
S
I
K
Q
E
K
P
A
Site 22
S160
F
A
G
A
E
E
R
S
P
G
L
G
G
G
E
Site 23
S170
L
G
G
G
E
G
G
S
H
G
V
I
Q
D
L
Site 24
S198
H
H
R
D
V
L
L
S
S
S
S
R
T
D
D
Site 25
S199
H
R
D
V
L
L
S
S
S
S
R
T
D
D
H
Site 26
S200
R
D
V
L
L
S
S
S
S
R
T
D
D
H
H
Site 27
S201
D
V
L
L
S
S
S
S
R
T
D
D
H
H
G
Site 28
T203
L
L
S
S
S
S
R
T
D
D
H
H
G
T
E
Site 29
T209
R
T
D
D
H
H
G
T
E
E
P
K
Q
D
T
Site 30
S228
A
K
R
P
K
P
E
S
Q
G
I
K
A
K
R
Site 31
S238
I
K
A
K
R
K
P
S
A
S
S
K
P
S
L
Site 32
S240
A
K
R
K
P
S
A
S
S
K
P
S
L
V
G
Site 33
S241
K
R
K
P
S
A
S
S
K
P
S
L
V
G
D
Site 34
S244
P
S
A
S
S
K
P
S
L
V
G
D
G
E
G
Site 35
S255
D
G
E
G
A
I
L
S
P
S
Q
K
P
H
I
Site 36
S257
E
G
A
I
L
S
P
S
Q
K
P
H
I
C
D
Site 37
S273
C
S
A
A
F
R
S
S
Y
H
L
R
R
H
V
Site 38
Y274
S
A
A
F
R
S
S
Y
H
L
R
R
H
V
L
Site 39
T284
R
R
H
V
L
I
H
T
G
E
R
P
F
Q
C
Site 40
Y302
S
M
G
F
I
Q
K
Y
L
L
Q
R
H
E
K
Site 41
Y330
S
M
K
F
I
Q
K
Y
H
M
E
R
H
K
R
Site 42
S340
E
R
H
K
R
T
H
S
G
E
K
P
Y
K
C
Site 43
T349
E
K
P
Y
K
C
D
T
C
Q
Q
Y
F
S
R
Site 44
Y353
K
C
D
T
C
Q
Q
Y
F
S
R
T
D
R
L
Site 45
T357
C
Q
Q
Y
F
S
R
T
D
R
L
L
K
H
R
Site 46
T366
R
L
L
K
H
R
R
T
C
G
E
V
I
V
K
Site 47
S377
V
I
V
K
G
A
T
S
A
E
P
G
S
S
N
Site 48
S382
A
T
S
A
E
P
G
S
S
N
H
T
N
M
G
Site 49
S383
T
S
A
E
P
G
S
S
N
H
T
N
M
G
N
Site 50
T386
E
P
G
S
S
N
H
T
N
M
G
N
L
A
V
Site 51
S395
M
G
N
L
A
V
L
S
Q
G
N
T
S
S
S
Site 52
T399
A
V
L
S
Q
G
N
T
S
S
S
R
R
K
T
Site 53
S401
L
S
Q
G
N
T
S
S
S
R
R
K
T
K
S
Site 54
S402
S
Q
G
N
T
S
S
S
R
R
K
T
K
S
K
Site 55
T406
T
S
S
S
R
R
K
T
K
S
K
S
I
A
I
Site 56
S408
S
S
R
R
K
T
K
S
K
S
I
A
I
E
N
Site 57
S410
R
R
K
T
K
S
K
S
I
A
I
E
N
K
E
Site 58
S426
K
T
G
K
T
N
E
S
Q
I
S
N
N
I
N
Site 59
S438
N
I
N
M
Q
S
Y
S
V
E
M
P
T
V
S
Site 60
T443
S
Y
S
V
E
M
P
T
V
S
S
S
G
G
I
Site 61
S445
S
V
E
M
P
T
V
S
S
S
G
G
I
I
G
Site 62
S446
V
E
M
P
T
V
S
S
S
G
G
I
I
G
T
Site 63
T475
K
K
G
S
R
K
N
T
D
K
N
Y
L
N
F
Site 64
Y479
R
K
N
T
D
K
N
Y
L
N
F
V
S
P
L
Site 65
S484
K
N
Y
L
N
F
V
S
P
L
P
D
I
V
G
Site 66
S494
P
D
I
V
G
Q
K
S
L
S
G
K
P
S
G
Site 67
S496
I
V
G
Q
K
S
L
S
G
K
P
S
G
S
L
Site 68
S500
K
S
L
S
G
K
P
S
G
S
L
G
I
V
S
Site 69
S502
L
S
G
K
P
S
G
S
L
G
I
V
S
N
N
Site 70
S519
E
T
I
G
L
L
Q
S
T
S
G
K
Q
G
Q
Site 71
S521
I
G
L
L
Q
S
T
S
G
K
Q
G
Q
I
S
Site 72
S529
G
K
Q
G
Q
I
S
S
N
Y
D
D
A
M
Q
Site 73
Y531
Q
G
Q
I
S
S
N
Y
D
D
A
M
Q
F
S
Site 74
S538
Y
D
D
A
M
Q
F
S
K
K
R
R
Y
L
P
Site 75
Y543
Q
F
S
K
K
R
R
Y
L
P
T
A
S
S
N
Site 76
T546
K
K
R
R
Y
L
P
T
A
S
S
N
S
A
F
Site 77
S548
R
R
Y
L
P
T
A
S
S
N
S
A
F
S
I
Site 78
S549
R
Y
L
P
T
A
S
S
N
S
A
F
S
I
N
Site 79
S595
A
L
N
A
E
I
K
S
C
H
D
K
S
G
I
Site 80
S600
I
K
S
C
H
D
K
S
G
I
P
D
E
V
L
Site 81
S609
I
P
D
E
V
L
Q
S
I
L
D
Q
Y
S
N
Site 82
Y614
L
Q
S
I
L
D
Q
Y
S
N
K
S
E
S
Q
Site 83
S615
Q
S
I
L
D
Q
Y
S
N
K
S
E
S
Q
K
Site 84
S618
L
D
Q
Y
S
N
K
S
E
S
Q
K
E
D
P
Site 85
S620
Q
Y
S
N
K
S
E
S
Q
K
E
D
P
F
N
Site 86
T637
E
P
R
V
D
L
H
T
S
G
E
H
S
E
L
Site 87
S638
P
R
V
D
L
H
T
S
G
E
H
S
E
L
V
Site 88
S642
L
H
T
S
G
E
H
S
E
L
V
Q
E
E
N
Site 89
S651
L
V
Q
E
E
N
L
S
P
G
T
Q
T
P
S
Site 90
T654
E
E
N
L
S
P
G
T
Q
T
P
S
N
D
K
Site 91
T656
N
L
S
P
G
T
Q
T
P
S
N
D
K
A
S
Site 92
S658
S
P
G
T
Q
T
P
S
N
D
K
A
S
M
L
Site 93
Y671
M
L
Q
E
Y
S
K
Y
L
Q
Q
A
F
E
K
Site 94
S679
L
Q
Q
A
F
E
K
S
T
N
A
S
F
T
L
Site 95
S683
F
E
K
S
T
N
A
S
F
T
L
G
H
G
F
Site 96
S694
G
H
G
F
Q
F
V
S
L
S
S
P
L
H
N
Site 97
S696
G
F
Q
F
V
S
L
S
S
P
L
H
N
H
T
Site 98
T703
S
S
P
L
H
N
H
T
L
F
P
E
K
Q
I
Site 99
Y711
L
F
P
E
K
Q
I
Y
T
T
S
P
L
E
C
Site 100
T712
F
P
E
K
Q
I
Y
T
T
S
P
L
E
C
G
Site 101
S714
E
K
Q
I
Y
T
T
S
P
L
E
C
G
F
G
Site 102
S750
S
Q
P
G
L
Y
L
S
A
L
D
A
T
H
Q
Site 103
T760
D
A
T
H
Q
Q
L
T
P
S
Q
E
L
D
D
Site 104
S762
T
H
Q
Q
L
T
P
S
Q
E
L
D
D
L
I
Site 105
S771
E
L
D
D
L
I
D
S
Q
K
N
L
E
T
S
Site 106
S778
S
Q
K
N
L
E
T
S
S
A
F
Q
S
S
S
Site 107
S779
Q
K
N
L
E
T
S
S
A
F
Q
S
S
S
Q
Site 108
S783
E
T
S
S
A
F
Q
S
S
S
Q
K
L
T
S
Site 109
S784
T
S
S
A
F
Q
S
S
S
Q
K
L
T
S
Q
Site 110
S785
S
S
A
F
Q
S
S
S
Q
K
L
T
S
Q
K
Site 111
T789
Q
S
S
S
Q
K
L
T
S
Q
K
E
Q
K
N
Site 112
S790
S
S
S
Q
K
L
T
S
Q
K
E
Q
K
N
L
Site 113
S799
K
E
Q
K
N
L
E
S
S
T
G
F
Q
I
P
Site 114
S807
S
T
G
F
Q
I
P
S
Q
E
L
A
S
Q
I
Site 115
T825
K
D
I
E
P
R
T
T
Y
Q
I
E
N
F
A
Site 116
Y826
D
I
E
P
R
T
T
Y
Q
I
E
N
F
A
Q
Site 117
S837
N
F
A
Q
A
F
G
S
Q
F
K
S
G
S
R
Site 118
S841
A
F
G
S
Q
F
K
S
G
S
R
V
P
M
T
Site 119
S843
G
S
Q
F
K
S
G
S
R
V
P
M
T
F
I
Site 120
T848
S
G
S
R
V
P
M
T
F
I
T
N
S
N
G
Site 121
T851
R
V
P
M
T
F
I
T
N
S
N
G
E
V
D
Site 122
T863
E
V
D
H
R
V
R
T
S
V
S
D
F
S
G
Site 123
S864
V
D
H
R
V
R
T
S
V
S
D
F
S
G
Y
Site 124
S866
H
R
V
R
T
S
V
S
D
F
S
G
Y
T
N
Site 125
S869
R
T
S
V
S
D
F
S
G
Y
T
N
M
M
S
Site 126
Y871
S
V
S
D
F
S
G
Y
T
N
M
M
S
D
V
Site 127
S876
S
G
Y
T
N
M
M
S
D
V
S
E
P
C
S
Site 128
S879
T
N
M
M
S
D
V
S
E
P
C
S
T
R
V
Site 129
S883
S
D
V
S
E
P
C
S
T
R
V
K
T
P
T
Site 130
T884
D
V
S
E
P
C
S
T
R
V
K
T
P
T
S
Site 131
T888
P
C
S
T
R
V
K
T
P
T
S
Q
S
Y
R
Site 132
T890
S
T
R
V
K
T
P
T
S
Q
S
Y
R
_
_
Site 133
S891
T
R
V
K
T
P
T
S
Q
S
Y
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation