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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXOSC1
Full Name:
3'-5' exoribonuclease CSL4 homolog
Alias:
3'-5' exoribonuclease CSL4; CGI-108; CSL4; CSL4 exosomal core protein; Csl4p; EXOS1; exosome component 1; hCsl4p; p13; SKI4; Ski4p
Type:
EC 3.1.13.-; RNA binding protein; Ribonuclease
Mass (Da):
21452
Number AA:
195
UniProt ID:
Q9Y3B2
International Prot ID:
IPI00032823
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000178
GO:0005730
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004527
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006364
GO:0006364
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
A
P
P
V
R
Y
C
I
P
G
E
R
L
Site 2
S21
L
C
N
L
E
E
G
S
P
G
S
G
T
Y
T
Site 3
S24
L
E
E
G
S
P
G
S
G
T
Y
T
R
H
G
Site 4
T26
E
G
S
P
G
S
G
T
Y
T
R
H
G
Y
I
Site 5
Y27
G
S
P
G
S
G
T
Y
T
R
H
G
Y
I
F
Site 6
T28
S
P
G
S
G
T
Y
T
R
H
G
Y
I
F
S
Site 7
Y32
G
T
Y
T
R
H
G
Y
I
F
S
S
L
A
G
Site 8
S44
L
A
G
C
L
M
K
S
S
E
N
G
A
L
P
Site 9
T59
V
V
S
V
V
R
E
T
E
S
Q
L
L
P
D
Site 10
S98
G
S
M
P
L
K
N
S
F
R
G
T
I
R
K
Site 11
T102
L
K
N
S
F
R
G
T
I
R
K
E
D
V
R
Site 12
T111
R
K
E
D
V
R
A
T
E
K
D
K
V
E
I
Site 13
Y119
E
K
D
K
V
E
I
Y
K
S
F
R
P
G
D
Site 14
S121
D
K
V
E
I
Y
K
S
F
R
P
G
D
I
V
Site 15
Y142
L
G
D
A
Q
S
N
Y
L
L
T
T
A
E
N
Site 16
T177
C
E
M
Q
C
P
K
T
H
T
K
E
F
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation